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未契約
書籍名 Cyto-protection & biology Vol.15 1997年 第15回 サイトプロテクション研究会
出版社 癌と化学療法社
発行日 1997-12-12
著者
  • 真辺忠夫(当番世話人)
ISBN
ページ数 112
版刷巻号
分野
閲覧制限 未契約

1997年 第15回 サイトプロテクション研究会。本会では、特別講演の演者として名古屋市立大学医学部、岡本尚教授と、愛知がんセンター、神奈木玲児先生にお願いした。

目次

  • 表紙
  • 序文
  • 目次
  • 特別講演 I
    • 細胞内レドックス制御機構と転写因子NF-κBの活性化シグナル
  • 特別講演 II
    • 癌化と細胞接着性糖鎖の発現の転写制御機構
  • Session 胃
    • アンモニア性胃粘膜傷害 ―機序と抗潰瘍剤の効果―
    • カルバコール刺激下の胃粘液顆粒放出に及ぼすNOの影響
    • 胃炎とギャップ結合
  • Session 小腸
    • 十二指腸潰瘍治癒過程におけるTGF-αの発現
    • ストレプトゾトシン誘発高血糖ラットにおける十二指腸アルカリ分泌の異常と粘膜易損性の増大
    • Diamine oxidaseの変動からみたイレウスの病態に関する検討
  • Session 胆汁分泌
    • 肝灌流における胆汁分泌からみた保存肝のviabilityに関する研究
  • Session 肝II
    • C型肝炎ウイルスのコア蛋白とlymphotoxin-β receptorの結合の意義
  • Session 肝III
    • ラット肝冷却灌流におけるKupffer細胞と類洞内皮細胞の変化
  • Session 膵・腹膜
    • 外科手術後および急性膵炎における血中可溶性E-セレクチン濃度の変化
    • トリオレインおよびオレイン酸誘発膵障害に対するα-トコフェロールの保護効果
    • ポリミキシンB少量投与のエンドトキシン血症に対する効果
  • Session 血管内皮
    • 低酸素下の血管内皮細胞由来のIL-1と白血球との相互作用 ―虚血-再灌流臓器障害の発生機序の解析―
    • 脳梗塞時の血小板凝集活性化に及ぼす交感神経の役割
  • Session 生体防御
    • 心筋虚血再灌流障害におけるカルパインの活性化時期と動態
  • 研究会会則
    P.79閲覧
  • 役員リスト
    P.81閲覧
  • 会告
    P.82閲覧
  • 奥付

参考文献

特別講演 I

P.5 掲載の参考文献

  • 1) 岡本尚:活性酸素による遺伝子発現制御. 活性酸素とシグナル伝達(井上正康・編), 講談社, 東京, 1996, pp.37-46.
  • 7) Los M, Schenk H, Hexel K, et al:IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase. EMBO J. 14:3731-3740, 1995.
  • 8) Tagaya Y, Okada M, Sugie K, et al:IL-2 receptor (p55) /Tac-inducing factor. Purification and characterization of adult T cell leukemia-derived factor. J.lmmunol. 140:2614-2621, 1988.
  • 11) Hayashi T, Ueno Y and Okamoto T:Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin. J. Biol. Chem. 268:11380-11388, 1993.
  • 12) Frame MC, Wilkie NM, Darling AJ, et al:Regulation of AP-1/DNA complex formation in vitro. Oncogene 6:205-209, 1991.
  • 13) Myrset AH, Bostad A, Jamin N, et al:DNA and redox state induced conformational changes in the DNA-binding domain of the Myb oncoprotein. EMBO J. 12:4625-4633, 1993.
  • 15) Nakamura K, Hori T, Sato N, et al:Redox regulation of a src family protein tyrosine kinase p56lck in T cells.Oncogene 8:3133-3139, 1993.
  • 17) Hayashi T, Sekine T and Okamoto T:Identifiction or a new serine kinase that activates NF-κB by direct phosporylation. J. Biol. Chem. 268:26790-26795, 1993.
  • 18) Naumann M and Scheidereit C:Activation of NF-kappa B in vivo is regulated by multiple phosphorylations. EMBO J. 13:4597-4607, 1994.
  • 22) Yang JP, Merin JP, Nakano T, et al:Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro. FEBS Lett. 361:89-96, 1995
  • 23) Schreck R, Rieber P and Baeuerle PA:Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J. 10:2247-2258, 1991.
  • 24) Tozawa K, Sakurada S, Kohri K, et al:Effects of anti-nuclear factor κB reagents in blocking adhesion of human cancer cell to nasular endothelial cells. Cancer Res. 55:4162-4167, 1995.

