書籍詳細

特別寄稿

P.5 掲載の参考文献

• 1) Palmer RMJ, Ferrige AG and Moncada S: Nitric oxide release accounts for the biological activity of endothelium-deried relaxing factor. Nature 327:524-526, 1987.

• 2) Maines MD: Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J. 2:2557-2568, 1988.
  pubmed

• 3) Maines MD, Trakshel GM and Kutty RK: Characterization of two constitutive forms of rat liver microsomal heme oxygenase: only one molecular species of the enzyme is inducible. J. Biol. Chem. 261:11131-11137, 1986.

• 4) Verma A, Hirsch DJ, Glatt CE, et al: Carbon monoxide: A putative neural messenger. Science 259:381-384, 1993.
  pubmed

• 5) Kharitonov V, Sharma VS, Pilz RB, et al: Basis of guanylate cyclase activation by carbon monoxide. Proc. Natl. Acad. Sci. USA 92:2568-2571, 1995.
  pubmed

• 6) Suematsu M, Kashiwagi S, Sano T, et al: Carbon monoxide as an endogenous modulator of hepatic vascular perfusion. Biochem. Biophys. Res. Commun. 205(2):1333-1337, 1994.
  pubmed

• 7) Bissell DM, Hammaker L and Schmid R: Hemoglobin and erythrocyte catabolism in rat liver: The separate roles of parenchymal and sinusoidal cells. Blood 40:812-822, 1972.
  pubmed

• 8) Obolenskaya MY, Vanin AF, Mordvintcev P I, et al: EPR evidence of nitric oxide production by the regenerating rat liver. Biochem. Biophys. Res. Commun. 202:571-576, 1994.

• 9) Ma TT, Ischiropoulos H and Brass CA: Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescence during reperfusion. Gastroenterology 108(2):463-469, 1995.
  pubmed

• 10) Bautista AP and Spitzer JJ: Inhibition of nitric oxide formation in vivo enhances superoxide release by the perfused liver. Am. J. Physiol. 266:G783-G788, 1994.
  pubmed

• 11) Suematsu M, Goda N, Sano T, et al: Carbon monoxide: An endogenous modulator of sinusoidal tone in the perfused rat liver. J. Clin. lnvest. 96:2431-2437, 1995.

• 12) Tanaka AK, Katagiri M, Hoshino T, et al: Endothelin-1 stimulates bile acid secretion and vesicular transport in the isolated perfused rat liver. Am. J. Physiol. 266(2 Pt 1):G324-G329, 1994.

• 13) Kietzmann T, Schmidt H, Unthan-Fechner K, et al: A ferro-heme protein senses oxygen levels, which modulate the glucagon-dependent activation of the phophoenolpyruvate carboxykinase gene in rat hepatocyte cultures. Biochem. Biophys. Res. Commun. 195:792-798, 1993.

P.18 掲載の参考文献

• 1) 山田昌彦, 荻原正示, 斉藤利彦・他: 増殖因子による培養胃粘膜細胞の分化と増殖. Cyto-protection & biology 12:45-48, 1994.

• 2) Nakamura K, Rokutan K, Marui N, et al: Induction of heat shock proteins and their implication in protection against ethanoinduced damage in cultured guinea pig gastric mucosal cells. Gastroenterology 101:161-166, 1991.

• 3) Hamlin JL and Pardee AB: S phase synchrony in monolayer CHO cells. Exp. Cell Res. 100:265-275, 1976.

• 4) Kutsumi H, Kawai K, Johnston RB, et al: Evidence for participation of vicinal dithiols in the activation sequence of the respiratory burst of human neutrophils. Blood 85:2559-2569, 1995.
  pubmed

• 5) Dignam JD, Lebovits RM and Roeder RG: Accurate transcription initiation by RNA polimerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489, 1983.

• 6) Terano A, Ivey KJ, Stachura J, et al: Cell culture of rat gastric funding mucosa. Gastroenterology 101:161-166, 1991.

• 7) Sppaargaren M, Defize LHK, Boonstra J, et al: Antibody-induced dimerrization activaes the epidermal growth factor receptor tyrosin kinase. J. Biol. Chem. 266:1733-1739, 1991.

• 8) Ruff-Jamison S, Chen K and Cohen S: Induction by EGF and interferon-γ of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei. Science 261:1733-1736, 1993.

