書籍詳細

II. 歴史

P.7 掲載の参考文献

• 1) Herzenberg, L. A. et al:Fluorescence activated cell sorting. Scientific American, 234:108, 1976.
  pubmed

• 2) Van Dilla, M. A. et al:Cell microfluorometry:A method for rapid fluorescence measurement. Science. 163:1213, 1969.
  pubmed

• 3) Gohde, W.:Automation of cytofluorometry by use of the impulsmicrophotometer. In:Fluorescence technique in cell biology Eds. by Thaer, A. A. and Sernetz, M. Springer, Berlin, P. 79, 1973.

• 4) Nicolini, C. et al:Physical-chemical characterization of living cells by laser-flow microfluorometry. Cancer Treat. Rep. 60:1819, 1976.
  pubmed

• 5) Gohde, et al:Simultarre impulsfluorimetrie des DNS-und proteingehaltes von tumorzellen. Z. Anal, Chem. 252:328, 1970.

• 6) Loken, M. R. et al:Analysis of cell populations with a fluorescence-activated cell sorter. Ann. N. Y. Acad. Sci. 254:163, 1975.
  pubmed

• 7) Stout, R. D. et al:The Fc receptor on thymusderived lymphocytes. I. Detection of a subpopulation of murine T lymphocytes bearing the Fc receptor. J. Exp. Med 142:611, 1975.
  pubmed

• 8) Okumura, K. et al:Specific enrichment of the suppressor T cell bearing I-J determinants. Parallel functional and serological characterizations. J, Exp. Med. 146:1234, 1977.
  pubmed

• 9) 奥村 康・他:FACSとその応用. 感染・炎症・免疫 7:202, 1977.

• 10) Melamed, M. R. et al:Acridine orange metachromasia for characterization of leukocytes in leukemia, lymphoma and other neoplasmas. Cancer. 29:1361, 1972.

• 11) Yataganas, X. et al:Flow-microfluorometric analysis of cell killing with cytotoxic drugs. J. Histochemi. Cytochemi. 22:651, 1974.

• 12) Yataganas, X et al:Evaluation of a feulgentype reaction in suspension using flow microfluorometry and a cell separation technique. Acta Cytol. 19:71, 1975.

• 13) Adams, LR. et al:Machine characterization of human leukocytes by acridine orange fluorescence. Acta Cytol. 15:289, 1971.
  pubmed

• 14) Trujillo, T. T. et al:Adaptation of the fluorescent feulgn reaction to cell in suspension for flow microfluorometry. Acta Cytol. 16:26, 1972.
  pubmed

• 15) Krishan, A.:Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell Biol. 66:188, 1975.
  pubmed

• 16) Lepecq, J. B. et al:A fluorescent complex between ethidium bromide and nucleic acids. J. Mol. Biol. 27:87, 1967.
  pubmed

• 17) Tobey, R. A. et al:Use of flow microfluorometry in detailed analysis of effects of chemical agents on cell cycle progression. Cancer Res. 32:2726, 1972.
  pubmed

• 18) Fried, J. et al:Kinetic response of human leukemic and lymphoma cells in vivo to combination chemotherapy using flow microfluorometry. Cancer Treat. Rep. 60:1937, 1976.
  pubmed

• 19) 御供泰治・他:DNA瞬間自動測定装置およびその応用. 医学のあゆみ 97:863, 1976.

• 20) 太田和雄・他:DNA瞬間自動測定装置. 癌と化学療法 4:179, 1977.
  Medical*Online

• 21) Buchner, T. et al:Accumulation of S-phase cells in the bone marrow of patients with acute leukemia by cytosine arabinoside. Blut. 28:299, 1974.
  pubmed

III. 定義および原理

P.21 掲載の参考文献

• 1) Melamed, M. R. et al(eds) :Flow cytometry and sorting, John Wiley and Sons. Inc., New York, 1979.

• 2) 太田和雄・他:Flow cytometry(FCM) の癌臨床への応用. 癌と化学療法 9:1140, 1982.
  Medical*Online

• 3) 野口義夫:種々のフロー・サイトメーターの現状についての調査. 電子技術総合研究所彙報 44:160, 1980.

• 4) Van Dilla, N. A. et al:Cell microfluorometry :a method for rapid fluorescence measurement. Science 163:1213, 1969.

• 5) Crissman, H. A. et al:Cell cycle analysis in 20 minutes. Science 184:1297, 1974.
  pubmed

• 6) Herzenberg, L. A. et al:Analysis and separation using the fluorescence activated cell sorter(FACS) in Handbook of Experimental Immunology. Weir, D. M. (ed.) pp.22. 1, Blackwell Scientific pub., Oxford, 1978.

• 7) Davies, K. E. et al.:Cloning of a representative genomic library of the human Xchromosome after sorting by flow cytometry. Nature 293:374, 1981.

• 8) 御供泰治・他:DNA瞬間自動測定装置およびその応用. 医学のあゆみ97:863, 1976.

• 9) 太田和雄・他:DNA瞬間自動測定装置. 癌と化学療法4:179, 1977.

• 10) Trujillo, T. T. et al:Adaptation of the fluorescent feulgen reaction to cells in suspension for flow microfluorometry. Acta Cytologica, 16:26, 1972.
  pubmed

• 11) Yataganas, X. et at:Evaluation of a Feulgen type reaction in suspension using flow-microfluorimetry and a cell separation technique. Acta Cytologica. 19:71, 1975.

• 12) Gohde, W. et al:Simultarre impuls-fluorimetric des DNS-und proteingehaltes von tumor Zellen, Z. Anal. Chem. 252:328, 1970.

• 13) Buchner, T. et al:Die Impuls cytophotometrie in der hamatologischen Cytologie. Klin. Wochenschr. 49:1090, 1971.

• 14) Herzenberg, LA. et al:Fluorescence-activated cell sorting. Sci. Am., 234:108, 1976.
  pubmed

• 15) Wheeless, L. L., et al:Slit-scan flow system for automated cytopathology. Acta Cytol., 19:45, 1975.

• 16) Dean, P. (Lawrence Livermore 研究所C. A. U. S. A) :私信

• 17) Salzman, G. C. et al:Cell classification by laser light scattering :Indentification and separation of unstained leukocytes. Acta Cytologica. 19:374, 1975.

• 18) Moldavan, A.:Photo-electric technique for the counting of microscopical cells. Science 80:188, 1934.

• 19) Crossland-Taylor, P. J.:A device for counting small particles suspended in a fluid through a tube. Nature 171:37, 1953.

• 20) Reynolds, O.:An experimental investigation of the circumstances which determine whether the motion of water shall be direct or sinuous, and of the law of resistance in channels. Phil. Trans., 935, 1883.

IV. 試料作製法

P.29 掲載の参考文献

• 1) 高倉公朋:Flow cytometry の臨床的応用. 臨床免疫 11(1) :1, 1979.

• 2) 中井準之助・他:組織培養. 朝倉書店, 東京, 1976.

• 3) Weizsaeker, M. et al:Cytokinetic and cytotoxic effects of antimetabolites on 9L rat brain tumor cell in vitro. Cancer Res. 41:3835, 1981.
  pubmed

• 4) 高本 滋・他:F. M. F. による制癌剤の作用機序に関する研究. 癌と化学療法 5:145, 1978.
  Medical*Online

• 5) 野村和弘・他:脳腫瘍の化学療法に対する flow cytometry分析の応用. 脳と神経 33:341, 1981.

• 6) Shitara, N. et al:Flowcytometric and cytogenetic analysis of human cultured cell lines derived from high and low-grade astrocytomas. Acta Neuropathol. 60:40, 1983.
  pubmed

• 7) Hoshino, T. et al:Clonogenicity of multiple populations of human glioma cells in vitro sorted by DNA content. Cancer 50:997, 1982.
  pubmed

• 8) Darzynkiewicz, Z. et al:Rapid analysis of drug effects on cell cycle. Cytometry 1:279, 1981.
  pubmed

• 9) Deen, D. F. et al:Development of a 9L rat brain tumor cell multicellular spheroid system and its response to BCNU and radiation. JNCI 64:1373, 1980.
  pubmed

P.41 掲載の参考文献

• 1) Takahashi, M.:A multichannel method for the analysis of DNA content distribution using flow cytometric data. Comp. Biomed. Res. 14:506, 1981.

• 2) Fried, J. et al:Quantitative analysis of cell cycle progression of synchronous cells by flow cytometry. Experimental Cell Research 126:63, 1980.
  pubmed

• 3) 渡部郁雄:新しい技法による細胞動態の研究. 遺伝 34:197, 1980.

• 4) 佐藤 博:腹水肝癌語録. 医学と薬学 2:833, 1979.
  Medical*Online

• 5) Brattain, M. G.:Tissue Disaggregation Flow Cytometry and Sorting. John Willey & Sons, New York, 1979.

• 6) 杉田道夫・他:核DNA分析における新しい組織分散法の応用. 癌の臨床28:1530, 1982.

• 7) Wolley, R. C. et al:The Monodisperse Cervical Smear. Analytical and Quantitative Cytology 1:43, 1979.
  pubmed

• 8) Parry, J. S. et al:Ultrasonic Dispersal of Cervical Cell aggregation. Acta Cytol. 15:163, 1971.
  pubmed

• 9) Lopez, P. A. et al:Syringing as a Method of Cell Dispersal. Analytical and Quantitative Cytology 3:235, 1981.
  pubmed

• 10) 塩沢勇治・他:子宮癌細胞診自動化のための検体処理法の検討. 日臨細胞会誌 18:120, 1979.

• 11) 阪口耀子・他:Flow-Cytometryのための組織細胞分散法の確立. 日臨細胞会誌 22:228, 1983.

• 12) Brattain, M. G. et al:Partial purification of human colonic carcinoma cells by sedimentation. Brit. J. Cancer 35:850, 1977.
  pubmed

• 13) Kreisberg, J. I. et al:Separation of proximal tubule cells from suspensions of rat kidney cells in density gradients of Ficoll in tissue culture medium. Am. J. Pathol. 86:591, 1977.
  pubmed

• 14) Willson J. K. V. et al:A method for the separation of lymphocytes and plasma cells from the human palatine tonsil using sedimentation in isokinetic gradient of Ficoll in tissue culture medium. Immunology 28:161, 1977.

• 15) Dow S. H. et al:Separation of cells exhibiting acid phosphatase activity from disaggregated hamster prostate cells in an isokinetic gradient of Ficoll in tissue culture medium. J. Natl. Cancer Inst. 54:147, 1975.

• 16) Aspray, D. W. et al:Separation of epithelial cells from suspensions of cells from the hamster parotid gland in an isokinetic density gradient of Ficoll in tissue culture medium, Anal. Biochem. 66:353, 1975.

• 17) Pretlow, T. P. et al:Purification of malignant cells and lymphocytes from arat transplantable mucinous adenocarcinoma of the colon by isokinetic sedimentation in gradients of Ficoll J. Natl. Cancer Inst. 59:981, 1977.

• 18) Montes De Oca, H. et al:Dispersion and cultivation of Renal cells after Short-Term Storage of kidneys. J. of Clinical Microbiology, 2:243, 1975.

• 19) Bonar, R. A. et al:Carine Urinary Bladder Epithelial Cells:preparation for Cell Culture by Enzyme Dispersion, Urological Research 5:87, 1977.

• 20) Helms, S. R. et al:Separation of cells with histochemically demonstrable acid phosphatase activity from suspensions of human prostatic cells in an isokinetic gradient of Ficoll in tissue culture medium. Am. J. Pathol. 80:79, 1975.

• 21) Helms. S. R. et al:Separation of cells with histochemically demonstrable acid phosphatase activity from suspensions of cells from human prostatic carcinoma in an isokinetic gradient of Ficoll in tissue culture medium. Cancer Research 36:481, 1976.

• 22) Pretlow, T. G. et al:Separation of acinar cells from lactating mammary gland using velocity sedimentation in an isokinetic gradient of Ficoll in tissue culture medium Am. J. pathol. 76:95, 1974.

• 23) Pretlow, T. G. et al:Separation of cells having histochemically demonstrable glucose-6-phosphate from suspensions of hamster kidney cells in an isokinetic density gradient of Ficoll in tissue culture medium. Am. J. Pathol. 94:275, 1974.

• 24) Blachmon, j. et al:Separation of lipase-positive cells from suspensions of pancreas cells in an isokinetic gradient of Ficoll in tissue culture medium. Am. J. Pathol. 72:417, 1973.

• 25) Stewart, M. J. et al:Separation of ascites myeloma cells, lymphocytes and macrophages byzonal centrifugation on an isokinetic gradient. Am. J. Pathol. 68:163, 1972.

• 26) Pretlow, T. G. et al:Separation of lymphocytes and mast cells from the Furth transplantable mast cell tumor in an isokinetic gradient of Ficoll in tissue culture medium. Cancer Res. 37:578, 1977.

• 27) Pretlow, T. G. et al:Pathogenesis of Hodgkins disease. Cancer 31:1120, 1973.
  pubmed

• 28) Willson, J. K. V. Jr. et al:Functional characterization of Cells separated from suspensions of Hodgkins disease tumor cells in an isokinetic gradient. Blood 80:783, 1977.

• 29) Takaoka, T. et al:A simple method for the cultivation of rat liver cells. Jpn J. Exp. Med. 45:317, 1975.
  pubmed

• 30) Huh, N. et al:Establishment of Epithelial cell lines from Rat Glandular Stomachs. Jpn. J. Exp. Med. 47:413, 1977.
  pubmed

• 31) 天神美夫・他:癌性腹膜炎の化学療法への応用と評価. 癌と化学療法 9:1170, 1982.

P.53 掲載の参考文献

• 1) 辻公美・他(分担執筆) :第5部, 免疫細胞, 免疫実験操作A:426, 日本免疫学会編, 1975.

• 2) 加納康彦・他(分担執筆) :血液細胞の分離. 臨床病理 44:55, 1981.

• 3) Krishan, A.:Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell Biol. 66:188, 1975.
  pubmed

• 4) Boyum, A.:Separation of leukocytes from blood and bone marrow. Scand. J. Clin. Lab. Invest., 21 (Suppl.) :97, 1968.