P.15 掲載の参考文献

  • 1) 神奈木玲児:癌の転移と細胞接着分子 "臨床医のための実験医学シリーズ. 細胞接着分子と関連疾患"(神奈木玲児・編), 羊土社, 東京, 1994, pp.24-36.
  • 2) Kannagi R:Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer. Glycoconj. J. 14:577-584, 1997.
  • 3) 桐山幸三, 渡辺 正:癌の浸潤, 転移と糖鎖抗原. "最新医学からのアプローチ:複合糖質" (神奈木玲児・編), メジカルビュー社, 東京, 1994, pp.67-75.
  • 4) Shimono R, Mori M, Akazawa K, et al:Immunohistochemical expression of carbohydrate antigen 19-9 in colorectal carcinoma. Am. J. Gastroenterol, 89:101-105, 1994.
  • 10) Nakashio T, Narita T, Sato M, et al:The association of metastasis with the expression of adhesion molecules in cell lines derived from human gastric cancer. Anticancer Res. 17:293-299, 1997.
  • 12) Kannagi R, Fukushi Y, Tachikawa T, et al:Quantitative and qualitative characterization of cancer-associated serum glycoprotein antigens expressing fucosyl or sialosyl-fucosyl type 2 chain polylactosamine. Cancer Res. 46:2619-2626, 1986.
  • 15) Takada A, Ohmori K, Yoneda T, et al:Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium. Cancer Res. 53:354-361, 1993.
  • 17) Kawakami-Kimura N, Narita T, Ohmori K, et al:Involvement of hepatocyte growth factor in increased integrin expression on HepG2 cells triggered by adhesion to endothelial cells. Br. J. Cancer 75:47-53, 1997.
  • 20) 神奈木玲児, 木村尚子:血管新生に関与するセレクチンとインテグリン. 臨床免疫 29 (3):378-384, 1997.
  • 21) 神奈木玲児:細胞接着分子としての糖鎖抗原. 日外会誌 97:131-139, 1996.
  • 22) Holmes EH, Ostrander GK and Hakomori S:Enzymatic basis for the accumulation of glycolipids with X and dimeric X determinants in human lung cancer cells (NCI-H69). J. Biol. Chem. 260:7619-7627, 1985.
  • 23) Holmes EH, Ostrander GK and Hakomori S:Biosynthesis of the sialyl-Lex determinant carried by type 2 chain glycosphingolipids (IV3NeuAcIII3 FucnLc4, VI3NeuAcV3FucnLc6, and VI3NeuAcIII3V3 Fuc2nLc6) in human lung carcinoma PC9 cells. J. Biol. Chem. 261:3737-3743, 1986.
  • 24) Kukowska-Latallo JF, Larsen RD, Nair RP, et al:A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group α (1,3/1,4) fucosyltransferase. Genes Dev. 4:1288-1303, 1990.
  • 25) Lowe JB, Kukowska-Latallo JF, Nair RP, et al:Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion.J.Biol.Chem. 266:17467-17477, 1991.
  • 27) Weston BW, Smith PL, Kelly RJ, et al:Molecular cloning of a fourth member of a human α (1,3) fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. J. Biol. Chem. 267:24575-24584, 1992.
  • 28) Weston BW, Nair RP, Larsen RD, et al:Isolation of a novel human α (1,3) fucosyltransferase gene and molecular comparison to the human Lewis blood group α (1,3/1,4) fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. J. Biol. Chem. 267:4152-4160, 1992.
  • 29) Koszdin KL and Bowen BR:The cloning and expression of a human α-1,3 fucosyltransferase capable of forming the E-selection ligand. Biochem. Biophys Res. Commum. 187:152-157, 1992.
  • 30) Akamatsu S, Yazawa S, Tachikawa T, et al:α 2→3 Sialyltransferase associated with the synthesis of CA 19-9 in colorectal tumors.Cancer 77 (Suppl.):1694-1700, 1996.
  • 32) Yago K, Zenita K, Ginya H, et al:Expression of α (1,3) fucosyltransferases which synthesize sialyl Lex and sialyl Lea, the carbohydrate ligands for E- and P-selectins, in human malignant cell lines. Cancer Res. 53:5559-5565, 1993.
  • 34) Hakomori S, Ichikawa D, Withers DA, et al:Expression vs. deletion of histo-blood group A and B genes in human tumors as related to malignancy. International Symposium on Glycosyltransferases and Cellular Communication (Organized by N. Taniguchi) , Osaka, Japan, 1997, Abstract, p.71.
  • 35) 澤田正志, 森谷節子, 矢守隆夫・他:マウス結腸癌colon26細胞の転移能に関与するシアリダーゼの検索. 第6回がん転移研究会, 広島, 1997, 第6回がん転移研究会アブストラクト, p.60.
  • 36) Ohmori K, Yoneda T, Shigeta K, et al:Sialyl SSEA-1 antigen as a carbohydrate marker of human natural killer cells and immature lymphoid cells. Blood 74:255-261, 1989.
  • 37) Ohmori K, Takada A, Ohwaki I, et al:A distinct type of sialyl Lewis X antigen defined by a novel monoclonal antibody is selectively expressed on helper memory T cells. Blood 82 (9):2797-2805, 1993.
  • 38) Furukawa Y, Tara M, Ohmori K, et al:Variant type of sialyl Lewis X antigen expressed on adult T cell leukemia cells is associated with skin involvement. Cancer Res. 54:6533-6538, 1994.
  • 39) Natsuka S, Gersten KM, Zenita K, et al:Molecular cloning of a cDNA encoding a novel human leukocyte α 1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant.J.Biol.Chem. 269:16789-16794, 1994.
  • 40) Sasaki K, Kurata K, Funayama K, et al:Expression cloning of a novel α 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes. J. Biol. Chem. 269:14730-14737, 1994.
  • 41) Hiraiwa N, Dohi T, Kawakami-Kimura N, et al:Suppression of sialyl Lewis X expression and E-selectin-mediated cell adhesion in cultured human lymphoid cells by transfection of antisense cDNA of an α 1→3 fucosyltransferase (Fuc-T VII). J. Biol. Chem. 271:31556-31561, 1996.
  • 43) Nagata K, Ohtani K, Nakamura M, et al:Activation of endogenous c-tos proto-oncogene expression by human T-cell lukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat.J.Virol. 63:3220-3226, 1989.
  • 44) Ohtani K, Nakamura M, Saito S, et al:Identification of two distinct elements in the long terminal repeat of HTLV-I responsible for maximum gene expression. EMBO J. 6:389-395, 1987.
  • 45) Hiraiwa N, Hiraiwa M and Kannagi R:Human T-cell leukemia virus-1 encoded Tax protein transactivates α 1→3 fucosyltransferase Fuc-T VII, which synthesizes sialyl Lewis X, a selectin ligand expressed on adult T-cell leukemia cells. Biochem. Biophys Res. Commun. 231:183-186, 1997.