P.22 掲載の参考文献

• 1) Mezey E and Palkovits M: Localization of targets for anti-ulcer drugs in cells of the immune system. Science 258:1662-1665, 1992.
  pubmed

• 2) Chew CS, Nakamura K and Petropoulos AC: Multiple actions of epidermal growth factor and TGF-α on rabbit gastric parietal cell function. Am. J. Physiol. 267: G 818-G 826, 1994.

• 3) Nakamura K, Aoike A, Hosokawa T, et al: Effect of food-restriction stress on immnune response in mice. J. Neuroimmunol. 30:23-29, 1990.

• 4) Gantz I, Uhler M, Yamada T, et al: Molecular cloning of a gene encoding the histamine H2 receptor. Proc. Natl. Acad. Sci. 88:429-433, 1991.
  pubmed

• 5) Saperas E, Yang H and Tache Y: Interleukin-1β acts at hypothalamic sites to inhibit gastric acid secretion in rats. Am. J. Physiol. 263: G 414-G418, 1992.

• 6) Price AB, Levi J and Dolby JR: Campylobacter pyloridis in peptic ulcer disease: microbiology, pathology, and scanning electron microscopy. Gut 26:1183-1188, 1985.

• 7) Uwe E, Mai H, Smith PD, et al: Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanisms. J. Clin. Invest. 87:894-900, 1991.

P.25 掲載の参考文献

• 1) Mine T, Yasuda H, Kataoka A, et al: Human chronic gastric ulcer and connexin. J. Clin. Gastroenterol. (in press)

• 2) Kanno Y and Matsui Y: Cellular uncoupling in cancerous stomach epithelium. Nature 218:775-776, 1968.
  pubmed

• 3) Kyoi T, Ueda F, Kimura K, et al: Development of gap junctions between gastric mucous cells during cell maturation in rats. Gastroenterology 102:1930-1935, 1992.
  pubmed

• 4) Ohkusa T, Yamamoto M, Kataoka K, et al: Electron microscopic study of intercellular junctions in human gastric mucosa with special reference to their relationship to gastric ulcer. Gut 34:86-89, 1993.
  pubmed

P.30 掲載の参考文献

• 1) 服部徳昭, 長町幸雄: ラットのシンコフェン急性胃粘膜病変 (AGML) における粘膜微小循環と組織反応. Cyto-Protection & biology 8:101-108, 1990.

• 2) Nagamachi Y: New way of inducing cinchopfen ulser in the dog. some studies on its pathogenesis. Progress in Peptic Ulcer (edited by Mozic Gy and Javor T), AKADEMIAI KIADO, Budapest, 1976, pp. 553-567.

• 3) Stevens RL, Katz HR and Seldin DC: Mast cell differentiation and Heterogenecity (edited by Befus AD, Bienenstock J and Denburg JA), Raven Press, New York, 1986, p. 183.

• 4) Nagamachi Y: Effect of cinchofen blood flow and tissue oxygen tennsion in dogs. Advances in Experimental Ulcer (edited by Umehara S and Ito H), Experimental Ulcer Forum of Japan, Tokyo, 1982, pp. 196-204.

• 5) 長町幸雄: 血液レオロジーと消化性潰瘍. Ther. Res. 5(4):21-50, 1986.

• 6) 斉藤博久, 坂口直哉, 松本健治・他: マスト細胞への刺激とその受容. マスト細胞とアレルギー (冨岡玖夫, 羅智靖・編), 医学出版社, 東京, 1993, pp. 72-74.

• 7) 長町幸雄, 緒方伸男, 西田保二・他: 血液レオロジーからみた実験潰瘍発生機序. 実験潰瘍 11:49-51, 1985.

• 8) 高橋 篤: 実験的急性胃粘膜病変形成期におけるsuperoxide anion と白血球の役割について. 日消誌 90(8):1623-1632, 1993.

P.34 掲載の参考文献

• 1) 長畑洋司, 裏川公章: ストレス潰瘍発生過程におけるドパミンの役割についての実験的研究. 日消誌 83:1289-1297, 1986.

• 2) 川北直人, 長畑洋司, 安積靖友・他: 急性潰瘍発生時における胃粘膜Dopamineの変動. Ulcer Res. 21:143-146, 1994.

• 3) Kawakita N, Nagahata Y and Saitoh Y: Immunohistochemical study of dopamine in rat gastric mucosa with acute gastric ulcer. J. Gastroenterol. 29:695-702, 1994.
  pubmed

• 4) Nagahata Y, Urakawa T, Itoh A, et al: Cytoprotective effects of dopamine on stress ulcer. CYTOPROTECTION and CYTOBIOLOGY 6:3-44, 1989.