• 5) Pertoft, H. et al:Separation of human monocytes on density gradients of percoll. J. Immunol. Methods, 33:221, 1980.
  pubmed

• 6) 高本滋・他:Percoll gradientによる血液細胞分離の試み-FCM分析を含めて-. 日本血液学会雑誌 46:489, 1983.

• 7) Andreeff, M.:私信

• 8) 山中 学:血液凝固C:血小板機能, 新版, 日本血液学全書13:415, 丸善, 東京, 1979.

• 9) Tanke, H. J. et al:Flow cytometry of human reticulocytes based on RNA fluorescence. Cytometry 1:313, 1980.

• 10) Mendelsohn, M. L. et al:The detection and sorting of rare sickle hemoglobin containing cells in normal human blood. In:Flow Cytometry IV, Laerum, O. D. et al. (eds) . Universitetsforlaget, Bergen-Oslo-Trondheim, 1980・

P.60 掲載の参考文献

• 1) Slocum HK, et al:Characterization of cells obtained by mechanical and enzymatic means from human melanoma, sarcoma, and lung tumors. Cancer Res. 41:1428, 1981.
  pubmed

• 2) Thornthwaite JT, et al:Preparation of tissues for DNA flow cytometric analysis. Cytometry 1:229, 1980.
  pubmed

• 3) Piwnicka M, et al:RNA and DNA content of isolated nuclei measured by multiparmeter flow cytometry. Cytometry 3:269, 1983.
  pubmed

• 4) Uchida A, et at:Natural killar cells in carcinomatous pleural effusions. Cancer Immunol. Immunother. 11:131, 1981.

• 5) Walle A, et al:A simple density gradient for enriching subfractions of solid tumor cells. Cytometry 3:402, 1983.

P.68 掲載の参考文献

• 1) Herman, C. J. et al:Clinical Cytology Specimens for Cancer Detection Flow Cytometry and Sorting, John Wiley & Sons, New York. 1979,

• 2) Braylan R. C.:Flow Cytometry. Arch. Pathol. Lab. Med. 107:1, 1983.
  pubmed

• 3) 阪口耀子・他:Flow-cytometryのための組織細胞分散法の確立. 日臨細胞会誌 22:228, 1983.

• 4) 杉田道夫・他:核DNA分析における新しい組織分散法の応用. 癌の臨床 28:1530, 1982.

• 5) 谷本一夫・他:検体処理及び標本作製に関する検討. 厚生省がん助成金による自動細胞診システムに関する研究班報告書, 昭和51, 52, 53年度, 39, 1979.

• 6) 岸上義彦・他:自動スクリーニングに適した腟スメアの作製法, 特に好中球の除去について. 日臨細胞会誌 20:523, 1981.

• 7) 杉下 匡・他:子宮頸部の境界病変に対するflow-cytometryによる核DNA分析の研究. 日産婦東京会報 28:25, 1979.

• 8) Gieseking, F. et al:Prescreening of Cervical Smears Using Two-Parameter Flow Cytometry. Analytical and Quantitative Cytology 3:299, 1981.
  pubmed

• 9) Matsumura, T. et al:Action of bacterial neutral protease on dispersion of mammalian cells in tissue culture. Jpn J. Exp. Med. 45:383, 1975.
  pubmed

• 10) Huh, N. et al:Establishment of epithelial cell lines from rat glandular stomachs. Jpn J. Exp. Med. 47:413, 1977.
  pubmed

P.79 掲載の参考文献

• 1) Hudson, B, et al:The use of ethidium bromide analogue in the dye-buoyant density procedure for the isolation of closed circular DNA:The variation of the superherix density of mitochondrial DNA. Proc Natl. Acad Sci. USA. 62:813, 1969.
  pubmed

• 2) Lepecq, J. B.:Use of ethidium bromide for separation and determintion of various conformational forms and measurement of thir associated enzymes, Method of Biochemical Analysis, Edited by D GIick. vol 20, Interscience Publishers, New York, 1971, p. 41-86.

• 3) Gohde, W. et al:Simultane Impulsfluorimetrie das DNA-und Proteingehaltes von Tumorzellen. Z. Aal. Chem. 252:328, 1970.

• 4) Protocol#16 Cellular DNA content, RNA removal by Ba(OH) 2, Bio/Physics, System, Inc. Bald win Place Road, Mahopac, New York, 10541.

• 5) Crissman, H. A. et al:Technique for quantitative staining of cellular DNA for flow cytometric analysis. Flow Cytometry and Sorting. Edited by Melamed MR et al., Wiley Medical Publishers, New York, pp.243-261, 1979.

• 6) Vindelov, LL. et al:Flowmicrofluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. Virchows. Arch. Cell Pathol. 23:227, 1977.

• 7) Krishan, A, :Rapid flow cytometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell. Biol. 66:188, 1975.

• 8) Anton, C. M. et al:The fluorescence intensity of propidinm iodide bound to DNA depends on the concentration of sodium chloride. Cytometry 2:24, 1981.

P.92 掲載の参考文献

• 1) Pearse, A. G. E.:Histochemistry, Theoretical and Applied, 3rd ed., vol. 2, Williams and Wilkins, Baltimore, 1186, 1972.

• 2) Zanker, H. V.:Uber den Nachweis definierter reversibler Assoziate des Acridinorange durch Absorption und Fluoreszenzmessungen in Wassriger Losung. Z. phys. Chem., 199:225, 1952.

• 3) Rigler, R. Jr.:Microfluorometric characterization of intracellular nucleic acids and nucleoproteins by acridine orange. Acta Physiol. Scand., 67 (suppl) :267, 1966.

• 4) Darzynkiewicz, Z.:Acridine orange as a molecular probe in studies of nucleic acids in situ. Flow Cytometry and Sorting, John Wiley, New York, 285, 1979.

• 5) Darzynkiewicz, Z, et al:Conformation of RNA in situ as studied by acridine orange staining and automated cytofluorometry. Exp. Cell Res., 95:143, 1975.
  pubmed

• 6) Traganos, F, et al:Simultaneous staining of ribonucleic alld deoxyribonucleic acids in unfixed cells using acridine orange in a flow cytofluorometric system. J. Histochem. Cyrtochem. 25:46, 1977.

• 7) Piwnicka, M, et al:RNA and DNA content of isolated cell nuclei measured by multiparameter How cytometry. Cytometry 3:269, 1983.
  pubmed

• 8) Melamed, M, R, et al:Acridine orange as a quantitative cytochemical probe for now cytometry. Histochemistry:The Widening Horizons, John Wiley & Sons, 237, 1981.

• 9) Darzynkiewicz, Z, et al:New cell cycle compartments identified by multiparameter How cytometry. Cytometry 1:98, 1980.
  pubmed

• 10) Darzynkiewicz, Z, et al:Different sensitivity of DNA in situ in interphase and metaphase chromatin to heat denaturation. J. Cell Biol. 73:128, 1977.
  pubmed

• 11) Darzynkiewicz, Z, et al:Interphase and metaphase chromatin. Different stainability of DNA with acridine orange after treatment at low pH. Exp. Cell Res., 110:201, 1977.

• 12) Narin, R. C.:Fluorescent Protein Tracing 3rd ed. Williams & Wilkins, Baltimore, 503, 1969.

• 13) Freeman, D, A, et al:Evaluation of six flourescent protein stains for use in flow microfluorometry. Stain Technol., 50:279, 1975.

• 14) Crissman, H, A, et al:Rapid staining methods for analysis of deoxyribonucleic acid and protein in mammalian cells. J. Histochem. Cytochem., 24:64, 1976.

• 15) Steinkamp J, A, et al:Automated analysis of Deoxyribonucleic acid, protein and nuclear to cytoplasmic relationships in tumor cells and gynecologic specimens. J. Histochem. Cytochem., 22:616, 1974.
  pubmed

• 16) 西谷厳・他:Flow cytometry-Computer連動による子宮癌細胞のMultiparameter解析. 癌と化学療法 9:1164, 1982,

P.100 掲載の参考文献

• 1) Waring, M.:Variations of the supercoils in closed circular DNA by binding of antibiotics and drugs:Evidence for molecular models involving lntercalation. J. Mol. Biol. 54:247-279, 1970.
  pubmed

• 2) Ward DC et al:Base specificity in the interaction of polynucleotides with antibiotic drugs. Science 149:1259-1263, 1965.
  pubmed

• 3) Crissman, H. A. et al:Cell cycle analysis in 20 minutes. Science 184:1297-198, 1974.
  pubmed

• 4) Crissman, H. A. et al:Rapid staining methods for analysis of deoxyribonucleic acid and protein in mammalian cells. J. Histochem. Cytochem. 24:64-71, 1976.

• 5) Crissman, H. A. et al:Techniques for quantitative staining of cellular DNA for flow cytometric analysis. in(Melamed MR et al. ed.) Flow Cytochem and Sorting. Wiley Medical Publishers, New York, 1979. pp.243-261.

• 6) Kersten, W. et al:physicochemical properties of complexes between deoxyribonucleic acid and antibiotics which affect ribonucleic acid synthesis(actinomycin, daunomycin. cinerubin. nogalamycin, chromomycin, mithramycin, olovomycin) . Biochemistry 5:236-244, 1966.

• 7) Swartzendruber, D. E.:Microfluorometric analysis of cellular DNA following incorporation of bromodeoxyuridine. J. Cell. Physiol. 90:445-454, 1977.
  pubmed

• 8) Swartzendruber. D. E:A bromodeoxyuridine-mithramycin technique for detecting cycling and noncycling cells by flow microfluorometry. Exp. Cell Res. 109:439-443, 1977,
  pubmed

• 9) Latt, S. A.:Microfluorometric detection of deoxyribnucleic acid replication in human metaphase chromosomes. Proc. Natl. Acad. Sci. USA 170:3395-3399, 1973.

• 10) Latt, S. A. et al.:Spectral studies on 33258 Hoechst and related bisbenzimidazole dyes for fluorescent detection of deoxyribonucleic acid synthesis. J. Histochem. Cytochem. 24:24-33, 1976.
  pubmed

P.108 掲載の参考文献

• 1) Loewe, H, et al:Basisch substituerte 2, 6-bis-benzimidazol-derivate, eine neue chemotherapeutisch active korperklasse. Arzneim. Forsch. 24:1927, 1974.

• 2) Latt, S. A.:Microfluorometric detection of deoxyribonucleic acid in human metaphase chromosomes. Proc. Natl. Acad. Sci. USA 70:3395, 1973.
  pubmed

• 3) Weisblum, B, , et al:Fluorometric properties of the bis-benzimidazole derivative Hoechst 33258, a fluorescent probe specific for AT concentration in chromosomal DNA. Chromosoma 46:225, 1974.

• 4) Latt, S. A., et al:Optical studies of the interaction of 33258 Hoechst with DNA, chromatin and metaphase chromosomes. Chromosoma 52:297, 1975.
  pubmed

• 5) Bontemps, J., et al:Physico-chemical stuby of the complexes of"33258 Hoechst"with DNA and nucleohistone. Nucl Acids Res. 2:971, 1975.

• 6) Comings, D. E., Mechanim of chromosome banding. VIII. Hoechst 33258-DNA interaction. Chromosoma 52:229, 1975.

• 7) Arndt-Jovin, D. J., et al:Analysis and sorting of living cells according to deoxyribonucleic acid content. J. Histochem Cytochem. 25:585, 1977.

• 8) Pallavicini, M. G., et al:Cell cycle distribution of chronically hypoxic cells and determination of the clonogenic potential of cells accumlated in G2+M phases after irradiation of a solid tumor in vivo. Cancer Res. 39:1891, 1979.

• 9) Hoshino, T., et al:Clonogenicity of multiple populations of human glioma cells sorted by DNA content. Cancer 50:997, 1982.
  pubmed

• 10) Latt, S. A., :Detection of DNA synthesis in interphase nuclei by fluorescence microscopy. J. Cell Biol. 62:546, 1974.
  pubmed

• 11) Perry, P., et al:New Giemsa method for the differential staining of sister chromatids. Nature 251:156, 1974.
  pubmed

• 12) Kim, M. A., :Chromatid exchange and heterochromatin alteration of human chromosomes with BUdR-labelling demonstrated by bellzilnidazol fluorochrome and Giemsa stain. Humangetik 25:179, 1974
  pubmed

• 13) Park, C. H., et al:Superiority of DAPI over Hoechst 33342 for viable cell sorting. 7th Cell Kinetic Society Meeting, Baltimore MD, March, 1983.

P.120 掲載の参考文献

• 1) Coons, A. H. et al:The demonstration of pneumococcal antigen in tissues by the use of fluorescent antibody. J. Immunol., 45:159, 1942・

• 2) Riggs, J. L. et al:Isothiocyanate compounds as fluorescent labeling agents for immune serum. J. Clinic. Path., 34:1081, 1958.

• 3) Hiramoto, R. et al:Tetramethyl rhodamine as an immunohistochemical fluorescent label in the study of chronic thyroiditis. Proc. Soc. Med., 97:611, 1958.

• 4) Shapiro, H. M. et al:Multistation multiparameter flow cytometry:a critical review and rationale, Cytometry 3:227, 1983.
  pubmed

• 5) Sidney, U.:Fluorescent assay in biology and medicine. In:Molecular Biology, Bernard, H. et al. (eds) Academic Press, London, 1969.

• 6) Butcher, E. C.:Direct fluorescent labeling of cells with fluorescein or rhodamine isothiocyanate. l. technical aspect. J. Immunol. Meth., 37:97, 1980.

• 7) Steinkamp, J. A.:Quantitation of lectin binding by cells. In:Flow Cytemetry and Sorting, Melamed, MR. et al. (eds) p. 497, John Wiley and Sons, New York, 1979.

• 8) Blackledge, G. et al:Flow cytometric analysis of lectin binding to human peripheral blood lymphocyte. Biochem. J., 203:69, 1982.

• 9) Murphy, R. F. et al:Flow cytofluorometric analysis of insulin binding and internalization by Swiss 3T3 cells. Cytometry 2:402, 1982・

• 10) Reinherz, E. L et al:A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J. Immnnol., 123:1312, 1979.

• 11) Reinherz E. L. et al:the differentiation and function of human T lymphocytes. Cell 19:821, 1980.

• 12) Ip, S. H. et al:Rapid enumeration of T lymphocytes by a flow cytometric immunofluorescence method. Clin. Chem., 28:1905, 1982.
  pubmed

• 13) Yoshida J. et al:Human glioma associated and related antigens identified by monoclonal antibodies. Neurosurg. Rev., (in press) .