P.21 掲載の参考文献

  • 1) Warren JR and Marshall BJ:Unidentified curved bacilli on gastric epithelium in active chronic gastritis, Lancet ii:1273-1275, 1983.
  • 2) 松井邦泰, 田村和也, 寺田昭・他:Campylobacter pyloriと胃疾患. 日消病会誌 84:1864, 1987.
  • 5) Kawano S, Tsujii M, Tsuji S, et al:Effects of ammonia on Helicobacter pylori-associated gastric disease. Eur. J. Gastroenterol. Hepatol, 5 (Suppl.1):S29-S33, 1993.

P.26 掲載の参考文献

P.29 掲載の参考文献

  • 3) Mine T, Yasuda H, Kataoka A, et al:Human chronic gastric ulcer and connexin. J. Clin. Gastroenterol. 21 S104-S107, 1995.
  • 6) Correa P, Malnizel W, Cuello C, et al:Gastric pre- cancerous process in a high risk population:cross-sectional studies. Cancer Res. 50:4731-4736, 1990.

P.33 掲載の参考文献

  • 1) 野口哲也, 笹野公伸, 加藤勝章・他:ラット酢酸潰瘍の治癒過程におけるTGF-αとEGFR発現の免疫組織学的検討. 日消病会誌 91:568, 1994.
  • 2) Brzozowski T, Majka J, Garlicki J, et al:Role of polyamines and Prostaglandins in gastroprotective action of epidermal growth factor against ethanol injury. J. Clin. Gastroenterol. 13:S98-S102, 1992.
  • 3) Polk WH, Dempsey PJ, Russell WE, et al:Increased production of transforming growth factor α following acute gastric injury. Gastroenterology 102:1467-1474, 1992.
  • 4) 中島典子, 桑山 肇:胃粘膜上皮細胞回転と粘膜修復. G.I.Research 1 (6):699-704.1993.

