書籍詳細

特別講演1. ミクロビオームワイド関連研究 (MiWAS) : 代謝疾患における腸内フローラの役割

P.7 掲載の参考文献

• 1) Chenhong Zhang, Liping Zhao et al.:Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. The ISME Journal 2010, 4:232-241

• 2) Chenhong Zhang, Liping Zhao et al.:Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations. The ISME Journal 2012, 6:1848-1857

• 3) Liping Zhao et al.:Targeting the human genome-microbiome axis for drug discovery:Inspirations from global global system biology and traditional chinese medicine. Journal of Proteome Research 2012, 11 (7):3509-3519

P.12 掲載の参考文献

• 1) Sleeth ML, Thompson EL, Ford HE, Zac-Varghese SEK, Frost G:Free fatty acid receptor 2 and nutrient sensing:A proposed role for fibre, fermentable carbohydrates and short-chain fatty acids in appetite regulation. Nutr Res Rev 2010, 23:135-145

• 2) Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ:Review article:The role of butyrate on colonic function. Aliment Pharmacol Ther 2008, 27:104-119

• 3) Barcenilla A, Pryde SE, Martin J, Duncan SH, Stewart CS, Henderson C, Flint HJ:Phylogenetic relationships of dominant butyrate producing bacteria from the human gut. Appl Environ Microbiol 2000, 660:1654-1661

• 4) Louis P, Duncan SH, McCrae SI, Millar J, Jackson MS, Flint HJ:Limited distribution of butyrate kinase among human colonic bacteria. J Bacteriol 2004, 186:2099-2106

• 5) Flint HJ, Scott KP, Duncan SH, Louis P, Forano E.:Microbial degradation of complex carbohydrates in the gut. Gut Microbes 2012, 3:289-306

• 6) Walker AW, Ince J, Duncan SH, Webster LM, Holtrop G, Ze X, Brown D, Stares MD, Scott P, Bergerat A et al.:Dominant and diet-responsive groups of bacteria within the human colonic microbiota. ISME J 2011, 5:220-230

• 7) Louis P, Young P, Holtrop G, Flint HJ:Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene. Environ Microbiol 2010, 12:304-314

• 8) Louis P, Flint HJ:Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS Microbiol Lett 2009, 294:1-8

• 9) Duncan SH, Belenguer A, Holtrop G, Johnstone AM, Flint HJ, Lobley GE:Reduced dietary intake of carbohydrate by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl Environ Microbiol 2007, 73:1073-1078

• 10) Russell WR, Gratz S, Duncan SH, Holtrop G, Ince J, Scobbie L, Duncan G, Johnstone AM, Lobley GE, Wallace RJ et al.:High protein, reduced carbohydrate diets promote metabolite profiles likely to be detrimental to colonic health. Am J Clin Nutrition 2001, 93:1062-1072

• 11) Duncan SH, Louis P, Flint HJ:Lactate-utilising bacteria, isolated from human faeces, that produce butyrate as a major fermentation product. Appl Environ Microbiol 2004, 70:5810-5817

• 12) Allen-Vercoe E, Daigneault M, White A, Panccione R, Duncan SH, Flint HJ, O'Neal L, Lawson PA:Anaerostipes hadrus comb nov., a dominant species within the human colonic microbiota; reclassification of Eubacterium hadrum Moore et al. 1976. Anaerobe 2012, 18:523-529.

• 13) Belenguer A, Holtrop G, Duncan SH, Anderson SE, Calder AG, Flint HJ, Lobley GE:Rates of production and utilization of lactate by microbial communities from the human colon. FEMS Microbiol Ecol 2011, 77:107-119

• 14) Neville BA, Sheridan PO, Harris HMB, Coughlan S, Flint HJ, Duncan SH, Jeffrey IB, Claesson MJ, Ross RP, Scott KP et al.:Pro-inflammatory flagellin proteins of prevalent motile commensal bacteria are variably abundant in the intestinal microbiome of elderly humans. PLoS One 2013 (in press).