• 14) Hoffman, R. A. et al:Immunofluorescent analysis of blood cells by flow cytometry. Int. J. Immunopharmac., 3:249, 1981.

• 15) Crissman, H. A. et al:Simultaneous measurement of DNA, protein, and cell volume in single cells from large mammalian cell populations. J. Cell. Biol., 59:766, 1973.
  pubmed

• 16) Roti Roti, J. L. et al:Cell cycle position and nuclear protein content. Cytometry 3:91, 1982.
  pubmed

• 17) Loken, M. R. et al.:Lymphoid cell analysis and sorting. In:Flow Cytometry and Sorting, Melamed, M. R. et al. (eds) p. 505, John Wiley & Sons, New York, 1979.

• 18) Crissman, H. A. et al:Rapid one step staining procedures for analysis of cellular DNA and protein by single and dual laser flow cytometry. Cytometry 3:84, 1982.
  pubmed

• 19) Gray, J. W. et al:High resolution chromosome analysis:one and two parameter flow cytometry. Chromosoma 73:9, 1979.

• 20) 浜島義博・他:螢光抗体法・酵素抗体法. 医学書院, 1978.

• 21) 八木国夫・他:螢光(理論, 測定, 応用) . 南江堂, 1958.

• 22) 青木重久・他:螢光標識抗原および抗体を用いた組織化学的方法に関する研究とくに螢光色素について. 感光色素 64:1, 1961.

P.129 掲載の参考文献

• 1) Fulwyler, M. J.:Standards for flow cytometry. In:Flow cytometry and sorting(M. R. Melamed, et al. eds.) pp.351, John Wiley and Sons. Inc., New York. 1979.

• 2) Herzenberg, L. A. et al:Analysis and separation using the fluorescence activated cell sorter(FACS) . In:Handbook of experimental immunology, Weir, D. M. (ed) . pp.221, Blackwell Scientific Publications, Oxford, 1978.

• 3) Dow Diagnostics, P. O. Box 68511, Indianapolis, IN 46268, U. S. A.

• 4) Polysciences, Inc., Paul Valley Industrial Park, Warrington, PA 18976, U. S. A.

• 5) Duke Standards Co., 445 Sherman Ave., Palo Alto, CA 94306, U. S. A.

• 6) Coulter Electronics, Inc., 590 W. 20th Street Hialeah, FL 33010, U. S. A.

• 7) Cram, LS. et al:Flow microfluorometric DNA content measurements of tissue culture cells and peripheral lymphocytes. Human Genet., 37:201, 1977.
  pubmed

• 8) Schackney, S. E. et al:The T-lymphocytes as a diploid reference standard for flow cytometry. Cancer Res., 39:4418, 1979.

• 9) Barlogie, B. et al:Flow cytometric analysis of DNA content for ploidy determination in human solid tumors. J. Histochem, Cytochem., 27:505, 1979.
  pubmed

• 10) Noguchi, P. D. et al:The use of chicken erythrocyte nuclei as a biological standard for flow microfluorometry. J. Histochem. Cytochem., 26:761, 1978.
  pubmed

• 11) Tannenbaum, E. et al:Measurement of cellular DNA mass by flow microfluorometry with use of a biological internal standard. J. Histochem. Cytochem., 26:145, 1978.

• 12) Particle Information Service, 600 South Springer Road, Los Altos, CA 94022, U. S. A.

• 13) Andreeff, M. et al:Discrimination of human leukemia subtypes by flow cytometric analysis of cealysis of cellular DNA and RNA. Blood 55:282, 1980.
  pubmed

• 14) Barlogie, B. et al :Correlation of DNA distribution abnormalities with cytogenetic findings in human adult leukemia and lymphoma. Cancer Res., 37:4400, 1977.
  pubmed

• 15) Vindelov, L. L. et al:Clonal heterogeneity of small cell anaplastic carcinoma of the lung demonstrated by flow cytometric DNA analysis. Cancer Res., 40:4295, 1980.
  pubmed

• 16) Hoshino, T. et al:The distribution of nuclear DNA from human braintumor cells. J. Neurosurg., 49:13, 1978.

• 17) Vindelov, L. L. et al:Standardization of high-resolution flow cytometric DNA analysis by the simultaneous use of chicken and trout red blood cells as internal reference standards. Cytometry 3:328, 1983.
  pubmed

• 18) 高本 滋・他:FCMのための標準試料に関する研究. 第1回 FCM&Cell Biology 研究会発表, 7月2日. 1983.

V. セル・ソーティング

P.139 掲載の参考文献

• 1) Sweet, R. G.:High frequency recording with electrostatically deflected ink jet. Rev. Sci. Inst. 36:131, 1965.

• 2) Sweet, R. G.:Flow sorters for biologic cells. in Melamed MR, Mullaney PF, Mendelsohn ML(ed.) "Flow Cytometry and Sorting"Wiley & Son, New York, pp.177-189, 1979.

VI. 応用

P.156 掲載の参考文献

• 1) Fox R. et al:Synovial fluid lymphocytes differ from peripheral blood lymphocytes in patients with rheumatoid arthritis. J. Immunol. 128:351, 1982.
  pubmed

• 2) Bonnyns M. et al:Heterogeniety of immunoregulatory T cells in human thyroid autoimmunity:influence of thyroid status. Clin. Exp. Immunol. 521:629, 1983.

• 3) Skolnik P. et al:Monoclonal antibody analysis of blood T-cell subsets in myasthenia gravis. Ann Neurol. 11:170, 1981.

• 4) Smolen JS. et al:Heterogeneity of immunoregulatory T cell subsets in systemic lupus erythematosus. Am. J. Med. 72:783, 1982.
  pubmed

• 5) Morimoto C. et al:Characteristics of anti-T cell antibodies in SLE:evidence for serective reactivity with normal suppressor cells defined by monoclonal antibodies, J. Clin. Immunol. Immunopthol. 16:474, 1980,

P.162 掲載の参考文献

• 1) Bernengo MG, et al:T-cell subsets in melanoma patients evaluated by anti-T-cell monoclonal antibodies. Thymus 5:223, 1983.
  pubmed

• 2) Blanca I, et al:Immunolgy of human gastric cancer. A preliminary report. Cancer 49:1810, 1982.

• 3) Bolton PM, et al:Cellular immunity in cancer:Comparison of delayed hypersensitivity skin tests in three common cancers. Brit. Med. J. 3:18, 1975.
  pubmed

• 4) Karavodin LM, et al:T lymphocyte subsets in patients with malignant melanoma. Cancer. Immunol. Immunother. 11:251, 1981.

• 5) 小島 治・他:胃癌患者における末梢リンパ球数測定の臨床的意義, 細胞性免疫能 および, 胃癌の進行度, 予後との相関. J. Jap. Soc, Cancer. Ther. 15:828. 1980.

• 6) Lala PK, et al:An analysis of T lymphocyte subsets in tumor-transplanted mice on the basis of Lyt antigenic markers anu functions. Immunology. 47:663, 1982.

• 7) Ledbetter JA, et al:Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulation in mouse and man. J. Exp. med. 153:310, 1981.

• 8) McCluskey DR, et al:T lymphocyte subsets in the peripherol blood of patients with benign and malignant breast disease. Brit. J. Cancer. 47:307, 1983.

• 9) Orita K, et al:Preoperative cell-mediated immune status of gastric cancer patients. Cancer 38:2343, 1976.
  pubmed

• 10) Reinherz EL, et al:Regulation of the immune response-inducer and suppressor T-lymphocyte subsets in human beings. N. Engl. J. med. 303:370, 1980.
  pubmed

• 11) Stahl RE, et al:Immunologic abnormalities in homosexual men. Relationship to Kaposi's sarcoma. Am. J. med. 73:171, 1982.
  pubmed

• 12) 渡辺卓・他:胃癌患者における末梢血Tリンパ球サブセットの解析. 日本癌学会総会記事:147, 1983.

P.185 掲載の参考文献

• 1) Van Dilla, M. A., et al:Cell microfluorometry:a method for rapid fluorescence measurement. Science(Wash. D. C.) 163:1213, 1968.

• 2) Crissman, H. A., et al:Cell cycle analysis in 20 minutes. Science(Wash. D. C.) , 184:1297, 1974.

• 3) 太田和雄・他:DNA瞬間自動測定装置. 癌と化学療法4:179, 1977.

• 4) Herzenberg, L. A., et al:Fluorescence-activated cell sorting. Sci. Am., 234 :108, 1976.
  pubmed

• 5) Herzenberg, L. A., et al:Analysis and separation using the fluorescence activated cell sorter(FACS) . In Weir, D. M. (ed.) . Handbook of Experimental Immullology. pp.22. 1. Blackwell Scientific Pub., Oxford, 1978.

• 6) Kohler, G., et al:Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495. 1975.
  pubmed

• 7) Ueda, R., et al:Serological analysis of cell surface antigens of null cell acute lymphoblastic leukemia by mouse monoclonal antibodies. Proc. Natl. Acad. Sci., 79:4386, 1982.

• 8) Levy, R., et al:A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies. Proc. Natl. Acad. Sci., 76:6552, 1979.

• 9) Ritz, J., et al:A monoclonal antibody to human acute lymphoblastic leukemia antigen. Nature 283:583, 1980.

• 10) Kersey, J. H., et al:p. 24:A human leukemia-associated and lymphohemopoietic progenitor cell surface structure identified with monoclonal antibody. J. Exp. Med., 153:726, 1981.
  pubmed

• 11) Deng, C-T., et al:Monoclonal antibody specific for human T acute lymphoblastic leukemia. Lancet 1:10, 1982.

• 12) Koprowski, H., et al:Study of antibodies against human melanoma produced by somatic cell hybrids. Proc. Natl. Acad. Sci., 75:3405, 1978.
  pubmed

• 13) Dippold, W. G., et al:Cell surface antigens of human malignant melanoma:Definition of six antigenic systems with mouse monoclonal antibodies. Proc. Natl. Acad. Sci., 77:6114, 1980.
  pubmed

• 14) Imai, K., et al:Characterization of monoclonal antibodies to human melanoma-associated antigens. J. Natl. Cancer lnst., 66:489, 1981.

• 15) Herlyn, M., et al:Colorectal carcinoma-specific antigen:Detection by means of monoclonal antibodies. Proc. Natl. Acad. Sci., 76:1438, 1979.
  pubmed

• 16) Sears, H. F., et al:Phase-I clinical trial of monoclonal antibody in treatment of gastrointestinal tumours. Lancet 1:762, 1982.
  pubmed

• 17) Miller R. A., et al:In vivo effects of murine hybridoma monoclonal antibody in a patient with T cell leukemia. Blood 58:78, 1981.

• 18) Ritz, J., et al:Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma. Blood 59:1, 1982.
  pubmed

• 19) 高本 滋・他:Flow cytometry(FCM) によるモノクローナル抗体を用いた白血病の細胞表面抗原の解析およびその応用. 癌と化学療法 9:1191, 1982.

• 20) Kamoun, M., et al:A novel human T cell antigen preferentially expressed on mature T cells and shared by both well and poorly differentiated B cell leukemias and lymphomas. J. Immunol., 127:987, 1981.

• 21) Ritz, J., et al:Modulation of human acute lymphoblastic leukemia antigen induced by monoclonal antibody in vitro. J. Immunol., 125:1506, 1980.
  pubmed

• 22) Benett, J. M., et al:Proposals for the classification of the acute leukemias. Brit. J. Haemat., 33:451, 1976.

• 23) Greaves, M. F., et al:Antisera to acute lymphoblastic leukemia cells. Clin. Immunol. Immunopathol., 4:67, 1975.
  pubmed

• 24) 上田龍三・他:白血病細胞の解析, -特にNull-ALL関連抗原を中心にして . 臨床免疫 14〔Suppl, b〕 :182, 1982.

• 25) 上田龍三:急性白血病亜分類とモノクローナル抗体. 癌と化学療法 10:559, 1983.
  Medical*Online

• 26) Kennet. R. H., et al:Hybrid myelomas producing antibodies against a human neuroblastoma antigen present on fetal brain. Science 203:1120, 1979.

• 27) Jones, N. H., et al:Characteristics and distribution of a 24000 dalton antigen defined by a monoclonal antibody generated to common acute lymphoblastic leukemia cells. In:Advances in Comparative Leukemia Research 1981, Yohn, D. S., et al(eds) :pp.517, Elsevier North-Holland, Amsterdam, 1982.

• 28) Namikawa, R, et al:Serological analysis of cell surface antigens of HL-60cells before and after treatment with a phorbol ester tumor promotor. Leukemia Res., 7:375, 1983.

• 29) 並川玲子・他:モノクローナル抗体の白血病診断への応用 -顆粒球-単球系を中心として . 臨床科学 19:268, 1983.

• 30) 高本滋・他:Flow cytometry(FCM) による, 顆粒球-単球系細胞に反応を示すモノクローナル抗体の血清学的解析. 第42回日本癌学会総会記事. 154, 1983.

• 31) Uchiyama, T., et al:A monoclonal antibody(anti-Tac) reactive with activated and functionally mature human T cells. J. Immunol., 126:1393, 1981.

• 32) Hinuma, Y., et al:Adult T cell leukemia:Antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc. Natl. Acad. Sci., 78:6476, 1981.

• 33) Hattori, T., et al:Surface phenotype of Japanese adult T cell leukemia cells characterized by monoclonal antibodies. Blood 58:645, 1981.
  pubmed

• 34) 淀井清司・他:IL-2レセプター, 成人T細胞白血病(ATL) における異常発現-. 医学のあゆみ 126:387, 1983.

• 35) Tsudo, M, et al:Failure of regulation of Tac antigen/TCGF receptor on adult T cell leukemia cells by anti-Tac monoclonal antibody. Blood 1983 (in press)

• 36) 西田敬子・他:成人T細胞白血病(ATL) 関連抗原に対するモノクローナル抗体の作製とその解析. 第42回日本癌学会総会記事. 100, 1983.

• 37) Cossman, J., et al :Polymorphonuclear neutrophils express the common acute lymphoblastic leukemia antigen. J. Exp. Med., 157:1064, 1983.
  pubmed

• 38) Metzgar, R. S., et al:Distribution of common acute lymphoblastic leukemia antigen in nonhematopoietic tissues. J. Exp. Med., 154:1249, 1981.
  pubmed

• 39) Korsmeyer, S. J., et al:Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc. Natl. Acad. Sci., 78:7096, 1981.

