書籍詳細

I. サイトプロテクションの概念の推移と今後の医療への応用

P.6 掲載の参考文献

• 1) Nylander B, Robert A and Andersson S: Gastric secretary inhibition by certain methyl analogs of prostaglandin E2 following intestinal administration in man. Scand. J. Gastroenterol.4: 759-762,1974.

• 2) Robert A: Cytoprotection by prostaglandins. Gastroenterology 77: 761-767,1979.
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• 3) Robert A, Nezamis JE, Lancaster C, et al: Cytoprotection by prostaglandins in rats: Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 77: 433-443, 1979.
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• 4) Miller TA: Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am. J. PhysioL 245: G601-G623,1983.
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• 5) Lacy ER and Ito S: Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Gastroenterology 83: 619-625,1982.

II. 再生医療とサイトプロテクション

P.16 掲載の参考文献

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• 3) Fietz MJ, Concordet JP, Barbosa R, et al: The hedgehog gene family in Drosophila and vertebrate development. Development (Suppl.): 43-51,1994.
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• 4) Ramalho-Santos M, Melton DA and McMahon AP: Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127: 2763-2772,2000.
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• 5) Burke R, Nellen D, Bellotto M, et al: Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell 99: 803-815,1999.

• 6) Watkins DN and Peacock CD: Hedgehog signalling in foregut malignancy. Biochem. Pharmacol.68: 1055-1060,2004.
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• 7) Tian H, Tenzen T and McMahon API Dose dependency of Displ and genetic interaction between Displ and other hedgehog signaling components in the mouse. Development 131: 4021-4033,2004.

• 8) Motoyama J, Milenkovic L, Iwama M, et al: Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev. Biol. 259: 150-161,2003.
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• 9) Sekimizu K, Nishioka N, Sasaki H, et al: The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Development 31: 2521-2532,2004.

• 10) van den Brink GR, Hardwick JC, Tytgat GN, et al: Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology 121: 317-328,2001.
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• 11) van den Brink GR, Hardwick JC, Nielsen C, et al: Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut 51: 628-633,2002.
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• 12) Suzuki H, Mori M, Seto K, et al: Helicobacter pylori-associated gastric pro and antioxidant formation in Mongolian gerbils. Free Radic. Biol. Med.26: 679-684,1999.
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• 13) Suzuki H, Masaoka T, Hosoda H, et al: Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils. Gut 53: 187-194,2004.
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• 14) Suzuki H, Minegishi Y, Nomoto Y, et al: Down regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils. J Pathol. 206: 186-197,2005.
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• 15) van den Brink GR, Bleuming SA, Hardwick JC, et al: Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat. Genett.36: 277-282,2004.

• 16) Jankowski JA, Harrison RF, Perry I, et al: Barrett's metaplasia. Lancet 356: 2079-2085, 2000.

• 17) Chen JK, Taipale J, Cooper MK, et al: Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes. Dev.16: 2743-2748,2002.
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• 18) Taipale J, Chen JK, Cooper MK, et al: Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406: 1005-1009,2000.
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• 19) Williams JA, Guicherit OM, Zaharian BI, et al: Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc. Natl. Acad. Sci. USA 100: 4616-4621,2003.
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• 20) Lee Y, Miller HL, Jensen P, et al: Amolecular fingerprint for medulloblastoma. Cancer Res. 63: 5428-5437,2003.

• 21) Romer JT, Kimura H, Magdaleno S, et al: Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1 (+/-) p53 (-/-) mice. Cancer Cell 6: 229-240,2004.
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• 22) Stecca B, Mas C and Ruiz i Altaba A: Interference with HH-GLI signaling inhibits prostate cancer. Trends.Mol. Med.11: 199-203, 2005.
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• 23) Sanchez P, Hernandez AM, Stecca B, et al: Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc. Na t1. Acad. Sci. USA 101: 12561-12566,2004.

• 24) Berman DM, Karhadkar SS, Maitra A, et al: Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425: 846-851,2003.
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• 25) Qualtrough D, Buda A, Gaffield W, et al: Hedgehog signaling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. Int. J. Cancer 110: 831-837,2004.
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• 26) Ma X, Chen K, Huang S, et al: Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 26: 1698-1705,2005.
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• 27) Shiotani A, Iishi H, Uedo N, et al: Evidence that loss of sonic hedgehog is an indicator of Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer. Am. J. Gastroentrol.100: 581-587,2005.

P.25 掲載の参考文献

• 1) Jonsson J, Carlsson L, Edlund T, et al: Insulin-promoter-factor 1 is required for pancreas development in mice. Na ture 371: 606-609, 1994.

• 2) Offield MF, Jetton TL, Labosky PA, et al: PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122: 983-995,1996.
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• 3) Fukuda A, Kawaguchi Y, Furuyama K, et al: Loss of the Major Duodenal Papilla results in Brown Pigment Billiary Stone Formation in Pdx1 null mice. Gastroenterologyt (in press)

• 4) Kawaguchi Y. Cooper B, Gannon M, et al: The role of the transcriptional regulator Ptflain converting intestinal to pancreatic progenitors. Nat. Genet.32: 128-134,2002.
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• 5) Gu G, Dubauskaite J and Melton DA: Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129: 2447-2457, 2002.
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• 6) Gradwohl G, Dierich A, LeMeur M, et al: neurogenin3 is required fbr the development of the fbur endocrine cell lineages of the pancreas. Proc. Natl. A cad. Sci. USA 97: 1607-1611, 2000.

• 7) Kageyama R, Ohtsuka T and Tomita K: The bHLH gene Hesl regulates differentiation of multiple cell types. Mol. Cells 10: 1-7,2000.