• 15) Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermudez-Humaran LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G et al.:Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Nat Acad Sci USA 2008, 105:16731-16736

• 16) Martens EC, Koropatkin NM, Smith TJ, Gordon JI:Complex glycan catabolism by the human gut microbiota:The Bacteroidetes sus-like paradigm. J Biol Chem 2009, 284:24673-24677

• 17) Salyers AA, Vercellotti JR, West HE, Wilkins TD:Fermentation of mucin and plant polysaccharides by strains of Bacteroides from the human colon. Appl Environ Microbiol 1977, 33:319-322

• 18) Walker AW, Duncan SH, Harmsen HJM, Holtrop G, Welling GW, Flint HJ:The species composition of the human intestinal microbiota differs between particle-associated and liquid phase communities. Environ Microbiol 2008, 10:3275-3283

• 19) Flint HJ, Bayer EA, Rincon MT, Lamed R, White BA:Polysaccharide utilization by gut bacteria:Potential for new insights from genomic analysis. Nature Rev Microbiol 2008, 6:121-131

• 20) Ze X, Duncan SH, Louis P, Flint HJ:Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon. ISME J 2012, 6:1535-1543

• 21) Ze X, Le Mougen F, Duncan SH, Louis P, Flint HJ:Some are more equal than others:the role of keystone species in the degradation of recalcitrant substrates. Gut Microbes 2013, 4:236-240

• 22) Flint HJ, Scott KP, Louis P, Duncan SH:The role of the gut microbiota in nutrition and health. Nature Revs Gastro Hepatol 2012, 9:577-589

• 23) Abell GCJ, Cooke CM, Bennett CN, Conlon MA, McOrist AL:Phylotypes related to Ruminococcus bromii are abundant in the large bowel of humans and increase in response to a diet high in resistant starch. FEMS Microbiol Ecol 2008, 66:505-515

• 24) Martinez I, Kim J, Duffy PR, Schlegel VL, Walter J:Resistant starches types 2 and 4 have differential effects on the composition of the fecal microbiota in human subjects. PLoS One 2010, 5:e15046
  pubmed

• 25) Ramirez-Farias C, Slezak K, Fuller Z, Duncan A, Holtrop G, Louis P:Effect of inulin on the human gut microbiota:stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii. Br J Nutr 2009, 101:541-550

• 26) Bouhnik Y, Raskine L, Simoneau G, Vicaut E, Neut C, Fourie B, Brouns F, Bornet FR:The capacity of nondigestible carbohydrates to stimulate fecal bifidobacteria in healthy humans:A double-blind, randomized, placebo-controlled, parallel-group, dose-response relation study. Am J Clin Nutr 2004, 80:1658-1664

• 27) Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbough SA, Bewtra M, Knights D, Walters WA, Knight R et al.:Linking long-term dietary patterns with gut microbial enterotypes. Science 2011, 334:105-108

• 28) De Filippo C, Cavalieri D, Ramazotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P:Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sc i. USA 2010, 107:14691-14696

P.20 掲載の参考文献

• 1) Qin J, Li R, Raes J et al.:A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010, 464:59-65

• 2) Lozupone CA, Knight R:Species divergence and the measurement of microbial diversity. FEMS Microbiol Rev 2008, 32:557-578

• 3) Hooper LV, Gordon JI:Commensal host-bacterial relationships in the gut. Science 2001, 292:1115-1118

• 5) Baker M. Genomics:The search for association. Nature 2010, 467:1135-1138

• 6) Badman MK, Flier JS:The adipocyte as an active participant in energy balance and metabolism. Gastroenterology 2007, 132:2103-2115.
  pubmed

• 7) Olszak T, An D, Zeissig S, et al.:Microbial exposure during early life has persistent effects on natural killer T cell function. Science 2012, 336:489-493

• 8) Khor B, Gardet A, Xavier RJ:Genetics and pathogenesis of inflammatory bowel disease. Nature 2011, 474:307-317

• 9) Bloom SM, Bijanki VN, Nava GM et al.:Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe 2011, 9:390-403

• 10) Sartor RB:Therapeutic correction of bacterial dysbiosis discovered by molecular techniques. Proc Natl Acad Sci USA 2008, 105:16413-16414

• 11) Garrett WS, Lord GM, Punit S et al.:Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 2007, 131:33-45

• 12) Elinav E, Strowig T, Kau AL, et al.:NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011, 145:745-757

• 13) Virgin HW, Todd JA:Metagenomics and personalized medicine. Cell 2011, 147:44-56

• 14) Spor A, Koren O, Ley R:Unravelling the effects of the environment and host genotype on the gut microbiome. Nat Rev Microbiol 2011, 9:279-290

• 15) Turnbaugh PJ, Hamady M, Yatsunenko T et al.:A core gut microbiome in obese and lean twins. Nature 2009, 457:480-484

