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未契約
書籍名 腸内フローラと難病・自己免疫疾患
出版社 医薬出版
発行日 2015-10-20
著者
  • 神谷茂(編)
ISBN 9784990673932
ページ数 103
版刷巻号 初版第1刷
分野
閲覧制限 未契約

第23回 腸内フローラシンポジウムでの講演及び議論を収録。今回のテーマは「腸内フローラと難病・自己免疫疾患」

目次

  • 表紙
  • 目次
  • はじめに
  • 特別講演1. 腸内細菌とリウマチ性疾患
    • 要約
    • 1. はじめに
    • 2. 腸内フローラと関節炎
    • 3. 関節リウマチの臨床・免疫病理
    • 4. 腸内細菌感作による実験的関節炎
    • 5. 関節リウマチの病因・病態 - 特に腸内細菌との関連
      • 1) 関節リウマチの腸内細菌共通抗体
      • 2) 関節リウマチにおける自然免疫の関与
      • 3) HLAと腸内細菌との分子相同性
      • 4) 関節リウマチの亜群 ( rheumatoid arthritis subgroup )
      • 5) 関節リウマチと腸内フローラの構成変化 ( dysbiosis )
      • 6) DysbiosisからみたRA subgroupの発生機序
    • 6. 関節リウマチの原因療法を目指して - dysbiosisの改善
      • 1) 絶食療法
      • 2) プロバイオティクスによる治療
    • 7. まとめ
    • 謝辞
    • 文献
    • 質疑応答
  • 特別講演2. 粘膜バリアにおける免疫システム - 腸内細菌のクロストーク
    P.39閲覧
    • 要約
    • 1. 序論
    • 2. 獲得免疫機構と腸内細菌
    • 3. 免疫グロブリン ( Ig ) A
    • 4. IgA多様化制御 : GC T細胞の役割
    • 5. 結論
    • 文献
    • 質疑応答
  • 講演1. 腸内細菌叢と関節破壊
    P.45閲覧
    • 要約
    • 1. 無菌マウス
    • 2. Toll様受容体 ( TLRs ) と関節炎
    • 3. マウスにおけるTLR4アンタゴニストとヒト化関節炎モデル
    • 4. 歯周炎併発による関節炎の増悪化
    • 文献
    • 質疑応答
  • 講演2. 腸内細菌と1型糖尿病
    P.49閲覧
    • 要約
    • 1. 序論
    • 2. 腸内細菌は自己免疫疾患の誘導因子にも抑制因子にもなり得る
    • 3. 腸内細菌叢の影響は同じ個体でも器官により異なる可能性がある
    • 4. 腸内細菌叢はどのようにTIDの進行に影響を及ぼすのか ?
    • 5. どのような細胞種がMyD88欠損マウスのTIDを防ぐのか ?
    • 6. MyD88が存在しない場合におけるTIDの抑制に重要なシグナル経路について
    • 7. 腸内細菌叢に関連してTIDに影響を及ぼす他の因子について
    • 文献
    • 質疑応答
  • 講演3 腸内フローラと炎症性腸疾患
    P.53閲覧
    • 要約
    • 1. はじめに
    • 2. マウス腸管における自然免疫系細胞の解析
    • 3. ヒト腸管における自然免疫系細胞の解析
    • 4. ヒト腸管より単離したHLA - DRhighLin - CD14 + CDI63low細胞
    • 5. おわりに
    • 文献
    • 質疑応答
  • 講演4. 腸内細菌叢と多発性硬化症
    P.63閲覧
    • 1. はじめに
    • 2. MSの病態とT細胞
    • 3. 動物モデルの解析
    • 4. 今後の展望
    • 文献
    • 質疑応答
  • 講演5. 炎症関連大腸がんモデルにおける大腸粘膜付随細菌叢の破綻
    P.67閲覧
    • 要約
    • 1. 序論
    • 2. 炎症と発がん
    • 3. サイトカインシグナルと炎症関連大腸発がん
    • 4. CACの発症過程におけるIL6 trans - signalingを介したIL6 / Stat3路の重要性
    • 5. 腸内細菌叢と大腸発がん
    • 6. IL6 trans - signalingの生成と腸内細菌
    • 7. 大腸粘膜付随細菌叢の特性について
    • 8. おわりに
    • 文献
    • 質疑応答
  • 総合討論
    P.77閲覧
  • SUMMARY : Intestinal Microbiota, Intractable disease and Autoimmunity
    P.87閲覧
  • 奥付

参考文献

特別講演1. 腸内細菌とリウマチ性疾患

P.33 掲載の参考文献

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特別講演2. 粘膜バリアにおける免疫システム - 腸内細菌のクロストーク

P.42 掲載の参考文献

  • 19) N. Wang et al.:Selective IgA deficiency in autoimmune diseases. Mol Med 2011, 17:1383-1396

講演1. 腸内細菌叢と関節破壊

P.46 掲載の参考文献

  • 1) Abdollahi-Roodsaz S, Joosten LA, Koenders MI, Devesa I, Roelofs MF, Radstake TR, Heuvelmans-Jacobs M, Akira S, Nicklin MJ, Ribeiro-Dias F, van den Berg WB:Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest. 2008, 118 (1):205-216
  • 2) Abdollahi-Roodsaz S, Joosten LA, Helsen MM, Walgreen B, van Lent PL, van den Bersselaar LA, Koenders MI, van den Berg WB:Shift from TLR2 toward TLR4 dependency in the erosive stage of chronic SCW arthritis coincides with TLR4 mediated IL-17 production. Arthritis Rheum. 2008,58(12):3753-3764

講演2. 腸内細菌と1型糖尿病

P.51 掲載の参考文献

講演3 腸内フローラと炎症性腸疾患

P.58 掲載の参考文献

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講演4. 腸内細菌叢と多発性硬化症

P.65 掲載の参考文献

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講演5. 炎症関連大腸がんモデルにおける大腸粘膜付随細菌叢の破綻

P.73 掲載の参考文献

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