• 5) Nagahata Y, Kuroda H, Idei H, et al: Pathogenesis of acute gastric ulcer on the change of catecholamines in hypothalamus and gastric mucosa. CYTOPROTECTION and CYTOBIOLOGY 9:55-60, 1992.

P.37 掲載の参考文献

• 1) Kerr JFR, Wyllie AH and Currie AR: Apoptosis: a basic biological phenomenon with wideranging implications in tissue kinetics. Br. J. Cancer 26:239-245, 1972.

• 2) Tamm I, Kikuchi T and Zychlinsky A: Acidic and basic fibroblast growth factors are survival factors with distinctive activity in quiescent BALB/c 3T3 murine fibroblast. Proc. Natl. Acad. Sci. USA 88:3372-3376, 1991.
  pubmed

• 3) Yonehara S, Ishii A and Yonehara M: A cell-killing monoclonal antiboby (Anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med. 169:1747-1756, 1989.

• 4) Shi Y, Glynn JM, Guilbert L, et al: Role for cmyc in activation-induced apoptotic cell death in T cell hybridomas. Science 257:212-214, 1992.

• 5) Lowe SW, Schmitt EM, Smith SW, et al: p53 is required for radiation induced apoptosis in mouse thymicytes. Nature 362:847-849, 1993.
  pubmed

• 6) Lowe SW, Ruley HR, Jacks T, et al: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967, 1993.

P.42 掲載の参考文献

• 1) Shiga T, Hwang KJ and Tyuma I: Electron paramagnetic resonance of nitric oxide hemoglobin derivatives. I. Human hemoglobin subunits. Biochemistry 8:378-383, 1969.
  pubmed

• 2) Kosaka H, Watanabe M, Yoshihara H, et al: Detection of nitric oxide production in lipopolysaccharide-treated rats by ESR using carbon monoxide hemoglobin. Biochem. Biophys. Res. Commun. 184:1119-1124, 1992.
  pubmed

• 3) Kosaka H, Sawai Y, Sakaguchi H, et al: ESR spectral transition by arteriovenouscycle in nitric oxide hemoglobin of cytokine-treated rats. Am. J. Physiol. 266:C1400-C1405, 1994.
  pubmed

• 4) Kumura E, Yoshimine T, Tanaka S, et al: Nitrosyl hemoglobin production during reperfusion after focal cerebral ischemia in rats. Neurosci. Lett. 177:165-167, 1994.
  pubmed

• 5) Baker JE, Felix CC, Olinger GN, et al: Myocardial ischemia and reperfusion: Direct evidence for free radical generation by electron spin resonance spectroscopy. Proc. Natl. Acad. Sci. USA 85:2786-2789, 1988.
  pubmed

• 6) Kosaka H, Imaizumi K and Tyuma I: Mechanism of autocatalytic oxidation of oxyhemoglobin by nitrite. An intermediate detected by electron spin resonance. Biochem. Biophys. Acta 702:237-241, 1982.
  pubmed

• 7) Kumura E, Kosaka H, Shiga T, et al: Elevation of plasma nitric oxide end products during focal cerebral ischemia and reperfusion in the rats. J. Cereb. Blood Flow Metab. 14:487-491, 1994.
  pubmed

• 8) Malinski T, Bailey F, Zhang ZG, et al: Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 13:355-358, 1993.
  pubmed

• 9) Kader A, Franzzini VI, Solomon RA, et al: Nitric oxide production during focal cerebral ischemia in rats. Stroke 24:1709-1716, 1993.

P.46 掲載の参考文献

• 1) Wei HM, Chi OZ, Liu X, et al: Nitric oxide synthase inhibition alters cerebral blood flow and oxygen balance in focal cerebral ischemia in rats. Stroke 25: 445-450, 1994.
  pubmed

• 2) Kadota K, Niiro M, Kawanishi A, et al: Study of the branching pattern of the middle cerebral artery in rats-With special reference to reproducibility of focal cerebral infarction-Jpn. Stroke 16:87-94, 1994.