• 16) Palmer C, Bik EM, DiGiulio DB et al.:Development of the human infant intestinal microbiota. PLoS Biol 2007, 5:e177.
  pubmed

• 17) Koenig JE, Spor A, Scalfone N, et al.:Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci USA 2011, 108 (Suppl 1):4578-4585

• 18) Schwartz S, Friedberg I, Ivanov IV, et al.:A metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response. Genome Biol 2012, 13:R32
  pubmed

• 19) Roger LC, McCartney AL.:Longitudinal investigation of the faecal microbiota of healthy full-term infants using fluorescence in situ hybridization and denaturing gradient gel electrophoresis. Microbiology 2010, 156:3317-3328

• 20) Fallani M, Amarri S, Uusijarvi A et al.:Determinants of the human infant intestinal microbiota after the introduction of first complementary foods in infant samples from five European centres. Microbiology 2011, 157:1385-1392

• 21) Fallani M, Young D, Scott J et al.:Intestinal microbiota of 6-week-old infants across Europe:geographic influence beyond delivery mode, breast-feeding, and antibiotics. J Pediatr Gastroenterol Nutr 2010, 51:77-84

• 22) Faith JJ, McNulty NP, Rey FE et al.:Predicting a human gut microbiota's response to diet in gnotobiotic mice. Science 2011;333:101-104

• 23) Muegge BD, Kuczynski J, Knights D et al.:Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science 2011, 332:970-974

• 24) Wu GD, Chen J, Hoffmann C et al.:Linking long-term dietary patterns with gut microbial enterotypes. Science 2011, 334:105-108

• 25) Arumugam M, Raes J, Pelletier E et al.:Enterotypes of the human gut microbiome. Nature 2011, 473:174-180

• 26) De Filippo C, Cavalieri D, Di Paola M et al.:lmpact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 2010, 107:146911469-6

• 27) Yatsunenko T, Rey FE, Manary MJ et al.:Human gut microbiome viewed across age and geography. Nature 2012;486:222-7.
  pubmed

• 28) Lozupone CA, Stombaugh JI, Gordon JI et al.:Diversity, stability and resilience of the human gut microbiota. Nature 2012, 489:220-230

• 29) Faust K, Sathirapongsasuti JF, Izard J et al.:Microbial co-occurrence relationships in the human microbiome. PLoS Comput Biol 2012, 8:e1002606
  pubmed

• 30) Wang Z, Klipfell E, Bennett BJ et al.:Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011, 472:57-63

• 31) Molodecky NA, Soon IS, Rabi DM et al.:Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 2012, 142:46-54 e42; quiz e30

• 32) Lashner BA.:Epidemiology of inflammatory bowel disease. Gastroenterol Clin North Am 1995, 24:467-474

• 33) Chapman-Kiddell CA, Davies PS, Gillen L et al.:Role of diet in the development of inflammatory bowel disease. Inflamm Bowel Dis 2010, 16:137151

• 34) Hou JK, Abraham B, El-Serag H.:Dietary intake and risk of developing inflammatory bowel disease:a systematic review of the literature. Am J Gastroenterol 2011, 106:563-573

• 35) Devkota S, Wang Y, Musch MW et al.:Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in I110-/-mice. Nature 2012, 487:104-108

• 36) Sandhu BK, Fell JM, Beattie RM et al.:Guidelines for the management of inflammatory bowel disease in children in the United Kingdom. J Pediatr Gastroenterol Nutr 2010
  pubmed

• 37) Caprili R, Gassull MA, Escher JC et al.:European evidence based consensus on the diagnosis and management of Crohn's disease:special situations. Gut 2006, 55 (Suppl 1):i36-58

• 38) Takagi S, Utsunomiya K, Kuriyama S et al.:Effectiveness of an:`half elemental diet as maintenance therapy for Crohn's disease:A randomized-controlled trial. Aliment Pharmacol Ther 2006, 24:1333-1340

• 39) Zachos M, Tondeur M, Griffiths AM.:Enteral nutritional therapy for inducing remission of Crohn's disease. Cochrane Database Syst Rev 2001:CD000542
  pubmed

• 40) Leach ST, Mitchell HM, Eng WR et al.:Sustained modulation of intestinal bacteria by exclusive enteral nutrition used to treat children with Crohn's disease. Aliment Pharmacol Ther 2008, 28:724-733