• 8) Jensen J, Pedersen EE, Galante P, et al: Control of endodermal endocrine development by Hes-1. Nat. Genet.24: 36-44,2000.
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• 9) Sumazaki R, Shiojiri N, Isoyama S, et al: Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat. Genet.36: 83-87, 2004.
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• 10) Lammert E, Cleaver O and Melton DA: Induction of pancreatic differentiation by signals from blood vessels. Science 294: 564-567, 2001.

P.29 掲載の参考文献

• 1) Edlund H: Pancreatic organogenesis developmental mechanisms and implications for therapy. Nat. Rev. Genet.3: 524-532,2002.
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• 2) Slack JM: Developmental biology of the pancreas. Development 121: 1569-1580,1995.
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• 3) Jonsson J, Carlsson L, Edlund T, et al: Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371: 606-609, 1994.
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• 4) Kawaguchi Y, Cooper B, Gannon M, et al: The role of the transcriptional regulator Ptfla in converting intestinal to pancreatic progenitors. Nat. Genet.32: 128-134,2002.

• 5) Jacquemin P, Lemaigre FP and Rousseau GG: The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade. Dev. BioL 258: 105-116,2003.
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• 6) Lee CS, Sund NJ, Behr R, et al: Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev.Biol.278: 484-495,2005.
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• 7) Ahlgren U, Jonsson J, Jonsson L, et al: Beta-cellspecific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev.12: 1763-1768,1998.

• 8) Kaneto H, Nakatani Y, Miyatsuka T, et al: PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes 54: 1009-1022,2005.
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• 9) Koizumi M, Doi R, Toyoda E, et al: Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer. Surgery 134: 260-266,2003.
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• 10) Song, SY, Gannon MK, Washington CR, et al: Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor α.Gastroenterology 117: 1416-1426,1999.

P.35 掲載の参考文献

• 1) Evans MJ and Kaufman MH: Establishment in culture of pluripotential cells from mouse embryos. Nature 292: 154-156,1981.
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• 2) Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al: Embryonic stem cell lines derived from human blastocysts. Science 282: 1145-1147,1998.
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• 3) Chinzei R, Tanaka Y, Shimizu-Saito K, et al: Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytes. Hepatology 36: 22-29,2002.
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• 4) Kuai xL, Cong xQ, Li xL, et al: Generation of hepatocytes from cultured mouse embryonic stem cells. Liver TranspL 9: 1094-1099,2003.
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• 5) Rambhatla L, Chiu CP, Kundu P, et al: Generation of hepatocyte-like cells from human embryonic stem cells. Cell Transplant.12: 1-11, 2003.
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• 6) Choi D, Oh HJ, Chang UJ, ct al: In vivo differentiation of mouse embryonic stem cells into hepatocytes. Cell Transplant.11: 359-368, 2002.

• 7) Teramoto K, Hara Y, Kumashiro Y, et al: Teratoma formation and hepatocyte differentiation in mouse liver transplanted with mouse embryonic stem cell-derived embryoid bodies. Transplant. Proc.37: 285-286,2005.
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• 8) Kumashiro Y, Asahina K, Ozeki R, et al: Enrichment of hepatocytes differentiated from mouse embryonic stem cells as a transplantable source. Transplantation 79: 550-557,2005.
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• 9) Terada N, Hamazaki T, Oka M, et al: Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 416: 542-545,2002.
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P.40 掲載の参考文献

• 1) Grisham JW and Thorgeirsson SS: Liver stem cells. Manchester, Academic Press Inc,1997, pp.233-282.

• 2) Theise ND, Nimmakayalu M, Gardner R, et al: Liver from bone marrow in humans. Hepatology 32: 11-16,2000.
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• 3) Terai S, Sakaida I, Yamamoto N, et al: An in vivo model for monitoring transdifferentiation of bone marrow cells into functional hepatocytes.J. Biochem. (Tokyo) 134: 551-558,2003.

• 4) Nishina H, Vaz C, Billia P, et al: Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK lIMKK4. Development 126: 505-516,1999.

• 5) Omori K, Terai S, Ishikawa T, et al: Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression. FEBS Lett.578: 10-20,2004.
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• 6) Krause DS, Theise ND, Collector MI, et al: Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell Cell 105: 369-377,2001.
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• 7) Terada N, Hamazaki T, Oka M, et al: Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.Nature 416: 542-545,2002.
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• 8) Wang X, Willenbring H, Akkari Y, et al: Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422: 897-901, 2003.
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• 9) Schwartz RE, Reyes M, Koodie L, et al: Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells.J. Clin. Invest.109: 1291-1302,2002.

• 10) Yamamoto N, Terai S, Ohata S, et al: A subpopulation of bone marrow cells depleted by anovel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver.Biochem. Biophys. Res. Commun.313: 1110-1118,2004.

• 11) Ishikawa T, Terai S, Urata Y, et al: Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res.14: 1-11,2005.

• 12) Sakaida I, Terai S, Yamamoto N, et al: Transplantation of bone marrow cells reduces CC14-induced liver fibrosis in mice. Hepatology 40: 1304-1311,2004.

P.46 掲載の参考文献

• 1) Pinto D, Gregorieff A, Begthel H, et al: Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev.17: 1709-1713,2003.
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• 2) He XC, Zhang J, Tong WG, et al: Bmp signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat. Genet.36: 1117-1121, 2004.
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• 3) Okamoto R, Yajima T, Yamazaki M, et al: Damaged epithelial regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nat. Med.8: 1011-1017,2002.
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• 4) van Es JH, van Gijn ME, Riccio O, et al: Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435: 959-963,2005.
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• 5) Matsumoto T, Okamoto R, Tsuchiya K, et al: Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology 128: 1851-1867,2005.
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III. 情報伝達とサイトプロテクション

P.58 掲載の参考文献

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P.69 掲載の参考文献

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