• 3) Bederson J, Pitts LH, Germano S, et al: Evaluation of 2, 3, 5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17:1304-1308, 1986.
  pubmed

• 4) Dawson TM, Dawson VL and Snyder SH: A novel neuronal messenger molecule in brain: the free radical, nitric oxide. Ann. Neurol. 32:297-311, 1992.
  pubmed

• 5) Nowicki JP, Duval D, Poignet H, et al: Nitric oxide mediate neuronal death after focal cerebral ischemia in the mouse. Eur. J. Pharmacol. 204:339-340, 1991.
  pubmed

• 6) Buisson A, Plotkine M and Boulu RG: The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischemia. Br. J. Pharmacol. 106:766-767, 1992.

• 7) Muhonen MG, Heistad DD, Faraci FM, et al: Augumentation of blood flow through cerebral collaterals by inhibition of nitric oxide synthase. J. Cereb. Blood Flow Metab. 14:704-714, 1994.

• 8) Ashwal S, Cole DJ, Osborne TN, et al: Low dose L-NAME reduces infarct volume in the rat MCAO/reperfusion model. J. Neurosurg. Anesth. 5:241-249, 1993.

• 9) Morikawa E, Huang A and Moskowitz MA: L-arginine decreases infarct size caused by middle cerebral artery occlusion in SHR. Am. J. Physiol. 263 (10):H1632-H1635, 1992.

• 10) Dawson DA, Kusumoto K, Graham DI, et al: Inhibition of nitric oxide synthesis does not reduce infarct volume in a rat model of focal cerebral ischemia. Neurosci. Lett. 142:151-154, 1992.
  pubmed

P.49 掲載の参考文献

• 1) Morooka H and Nishimoto A: The role of adrenergic activity and histamine in ischemic brain edema. Brain Edema (edited by Inaba Y, Klatzo I and Spatz M), Springer-Verlag, Berlin-Heidelberg, New York, Tokyo, 1985, pp. 302-309.

• 2) Armstead WM, Mirro R, Busija DW, et al: Postischemic generation of superoxide anion by newborn pig brain. Am. J. Physiol. 255:401-403, 1988.

• 3) Pellegrini-Giampietro DE, Cherici G, Alesiani M, et al: Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J. Neuro. Sci. 10:1035-1041, 1990.

• 4) Ohkawa H, Ohishi N and Yagi K: Assay for lipidperoxide in animal tissue by thio-barbituric acid reaction. Anal. Biochem. 95:351-358, 1979.

• 5) Guilbault GG, Brignac PJ and Juneau M: New substrates for the fluorometric determination of oxidative enzymes. Anal. Chem. 40:1256-1263, 1954.

• 6) Sinet PM, Heikkila RE and Cohen G: Hydrogen peroxide production by rat brain in vivo. J. Neurochem. 34:1421-1428, 1980.
  pubmed

• 7) Chan PH, Fishimann RA, Caronna J, et al: Induction of brain edema following intracerebral injection of arachidonic acid. Ann. Neurol. 13:625-632, 1983.

• 8) McCord JM: Oxygen-derived free radicals in postischemic injury. N. Engl. J. Med. 312:159-163, 1985.
  pubmed

• 9) Del Maestro RF: An approach to free radicals in medicine and biology. Acta. Physiol. Scand. 492 (Suppl. ):153-168, 1980.

• 10) Morooka H, Sasayama H, Sakai K, et al: Therole of catecholamine-induced lipid peroxidation and histamine in ischemic brain edema. Intracranial Pressure VII (edited by Hoff JT and Betz AL), Springer-Verlag. Berlin Heidelberg, New York, 1989, pp. 818-820.

P.54 掲載の参考文献

• 1) Moncada S, Palmer RM and Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:109-142, 1991.
  pubmed

• 2) Hyman BT, Marzloff K, Welmiger JJ, et al: Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease. Ann. Neurol. 32:818-820, 1992.

• 3) Hunter D and Russell DS: Focal cerebral and cerebellar atrophy in a human subject due to orgnanic mercury compounds. J. Neurol. Neurosurg. Psychiatry 17:235-241, 1954.

• 4) Tokuomi H, Uchino M, Imamura S, et al: Minamata disease (organic mercury poisoning): Neuroradiologic and electrophysiologic studies. Neurology 32:1369-1375, 1982.
  pubmed

• 5) Bredt DS, Hwang PM and Snyder S H: Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768 770, 1990.

• 6) Albery WJ, Boutelle MG and Galley PT: The dialysis electrode- a new method for in vivo monitoring. J. Chem. Soc. Chem. Commun.: 900-901, 1992.