• 40) Brown. S., et al:Immunoglobulin secretion by mouse X human hybridomas:an approach for the production of anti-idiotype reagents useful in monitoring patients with B cell lymphoma. J. Immunol., 126:1037, 1980.

P.200 掲載の参考文献

• 1) 上村伯人・他:末梢白血球Cytofluorogramによる造血器腫瘍の診断と治療への応用-特に悪性リンパ腫におけるその有用性. 癌と化学療法9(7) :1285, 1982.

• 2) 福井谷祐一・他:Flow cytometryの悪性リンパ腫の診断と治療への応用. 臨床血液 24(4) :390, 1983.

• 3) Miller, D. G.:Immunologic aspects of lymphoproliferative disease. "Lymphoproliferative blisease"Mollander, D. W. (ed) , Charles C. Thomas Publisher, Springfield, Illinois, pp.37-80, 1975.

• 4) Jones, S. E. et al:Blood. 49:335, 1977.
  pubmed

• 5) 糸山進次・他:悪性リンパ腫細胞の末梢血液中出現について. 日病会誌69:299, 1980.

• 6) Ligler, FS, et al:An immunologic approach for the detection of tumor cells in the peripheral blood of patients with malignant lymphoma:implication for the diagnosis of minimal disease. The Journal of Immunology. 123(3) 1123, 1979.
  pubmed

• 7) 糸賀 敬:白血性悪性リンパ腫. 内科 41(3) :418, 1978.

P.209 掲載の参考文献

• 1) Schwartz, F. G.:The development in the hunan liver of multiple deoxyribose nucleic acid(DNA) classes and their relationship to the age of the individual. Chromosoma 8:53, 1956.

• 2) Johnson, H. A. et al:A radioautographic study of a human brain and glioblastoma multiforme after in vivo uptake of tritiated thymldine. Cancer 13:636, 1960.
  pubmed

• 3) Hoshino. T. et al:Cell kinetics of human gliomas. J. Neurosurg. 37:15, 1972.
  pubmed

• 4) Scholtz, F. J.:Presented at the 52nd annual meeting of American association of neuropathologist, June 11-13, 1976. San Francisco. Calif, 1976.

• 5) Hoshino, T. et al:Differences in brain nuclear DNA as determined by flow cytometry. Neurologia Medico-chirurgica 7:87, 1977.

• 6) Kato, T. et al:Isolation of cell nuclei from the mammalian cerebral cortex and their assortment on a morphological basis. J. Cell Bilo. 32:649, 1967.

• 7) Hoshimo, T. et al:Flow cytometry of isolated nuclei prepared from 9L rat brain tumor. Laboratory Investigation. 41:72, 1979.

• 8) Moore, K. L. et al:Morphology of the nerve cell nucleus in mammals, with special reference to the sex chromatin. J. Comp Newrol. 98:213, 1953.

• 9) Agrell, I. et al:Cytochemical studies on DNA-complexes during cell multiplication and cell differentiation. Comp. Biochem 2. Physiol. 22:189, 1967.

• 10) Anderson, GK.:A study of DNA depolymerisation during feulgen acid hydrolysis. Histochemistry 43:123, 1975.

• 11) Gray, J. W. et al:High-speed quantitive karyotyping by flow microfluorometry. Clin. Chem. 21:1258, 1975.
  pubmed

• 12) Blinkov, S. M. et al:The human brain in figures and tables. New York, plenum Press, 1968.

P.224 掲載の参考文献

• 1) Hayflick, L. and Moorhead, P. S.:The serial cultivation of human diploid cell strains. Exp. Cell Res. 25:585-621, 1961.
  pubmed

• 2) Hayflick, L.:The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:614-636, 1965.
  pubmed

• 3) Cristofalo, V. J. and Stanulis-Praeger, B. M.:Cellular senescence in vitro. in Advances in Cell Culture vol. 2, (Maramorosch, K. ed.) . 1982, pp.1-68, Academic Press, New York.

• 4) Hayflick, L.:Cell aging. in Annal Review of Gerontology and Geriatrics, vol. 1(Eisdorfer, C. ed.) 1980. pp.26-67, Springer Publishing Co.

• 5) Matsumura, T., Zerrudo, Z. and Hayflick, L.:Senescent human diploid cells in culture:Survival, DNA synthesis and morphology. J. Geront. 34:328-334, 1979.
  pubmed

• 6) Kaji, K. and Matsuo, M.:Aging of chick embryo fibroblasts in vitro. III. Polyploid cell accumulation. Exp. Cell Res. 119:231-236, 1979.
  pubmed

• 7) Kaji, K. and Matsuo, M.:Aging of chink embryo fibroblast in vitro. V. Time course studies on polyploid nucleus accumulation. Exp. Cell Res. 131:410-412, 1981.

• 8) Yanishevsky, R. and Carrano, A. V.:Prematurely condensed chromosomes of dividing and non-dividing cells in aging human cell cultures. Exp. Cell Res. 90:169-174, 1975.
  pubmed

• 9) Kali, K. and Matsuo, M.:Aging of chick embryo fibroblast in vitro-I. Saturation density and population doubling rate. Exp. Geront. 13:439-445, 1978.

• 10) Matsuo, M. and Kaji, K.:Aging of chick embryo fibroblast in vitro-VI. Different aging patterns of population doubling rate and polyploidization. Exp. Geront., 16:25-30, 1981.

• 11) Matsuo, M., Kaji, K., Utakoji, T. and Hosoda, K.:Ploidy of human embryonic fibroblasts during in vitro. Aging. 37:33-37, 1982.
  pubmed

• 12) Thompson, K. V. A. and Holliday, R.:Chromosome changes during the in vitro aaging of MRC-5 human fibroblasts. Exp. Cell Res. 96:1-6, 1975.

• 13) Mitsui, Y. and Schneider, E. L.:Increased nuclear sizes in senescent human diploid fibroblasts cultures. Exp. Cell Res. 100:147-152, 1976.
  pubmed

• 14) Lee, S. -C., Bemilller, P. M., Bemiller, J. N. and Pappelis, T. J.:Nuclear area changes in senescing human diploid fibroblasts. Mech. Age. Develop. 7:417-424, 1978.

• 15) Miller, R. C., Nichols, W. W., Pottash, J. and Aronson, M. M.:In vitro aging:Cytogenetic comparison diploid human fibroblast and epithelioid cell lines. Exp. Cell Res. 110:63-73, 1977.
  pubmed

• 16) Schneider, E. L. and Fowlkes, B. J.:Measurement of DNA content and cell volume in senescent human fibroblasts utilizing flow multiparameter single cell analysis. Exp. Cell Res. 98:298-302, 1976.
  pubmed

• 17) Reis, R. J. and Goldstein, S.:Loss of reiterated DNA sequences during serial passage of human diploid fibroblasts. Cell:21:739-749, 1980.

• 18) Todaro, G. J. and Green, H.:Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 17:299-313, 1963.

• 19) Shima, A. and Sugahara, T.:Age-dependent ploidy class changes in mouse hepatocyte nuclei as revealed by feulgen-DNA cytofluorometry. Exp. Geront. 11:193-203, 1976.

• 20) Thompson, K. V. A. and Holliday, R.:The longevity of diploid and polyploid human fibroblasts:Evidence against the somatic mutation theory of cellular ageing. Exp. Cell Res. 112:281-287, 1978.
  pubmed

P.239 掲載の参考文献

• 1) Buchner, T. et al :Die Impulscytophotometrie in der hamatologischen Cytologie. Klin. Wochenschr, 49:1090, 1971.

• 2) Adams, L. R. et al:Machine characterization of human leukocytes by acridine orange fluorescence. Acta Cytol. 15:289, 1971.
  pubmed

• 3) Kaplow, L. S.:Leukocyte peroxidase and nonspeciffic esterase. In:Flow cytometry and Sorting, Melamed, M. R., Mullaney, P. F., Mendelsohn, M. L. (eds) . John. Wiley and Sons, New York, 1979, p. 531.

• 4) Tanke, H. J. et al:Flow cytometry of human reticulocytes based on RNA fluorescence. Cytometry 1:313, 1980.

• 5) Mendelsohn, M. L. et al:The detection and sorting of rare sickle-hemoglobin containimg cells in normal human blood. In:Flow Cytometry IV, Laerum, O. D., Lindmo, T., Thorud, E. (eds.) . Universitetsforlaget, Bergen-Oslo-Trondheim, 1980, p. 311.

• 6) Howard, R. J. et al:Plasmodium-infacted blood cells analyzed and sorted by flow fluorimetry with the deoxyribonucleic acid binding dye 33258 Hoechst. J. Histochem. Cytochem 27:803, 1979.
  pubmed

• 7) van den Engh, G. et al:Concentration of hemopoietic stem cells using a light-activated cell sorter. Blood Cells, 6:609, 1980.
  pubmed

• 8) Grogan, W. M. et al:Applications of light scatter to separation of stem cells. Blood Cells, 6:625, 1980.
  pubmed

• 9) Bassφe, C-F. et al:Quantitation of single cell phagocytic capacity by flow cytometry. In:Flow Cytometry IV, Laerum, O. D., Lindmo, T., Thorud, E. (eds) Universitetsforlaget, Bergen-Oslo, Trondheim, 1980, p. 170.

• 10) Nakeff, A.:Flow cytometric analysis of megakaryocytopoiesis:Strategy for defining mitotic and endoreduplicative events in the committed progenitor compartment. Blood cells, 6:665, 1980.
  pubmed

• 11) Barlogie, B. et al:Determination of ploidy and proliferative characteristics of human solid tumors by pulse cytophotometry. Cancer Res., 38:3333, 1978.
  pubmed

• 12) Carrano, A. V. et al:Flow cytogenetics:A new approach to chromosome analysis in "Flow cytometry and sorting"pp.421, John Wiley and Sons. New York, 1979.

• 13) Vindelov, L. L. et al:Clonal heterogeneity of small-sell anaplastic carcipoma of the lung demonstrated by flow-cytometric DNA analysis. Cancer Res., 40:4295, 1980.

• 14) Moore, M. A. S. et al:Agar Culture studies in 127 cases of untreated acute leukemia:The prognostic value of reclassification of leukemia according to in vitro growth characteristics. Blood 44:1, 1974.

• 15) Sandberg, A. A. et al:Chromosomes and causation of human cancer and leukemia. V. Karyotype aspects of acute leukemia. Cancer 22:1268, 1968.
  pubmed

• 16) Trujillo, J. M. et al:clinical implications of aneuploid cytogenetic profiles in adult acute leukemia. Cancer 33:824, 1974.
  pubmed

• 17) Zuelzer, W. W. et al:Long term cytogenetic studies in acute leukemia of children:The nature of relapse. Am. J. Hematol., 1:143, 1976.
  pubmed

• 18) Barlogie, B. et al:Correlation of DNA distribution abnormalities with cytogenetic findings in human adult leukemia and lymphoma. Cancer Res., 37:4400, 1977.
  pubmed

• 19) Andreeff, M. et al:Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA. Blood 55:282, 1980.
  pubmed

• 20) Andreeff, M. 私信

• 21) Diamond, L. W. et al:Flow cytometry in the diagnosis and classification of malignant lymphoma and leukemia. Cancer 50:1122, 1982.
  pubmed

• 22) Bloomfield, C. D. et al:Nonrandom Chromosome abnormalities in lymphoma. Cancer Res., 43:2975, 1983.
  pubmed

• 23) Shackney, S. E. et al:Dual parameter flow cytometry studies in human lymphomas. J. Clin. Invest., 66:1281, 1980.
  pubmed

• 24) Drewinko, B. et al:Effects of chemotherapy on the labeling index of myeloma cells. Cancer 34:526, 1980.

• 25) Sandberg A. A.:The chromosomes in human cancer and leukemia. vol. 15, pp.416 Elsevier. New York, 1980.

• 26) Latreille, J. et al:Cellular DNA content as a marker of human multiple myeloma. Blood 55:403, 1980.
  pubmed

• 27) Latreille, J. et al:Ploidy and proliferative characteristics in monoclonal gammopathies. Blood, 59:43, 1982.
  pubmed

• 28) Bunn, Jr., P. A. et al:Flow cytometric analysis of DNA content of bone marrow cells in patients with plasma cell myeloma:Clinical implications. Blood 59:528, 1982.

• 29) Lewensohn, R. et al:DNA content of human myeloma cells. Eur. J. Cancer Clin. Oncol., 19:59, 1983.

• 30) Braylan, R. C. et al:Flow analysis of hairy cell leukemia. Leukemia Res., 4:177, 1980.
  pubmed

• 31) Bunn, Jr., P. A. et al:DNA content analysis by flow cytometry and cytogenetic analysis in mycosis fungoides and Sezary syndrome. J. Clin. Invest., 65:1440, 1980.

• 32) Rosenthal, S. et al:Blast crisis of chronic granulocytic leukemia. Morphologic variants and therapeutic implications. Am. J. Med., 63:542, 1977.
  pubmed

• 33) Brodeur, G. M. et al:Near-haploid acute lymphoblastic leukemia:A unique subgroup with a poor prognosis?. Blood 58:14, 1981.
  pubmed

• 34) 太田和雄・他:癌細胞の動態と治療法との関係. 癌の科学5. 癌の制圧-最近の治療学-. 太田邦夫・他編. pp.19. 南江堂. 東京. 1979.

• 35) 太田和雄:II. H3-サイミジンの血液学への応用. a. 白血病および腫瘍における細胞回転. 日本血液学会雑誌 27:693, 1964.

• 36) Aardal, N. P. et al:Sequential flow cytometric analysis of cellular DNA content in peripheral blood during treatment for acute leukaemia. Scand. J. Haematol., 22:25, 1979.
  pubmed

• 37) 高本滋・他:Flow-micro-fluorometer(F. M. F.) による白血病細胞回転に関する研究(第1報) . 日本臨床血液学会総会抄録. 149, 1976.

• 38) 御供泰治・他:Flow microfluorometryによる慢性骨髄性白血病の細胞回転に関する研究(第1報) . 日本血液学会雑誌 41:859, 1978.