• 41) Lionetti P, Callegari ML, Ferrari S et al.:Enteral nutrition and microflora in pediatric Crohn's disease. JPEN J Parenter Enteral Nutr 2005, 29:S173-5; discussion S175-8, S184-188

• 42) Claesson MJ, Jeffery IB, Conde S et al.:Gut microbiota composition correlates with diet and health in the elderly. Nature 2012, 488:178-184

講演1. 胆汁酸と腸内フローラ

P.30 掲載の参考文献

• 1) Margolles A, Yokota A:Bile acid stress in lactic acid bacteria and bifidobacteria. In:Sonomoto K, Yokota A, ed. Lactic Acid Bacteria and Bifidobacteria:Current Progress in Advanced Research. Norfolk, UK:Caister Academic Press, 2011:111-142

• 2) Islam KBMS, Fukiya S, Hagio et al.:Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 2011, 141:1773-1781

• 3) Yokota A, Fukiya S, Islam KBMS et al.:Is bile acid a determinant of the gut microbiota on a high-fat diet? Gut Microbes 2012;3:455-459

• 4) Turnbaugh PJ, Ley RE, Mahowald MA et al.:An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444:1027-1031

• 5) Ley RE, Turnbaugh PJ, Klein S et al.:Human gut microbes associated with obesity. Nature 2006, 444:1022-1023

• 6) Turnbaugh PJ, Backhed F, Fulton L et al.:Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 2008, 3:213-223

• 7) Larsen N, Vogensen FK, van den Berg FW et al.:Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One, 2010;5:e9085
  pubmed

• 8) Vijay-Kumar M, Aitken JD, Carvalho, FA et al.:Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010, 328:228-231

• 9) Gophna U.:The guts of dietary habits. Science 2011, 334:45-46

• 10) Reddy BS.:Diet and excretion of bile acids. Cancer Res 1981, 41:3766-3768

• 11) Ridlon JM, Kang DJ, Hylemon PB.:Bile salt biotransformations by human intestinal bacteria. J Lipid Res 2006, 47:241-259

• 12) Kurdi P, Kawanishi K, Mizutani K et al.:Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria. J Bacteriol 2006, 188:1979-1986

• 13) Stacey M, Webb M:Studies on the antibacterial properties of the bile acids and some compounds derived from cholanic acid. Proc R Soc Lond B 1947, 134:523-537

• 14) Begley M, Gahan CGM, Hill C:The interaction between bacteria and bile. FEMS Microbiol Rev 2005, 29:625-651

• 15) Bernstein H, Bernstein C, Payne CM et al.:Bile acids as carcinogens in human gastrointestinal cancers. Mutat Res 2005, 589:47-65

• 16) Floch MH, Binder HJ, Filburn B et al.:The effect of bile acids on intestinal microflora. Am J Clin Nutr 1972, 25:1418-1426

• 17) Ley RE, Backhed F, Turnbaugh P et al.:Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 2005, 102:11070-11075

• 18) Eckburg PB, Bik EM, Bernstein CN et al.:Diversity of the human intestinal microbial flora. Science 2005, 308:1635-1638

• 19) Tap J, Mondot S, Levenez F et al.:Towards the human intestinal microbiota phylogenetic core, Environ Microbiol 2009, 11:2574-2584

• 20) Hildebrandt MA, Hoffmann C, Sherrill-Mix SA et al.:High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology 2009, 137:1716-1724

• 21) Turnbaugh PJ, Ridaura VK, Faith JJ et al.:The effect of diet on the human gut microbiome:a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med 2009, 1:6ra14. doi:10. 1126/scitranslmed. 3000322

• 22) Martinez I, Wallace G, Zhang C et al:Diet-induced metabolic improvements in a hamster model of hypercholesterolemia are strongly linked to alterations of the gut microbiota. Appl Environ Microbiol 2009, 75:4175-4184

• 23) De Filippo C, Cavalieri D, Di Paola M et al.:Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 2010, 107:14691-14696

• 24) Bekele AZ, Koike S, Kobayashi Y:Genetic diversity and diet specificity of ruminal Prevotella revealed by 16SrRNA gene-based analysis. FEMS Microbiol Lett 2010, 305:49-57

