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未契約
書籍名 血液凝固 ―止血と血栓・上
出版社 宇宙堂八木書店
発行日 1982-05-10
著者
  • 福武勝博(編集)
  • 山中學(編集)
ISBN
ページ数 313
版刷巻号 第1版
分野
  • 臨床医学:内科
  • 血液
閲覧制限 未契約

本書は現代凝血学の総輯的なものとしてその出版はまさに時宜をえたものであろう。上巻は総論的な内容を主として取り上げ、下巻は臨床の実際に直結する内容である。(序より)

目次

  • 表紙
  • 分担執筆者
  • 目次
  • 1. 血液凝固学説とその歩み
    • I. 凝血学の始め
      • A. フィブリンの発見
      • B. 血小板の発見
      • C. カルシウムの発見
    • II. 近代学説への展開
      • A. プロトロンビンの周辺
      • B. 血友病と類縁疾患
      • C. 接触因子系の発展
      • D. 促進因子の活性化
      • E. 阻止因子と制御
    • III. 線溶現象
      • A. 線溶と血栓
      • B. 線溶分解物
  • 2. 血栓
    P.45閲覧
    • I. 血栓の発生機序
      • A. 血栓形成の機序
        • 1. 血流
        • 2. 血管壁の性状
          • a. 血管壁と血小板
          • b. 血管壁と血液凝固
          • c. 血管壁と線維素溶解(線溶)
      • B. 凝固能亢進状態と血栓症
        • 1. 凝固能亢進状態の定義
        • 2. 凝固能亢進状態と血栓形成
          • a. 凝血因子活性の上昇と血栓形成
          • b. Antithrombin III の減少と血栓形成
          • c. 血小板機能の上昇と血栓形成
          • d. 線溶系因子の変化と血栓症
      • C. 凝固能亢進状態をひき起こす物質
      • D. 血栓の形態
        • 1. 血栓観察の歴史
        • 2. 血栓形成の微細形態
          • a. In vivoの血栓形成
          • b. 血栓の融解と器質化
      • E. 血栓症の診断
        • 1. 血液の変化による診断
          • a. Prethrombotic stateの変化
          • b. During thrombotic stateの変化
          • c. Postthrombotic stateの変化
        • 2. 血小板の変化による診断
      • F. 血栓に対する生体の防衛機構
        • 1. 活性型凝血因子の除去
        • 2. Antithrombins
        • 3. 線溶系の活性化
    • II. 血栓症の病理
      • A. 血栓の種類とその形成機序
        • 1. 赤色血栓
        • 2. 白色血栓
        • 3. フィブリン血栓
      • B. 血栓形成と関連する血管壁の性状
        • 1. 血管壁の凝固活性
        • 2. 血管壁の線溶活性
        • 3. 血管内皮の性状
      • C. 血流異常と血栓
      • D. 血液脂質と血栓症
      • E. 血栓溶解の機序
        • 1. 血栓溶解の機序に関する諸説とわれわれの考え
        • 2. 血栓の古さと血栓溶解
        • 3. 血栓溶解におけるプラスミノゲン組織アクチベータの意義
        • 4. 血栓溶解における好中球の意義
        • 5. 血栓溶解における抑制物質の意義
        • 6. 血栓溶解療法
        • 7. まとめ
      • F. 血栓と動脈硬化
        • 1. 粥状硬化の発生要因としての血栓
          • a. 血栓原性動脈硬化発生説とその批判
          • b. 局所線溶と血栓原性動脈硬化発生説
          • c. 動脈硬化の発生病理における血栓原説と血漿滲み込み説の位置づけ
        • 2. 粥状硬化の合併病変としての血栓
      • G. 冠状動脈血栓症と脳動脈血栓症
      • H. 癌と血栓
      • I. 血栓と出血
      • J. 血管内凝固症候群(DIC)の病理
        • 1. 血管内凝固症候群の概念
        • 2. 発生病理
        • 3. DICを起こす疾患
        • 4. 形態学的所見
      • K. 血栓症の地理病理と時代的推移
      • L. まとめ
  • 3. 血液凝固因子
    P.105閲覧
    • I. 凝固促進因子
      • A. 接触因子
        • 1. XII因子
          • a. 純化精製
          • b. 物理化学的性質
          • c. 凝血学的性質
        • 2. Fletcher因子(プレカリクレイン)
          • a. 純化精製および物理化学的性質
          • b. 凝血学的性質
        • 3. Fitzgerald
      • B. XI因子
        • 1. 純化精製
        • 2. 物理化学的性質
        • 3. 凝血学的性質
      • C. IX因子
        • 1. 純化精製
        • 2. 物理化学的性質
        • 3. 凝血学的性質
      • D. VIII因子
        • 1. 純化精製
        • 2. 一般的性質
        • 3. 構造と機能
          • a. VIII R: AG
          • b. VIII: C
        • 4. 産生器官
      • E. X因子
        • 1. 純化精製
        • 2. 物理化学的性質
        • 3. 凝血学的性質
      • F. 組織トロンボプラスチン
        • 1. 純化精製
        • 2. 物理化学的性質
        • 3. 凝血学的性質
      • G. VII因子
        • 1. 純化精製
        • 2. 物理化学的性質
        • 3. 凝血学的性質
      • H. V因子
        • 1. 純化精製
        • 2. 物理化学的性質
        • 3.凝血学的性質
      • I. II因子
        • 1. 純化精製
        • 2. 物理化学的性質
          • a. ビタミンKとγカルボキシグルタミン酸の生成
          • b. プロトロンビンの活性化
          • c. その他の化学的性質
        • 3. トロンビンの凝血学的性質
      • J. I因子
        • 1. 純化精製