• 7) Green LC, Wagner DA, Glogowski J, et al: Analysis of nitrate, Nitrite, and (15N) nitrate in biological fluids. Anal. Biochem. 126:131-138, 1982.
  pubmed

• 8) Dawson VL, Dawson TM, London ED, et al: Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88:6368-6371, 1991.
  pubmed

• 9) Aschner M, Du YL, Gamion M, et al: Methylmercury-induced alterations in excitatory amino acid transport in rat primary astrocyte cultures. Brain. Res. 602:181-186, 1992.

• 10) Ikeda J, Ochiai K, Morita I, et al: Endogenous nitric oxide blocks calcium influx induced by glutamate in neurons containing NADPH-diaphorase. Neurosci. Lett. 158: 193-196, 1993.
  pubmed

P.58 掲載の参考文献

• 1) Palmer RMJ, Ferrige, AG and Moncada S: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524-526, 1987.

• 2) Bredt DS, Hwang PM and Snyder SH: Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768-770, 1990.
  pubmed

• 3) Wiltrout RH, Mathieson BJ, Talmadge JE, et al: Augmentation of organ associated natural killer activity by biological response modifiers: isolation and characterization of large granular lymphocytes from the liver. J. Exp. Med. 160:1431-1449, 1984.

• 4) Amber IJ, Hibbs JB, Parker CJ, et al: Activated Macrophage Conditioned Medium: identification of the soluble factors inducing cytotoxicity and the L-arginine dependent effector mechanism. J. Leukoc. Biol. 49:610-620, 1991.

• 5) Decker K: Biologically active products of stimulated liver macrophages (Kupffer cells). Eur. J. Biochem. 192:245-261, 1990.
  pubmed

• 6) Shiratori Y, Tananka M, Kawase T, et al: Quantification of sinusoidal cell function in vivo. Semin. Liver Dis. 13:39-49, 1993
  pubmed

• 7) Spitzer JA: Cytokine stimulation of nitric oxide formation and differential reguration in hepatocytes and nonparenchymalcells of endotoxemic rats. Hepatology 19:217-228, 1994.

P.60 掲載の参考文献

• 1) Suematsu M, Goda N, Sano T, et al: Carbon monoxide: An endogenous modulator of hepatic sinusoidal tone in the perfused rat liver. J. Clin. Invest. 96:2431-2437, 1995.

• 2) Suematsu M, Kashiwagi S, Sano T, et al: Carbon monoxide as an endogenous modulator of hepatic vascular perfusion. Biochem. Biophys. Res. Commun. 205:1333-1337, 1994.
  pubmed

• 3) Oshio C and Phillips MJ: Contractility of bile canaliculi. Science 212:1041-1042, 1981.
  pubmed

P.63 掲載の参考文献

• 1) 中嶋俊彰: 薬物療法-肝庇護剤の意義. 肝炎-増補C型肝炎 (鈴木 宏・編), 改訂第2版, 南江堂, 東京, 1991, pp. 123-130.

• 2) 李 時珍: 牛の胆嚢. 本草綱目-動物1, 第50巻 (下), 1578.

• 3) 李 時珍: 熊の胆嚢. 本草綱目-動物2, 第50巻 (下), 1578.

• 4) Ohkawa H, Ohishi N and Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:351-358, 1979.
  pubmed

• 5) Matsumoto N, Nakashima T and Kashima K: Effectiveness of boville galistone (Goou) and bear gall powder (Yutan) on chronic liver diseases-a preliminary report. Tokai J. Exp. Clin. Med. 1995 (in press)

• 6) Nakashima T, Sano A, Seto Y, et al: Unusual trihydroxy bile acids in the urine of patients treated with chenodeoxycholate. ursodeoxycholate or rifampicin and those with cirrhosis. Hepatology 11:255-260, 1990.
  pubmed

• 7) 高木敬次郎, 木村正康, 原田正敏・他: 牛黄. 和漢薬物学, 第1版, 南山堂, 東京, 1969, p. 242.

• 8) 高木敬次郎, 木村正康, 原田正敏・他: 熊胆. 和漢薬物学, 第1版, 南山堂, 東京, 1969, p. 135.

• 9) Poupon R, Poupon RE, Calmus Y, et al: Is ursodeoxycholic acid effective treatment for primary biliary cirrhosis? Lancet i: 834-836, 1987.
  pubmed

• 10) Nakashima T, Takino T and Kuriyama K: Therapeutic effect of taurine administration on carbon tetrachloride-induce hepatic injury. Jpn. J. Pharmacol. 32:583-589, 1982.