• 25) Shah HN, Chattaway, MA, Rajakurana L et al.:Genus L Prevotella Shah and Collins 1990, 205VP emend. Willems and Collins 1995, 834VP. In:Krieg NR, Staley JT, Brown DR, Hedlund BP, Paster BJ, Ward NL, Ludwig W, Whitman WB, ed. "Bergey's Manual of Systematic Bacteriology", The Bacteroidetes, Spirochaetes, Tenericutes (Mollicutes), Acidobacteria, Fibrobacteres, Fusobacteria, Dictyoglomi, Gemmatimonadetes, Lentisphaerae, Verrucomicrobia, Chlamydiae, and Planctomycetes. Volume 4. 2nd ed. New York Dordrecht Heidelberg London:Springer, 2011:86-102

• 26) Song Y, Liu C, and Finegold SM, Genus I.:Bacteroides Castellani and Chalmers 1919, 959AL emend. Shah and Collins 1989, 85. In:Krieg NR, Staley JT, Brown DR, Hedlund BP, Paster BJ, Ward NL, Ludwig W, Whitman WB, ed. "Bergey's Manual of Systematic Bacteriology", The Bacteroidetes, Spirochaetes, Tenericutes (Mollicutes), Acidobacteria, Fibrobacteres, Fusobacteria, Dictyoglomi, Gemmatimonadetes, Lentisphaerae, Verrumicrobia, Chlamydiae, and Planctomycetes. Volume 4. 2nd ed. New York Dordrecht Heidelberg London:Springer, 2011:27-41

• 27) Arumugam M, Raes J, Pelletier E et al.:Enterotypes of the human gut microbiome. Nature 2011, 473:174-180

• 28) Wu GD, Chen J, Hoffmann C et al.:Linking long-term dietary patterns with gut microbial enterotypes. Science 2011, 334:105-108

講演2. 大腸粘膜における化学受容機構について

P.42 掲載の参考文献

• 1) Uneyama H and Takeuchi K:New frontiers in gut nutrient sensor research--from taste physiology to gastroenterology:preface. J Pharmacol Sci 2010, 112:6-7
  pubmed

• 2) Fujita T and S Kobayashi:Structure and function of gut endocrine cells. Int Rev Cyrol Suppl 1977, 6:187-233

• 3) Tazoe H, Y Otomo, SI Karaki, I Kato, Y Fukami, M Terasaki and A Kuwahara:Expression of short-chain fatty acid receptor GPR41 in the human colon. Biomed Res 2009, 30:149-156

• 4) Solcia E:Update on Lausanne classification of endocrine cells. In Gut Hormones, 2nd. (ed by Bloom SR, Polak JM) Chrchill Livingstone, Edinburgh, 1982, p96-100

• 5) Hofer D and D Drenckhahn D:Idntification of brush cells in the alimentary and respiratory system by antibodies to villin and fimbrin. Histochemistry 1992, 98 (4):237-242

• 6) Hofer D, B Puschel and D Drenckhahn D:Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin. Proc Natl Acad Sci USA 1996, 93 (13):6631-6634

• 7) Perez CA, L Huang, M Rong, JA Kozak, AK Preuss, H Zhang, M Max and RF Margolskee:A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci 2002, 5 (11):1169-1176

• 8) Hass N, K Schwarzenbacher and H Breer:T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach. Cell Tissue Res 2010, 339 (3):493-504

• 9) Sbarbati A, P Bramanti, D Benati and F Merigo:The diffuse chemsensory system:exploring the iceberg toward the definition of functional roles. Prog Neurobiol 2010, 9 (1):77-89

• 10) Yajima T, R Inoue, M Matsumoto and M Yajima:Non-neuronal release of Ach plays a key role in secretory response to luminal propionate in rat colon. J Physiol 2011, 589 (Pt 4):953-962

• 11) Karaki SI, A Kuwahara:Propionate-induced epithelial K+ and C1/HCO3:secretion and free fatty acid receptor 2 (FFA2, GPR43) expression in the guinea pig distal colon. Pflugers Arch 2011, 461:141-152

• 12) Mitsui R, S Ono, SI Karaki and A. Kuwahara:Propionate modulates spontaneous contractions via enteric nerves and prostaglandin release in the rat distal colon. Jpn J Physiol 2005, 55:331-338

• 13) Ono S, SI Karaki and A. Kuwahara:Short-chain fatty acids decrease the frequency of spontaneous contractions of longitudinal muscle via enteric nerves in rat distal colon. Jpn J Physiol 2004, 54:483-493

• 14) Mitsui R, S Ono, SI Karaki and A Kuwahara:Neural and non-neural mediation of propionate-induced contractile responses in the rat distal colon. Neurogastroenterol Motil 2005, 17:585-594