• 39) Dosik, G. M. et al:Pretreatment flow cytometry of DNA content in adult acute leukemia. Blood 55:474, 1980.
  pubmed

• 40) Hillen, H. et al:Value of pulse-cytophotometry for diagnosis and prognosis in acute leukemia. In:Pulse-Cytophotometry II, Gohde, W., Schumann, J., Bdichner, T. (eds) . European Perss Medikon, Ghent, 1976, p. 392.

• 41) Scarffe, J. H. et al:Relationship between the pretreatment proliferative activity of marrow blast cells and prognosis of acute lymphoblastic leukemia of childhood. Brit. J. Cancer., 41:764, 1980.
  pubmed

• 42) 椿和央・他:Flow cytomertyによる白血病細胞の増殖動態観察と治療への応用. 臨床血液 22:1916, 1981.

• 43) Haanen, C.:Limitations and achievements of DNA-flow cytometry in monitoring human leukemias. In:Flow Cytometry IV, Laerum, O. D., Lindmo, T., Thorud, E. (eds) . Universitetsforlaget, Bergen-Oslo-Trondheim, 1980, p. 492.

• 44) Braylan, R. C. et al:Selective flow cytometric analysis of neoplastic and non-neoplastic cell populations of human B cell lymphomas. Basic. Appl. Histochem., 24:365, 1980.

• 45) Scarffe, J. H. et al:Pretreatmellt cell kinetic studies in human lymphoid malignancies as possible prognostic factors. In;Pulse-Cytophotometry III, Lutz, D. (ed) . European Press Medikon, Ghent, 1978, p. 675.

P.253 掲載の参考文献

• 1) Baserga, R. et al:A study on the establishment and growth of tumor metastasis with tritiated thymidine. Cancer Res. 20:910, 1960.

• 2) Mendelsohn, M. L., :Autoradiographic analysis of cell proliferation in spontaneous breast cancer of C3H mouse, IV the growth fraction. J. Natl. Cancer lnst. 28:1015, 1962.

• 3) Hoshino, T. et al:The distribution of nuclear DNA from braintumor cells, flow cytometric studies. J. Neurosurg. 40:13, 1978.

• 4) Kawamoto, K. et al:Flow cytometric analysis of the DNA distributioll in human brain tumors. Acta Neuropathol. 46:39, 1979.
  pubmed

• 5) 野村和弘・他:脳腫瘍の生長解析. 神経研究の進歩22:29, 1978.

• 6) 野村和弘:Cell kinetics. 治療学 7:209, 1981.

P.276 掲載の参考文献

• 1) Carrano, A. V., et al:Flow cytogenetic:Progress towards chromosomal aberration detection. In:Mutagen Induced Chromosome Damage in Man, Evan, H. J. and Lloyd, D. C. (eds) . Edinburgh University Press, Edinburgh, 1978, p. 326-338.

• 2) Gray, J. W., et al:High resolution chromosome analysis:One and two parameter flow cytometry. Chronosoma 73:9-27, 1979.

• 3) Carrano, A. V., et al:Flow cytogenetics:A new approach to chromosome analysis. In:Flow Cytometry and Sorting, Melamed, M. R., et al(eds) . John Wiley & Sons, Inc., New York, 1979, p. 421-451.

• 4) Otto, J. F. and Oldigers, H.:Flow cytogenetic studies in chromosomes and whole cells for the detection of clastogenic effects. Cytometry 1:13-17, 1980.

• 5) Matsson, P. and Rydberg, B.:Analysis of chromosomes from human peripheral lymphocytes by flow cytometry. Cytometry 1:369-372, 1981.
  pubmed

• 6) Sandberg, A. A.:Solid tumors and metastatic cancer. In:The Chromosomes in Human Cancer and Leukemia, Sandberg, A. A. (ed) . Elsevier, New York, 1980, p. 458-565.

• 7) Nesiell, M., et al:Cytomorphological grading and Feulgen DNA-analysis of metaplastic and neoplastic bronchial cells. Cancer. 41:1511-1521, 1978.

• 8) Pak, H. Y., et al:Quantitative DNA determinations by image analysis. I. Application to human pulmonary cytology. Analyt. Quant. Cytol. 4:95-98, 1982.

• 9) Adams, LR. and Dahlgren, S. E.:Cytophotometric measurements of the DNA content of lung tumours. Acta Path. Microbiol. Scandinav. 72:561-574, 1968.

• 10) 井坂英彦:腫瘍細胞の形質, 染色体. 腫瘍病理学. 菅野晴夫, 小林博(編) 朝倉書店, 東京, 1970, p. 111-122.

• 11) Atkin, N. B. and Kay, R.:Prognostic significance of modal DNA value and other factors in malignant tumours, based on 1465 cases. Brit. J. Cancer. 40:210-221, 1979.
  pubmed

• 12) Blondal, T. and Lindgren, A.:Fluorescence cytophotometric measurements of nuclear DNA in adenocarcinoma of the lung:Relation of proliferative activity and DNA ploidy to prognosis. Analyt. Quant, Cytol. 4:225-232, 1982.

• 13) Barlogie, B., et al:Cellular DNA content as a marker of neoplasia in man. Am. J. Med. 69:195-203, 1980.

• 14) Olszewski, W., et al:Flow cytometry of lung carcinoma. A comparison of DNA stemline and cell cycle distribution with histology. Analyt. Quant. Cytol. 4:90-94, 1982.

• 15) Raber, M., et al:Determination of ploidy abnormality and cell cycle distribution in human lung cancer using DNA flow cytometry. Proc. Amer. Associ. Cancer Res. 21:40, 1980.

• 16) Bunn, P., et al:Comparison of cytology and DNA content analysis by flow cytometry(FCM) in specimens from lung cancer patients. Proc. Amer. Associ. Cancer Res. 21:40, 1980.

• 17) Vindelov, L. L., et al:Clonal heterogeneity of small cell anaplastic carcinoma of the lung demonstrated by flow-cytometric DNA analysis. Cancer Res. 40:4295-4300, 1980.
  pubmed

• 18) Fried. J. and Mandel, M.:Multi-user system for analysis of data from fiow cytometry. Comput. Programs Biomed. 10:218-230, 1979:

• 19) Christensen, I., et al:Statistical analysis of DNA distributions from cell populations with partial synchrony. In:Pulsecytophotometry, Lutz, D. (ed) , European Press Medicon, Ghent, Belgium, 1978, p. 71-78.

• 20) Terz, J. J., et al:Anlysis of the cell kinetics of human solid tumors. Cancer. 28:1100-1110, 1971.

• 21) Muggia, F. M., et al:Cell kinetics studies in patients with small cell carcinoma of the lung. Cancer. 34:1683-1690, 1974.
  pubmed

• 22) Straus, M. J. and Moran, R. E.:Cell cycle parameters in hman solid tumors. Cancer 40:1453-1461, 1977.

• 23) Darzynkiewicz, Z., et al:Lymphocyte stimulation:A rapid multiparameter analysis. Proc. Natl. Acad. Sci. USA. 73:2881-2884, 1976.
  pubmed

• 24) Auer, G., et al:Determination of the fraction of G cells in cytologic samples by means of simultaneous DNA and nuclear protein allalysis. Analyt. Quant. Cytol. 5:1-4, 1983.

P.293 掲載の参考文献

• 1) J. F. Gusella, C, Keys, A. Varsanyi-Breiner, F. T. Kao, C. Jones, T. T. Puck and D. Housman:Isolation and localization of DNA segments from specific human chromosomes. Proc. Natl. Acad. Sci. USA. 77:2829, 1480.

• 2) B. J. Schmeckpeper, K. D. Smith, B. P. Dorman, F. Ruddle and. C. C. Conover.:Partial Purification and characterization of DNA from the human Xchromosome. Proc. Natl. Acad. Sci. U. S. A. 75:6525, 1979.

• 3) A. Carrano, M. A. Van Dilla, J. W. Gray:Flow cytogenetics:A new approach to chromosome analysis, In"Flow cytometry and cell Sorting"eds. Mendelsohn, M. L, Melamed, M. R. and Mullaney, P. E. (Wiley, New York) , p. 421.

• 4) J. W. Gray, A. V. Carrano, L. L Steinmetz, M. A. Van Dilla, D. H. Moore, B. H. Mayall, M. L. Mendelsohn:Chromosome measurement and sorting by flow systems. Proc. Natl. Acad. Sci. U. S. A. 72:1231, 1975.

• 5) A. V. Carrano, J. W. Gray, R. G. Langlois, K. J. Burkhart-Schultz and M. A. Van Dilla:Measurement and Purification of human chromosomes by flow cytometry and Sorting. Proc. Natl. Acad. Sci. U. S. A., 76:1382, 1979.

• 6) R. Sillar and B. D. Young:A new method for the preparation of metaphase chromosomes for Flow analysis. J. Histochem. Cytochem. 29:74, 1981.

• 7) B. D. Young, M. A. Fergusos-Smith, R. Sillar and E. Boyd. High resolution analysis of human peripheral tymphocyte chromosomes by flow cytometry. Proc. Natl. Acad. Sci. U S. A. 78:7727, 1981.

• 8) FJ. Otto, H. Oldiges, W. Gohde, B. Barlogie, J. Schumann:Flow cytogenetics of uncloned and cloned chinese hamster, Cytoget. Cell. Genet. 27:52, 1980.

• 9) A. B. Blumenthal, J. D. Dieden, L. N. Kapp and J. W. Sedat:Rapid isolation of metaphase chromosomes containing high molecular weight DNA. J. Cell Biology. 81:255, 1979.

• 10) MT. Kuo:Comparison of chromosomal structures isolated under different conditions. Exp. Cell Res. 138:221, 1982.
  pubmed

• 11) R. V. Lebo:Chromosome sorting and DNA sequence localization. Cytometry 3:145, 1982.

• 12) J. Th. Bijma:Optimization of mammalian chromosome suspension preparations employed in a flow cytometric analysis. Cytometriy 3:354, 1983.

• 13) A. V. Carrano, J. W. Gray. D. H. Moore, J. L. Minklev, B. H. Mayall, M, A. Van Dilla and M. L, Mendelsohn:Purification of the chromosomes of the indian muntjac by flow sorting. J. Histochom. Cytochem. 24:348, 1976.

• 14) R. V. Lebo, A. V. Carrano, K. Burkhart-Schultz, A. Dozy, L-G Yu and Y. W. Kan:Assignment of human β-, γ-andδ-globin genes to the short arm of chromosome 11 by chromosome sorting and DNA restriction enzyme analysis. Proc. Natl. Acad. Sci. USA. 75:5804, 1979.

• 15) L-C. Yu, J. Aten, J. Gray and A. V. Carrano:Human chromosome isolation from short-term lymphocyte culture for flow cytometry. Nature 293:154, 1981.

• 16) R. G Langlois, LC. Yu J. W. Gray and A. V. Carrano:Quantitative karyo typing of human chromosomes by dual beam flow cytometry. Proc. Natl. Acad. Sci. U. S. A. 79:7876, 1982.

• 17) K. E. Davies, B. D. Young, R. G. Elles, M. E. Hill and R. Williamson (1981) :Cloning of a representative genomic library of the human X-chromosome after sorting by flow cytometry. Nature 293:374, 1981.

• 18) R. V. Lebo, A. M. Bastian:Design and operation of a duel laser chromosome sorter. Cytometry 3:213, 1982. C. Cremer and J. W. Gray:Replication kinetics of chinese hamster chromosomes as revealed by bivariate flow karyotyping. Cytometry 3:282, 1983.

• 19) P. K. Horan and L. L. Wheeless:Quantitative single cell analysis and sorting. Science 198:149, 1977.

• 20) R. Krumlauf, M. Jeanpierre, B. D. Young:Construction and chracterization of genomic libraries from specific human chromosomes. Proc. Natl. Acad. Sci. U. S. A. 79:2971, 1982.

• 21) L. M. Kunkel, U. Tantravahi, M. Eisenhard and S. A. Latt;Regional localization on the human X of DNA segments cloned from flow sorted chromosomes. Nucleic Acid. Res. 10:1557, 1982.

• 22) J. M. Murray, K. E. Davies, P. S. Harper, P. S. Harper, L. Meredith, C. R. Mueller and R. Williamson:Linkage relationship of a cloned DNA sequence or the short arm of the X chromosome to Duchenne muscular dystrophy. Nature. 300:69, 1982.
  pubmed

• 23) C. M. Disteche, A. V. Carrano, L. K. Ashworth, K. Burkhart-Schultz and S. A. Latt:Flow sorting of the mouse Cattanach X chromosome, T(X;7) 1 Ct, in an active or inactive state. Cytogenet. Cell. Genet. 29:189, 1981.
  pubmed

• 24) C. M. Disteche, L. M. Kunkel, A. Lojewski, S. H. Orkin, M. Eisenhard, E. Sahar, B. Travis and S. A. Latt:Isolation of mouse X-chromosome specific DNA from X-enriched lambda phage library derived from Flow sorted chromosomes. Cytometry 2:282, 1982.

• 25) 貞包雄次郎, 渡辺武:Flow cytometry法によるヒト染色体のhigh resolution analysisおよびsorting. 医学のあゆみ 125:1006, 1983.

P.312 掲載の参考文献

• 1) Bruce, W. R., et al:Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo., J. Nat. Cancer Inst. 37:233, 1966.
  pubmed

• 2) Bhuyan. B. K., et al:Cell proliferation kinetics and drug sensitivity of exponential and stationary populations of cultured L1210 cells. Cancer Res. 37:1057, 1977.
  pubmed

• 3) Sinclair, W. K.:Hydroxyurea. Effects on chinese hamster cells grown in culture, Cancer Res. 27:297, 1967,
  pubmed

• 4) 太田和雄・他:癌細胞の動態と治療法の関係, 「癌の科学, 5, 癌の制圧-最近の治療学-」太田邦夫他編, pp.19, 南江堂, 東京, 1979.

• 5) Baisch, H., et al:A comparison of mathematical methods for the analysis of DNA histograms obtailled by flow cytometry. Cell Tissue Kinet, 15:235, 1982.
  pubmed

• 6) Fried, J., et al:Multi-user system for analysis of data from flow cyto, metry. Comput. Programs Biomed. 10:218, 1979.

• 7) 野村和弘・他:悪性脳腫瘍の化学療法への応用. 癌と化学療法9:1151, 1982.