P.68 掲載の参考文献

• 1) Inoue M: Interorgan metabolism and membrane transport of glutathione and related compounds. In Renal Biochemistry (edited by Kinne R), Elsevier, Amsterdam, 1985, pp. 225-270.

• 2) Hirota M, Inoue M, Ando Y, et al: Role of hepatic glutathione turnover in the pathogenesis of stress-induced gastric niucosal injury. In Medical Biochemical and Chemical Aspects of Free Radicals (edited by Hayaishi O, et al), Elsevier, Amsterdam, 1989, pp. 1437-1440.

• 3) Hirota M, Inoue M, Ando Y, et al: Inhibition of stress-induced gastric injury by glutathione. Gastro enterology 97: 852-859, 1989.

• 4) Hirota M, Sugi K and Inoue M: Dynamic aspects of glutathione metabolism in obstructive jaundice. J. Gastroenterol. 29:588-592, 1994.
  pubmed

• 5) Hirayama K, Yasutake A and Inoue M: Effect of sex hormone on glutathione metabolism and the fate of methylmercury in mice. Biochem. Pharmacol. 36:1919-1924, 1987.
  pubmed

• 6) Orlowski M and Meister A: Isolation of highly purified γ-glutamylcysteine synthetase from rat kidney. Biochemistry 10:372-380, 1971.

• 7) Hirota M, Sugi K and Inoue M: Asialofetuin metabolism in animals with obstructive jaundice. Int. Hepatol. Commun. 3:184-189, 1995.

P.71 掲載の参考文献

• 1) Samuelsson B, Goldyne M, Granstrom E, et al: Prostaglandins and Thromboxanes. Ann. Rev. Biochem. 47:997-1029, 1987.

• 2) Ishiguro S, Arii S, Monden K, et al: Identification of the thromboxane A2 receptor in hepatic sinusoidal endothelial cells and its role in endotoxin-induced liver injury in rats. Hepatology 20(5):1281-1286, 1994.
  pubmed

• 3) Ishiguro S, Arii S, Monden K, et al: Involvement of thromboxane A2-Thromboxane A2 receptor system of the hepatic sinusoid in pathogenesis of cold preservation/reperfusion injury in the rat liver graft. Transplantation 59(7):957-961, 1995.
  pubmed

• 4) Oda M, Tsukada N, Watanabe N, et al: Functional implications of the sinusoidal endothelial fenestrae in the regulation of the hepatic microcirculation. Hapatogy 4:754, 1984.

P.76 掲載の参考文献

• 1) Flaherty J and Weisfeldt M: Reperfusion injury. Free Radic. Biol. Med. 5:409-419, 1988.
  pubmed

• 2) Dinarello C: The proinflammatory cytokines interleukin-1 and tulnor necrosis factor and treatment of the septic shock syndrome. J. Infect. Dis. 113:1177-1184, 1991.

• 3) Repine J, Cheronis T, Rodell T, et al: Pulmonary oxygen toxicity and ischemia reperfusion injury. Am. Rev. Respir. Dis. 136:483-485, 1987.

• 4) Colletti L, Remick D, Burtch G, et al: Role of tumor necrosis factor-α in the pathophysiologic alternations after hepatic ischemic/reperfusion injury in the rat. J. Clin. Invest. 85:1936-1945, 1990.

• 5) Koga S, Ogawa S, Kuwabara K, et al: Synthesis and release of interleukin 1 by reoxy-genated human mononuclear phagocytes. J. Clin. Invest. 90: 1007-1015, 1992.

• 6) Bevilacqua M P, Pober JS, Mendrick DL, et al: Identification of an incredible endothelial-leukocyte adhesion molecule. Proc. Natl. Acad. Sci. USA 84:9238-9242, 1987.

P.79 掲載の参考文献

• 1) Greig PD, Woolf GM, Levy GA, et al: Treatment of primary liver graft nonfunction with prostagladin E1. Transplantation 48:147 453, 1989.

• 2) Hayakawa T, Katagiri K, Boyer JL, et al: Papaverine inhibits transcytotic vesicle transport and lipid excretion into bile in isolated perfused liver. Hepatology 16:1036-1042, 1992.
  pubmed

• 3) Suzuki H, Suematsu M, Tsuchiya M, et al: Prostaglandin E1 abrogates early reductive stress zone specific paradoxical oxidative injury in hypoperfused rat liver. J. Clin Invest. 93:155-164, 1994.