P.38 掲載の参考文献

  • 1) Falchuk KR and Conlin D:The intestinal and liver complications of diabetes mellitus. Adv. Intern. Med. 38:269-286, 1993.
  • 2) O'Reilly D and Long RG:Diabetes and the gastrointestinal tract. Dig. Dis. Sci. 5:57-64, 1987.
  • 7) Lincoln J, Bokor JT, Crowe R, et al:Myenteric plexus in streptozotocin-treated rats:Neurochemical and histochemical evidence for diabetic neurophathy in the gut. Gastroenterology 86:654-661, 1984.

P.42 掲載の参考文献

  • 1) Greber GM, Wukich DK, Cafferty PJ, et al:Changes in peripheral serum creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) in acute experimental colonic infarction. Ann. Surg. 194:708-715, 1981.
  • 2) 前田壽哉, 湯浅英樹, 有村俊寛・他:絞扼性イレウス早期鑑別診断における血清creatine phosphokinase値の有用性. 日消外会誌 26:1007-1012, 1993.
  • 3) 和田哲成, 長畑洋司, 安積靖友・他:複雑性イレウスにおける血液凝固線溶系因子の検討. 神戸大医紀 57:1-9, 1996.
  • 5) Agostino L, Daniel B, Pignata S, et al:Modifications in enterocyte diamine oxidase distribution induced by heparin in the rat. Biochem. Pharmacol. 38:47-49, 1994.
  • 6) 和田哲成, 長畑洋司, 安積靖友・他:ラットにおける新しいイレウスモデルの作成. 日消外会誌 27:1870, 1994.
  • 8) Agostino D, Pignata S, Daniele B, et al:Postheparin plasma dianime oxidase values in the follow up of patients with small bowel Crohn disease. Gut 32:932-935, 1991.

P.50 掲載の参考文献

  • 4) Shih CM, Lo S, Miyamura T, et al:Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J. Virol. 67:5823-5832, 1993.
  • 7) Ware C, VanArsdale T, Crowe P, et al:The ligands and receptors of the lymphotoxin system. Curr. Top. Microbiol. Immunol. 198:175-218, 1995.
  • 9) Crowe P, VanArsdale T, Walter B, et al:A lymphotoxin-β-specific receptor. Science 264:707-710, 1994.
  • 10) Browing J, Miatkowski K, Sizing I, et al:Signaling through the lymphotoxin β receptor induces the death of some adenocarcinoma tumor lines. J. Exp. Med. 183:867-878, 1996.
  • 11) Kato N, Ootsuyama Y, Sekiya H, et al:Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C virus infection. J. Virol. 68:4776-4784, 1994.

P.54 掲載の参考文献

  • 2) 山中若樹, 岡本英三, 古川一隆・他:表面冷却下肝切除術. 手術 50:621-625, 1996.
  • 3) Ion VD, Gregory JB, Charle HL, et al:Hyaluronic Acid Uptake by the Isolated, Perfused Rat Liver:An Index of Hepatic Sinusoidal Endothelial Cell Function. Hepatology 17:266-272, 1993.
  • 4) Patricia EG, Barbara K, Steven NL, et al:A New Method to Monitor Kupffer Cell Phagocytosis Continuously in Perfused Rat Liver. Hepatology 13:567-576, 1991.
  • 5) 岡上 武, 坂本真一, 伊藤義人:類洞皮細胞の形態と機能. 病理と臨 13:309-314, 1995.
  • 6) 内藤 真:Kupffer細胞の形態, 分化と機能. 病理と臨 13:315-323. 1995.
  • 9) Holscher M and Groenewoud AF:Current Status of the HTK Solution of Bretschneider in Organ Preservation. Transplant. Proc. 23:2334-2337, 1991.
  • 10) 持田 智, 藤原研司:Kupffer細胞 実験的肝障害における役割. 肝胆膵 24:889-899, 1992.