• 8) Takamoto, S., et al:Flow cytometric analysis of the effect of THP-adriamycin on the cell cycle traverse of RPMI-8402 cells. The 13th International Congress of Chemotherapy proceedings. P. S. 12, 4, 8, -7, 1983.

• 9) 高本 滋・他:抗癌性抗生物質の細胞回転に及ぼす影響 -Flow microfluorometry 分析による-. 癌と化学療法 6:59, 1979.

• 10) 高本 滋・他:Cell Kineticsよりみた抗白血病剤の選択. 医学と薬学 10:351, 1983.
  Medical*Online

• 11) 高本滋・他:F. M. F. による制癌剤の作用機序に関する研究, 第6報-代謝拮抗剤, アルカロイドを中心に- . 日本血液学会誌 41 (2) :298, 1978.

• 12) 高本滋・他:F. M. F. による制癌剤の作用機序に関する研究, 第8報-アルキル化剤を中心に- . 日本癌学会総会記事:140, 1978.

• 13) Krishan. A., et al:Flow microfluorometric patterns of human bone marrow and tumor cells in response to cancer chemotherapy. Cancer Res., 36:3813, 1976.
  pubmed

• 14) Smets, L. A., et al:Early responses to chemotherapy detected by pulse cytophotometry. Brit. J. Cancer 34:153, 1976.
  pubmed

• 15) Kremer, W. B., et al:An attempt at synchronization of bone marrow cells in acute leukemia. Relationship to therapeutic response. Cancer 37:390, 1976.
  pubmed

• 16) Kufe, D. W., et al:High dose thymidine infusion in patients with leukemia and lymphoma. Blood 55:580, 1980.
  pubmed

• 17) 高本 滋・他:FMF(Flow microfluorometry) によるcell cycleの解析, 現代臨床機能検査. 日本臨床 37:1561, 1979.

P.323 掲載の参考文献

• 1) Waxman, S. and Scanlon, K. J.:Molecular biology of anticancer agents. In:Clinical Interpretation and Practice of Cancer Chemotherapy, Greenspan, E. M. (ed) , Raven Press, New York 1982, p. 39-52.

• 2) Laird, A. K.:Dynamics of growth in tumors and in normal organisms. Natl. Cancer lnst. Monogr. 30:15-28, 1969.

• 3) Cline, M. J. and Haskell, C. M.:Introduction to chemotherapy. In:Cancer Chemotherapy, Cline, M. J. and Haskell, C. M. (eds) , W. B. Saunders Company Philadelphia, 1980, p. 1-12.

• 4) Prescott, D. M.:The G1 period. In:Reproduction of Eukaryotic Cells, Prescott, D. M. (ed) , Academic Press, New York, 1976, p. 36-59.

• 5) Brent, T. P., at al.:Variations in phosphokinase activities during the cell cycle in synchronous populations of Hela cells. Nature 207:176-177, 1965.

• 6) Spadari, S. and Weissbach, A.:The interrelation between DNA synthesis and various DNA polymerase activities in synchronized Hela cells. J. Mol. Biol. 86:11-20, 1974.
  pubmed

• 7) Johnson, L. F., et al:Regulation of dihydrofolate reductase gene expression in mouse fibroblasts during the transition from the resting to growing state. J. Cell Physiol. 97:397-406, 1978.

• 8) Larsson, A.:Ribonucleotide reductase from regenerating rat liver. Europ. J. Biochem. 11:113-121, 1969,
  pubmed

• 9) Baserga, R.:The cell cycle. New Engl. J. Med. 304:453-459, 1981.
  pubmed

• 10) Darzynkiewicz, Z., et al:Correlation between cell cycle duration and RNA content. J. Cell. Physiol. 100:425-438, 1979.

• 11) Skipper, H. E.:The cell cycle and chemotherapy of cancer. In:The Cell Cycle and Cancer, Baserga, R. (ed) , Marcel Dekker, Inc., New York, 1971, p. 358-387.

• 12) Spiegel, R. J. and Muggia, F. M.:Cancer chemotherapy. In:Concepts in Cancer Medicine, Kahn, S. B., et al(eds) , Grunn&Stratton Inc., New York, 1983, p. 337-366.

• 13) Steel, G. G.:Cell populationkinetics and therapeutic response. In:Growth Kinetics of Tumours. Steel, G. G. (ed) , Clarendon Press, Oxford, 1977, p. 268-306.

• 14) Van Putten, LM., et al:Perspectives in cancer research, synchronizaticn in tumour chemotherapy. Europ. J. Cancer 12:79-85, 1976.

• 15) Barlogie, B., et al:The effect of adriamycin on the cell cycle traverse of a human lymphoid cell line. Cancer Res. 36:1975-1979, 1976.
  pubmed

• 16) Barranco, S. C., et al:Enhanced cell killing through the use of cell Kinetics-directed treatment schedules for two-drug combinations in vitro. Cancer Res. 42:2894-2898, 1982.
  pubmed

• 17) Fried, J. and Mandel, M.:Multi-user system for analysis of data from flow cytometry. Comput. programs Biomed. 10:218-230, 1979.
  pubmed

• 18) Vindelov, L. L., et al:Clonal heterogeneity of small cell anaplastic carcinoma of the lung demonstrated by flow-cytometric DNA analysis. Cancer Res. 40:4295-4300, 1980.
  pubmed

• 19) Moses, H. L., et al:Mechanism of growth arrest of chemically transformed cells in culture. Cancer Res. 38:2807-2812, 1978.
  pubmed

• 20) Auer, G., et al:Determination of the fraction of Go cells in cytologic samples by means of simultaneous DNA and nuclear protein analysis. Analyt. Quant. Cytol. 5:1-4, 1983.

• 21) Darzynkiewicz, Z., et al:Lymphocyte stimulation:A rapid multiparameter analysis. Proc. Natl. Acad. Sci. USA 73:2881-2884, 1976.
  pubmed

• 22) Tannock, L. F.:The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour. Brit. J. Cancer. 22:258-273, 1968.

• 23) Barlogie, B., et al:Cellular DNA content as a marker of neoplasia in man. Am. J. Med. 69:195-203, 1980.

• 24) Howell, P. C.:Cytogellesis. In:Cancer I, Becker, F. F. (ed) , Plenum Press, New York, 1982, p. 3-46.

• 25) Roti, Roti, J. L., et al:Cell-cycle position and nuclear protein content. Cytometry 3:91-96, 1982.
  pubmed

• 26) Darzynkiewicz, Z., et al:Interactions of rhodamine 123 with living cells studied by flow cytometry. Cancer Res. 42:799-806, 1982.
  pubmed

P.338 掲載の参考文献

• 1) Wright, J. C. et al:Investigation of the relation between clinical and tissue culture to chemotherapeutic agents on human cancer. New Eng. J. Med. 257:1207, 1957.
  pubmed

• 2) Holms, H. L., et al:Tissue culture microtest for predicting response of human cancer to chemothrapy. Lancet 985, 1974.

• 3) 下山正徳:培養株の薬剤感受性測定とその臨床的意義. 組織培養 6:142, 1980.

• 4) Rosenblum, M. L., et al:Developement of a clonogenic cell assay for human brain tumors. Cancer 41:2305, 1978.

• 5) Povlsen, C. O., et al:Chemotherapy of a humall malignant melanoma transplanted in the nude mouse. Cancer Res. 35:2790, 1975.
  pubmed

• 6) Shimosato, et al:Transplantation of human tumors in nude mice. J. Natt Cancer Inst. 56:1251, 1976.

• 7) 野村和弘・他:悪性脳腫瘍の化学療法への応用. 癌と化学療法9:1151, 1982.

• 8) Nomura, K., et at:BCNU-induced perturbation in the cell cycle of 9L rat brain cells. Cancer Treat. Rep. 62:747, 1978.

• 9) 癌細胞の動態と治療法との関係. 癌の科学, 第5巻・癌の制圧p. 19-58, 南江堂 1979.

• 10) 野村和弘:Cell Kinetics. 治療学 7:209, 1981.

• 11) Rosenblum, M, L., et al:In vivo clonogenic tumor cell kinetics following 1, 3-Bis(2-chloroethyl) -1-nitrosourea brain tumor therapy. Cancer Res. 36:3718, 1976.
  pubmed

• 12) Hoshino, T., et al:Cell kinetics of human gliomas. J. Neurosurgery, 37:15, 1972.

• 13) Frederiksen, et al:Flow cytometry in tumors of the brain. Acta Neuropathol. 41:1979, 1978.

P.347 掲載の参考文献

• 1) Hoshino, T. et al:The distribution of nuclear DNA from human brain tumor cells:Flow cytometric studies. J. Neurosurg. 49:13, 1978.

• 2) Frederiksen, P. et al:Flow cytometry in tumors of the brain. Acta Neuropathol. 41:1979, 1978.

• 3) Hamburger, A. W. et al:Primary bioassay of human tumor stem cells. Science 197:461, 1977.
  pubmed

• 4) Rosemblum, M. L. et al:Development of a clonogenic cell assay for human brain tumors. Cancer 41:2305, 1978.

• 5) Puck, T. T. et al:Clonal growth of mammalian cells in vitro. Growth characteristics of colonies from single HeLa cells with and without a feeder layer. J. Exp Med. 103:272, 1956.

• 6) Hoshino, T. et al:Clonogenicity of multiple populations of human glioma cells in vitro sorted by DNA content. Cancer 50:997, 1982.
  pubmed

• 7) Kobayashi, S. et al:Variable response to BCNU of human glioma cells sorted according to DNA content. J. Neurooncology(in print) .

P.355 掲載の参考文献

• 1) Sinclair, W.:Cell cycle dependence of the lethal radiation response in manmalian cells. Radiat. Res. 7:264, 1972,

• 2) Terashima, T., et al:Variation in several responses of HeLa cells to X-irradiation during the division cycle. Biophys. J. 3:11, 1963.

• 3) Dewey, W. C., et al:Relative radiosensitivity of different phases in the life cycle of L-P 59 mouse fibroblasts and ascites tumour cells. Radiat. Res. 16:503, 1962.

• 4) Shitara, J., et al:New approach to brain tumour chemotherapy with cellular synchronization by colcemid. Acta Neurochir. 35:123, 1976.

• 5) 設楽信行・他:脳腫瘍のPhase-synchronizationに関する基礎的研究. Neurol. Med. Chir. 17:55, 1977.
  Medical*Online

• 6) 山本博昭・他:同調培養細胞における生長解析と化学療法剤の作用機序. 脳と神経 33:781, 1981.

• 7) 高倉公朋・他:脳腫瘍cell cycleと併用療法. 癌と化学療法 5増刊:31, 1979.

• 8) 高倉公朋:第二次共同研究中間報告. 第4回脳腫瘍懇話会, 東京, 5月21日. 1983.

P.369 掲載の参考文献

• 1) O'Malley, W. et al:The receptors of steroid hormones, Science Am., 234:32, 1977.

• 2) Mc Carty, K. S. Jr. et al:Steroid hormone receptors in the regulation of differentiation, Am. J. Pathol., 86(3) :705, 1977.
  pubmed

• 3) Mc Guire, W. L, :Steroid hormone receptors in breast cancer treatment strategy. Recent. Hormone Rec., 36:135, 1980.

• 4) Pollow, K., et al:Progesterone and estradiol-binding Proteins from normal human endometrium and endometrial carcinoma:A comparative study, steroid receptors and hormone-dependent neoplasia, 69. Masson Publishing, USA. 1980.

• 5) 西谷巌・他:子宮腺・腺癌細胞の核機能とステロイドホルモンの調節機構. 日産婦学会誌53(8) :1156, 1983.

• 6) Melamed, M. R. et al:Flow cytometry & sorting, Ist Ed., 351, John Wiley & Sons, New York, 1979.

• 7) Lindner, H. R., et al:An approach to site-directed chemotherapy of hormone-sensitive cancer, Hormones and Cancer, Raven Press, New York, 1980.

P.379 掲載の参考文献

• 1) Buchner, T., et al:Die impulszytophotometrie in ger hamatologischen cytologie. Kin Wochenschr. 49:1090, 1971.

• 2) Bucher, T., et al:Zur praparation von blut-und knochenmarkenzellen fur die impulszytophotometrie. Blut. 28:191, 1974.

• 3) Barlogie, B., et al:DNA histogram analysis of human hemopoietic cells. Blood 48:245, 1976.
  pubmed

• 4) Dosik, G. M., et al:Pretreatment flow cytometry of DNA content in adult acute leukemia. Blood 55:474, 1980.
  pubmed

• 5) Scarffe, J. H., et al:Relationship between the pretreatment proliferative activity of marrow blast cells and prognosis of acute lymphoblastic leukemia of childhood. Brit. J. Cancer 41:764, 1980.
  pubmed

• 6) Hillen, H., et al:Value of pulse-cytophotometry for diagnosis and prognosis in acute leukemia. In:Pulsse-Cytophotometry 11, Gohde W (eds.) European Press Medikon, Ghent, 1976, p. 392-401.

• 7) Bennett, J. M., et al:Proposals for the classification of acute leukemias. Brit. J. Haemat 33:451, 1976.
  pubmed

• 8) Krishan, A:Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell Biol. 66:188, 1975.
  pubmed

• 9) Crissman, H. A., Steinkamp JA:Rapid simultaneous measurement of DNA, protein and cell volume in single cells from large mammalian populations. J. Cell Biol. 54:766, 1973.

• 10) Ogawa, M., et al:Studies of cellular proliferation in human leukemia. VI. The proliferative activity, generation time, and emergence time of neutrophil in granulocytes in chronic granulocyte leukemia. Cancer 25:1034, 1970.

• 11) Wagner, H. P., et al :Variability of proliferative pattern in acute lymphoid leukemia of children. Blood 39:176, 1972
  pubmed

• 12) Saunder, E. F., et al:Variation of proliferative activity in leukemic cell population of patterns with acute leukemia. J. Clin. Invest. 46:1356, 1967.

• 13) Andreeff, M., et al:Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA. Blood 55:282, 1980.
  pubmed

• 14) Frei, E., et al:Cytokinetic evaluation of the effectiveness of remission induction treatment in patients with acute leukemia. Advance in Bioscience 14. Workship on prognostic factors in human acute leukemia. Fliedner TM (eds.) press Vieweg, Oxford, New York, Tronoto-Sydney, 1975, p. 15-26.