• 4) Suematsu M, Suzuki H, Tsuchiya M, et al: Topgraphic disociation between mitochondrial dysfunction and cell death during low-flow hypoxia in perfused rat liver. Lab. Invest. 67:434-442, 1992.

• 5) Rappaport AM: The microcirculatory hepatic unit. Microvasc. Res 6:212 228, 1973.

• 6) Gumucio TT, Katz ME, Balabaud CP, et al: Bile salt transport after selective damage to acinar zone 3 hepatocytes by brombenzene in the rat. Toxicol. Appl. Pharmacol. 50:77-85, 1979.

P.84 掲載の参考文献

• 1) Meredith CG and Wade DN: A model of portal systemic shunting in the rat. Clin. Exp. Pharmacol. Physiol. 8:651-652, 1981.

• 2) Suematsu M, DeLano FA, Engler RT, et al: Spatial and temporal correlation between leukocyte behavior and cell injury in postischemic rat skeletal muscle microcirculation. Lab. Invest. 70:684-695, 1994.

• 3) 千賀省始, 鬼束惇義, 松波英寿・他: 脾臓皮下固着ラットを用いた全肝虚血モデルの検討. Cyto-protection & biology 7:443-450, 1989.

• 4) 若林 剛, 島津元秀, 市東昌也・他: エンドトキシン投与によるラット肝微小循環障害におけるIL-1とTNFの役割. 日本腹部救急医学会誌14:1027-1032, 1994.

• 5) 丸林誠二, 土肥雪彦, 松坂知恒・他: 肝虚血・再灌流障害. nanoGIGA 2:840-844, 1993.

• 6) Caldwell-Kenkel JC, Currin RT, Tanaka Y, et al: Reperfusion injury to endothelial cells following cold ischemic storage of rat liver. Hepatology 10:292-299, 1989.
  pubmed

• 7) 白杉 望, 若林 剛, 島津元秀・他: 肝虚血再灌流におけるフリーラジカルの産生とIL-1の関与. Cyto-protection & biology 11:151-154, 1993.

• 8) Mizoguchi Y, Tsutsui H, Miyajima K, et al: The protective effects of prostaglandin E1, in an experimental massive hepatic cell necrosis model. Hepatology 7:1184-1188, 1987.

P.88 掲載の参考文献

• 1) 河地茂行, 島津元秀, 若林剛・他: Prostaglandin E1の肝血流に及ぼす効果-特に門脈内投与の有用性について-. Cyto-protection & biology 12:61-64, 1994.

• 2) Abecassis M, Falk R, Blendis L, et al: Treatment of fulminant hepatic failure with a continuous infusion of prostin VR (PGE1). Hepatology 7:1104 (Abstract), 1987.

• 3) Greig PD, Woolf GM, Sinclair SB, et al: Treatment of primary liver graft nonfuction with prostaglandin E1. Transplantation 48:447-453, 1989.
  pubmed

• 4) 石井良知: ケノデオキシコール酸の培養ラット肝細胞に及ぼす影響とProstaglandin E1の細胞保護効果について. 日消誌 82:108-117, 1985.

• 5) 宇田川郁夫, 宮崎 勝, 越川尚男・他: 部分肝阻血時の肝ライソゾーム膜脆弱性より見た肝細胞障害およびプロスタグランジンE1誘導体の影響. 日外会誌 93:288-294, 1992.

• 6) Suzuki H, Suematsu M, Ishii H, et al: Prostaglandin E1, abrogates early reductive stress and zone specific paradoxical oxidative injury in hypoperfused rat liver. J. Clin. Invest. 93:155-164, 1994.

• 7) Mizoguchi Y, Tsutsui H, Miyajima K, et al: The protective effect of prostaglandin E1 in an experimental massive hepatic cell necrosis model. Hepatology 7:1184-1188, 1987.

• 8) Golub M, Zia P, Matsuno M, et al: Metabolism of prostaglandin A1 and E1 in man. J. Clin. Invest. 56:1404-1410, 1975.

• 9) 十束英志, 佐々木睦男, 森田隆幸・他: イヌ90分間温阻血モデルにおける門脈内prostaglandin E1 投与の効果. 日消外会誌 27:1923-1929, 1994.

• 10) Richardson PD and Withrington PG: Liver Blood Flow. Effects of drugs and hormones on liver blood flow. Gastroenterology 81:356-375, 1981.
  pubmed

• 11) Kiuchi T, Ozawa K, Yamamoto Y, et al: Changes in arterial ketone body ratio in the phase immediately after hepatectomy. Arch. Surg. 125:655-659, 1990.
  pubmed

P.92 掲載の参考文献

• 1) 音部好宏, 橋本 俊: 臨床応用を目的としたブタを用いた実験的生体部分肝移植. 名古屋市大医会誌 44:157-168, 1993.