P.58 掲載の参考文献

  • 1) Members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Committee:Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit. Care Med. 20:864-874, 1992.
  • 2) Cotran RS and Pober JS:Cytokine-endothelial interactions in inflammation, immunity and vascular injury. J. Am. Soc. Nephrol. 1:225-235, 1990.
  • 5) 広田昌彦, 野澤文昭, 小川道雄:活性化好中球による組織障害. 臨床免疫 29:1155-1160, 1997.
  • 6) 広田昌彦, 小川道雄:外科的侵襲と全身反応, 4. 免疫応答. 日外会誌 97:721-725, 1996.
  • 7) Okajima K, Uchiba M, Murakami K, et al:Plasma levels of soluble E-selectin in patients with disseminated intravascular coagulation. Am. J. Hematol. 1997. (in press)
  • 8) Newman W, Beal LD, Carson CW, et al:Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. J. Immunol. 150:644-654, 1993.
  • 9) Ogawa M, Ikei S, Sameshima H, et al:Increased cytokine release in severe acute pancreatitis is closely related to the development of organ failure. In The Immune Consequences of Trauma, Shock and Sepsis Vol. II (edited by Faist E, Baue AE and Schildberg FW), Monduzzi Editore, Bologna, 1996, pp. 332-337.

P.62 掲載の参考文献

  • 2) Havel RJ:Pathogenesis, differentiation and management of hyperlipidemia. Adv. Intern. Med. 15:117-154, 1969.
  • 3) Takeda S, Morita Y, Yoshikawa T, et al:K. Lipid peroxidation contributes to pancreatic acinar cell injury induced by unsaturated free fatty acids. Gastroenterology 106:A325, 1994.
  • 4) 牧野淳子:アミラーゼマルトオリゴ糖を用いた enzyme coupling. Med. Technol. 12:149, 1984.
  • 6) Allain CC:Enzymatic determination of total serum cholesterol. Clin. Chem. 21:470-475, 1974.

P.66 掲載の参考文献

  • 1) Morris DC and Jacobs DM:Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides. Immunochemistry 13:813-818, 1976.
  • 6) Mayumi T, Takezawa J, Takahashi H, et al:A small dose of intramuscular polymyxin B improves survival of septic rat. (submitted)
  • 8) Bender BS, Winchurch RA, Thupari JN, et al:Depressed natural killer cell function in thermally injured adults:successful in vivo and in vitro immunomodulation and the role of endotoxin. Clin. Exp. Immunol. 71:120-125, 1988.
  • 9) Yao YM, Tian HM, Sheng ZY, et al:Inhibitory effects of low-dose polymyxin B on hemorrhage-induced endotoxin bacterial translocation and cytokine formation in rats. J . Trauma 38:924-930, 1995.

P.70 掲載の参考文献

  • 4) Colletti L, Remick D, Burtch G, et al:Role or tumor necrosis factor-α in the pathophysiologic alternations after hepatic ischemic/reperfusion injury in the rat. J. Clin. Invest. 85:1936-1943, 1990.
  • 9) Shirasugi N, Wakabayashi G, Shimazu M, et al:IL-1 up-regulates oxygen free radicals production in the liver with ischemia-reperfusion injury. Lymphokine Cytokine Res. 12:393a, 1993.
  • 10) Humphreys M and Hopkins S:Simple sensitive and specific bioassay of interleukin-1. J. Immunol. Methods. 120:271-276,1 989.

P.74 掲載の参考文献

  • 5) Hernandez RH, Carvajal AR, Pajuelo JG, et al:The effect or doxazosin on platelet aggregation in normotensive subjects and patients with hypertension:An in vitro study. Am. Heart J. 121:389-394, 1991.
  • 7) 諸岡 弘, 大本堯史:脳卒中急性期脳微小循環障害におけるRadical生成と交感神経の役割. 脳虚血とフリーラジカル (佐野圭司, 高倉公明, 小暮久也・編), にゅーろん社, 東京, 1983, pp.189-199.
  • 9) Tofler GH, Brezinski D, Schafer AL, et al:Concurrent morning increase in platelet aggregability and risk of myocardial infarction and sudden cardiac death. N. Engl. J. Med. 316:1514-1518, 1987.
  • 10) 諸岡 弘:脳梗塞再発予防に対する最適抗血小板薬の検討. Cyto-protection & biology 14:67-70, 1996.

P.78 掲載の参考文献

  • 5) 鵜飼知彦:心筋虚血および再灌流障害におけるカルシウム依存性システインプロテアーゼ(カルパイン)の動態解析. 名市大医誌 47(2):155-168, 1996.