• 15) Kaji I, SI Karaki, R Tanaka and A Kuwahara:Density distribution of free fatty acid receptors 2 (FFA2)-expressing and GLP-1 producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide. J Mol Histol 2011, 42:27-38

• 16) Brown AJ, SM Goldsworthy, AA Barnes, MM Eilert, L Tcheang, D Daniels, AI Muir, MJ Wigglesworth, I Kinghorn, NJ Fraser, NB Pike, JC Strum, KM Steplewski, PR Murdock, JC Holder, FH Marshall, PG Szekeres, S Wilson, DM Ignar, SM Foord, A Wise and SJ Dowell:The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate ans other short chain carboxylic acids. J Biol Chem 2003, 278 (13):11312-11319

• 17) Le Poul E, C Loison, S Struyf, JY Springael, V Lannoy, ME Decobecq, S Brezillon, V Dupriez, G Vassart, J VanDamme, M Parmentier and M Detheux:Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 2003, 278 (28):25481-25489

• 18) Stoddart LA, NJ Smith and G Milligan:International Pharmacology. LXXI. Free fatty acid receptors FFAI, -2, and-3:pharmacology and pathophysiological functions. Pharmacol Rev 2008, 60:405-417

• 19) Karaki SI, R Mitsui, H Hayashi, I Kato, H Sugiya, T Iwanaga, JB Furness and A Kuwahara. Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res, 2006, 324 (3):353-360

• 20) Karaki SI, H Tazoe, H Hayashi, H Kashiwabara, K Tooyama, Y Suzuki and A Kuwahara. Expression of the short--chain fatty acid receptor, GPR43, in the human colon. J Mol Histol 2008, 39:135-142

• 21) Hirasawa A, K Tumaya, T Awaji, S Katsuma, T Adachi, M Yamada, Y Sugimoto, S Miyazaki and G Tsujimoto:Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 2005, 11 (1):90-94

• 22) Itoh Y, Y Kawamata, M Harada, M Kobayashi, R Fujii, S Fukushima, K Ogi, M Hosoya, Y Tanaka, H Uejima, H Tanaka, M Maruyama, R Satoh, S Okubo, H Kizawa, H Komatsu, F Matsumura, Y Noguchi, T Shinohara, S Hinuma, Y Fujisawa and M Fujino:Free aftty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 422:173-176, 2003

• 23) Kaji I, SI Karaki, Y Fukami, M Terasaki and A Kuwahara:Secretory effects of a luminal bitter testant and expression of bitter taste receptors, T2Rs, in the human and rat large intestine. Am J Physiol 2009, 296:G971-981

• 24) Kaji I, SI Karaki and A Kuwahara:Effect of luminal thymol on epithelial transport in human and rat colon. Am J Physiol 2011, 300:G1132-G1143

講演3. 炎症性腸疾患に対する腸内環境改善の有用性について

P.56 掲載の参考文献

• 1) Madsen KL, Doyle JS, Jewell LD et al.:Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice. Gastroenterology 1999, 116:1107-1114

• 2) Kruis W, Schutz E, Fric P, et al.:Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis. Aliment Pharmacol Ther 1997, 11:853-858

• 3) Venturi A, Gionchetti P, Rizzello F et al.:Impact on the composition of the faecal flora by a new probiotic preparation:preliminary data on maintenance treatment of patients with ulcerative colitis. Aliment Pharmacol Ther 1999, 13:1103-1108

• 4) Ishikawa H, Akedo I, Umesaki Y et al.:Randomized controlled trial of the effect of bifidobacteria-fermented milkonulcerative colitis. J Am Coll Nutr 2003, 22:56-63

• 5) Kato K, Mizuno S, Umesaki Y et al.:Randomized placebo-controlled trial assessing the effect of bifidobacteria--fermented milk on active ulcerative colitis. Aliment Pharmacol Ther 2004, 20:1133-1141

• 6) Lichtiger S, Present DH, Kornbluth A et al.:Cyclosporine in severe ulcerative colitis refractory to steroid therapy. N Engl J Med 1994, 330:1841-1845

• 7) Harig JM, Soergel KH, Komorowskj RA et al.:Treatment of diversion colitis with short-chain-fatty acid irrigation. N Engl J Med 1989, 320:23-28

• 8) Matts SGF:Quarterly Journal of Medicine 1961, 120:393-407

• 9) Rembacken BJ, Snelling AM, Hawkey PM et al.:Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis:a randomised trial. Lancet 1999, 21;354:635-639