• 15) 椿和央・他:flow microfluorometry(F. M. F.) の急性白血病治療への応用. 医学のあゆみ 109:613, 1979.

• 16) 岩永隆行, 雨宮洋一:成分輸血とLeukapheresis-白血病治療への応用と問題点-1. 血小板輸血. 臨床血液 18:587, 1977.

• 17) 長谷川広文・他:新しい移動式水平層流Clean bedによる急性白血病の治療. 感染症学雑誌椿 51:4, 1977.

• 18) 椿和央・他:Flow Cytometryによる白血病細胞の増殖動態観察と治療への応用. 臨床血液 22:1916, 1981.

• 19) Smets, L. A., et al :Early responces to chemotherapy detected by pulse cytophotometry Brit. J. Cancer 34:153, 1976.

• 20) Cullen, M. H., Capellaro DF:The use of the fluorescence activated cell sorter to monitor chemotherapy in acute leukemia. In:Pulse-Cytophotometry 111, Lutz D(eds.) European Press Medikon, Ghent, 1978, p. 643-657.

• 21) Buchner, T., et al:Flow cytometry and cell kinetics during treatment of human acute leukemias-kinetic manipulations of leukemic cells by cytosine arabinoside(Ara-C) in correlation to therapeutic responce, In:Flow Cytometry Iv, Laerum OD(eds.) Universitetsforlaget, Bergen-Oslo-Trondheim, 1980, p. 499-503.

• 22) Barlogie, B., et al:Correlation of DNA distribution abnormalities with cytogenetic findigs in human adult leukemia and lymphoma. Cancer Res. 37:440, 1977.

• 23) Kenneth, A., et al:Surface markers on leukemic and lymphoma cells:Recent advances. Blood 60:1, 1982.

• 24) Ritz, J, Schlossman SF:Utilization of monoclollal antibodies in the treatment of leukemia and lymphoma. Blood 59:1, 1982.
  pubmed

• 25) Paul, A., et al:Flow cytometric analysis of bone marrw cells in patient with plasma cell myeloma:clinical implications. Blood 59:528, 1982.

• 26) Latreille, J., et al:Cellular DNA content as a marker of human multiple myeloma. Blood 55:403, 1980.
  pubmed

• 27) Raul, C., et al :Cell volumes and DNA distributions of normal and neoplastic human lymphoid cells. Cancer, 41:201, 1978.

• 28) Stanley, E., et al:Dual parameter flow cytometry studies in human lymphomas. J. Clin. Invest. 66:1281, 1980.

• 29) Scarffe, J. H., Crowther D:Pretreatment cell kinetic studies in human lymphoid malignancies as possible prognostic factors. In:Pulse-Cytophotometry 111, Lutz D(eds.) European Press Medicon, Ghent, 1978, p. 675-682.

• 30) Diamond, L. W., Braylan RC:Flow analysis of DNA content and cell size in non-Hodgkin s lymphoma. Cancer Res. 40:703, 1980.
  pubmed

P.390 掲載の参考文献

• 1) Herman, C. J. et al:Clinical Cytology Specimens for Cancer Detection. Flow Cytometry and Sorting, John Wiley & Sons. New York 1979.

• 2) Braylan, R. C.:Flow Cytometry. Arch. Pathol. Lad. Meb. 107:1, 1983.

• 3) Brattain, M. C.:Tissue Disaggregation Flow Cytometry and Sorting. John Wiley & Sons. New York, 1979.

• 4) 天神美夫・他:癌性腹膜炎の化学療法への応用と評価. 癌と化学療法 9:1179, 1982.
  Medical*Online

• 5) 杉田道夫・他:化学療法の効果判定における腹水細胞診およびFlow Cytometryの応用. 日臨細胞会誌 22:9, 1983.

• 6) 太田和雄・他:細胞回転と制癌. 癌の臨床 27:1499, 1981.

• 7) 小川一誠:癌のCell kinetics. 臨床医 3:1580, 1977.

• 8) 高本 滋・他:細胞回転からみた抗白血病, 悪性リンパ腫治療薬の作用機序. 臨床医 8:460, 1982.

• 9) 高橋克俊・他:cis-Dichlorodiamineplatinum(H) の抗腫瘍効果および細胞周期内進行に及ぼす作用. 癌と化学療法 9:624, 1982.

• 10) Drewinko, B. et al:Action of cis-dichlorodiamineplatinum (II) at the cellular level. Cancer Chemother. Rep. 159:665, 1975.

• 11) Fravel, H. N. A. et al :G1 phase chinese hamster V79-379A cells are inherently more sensitive to platinum bound to their DNA than mid S phase or asynchronously treated cells. Biochemical Pharmacology 28:1575, 1979.
  pubmed

P.409 掲載の参考文献

• 1) Sandritter, W. et al:Zur Krebs Diagnostik an Vaginalen Zellausstrichen mittels Cytophotometry Messungen. Arch. Gynecol. 19:293, 1960.

• 2) 西谷巌・他:子宮癌細胞の計量診断と螢光顕微分光測光法. 産婦治療 33:98, 1976.

• 3) 下斗米啓介・他 :Information zur Kernforschung und kerntechnik, Nrl, 18. 1975.

• 4) 井筒俊彦:子宮頸癌検診の再編成. 第31回日産婦学会北日本連合地方部会特別講演要旨 40, 1983.

• 5) Melamed, M. R., et al:Flow cytometry and sorting, Ist Ed. 351, John Wiley & Sohns, New York, 1979.

• 6) 西谷巌:細胞群の選別・解析とその臨床応用. 臨床婦産 34:169, 1980.

• 7) 西谷 巌・他:細胞機能解析コンピューターの臨床における工夫と実践. 臨床婦産 36:316, 1982.

• 8) Soost, H. J., et al;Comparison of Papanicolaou staining and Feulgen staining for automated presreening. J. Analytical &Quantitative Cytol. 5:61, 1983.

• 9) Fowlkes, B. J., et al:Flow microfluorometric system for screening gynecologic cytology specimens using propidium iodide-fluorescein isothiocyanate, J. Histochem, Cytochem. 24:322, 1976.
  pubmed

• 10) Habersett, M. C., et al:Quantitative analysis of flow micro-fluorometric data for screening gynecologic cytology specimens. J. Histochem. & Cytochem., 27:536, 1979.

P.419 掲載の参考文献

• 1) Darzynkiewicz, Z.:Acridine orange as a molecular probe in sudies of nucleic acids in situ. In:Flow Cytometry and Sorting. Melamed, MR., Mullaney, PF., Mendelsohn, ML, (eds.) John Wiley and Sons, New York, 1979, p. 285-316.

• 2) Darzynkiewicz, Z. et al:Conformation of RNA in situ as studied by acridine orange and automated cytofluorometry. Exp. Cell Res 95:143, 1975.
  pubmed

• 3) Traganos, F., et al:Simultaneous staining of ribonucleic and deoxyribonucleic acid on unfixed cells using acridine orange in a flow cytofluorometric system. J. Histochem. Cytochem. 25:46, 1977.

• 4) Darzynkiewicz, Z. et al:New cell cycle compartments identified by multi-parameter flow cytometry. Cytometry 1:98, 1980.

• 5) Walle, A. et al:A simple density gradient for enriching subfractions of solid tumor cells, Cytometry 3:402, 1983.

• 6) Darzynkiewicz, Z. et al:Different sensitivity of chromatin to acid denaturation in quiescent and cycling cells revealed by flow cytometry. J. Histochem. Cytochem. 27:478, 1979.
  pubmed

• 7) Darzynkiewicz, Z. et al:Discrimination of cycling and noncycling lymphocytes by BUdR-suppressed acridine orange fluorescence in a flow cytometric system. Exp. Cell Res. 115:31, 1978.

• 8) Collste, LG., et al:Flow Cytometry in bladder cancer detection and evaluation using acridine orange metachromatic nucleic acid staining of irrigation cytology specimens. J. Urol. 123:478, 1980.
  pubmed

• 9) Klein, FA., et al:An evaluation of automated flow cytometry(FCM) in detection of carcinoma in situ of the urinary bladder. Cancer 50:1003, 1982.
  pubmed

• 10) Olzewski, W. et al:Flow cytometry of breast carcinoma, I. Relation of DNA ploidy level to histology and estrogen receptor. Cancer 48:980, 1981.

• 11) Wolley, RC. et al:DNA distribution in human colon carcinoma and its relationship to clinical behavior. J. Natl. Cancer Inst. 69:15, 1982.
  pubmed

• 12) Olzewski, W. et al:Flow cytometry of lung carcinoma:A comparison of DNA stemline and cell cycle distribution with histology. Anal. Quant, Clytol. 4:90, 1982.

• 13) Andreef, M. et al:Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA. Blood 55:282, 1980.

P.433 掲載の参考文献

• 1) Darzynkiewicz, Z., et al:Conformation of RNA in situ as studied by acridine orange staining and automated cytofluorometry. Exp. Cell Res. 95:143, 1975.
  pubmed

• 2) Traganeos, F., et al :Simultaneous staining of ribonucleic and deoxyribonucleic acids in unfixed cells using acridine orange in a flow cytofluorometric system. J. Histochem and Cytochem. 25:46, 1977.

• 3) Crissman, H. A., et al:Rapid simultaneous measurement of DNA, protein and cell volume in single cells from large mammalian cell populations. J. Cell Biol. 59:766, 1973.
  pubmed

• 4) Crissman, H. A., et al:Rapid staining methods for analysis of deoxyribonucleic acid and protein in mammalian cells. J. Histochem and Cytochem. 24:64, 1976.

• 5) Roti Roti, J. L., et al:Cell-cycle position and nuclear protein content. Cytometry 3:91, 1982.
  pubmed

• 6) Armstrong, R. D., et al:Metabolism and biological activity of 5-deoxy-5-fluorouridine, a novel fluoropyrimidine. Cancer Res 40:3333, 1980.
  pubmed

• 7) Rosenblum, M. L., et al:In vivo clonogenictumor cell kinetics following 1, 3-Bis (2-Chloroethyl) -1-nitrosourea brain tumor therapy. Cancer Res. 36:3718, 1976.
  pubmed

• 8) 野村和弘・他:フローサイトメトリーの癌臨床への応用, 悪性脳腫瘍の化学療法への応用. 癌と化学療法9:1151, 1982.

P.449 掲載の参考文献

• 1) 野田起一郎:子宮頸部上皮の癌化防止に関する研究. 日産婦誌 27(3) :735, 1975,

• 2) 岸上義彦・他:自動スクリーニングに通した腟スミアの作成法, 特に好中球の除去について. 日臨細胞誌 20(3) :523-531, 1981.

• 3) 阪口耀子・他:Flow-cytometryのための組織細胞分散法の確立. 日臨細胞誌 22(2) :228-234, 1983.

• 4) K. Goerttler., et al:Highlighting of progress by Research Groups in cytology Automation:The Automation of Cancer Cytology and Cell Image Analysis(Editors, Norman J. Pressman and George L. Wied) , 13-18, Tutorials of Cytology Chicago, Illinois, 1979.

• 5) M. Stoehr., et al:Dual Laser Flow Analysis and Sorting of Cells Including the Uterine Cerix:The Automation of Cancer Cytology and Cell Image Analysis(Editors, Norman J. Pressman and George L. Wied) ;75-80, Tutorials of Cytology Chicago, Illinois, 1979.

• 6) R. H. Jensen., et al:Multiparameter Flow Cytometry Applied Toward Diagnosis of Cervical Squamous cell Carcinoma:The Automation of Cancer Cytology and Cell Image Allalysis(Editors, Norman J. Pressman and George L. Wied) ;95-102, Tutorials of Cytology Chicago, Illinois, 1979.

P.465 掲載の参考文献

• 1) Mullaney P. F. et al:The Small Angle Light Scattering of Biological cells. Biophysical. Journal, 10:764, 1970.
  pubmed

• 2) Salzman G. C. et al:Cell Classification by Laser Light Scattering:Identification and Separation of unstained Leukocytes. Acta Cytologica, 19 (4) :374, 1975.

• 3) Van den Engh, G. J.:Concentration of Hemopoietic Cells using a Light-Activated Cell Sorter. Blood Cells., 6(4) :609, 1980.

• 4) 福井谷祐一・他:フローサイトメトリーの癌臨床への応用, 白血病診断への応用. 癌と化学療法 9(7) :1204, 1982.

• 5) Meyer. R. A. et al:Light Scattering from nucleated biological cells. Biophys. J. 15:191, 1975.
  pubmed

• 6) Otten. G. R.:Two Color Light Scattering Identifis Physical Differences between Lymphocyte Subpopulations. Cytometry 3(3) :182, 1982.
  pubmed

P.477 掲載の参考文献

• 1) 桃井宏直・編:Current Immunology, 1983, 7:ヘキスト・ジャパン社.

• 2) T. Casperson, G. Lomakka, L. Zech. The 24 fluorescence patterns of the human metaphase chromosomes. Distinguishing characters and variability. Hereditas 67:87-102, 1971.

• 3) 桃井宏直, 加藤礼, 渡辺京子, 谷口敦子:特許出願, 昭和46(1971) 54611, 登録番号, 特許第97373 染色体自動分類装置.

• 4) M. L. Mendelsohn, B. H. Mayall, E. Bogart, D. H. Moorell, and B. H. Perry:DNA centent and DNA-based centromeric index of the 24 human chromo. somes. Sczence 179:1126-1129, 1973.

• 5) J. W. Gray, D, Peters, T. Merrill, R. Martin, and M. A. Vau Dilla:Slit Scan flow cytometry of mammalian chromosomes. J. Histochem. Cytochem, 27:441-444, 1979.

• 6) A. V. Carrano 私信. (1983) .

• 6) A. V. Carrano, and L. H. Thompson in Sister Chromatid Exchange(ed S. Wolff) John Wiley d Sons New York 1981.

• 7) 高本滋, 矢野和美, 鈴木伸行, 太田和雄:FCMのための標準試料に関する研究, FCM・Cell Biology研究会第1回学術集会, 昭和58年7月2日.

• 8) P. N. Dean and D. Pinkel:High resolution dual laser flow cytometry. J. Histochem. Cytochem. 26:622, 1978.