        • 2. 物理化学的性質
          • a. トロンビンフィブリノゲン反応
          • b. フィブリンと安定化
          • c. FDP
        • 3. 代謝および分布
      • K. XIII因子
        • 1. 純化精製
        • 2. 物理化学的, 凝血学的性質
        • 3. 代謝
    • II. 凝固抑制因子
      • A. アンチトロンビン
        • 1. アンチトロンピンI
        • 2. アンチトロンビンII
        • 3. アンチトロンビンIII
        • 4. アンチトロンビンIV
        • 5. アンチトロンビンV
        • 6. アンチトロンビンVI
        • 7. α2-マクログロブリン
      • B. 活性化第X因子に対する抑制因子
      • C. 接触因子(XIおよびXII因子)の阻害
      • D. 燐脂質
      • E. ヘパリン
      • F. その他の抗凝固因子
      • G. Protein C
  • 4. 線維素溶解現象
    P.161閲覧
    • A. 序論
    • B. 線溶現象に関係する諸因子
      • 1. プラスミノゲン
        • a. 蛋白化学的性質
        • b. プラスミノゲンの生合成
        • c. プラスミノゲンの代謝
      • 2. プラスミノゲン・アクチベータ(とくにウロキナーゼとストレプトキナーゼ)
        • a. ウロキナーゼ
        • b. ストレプトキナーゼ
      • 3. 血管壁および組織プラスミノゲン・アクチベータ
        • a. 血管壁プラスミノゲン・アクチベータ
        • b. 組織プラスミノゲン・アクチベータ
        • c. その他
      • 4. プラスミンとミニプラスミン
        • a. プラスミン
        • b. ミニプラスミン
      • 5. プラスミンによるフィブリノゲンおよびフィブリン分解
      • 6. 線溶系諸因子の活性阻止物質
        • a. 血漿中に認められる阻止物質
        • b. 合成阻止物質
    • C. 線溶系と凝固系・キニン系
      • 1. 第XII因子とプラスミン
        • a. 第XII因子の活性化
      • 2. Fletcher因子とプラスミン
      • 3. Fitzgerald因子, Flaujeac因子とプラスミン
    • D. 線溶現象以外の現象でプラスミンが関係しているとみなされる現象
      • 1. 補体とプラスミン
      • 2. 細胞増殖とプラスミン
      • 3. その他
  • 5. 血小板
    P.201閲覧
    • I. 血小板の生成, 代謝と機能
      • A. 血小板の生成
        • 1. 巨核球の生成
        • 2. 血小板の生成と制御
          • a. 血小板生成
          • b. 血小板生成の制御
        • 3. 血小板寿命
        • 4. 血小板の分布
      • B. 血小板の代謝と機能
        • 1. 血小板機能
          • a. 毛細血管内皮支持機能
          • b. 止血における役割
        • 2. 血小板の代謝
          • a. エネルギー代謝
          • b. 血小板凝集とcyclic AMP(cAMP)
          • c. 血小板のagingと代謝
        • 3. 血小板機能異常症
          • a. 血小板酵素とその異常
          • b. 代謝の異常
    • II. 血小板の形態と機能
      • A. 静止相における正常血小板
        • 1. 外形
        • 2. 内部構造
          • a. 表衣
          • b. 形質膜
          • c. 開放小管系
          • d. 暗調小管系
          • e. 微細小管(微小管)
          • f. 顆粒
          • g. 細線維(微小系)
          • h. グリコゲン粒子
          • i. 糸粒体
          • j. Siderosome
          • k. 小胞体およびGolgi装置
      • B. 機能相における正常血小板
        • 1. 血小板粘着
        • 2. 凝集
        • 3. 放出反応
        • 4. 外形と機能
      • C. 病的血小板
        • 1. 形態
        • 2. 生成
        • 3. 形態と機能の関連
      • D. おわりに
  • 6. 毛細血管
    P.255閲覧
    • I. 毛細血管の構造
      • 1. 内皮細胞の核と細胞質の微細構造
      • 2. 内皮細胞の小胞構造といわゆる窓について
      • 3. 内皮細胞の表面構造
        • a. 内皮細胞の内腔面
        • b. 内皮細胞の基底側表面
        • c. 内皮細胞同士の接合面
      • 4. 基底膜
      • 5. 外膜
      • 6. 神経要素
      • 7. 毛細血管の分類
        • a. 閉鎖型毛細血管(筋型毛細血管)
        • b. 有窓性毛細血管(内臓型毛細血管)
        • c. 洞または類洞
      • 8. おわりに
    • II. 血管透過性
      • 1. 微小循環の解剖学
      • 2. 生理的血管透過
      • 3. 病的血管透過
        • a. 血管透過性亢進の検出法
        • b. 病的血管透過亢進の電顕像
        • c. 血管壁傷害による滲出
      • 4. 血管透過性因子
        • a. 血管作動性アミン
        • b. キニン
        • c. キニン生成系
        • d. キニン分解酵素キニナーゼ
        • e. カリクレインキニン系
        • f. その他の血管透過性因子
  • 索引
    P.291閲覧
  • 奥付

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1. 血液凝固学説とその歩み

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3. 血液凝固因子

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4. 線維素溶解現象

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5. 血小板

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