• 10) Tursi A, Brandimarte G, Giorgetti GM et al.:Low-dose balsalazide plus a high-potency probiotic preparation is more effective than balsalazide alone or mesalazine in the treatment of acute mild-to-moderate ulcerative colitis. Med Sci Monit 2004, 10:PI 126-131

• 11) Tursi A, Brandimarte G, Papa A et al.:Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment:a double-blind, randomized, placebo-controlled study. Am J Gastroenterol, 2010, 105:2218-2227

• 12) Bibiloni R, Fedorak RN, Tannock GW et al.:VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis. Am J Gastroenterol 2005, 100:1539-1546

• 13) Sood A, Midha V, Makharia GK et al.:The probiotic preparation, VSL#3 induces remission in patients with mild-to-moderately active ulcerative colitis. Clin Gastroenterol Hepatol 2009, 7:1202-1209

• 14) Kato K, Ishii Y, Mizuno S et al.:Usefulness of rectally administering [1-13C]-butyrate for breath test in active and quiescent ulcerative colitis patients. Scand J of Gastroenterol 2007, 42:207-214

• 15) Ohkusa T, Nomura T, Terai T et al.:Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis:a randomized, controlled pilot trial with long-term follow-up. Scand J Gastroenterol 2005, 40:1334-1342

• 16) Ohkusa T, Kato K, Terao S et al.:Newly developed antibiotic combination therapy for ulcerative colitis:A double-blind placebo-controlled multicenter trial. Am J of Gastroent 2010, 105:1820-1829

• 17) Uehara T, Kato K, Ohkusa T et al.:Efficacy of antibiotic combination therapy in patients with active ulcerative colitis, including refractory or steroid-dependent disease. J of Gastro and Hepatology 2010, 25:S62-66
  pubmed

• 18) Schroder KW, Tremaine WJ, Ilstrup DM:Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study:A randomized study. N Eng J Med 1987, 317:1625-1629

• 19) Plein K, Hotz J:Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea-a pilot study. Z Gastroenterol 1993, 31:129-134

• 20) Guslandi M, Mezzi G, Sorghi M et al.:Saccharomyces boulardii in maintenance treatment of Crohn's disease. Dig Dis Sci 2000, 45:1462-1464

• 21) Malchow HA:Crohn's disease and Escherichia coli. A new approach in therapy to maintain remission of colonic Crohn's disease? J Clin Gastroenterol 1997, 25:653-658

• 22) Prantera C, Scribano ML, Falasco G et al.:Ineffectiveness of probiotics in preventing recurrence after curativere section for Crohn's disease:a randomised controlled trial with Lactobacillus GG. Gut 2002, 51:405-409

• 23) Van Gossum A, Dewit O, Louis E et al.:Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LAI) on early endoscopic recurrence of Crohn's disease after lleo-caecal resection. Inflamm Bowel Dis 2007, 13:135-142

• 24) Feller M, Huwiler K, Stephan R, et al.:Mycobacterium avium subspecies paratuberculosis and Crohn's disease:a systematic review and meta-analysis. Lancet Infect Dis 2007, 7:607-613

• 25) Shafran I and Johnson LK:An open-label evaluation of rifaximin in the treatment of active Crohn's disease. Curr Med Res Opin 2005, 21:1165-1169

• 26) Prantera C, Lochs H, Grimaldi M, et al.:Rifaximin-extended intestinal release induces remission in patients with moderately active Crohn's disease, Gastroenterology, 2012, 142:473-481

講演4. 新生児のビフィズス菌は母親に起源する : 菌株レベルの証明

P.70 掲載の参考文献

• 1) Qin J, Li R, Raes J et al.:A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010, 464:59-65

• 2) Ley RE, Peterson DA, Gordon JI:Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell, 2006 124:837-848

• 3) Favier CF, Vos WMD, Akkermans AD:Development of bacterial and bifidobacterial communities in feces of newborn babies. Anaerobe 2003, 9:219-229

• 4) Turroni F, Ribbera A, Foroni E et al.:Human gut microbiota and bifidobacteria:from composition to functionality. Antonie Van Leeuwenhoek 2008, 94:35-50

• 5) Olszak T, An D, Zeissig S et al.:Microbial exposure during early life has persistent effects on natural killer T cell function. Science 2012, 336:489-493

• 6) Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R:Development of the human gastrointestinal microbiota and insights from high-through put sequencing. Gastroenterology 2011, 140:1713-1719