P.486 掲載の参考文献

• 1) J. V. Watson:Enzyme kinetic studies in Cell populations using fluorogenic substrates and flow cytometric techniques. Cytometry 1:143, 1980,

• 2) H. R. Hulett, W. A. Bonner, J. Barrett and LA. Herzenberg:Cell sorting:Automated separation of mammalian cells as a function of intracellular fluorescence. Science 166:747, 1969.

• 3) P. N. Dean and D. Pinkel:High resolution dual laser flow cytometry. J. Histochem. Cytochem 26:622, 1978.

• 4) A. R. Poole, K. J. Tiltman, A. D. Recklies, and A. M. Storert:Differences in secretion of the proteinases catepsin B at the edge of human breast carcinomas and fibroadenomas. Nature 273:545, 1978.

• 5) P. N. Dean:Dual beam flow cytometry and sorting:Application in biomedical research. Medical Tribune. 2:29, 1980 in Current Immunology ed. by H. Momoi, p. 186, 1983.

• 6) F. A. Dolbeare and W, Phares:Naphthol AS-BI(7-Bromo-3 hydroxy-2-naphtho-0-amisidine) phosphatase and naphthol AS-BI-B-D-glucuronidase in Chinese hamster overy cells:Biochemical and flow cytometric studies. J. Histochem. Cytochem. 27:120, 1979.

• 7) J. V. Watson:Enzyme Kinetic Studies in cell Populations Using Fluorogenic Substrates and Flow Cytometric Techniques. Cytochem:143, 1980.

P.496 掲載の参考文献

• 1) Darzynkiewicz, Z, et al:Rapid analysis of drug effects on the cell cycle. Cytometry 1:279, 1981.
  pubmed

• 2) 佐藤温重・他:フローサイトメトリーを応用した化学物質の細胞障害性の迅速検出, 変異原と扉性 51267, 1982.

• 3) 佐藤温重:細胞毒性, トキシコロジー. (浦口他編) , 1349, 地人書館1978.

• 4) Ortho Diagnostic Systems Protocols 1-4

• 5) Saxholm, H. J. K. d al:Progressive loss of DNA and lowering of the chromosomal mode in chemically transformed C3H/10T/cells during development of their oncogenic potential. Cancer Res. 40:4254, 1980.

• 6) Noguchi, P. D. et al.:The use of chicken erythrocyte nuclei as a biological standard for flow microfluorometry. J. Histochem. Cytochem. 26:761, 1978.
  pubmed

• 7) Sato, A. et al.:Cytopharmacology of heavy metals IV:Antagonistic action of sodium selenite against toxicity of mercuric chloride to V79 cells. Jpn. J. Pharmacol. 32:suppl. p. 53 1982.

• 8) Otto, F. J, et al:Flow Cytometric measurement of nuclear DNA content variations as a potential in vitro mutagenicity test. Cytometry 2:189, 1981.

• 9) Ozawa, K. et al.:Cytopharmacology of heavy metals III;The effects of cadmium chloride on cell cycle progression of V79 cells. Jpn. J. Pharmacol. 32:suppl. 290p, 1982.

• 10) Darzynkiewicz, Z. et al:Cell cycle related changes in nuclear chromatin of stimulated lymphocytes as measured by flow cytometry. Cancer Res. 37:4635, 1977.
  pubmed

• 11) Darzynkiewicz, Z. et al:New cell cycle compartments identified by multi-parameter flow cytometry. Cytometry 1:98, 1980.

P.505 掲載の参考文献

• 1) Miller, RG., et al:Usage of the flow cytometer-cell sorter, J. Immunol. Methods. 47:13, 1981.
  pubmed

• 2) Steinkamp, JA, et al:Phagocytosis. Flow cytometric quantitation with fluorescent microspheres. Science 215:64, 1982.
  pubmed

• 3) 吉永 秀:赤血球除去用トリス緩衡液. 免疫実験操作法A(日本免疫学会編) 450, 1973.

• 4) Herzenberg, LA., et al :Analysis and separation using the fluorescence activated cell sorter(FACS) . Textbook of Experimental Immunology Vol. 2. Cellular Immunology(ed by Weir, D. M.) Blackwell Scientific Publication, Oxford, London, Edinburgh, Melbourne, 22. 1, 1978.

• 5) Lanier, LL., et al:Paraformaldehyde fixation of hematopoietic cells for quantitative flow cytometry(FACS) analysis. J. Immunol. Methods. 47:25, 1981.
  pubmed

P.514 掲載の参考文献

• 1) Kreisberg, J. I. et al:Separation of proximal tubule cells from suspensions of rat kidney cells in density gradients of ficoll in tissue culture medium. Am. J. Pathol. 86:590, 1977.

• 2) Jones, D. P. et al:Use of isolated kidney cells for study of drug metabolism. Biochem. Pharmacol. 28:929, 1979.
  pubmed

• 3) Heidrich, H, G. et al:Homogeneous cell populations from rabbit kidney cortex. Proximal, distal tubule, and renin-active cell isolated by free-flow electrophoresis. J. Cell Biol. 74:780, 1977.
  pubmed

• 4) Thimmappayya, B. et al:Preparation of kidney cell suspensions and respiration of kidney and liver cell suspensions. Exp. Cell Res. 63:333, 1970.
  pubmed

• 5) Berry, M. N. et al:High-yield preparation of isolated rat liver parenchymal cells. J, Cell Biol. 43:506, 1969.

• 6) Roser, B. et al:The distribution of intravenously injected Kupffer cells in the mouse. J. Reticuloeudothelial. Soc. 5:455, 1968.

• 7) Mills, D. M. et al:Electron microscopic study of isolated Kupffer cells. Am. J. Pathol. 54:147, 1969.
  pubmed

• 8) Knok, D. L. et al:Separation of Kupffer and endothelial cells of the rat liver by centrifugal elutriation, Exp. Cell Ret. 99:444, 1976.

• 9) Endou, H. et al:Use of a flow cytometer for the separarion of isolated kidney cells. Biochemistry of Kidney Function (Ed. by Morel F.) , Elsevier North-Holland Biomedical Press pp.69, 1982.

• 10) Endou, H.:Cytchrome P450 monooxygenase system in the rabbit kidney;its intranephron localization and its induction. Jpn J. Pharmacol. 33:423, 1983.

• 11) Kohler, G. et al:Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:496, 1975.

• 12) 「Immunochemistry in Practice」Eds. by Johnstone, A. Blackwell Sciectific Puhlications. 1982.

• 13) Koseki, C. et al:Characteristics of the isolated kidney cell recognized specifically with the monoclonal antibody(γG6) . Jpn. J. Pharmacol. 33(Suppl.) :91, 1983.

• 14) 北条一夫・他:Cell sorter(Flow cytometer) を利用したKupffer細胞の単離とその特性. Acta Hepat. Jpn. 23:864, 1982.

• 15) Gumucio, JJ. et al:Transport of fluorescent compounds into hepatocytes and the resultant zonal labeling of the hepatic acinus in the rat. Gastroenterology 30:639, 1981.

• 16) 遠藤仁・他:肝小葉中心部並びに周辺部細胞の分取とP450局在の特異性. 第68回日本薬理学会関東部会講演要旨 p. 33, 1983.

P.526 掲載の参考文献

• 1) C. P. Stanners and J. E. Till:DNA synthesis in illdividual L-strain mouse cells. Biochim. Biophys. Acta. 37:406, 1960.

• 2) I. Watanabe and S. OKada, :Effects of temperature on growth rate of cultured mammalian cells(L5178Y) . J. Cell Biol. 32:309, 1967.
  pubmed

• 3) P. N. Dean and J. H. Jett, :Mathematical analysis of DNA distributions derived from flow microfluorometry. J. Cell Biol. 60:523, 1974.

• 4) I. Christensen et al:Statistical analysis of DNA distributions from cell populations with partial synchrony. In"Third International Symposium on Pulse-Cytophotometry", (Ed) , D. Lutz, p. 71. European Press, Ghent. 1978.

• 5) P. N. Dean, :A simplified method of DNA distribution analysis. Cell Tissue Kinet. 13:299, 1980.

• 6) H. Baisch et al :Analysis of PCP-data to determine the fraction of cells in the variouse phases of cell cycle. Rad. Environ. Biophys. 12:31, 1975.

• 7) H. Baisch and H. -P. Beck, :Comparison of cell kinetic parameters obtained by flow cytometry and autoradiography. In "Biomathematics and Cell Kinetics", (Eds) , A. -J. Valleron and P. D. M. Macdonald. p. 411, Elsevier/North Holland, Amsterdam. 1978.

• 8) J. Fried, :Method for the quantitative evaluation of data from flow microfluorometry. Comput. Biomed. Res. 9:263, 1976.

• 9) J. Fried and M. Mandel, :Multi-user system for analysis of data from flow cytometry. Comput. Biomed 10:218, 1979.

• 10) H. -P. Beck, :A new analytical method for determining duration of phases, rate of DNA synthesis and degree of synchronization from flow-cytometric data on synchronized populations. Cell Tissue Kinet, 11:139, 1978.

• 11) J. H. Jett, :Mathematical analysis of DNA histograms from asynchronous cell populations. In "Third International Symposium on Pulse-Cytophotometry", (Ed) , D. Lutz. p. 93, European Press, Ghent. 1978.

• 12) D. A. Johnston, et al:Automatic processing and interpretation of DNA distribution:Comparison of several techniques. Comput. Biomed. Res. 11:393, 1978.

• 13) S. Zietz and C. Nicolini, :Flow microfluorometry and cell kinetics:A review. In"Biomathematics and Cell kinetics", (Eds) , A. -J. Valleron and P. D. M. Macdonald, p, 357. Elsevier/North Holland, Amsterdam 1978.

• 14) J. M. Collins et al:Different rate of DNA synthesis during the S phase of log Phase HeLa S3, WI-38, and 2RA cells. J. Biol. Chem. 255:3585, 1980.

• 15) M. Takahashi, :A multichannel method for the analysis of DNA content distribution using flow cytometric data. Comput. Biomed. Res. 14:506, 1981.

• 16) J. W. Gray, :Cell cycle analysis from computer synthesis of deoxyribonucleic acid histograms. J. Histochem. Chytochem. 22:642, 1976.

• 17) J. W. Gray, :Cell-cycle analysis of perturbed cell populations:Computer simulation of sequential DNA distributions. Cell Tissue Kinet. 9:499, 1976.

• 18) J. V. Watson, :The application of age distribution theory in analysis of cytofluorometric DNA histogram data. Cell Tissue Kinet. 10:157, 1977.

• 19) S. Zietz, :FPi Analysis. I. Theoretical outline of a new method to analyze time sequences of DNA histograms. Cell Tissue, Kinet. 13:461, 1980.

• 20) H. Baisch et al:A comparison of mathematical methods for the analysis of DNA histogram obtained by flow cytometry. Cell Tissue Kinet. 15:235, 1982.

P.542 掲載の参考文献

• 1) Gray, J. W, Dean, P. N. and Mendelsohn, M. L.:Quantitative cell-cycle analysis, in Flow Cytometry and Cell Sorting(eds. Melamed, M. R., Mullaney, P. F. and Mendelsohn, M. L.) John Wiley and Sons, pp.383, 1979.

• 2) Barlogie, B, Drewinko, D. A, et al:Pulse cytophotometric analysis of synchronized cells in vitro. Cancer Res. 36:1176, 1976.

• 3) Takahashi, M.:A multichannel method for the analysis of DNA content distribution using flow cytometric data. Comput. Biomed. Res. 14:506, 1981.

• 4) Watson, J. W.:The application of age distribution theory in the analysis of cytofluorimetric DNA histogram data. Cell Tissue Kinet. 10:157, 1977.

• 5) Kim, M. and Perry, S.:Mathematical model for determining cell DNA synthesis rate and age distribution utilizing flow microfluorometry. J. Theoret. Biol. 68:27, 1977.

• 6) Woo, K. B.:The discrete-time kinetic model analysis of DNA distributions in experimental tumor cells. Cell Tissue Kinet. 12:111, 1979.
  pubmed

• 7) Kraemer, P. M, Petersen, D. F and Van Dilla, M. A.:DNA constancy in heteroploidy and the stem line theory of tumors. Science 174:714, 1971.
  pubmed

• 8) Kraemer, P. M, Deaven, L. L, Crissman, H. A. and Van, Dilla, M. A.:DNA constancy despite variability in chromosome number. Adv. Cell Molec. Biol. 2:47, 1972.

• 9) Fried, J.:Method for the quantitative evaluation of data from flow microfluorometry. Comput. Biomed. Res. 9:263, 1976.
  pubmed

• 10) Dean, P. N. and Jett, J. H.:Mathematical analysis of DNA distributions derived flom frow microfluorometry. J. Cell. Biol. 60:523, 1974.

• 11) Van der Linden, P. M.:An iterative method of analysis for DNA histograms. in Flow Cytometry IV, (eds. Laerum, O. D., Lindmo, T. and Thorud, E.) Universitetforlaget, pp.133, 1980.

• 12) Takahashi, M.:DNA histogram analysis of exponentially growing and perturbed cell populations. in Biomathematics and Cell Kinetics(ed. Roten. berg, M.) Elsevier/North-Holland, pp.211, 1981.

• 13) Dean, P. N, Gray, J. W. and Dolbeare, F. A.:The analysis and interpretation of DNA distributions measured by flow cytometry. Cytometry 3:188, 1982.
  pubmed

P.559 掲載の参考文献

• 1) Mullaney, P. F., et al:Pulse height light-scatter distributions using flow systems instrumentation. J. Histchem. Cytochem. 24:298, 1976.
  pubmed

• 2) Salzman, G. C., et al:Light-scattering approaches to cell characterization. pp.105-124, in Flow cytometry and Sorting, John Wiley and Sons, 1979.

• 3) Fulwyler, M. J.:Electronic separation of biological cells by volume. Science 150:910, 1965.
  pubmed

• 4) Hulett, H. R., et al:Cell sorting:Automated separation of mammalian cells as a function of intracellular fluorescence Science 166:747, 1969.

• 5) Herzenberg, L. A., et al:Fluorescence activated cell sorting. Scientific American, pp.108, March 1976.

• 6) Kamentsky, LA., et al:Spectrophotometer:New instrument for ultrarapid cell analysis. Science 150:630, 1965.
  pubmed

• 7) Kamentsky, LA., et al:Spectrophotometric cell sorter. Science 156:1364, 1967.
  pubmed