• 7) Dominguez-Bello MG, Costello EK, Contreras M et al.:Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA 2010, 107:11971-11975

• 8) Inoue R, Ushida K:Vertical and horizontal transmission of intestinal commensal bacteria in the rat model. FEMS Microbiol Ecol 2003, 46:213-219

• 9) Albesharat R, Ehrmann MA, Korakli M, Yazaji S, Vogel RF:Phenotypic and genotypic analyses of lactic acid bacteria in local fermented food, breast milk and faeces ofmothers and their babies. Syst Appl Microbiol 2011, 34:148-155

• 10) Matsumiya Y, Kato N, Watanabe K, Kato H:Molecular epidemiological study of vertical transmission of vaginal Lactobacillus species from mothers to newborn infants in Japanese, by arbitrarily primed polymerase chain reaction. J Infect Chemother 2002, 8:43-49

• 11) Mikami K, Takahashi H, Kimura M et al.:Influence of maternal bifidobacteria on the establishment of bifidobacteria colonizing the gut in infants. Pediatr Res 2009, 65:669-674

• 12) Gueimonde M, Laitinen K, Salminen S, Isolauri E:Breast milk:a source of bifidobacteria for infant gut development and maturatioll? Neonatology, 2007, 92:64-66

• 13) Martin R, Langa S, Reviriego C, E. Jimenez, et al.:The commensal microflora of human milk:new perspectives for food bacteriotherapy and probiotics. Trends Food Sci Technol 2004, 15:121-127

• 14) Perez PF, Dore J, Leclerc M et al.:Bacterial imprinting of the neonatal immune system:lessons from maternal cells? Pediatrics 2007, 119:724-732

• 15) Bilhere E, Lucas PM, Claisse O, Lonvaud-Funel A:Multilocus sequence typing of Oenococcus oeni:detection of two subpopulations shaped by intergenic recombination, Appl Environ Microbiol 2009, 75:1291-1300

• 16) Jost BH, Trinh HT, Songer JG:Clonal relationships among Clostridium perfringens of porcine origin as determined by multilocus sequence typing. Vet Microbiol 2006, 116:158-165

• 17) Ventura M, Canchaya C, Del Casale A:Analysis of bifidobacterial evolution using a multilocus approach. Int J Inst Evol Microbiol 2006, 56:2783-792

• 18) Janssen P, Coopman R, Huys G, et al.:Evaluation of the DNA fingerprinting method AFLP as a new tool in bacterial taxonomy. Microbiology 1996, 142:1881-1893

• 19) Vos P, Hogers R, Bleeker M et al.:AFLP:a new technique for DNA fingerprinting. Nucleic Acids Res 1995, 23:4407-4414

• 20) Matsuki T, Watanabe K, Tanaka R, Fukuda M, Oyaizu H:Distribution of bifidobacterial species in human intestinal microflora examined with 16S rRNA-gene-targeted species-specific primers. Appl Environ Microbiol 1999, 65:4506-4512

• 21) Zhu H, Qu F, zhu LH:Isolation ofgenomic DNAs from plants, fungi and bacteria using benzyl chloride. Nucleic Acids Res 1993, 21:5279-5280

• 22) Miyake T, Watanabe K, Watanabe T, Oyaizu H:Phylogenetic analysis of the genus Bifidobacterium and related genera based on 16S rDNA sequences. Microbiol lmmunol 1998, 42:661-667

• 23) Turner S, Pryer KM, Miao VP, Palmer JD:Investigating deep phylogenetic relationships among cyanobacteria and plastids by small subunit rRNA sequence analysis. J Eukaryot Microbiol 1999, 46:327-338

• 24) Makino H, Kushiro A, Ishikawa E et al.:Transmission of intestinal Bifidobacterium longum subsp. longum strains from mother to infant, determined by multilocus sequencing typing and amplified fragment length polymorphism. Appl Environ Microbiol 2011, 77:6788-6793

• 25) Diancourt L, Passet V, Chervaux C, Garault P, Smokvina T, Brisse S:Multilocus sequence typing of Lactobacillus casei reveals a clonal population structure with low levels of homologous recombination. Appl Environ Microbiol 2007, 73:6601-6611

• 26) Zhang W, Jayarao BM, Knabel SJ:Multi-virulence-locus sequence typing of Listeria monocytogenes. Appl Environ Microbiol 2004, 70:913-920