• 2) 花井拓美, 田中守嗣, 橋本 俊・他: 生体肝移植ドナー手術. 生体肝移植-チーム医療の経験を基にして- (由良二郎・監修), 第1版, 医歯薬出版株式会社, 東京, 1994, pp. 85-87.

• 3) 由良二郎, 橋本 俊, 音部好宏・他: 生体部分肝移植を施行したAlagille症候群の1例. 名古屋市大医会誌 43:1047-1054, 1992.

• 4) 宮脇武徳, 鮫島照子, 宮尾純子・他: 出血性低血圧ラットの肝ライソゾームに対するFOY (メシル酸ガベキセート) の効果-組織学的方法による検討-. 麻酔 33:263-268, 1984.
  Medical*Online

• 5) 末松 誠, 永田博司, 三浦総一朗・他: 侵襲時微小循環障害における局所血中多核白血球respratory burstおよび脂質過酸化反応の変動. 血管 9:119-125, 1986.

P.96 掲載の参考文献

• 1) Hayakawa T, Ng OC, Ma A, et al: Taurocholate stimulate transcytotic vesicular pathways labelled by horseradish peroxidase in the isolated perfused rat liver. Gastroenterology 99:216-228, 1990.
  pubmed

• 2) Iwanaka T, Kawarasaki H, Hashizume K, et al: Experimental orthotopic liver transplantation using TOM-2H solution, in which the major anion is Gluconate: A preliminary report. Transplant. Proc. 24:1602-1604, 1992.
  pubmed

• 3) He GW, Rosenfeldt FL, Argus JA, et al: Pharmacological relaxation of the saphenous vein during harvesting for coronary artery bypass grafting. Ann. Thorac. Surg. 55:1210-1217, 1993.

• 4) Montorsi F, Guazzoni G, Bergamaschi F, et al: Effectiveness and safety of multidrug intracavernous therapy for vasculogenic impotence. Urology 42:554-558, 1993.
  pubmed

• 5) Chazouilleres O, Ballet F, Chretien Y, et al: Protective effect of vasodilators on liver function after long hypothermic preservation: A study in the isolated perfused rat liver. Hepatology 9:824-829, 1989.
  pubmed

P.102 掲載の参考文献

• 1) Butcher E: Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 67:1033-1036, 1991.

• 2) Yoshida N, Granger DN, Anderson DC, et al: Anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells. Am. J. Physiol. 262:1891-1898, 1992.

• 3) Yoshida N, Takemura T, Granger DN, et al: Molecular determinants of aspirin induced neutrophil adherence to endothelial cells. Gastroenterology 105:715-724, 1993.
  pubmed

• 4) Yoshida N, Yoshikawa T, Nakamura Y, et al: Role of neutrophil-mediated inflammation in aspirin-induced gastric mucosal injury. Dig. Dis. Sci. 1995. (in press)

• 5) Yoshida N, Yoshikawa T, Nakamura Y, et al: Neutrophil-endothelial cell interactions induced by IL-1 under flow conditions. pathophysilogy 1 (Suppl. ):245, 1994.

• 6) 内藤裕二, 吉川敏一, 谷川 徹・他: スピントラッピング法を用いたヒト末梢血多形核白血球のスーパーオキシド産生能の検討. 炎症 9:323-327, 1989.

• 7) Laurent F, Benoliel AM, Capo C, et al: Oxidative metabolism of polymorphonuclear leukocytes. J. Leukoc. Biol. 49:217-226, 1991.
  pubmed

• 8) Suchard SJ and Boxer LA: Exocytosis of a subpopulation of specific granules coillcides with H2O2 production in adherent human neutrophils. J. Immunol. 152:290-300, 1994.
  pubmed

• 9) Nathan C: Respiratory burst in adherent human neutrophils: triggering by colony-stimulating factors CSF GM and CSF-G. Blood 73:301-306, 1989.
  pubmed

• 10) Shappel SB, Toman C, Anderson DC, et al: Mac-1(CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils. J. Immunol. 144:2702-2711, 1990.

P.106 掲載の参考文献

• 1) Biswas C and Toole BP: Modulation of the extracellular matrix by tumor cell fibroblast interactions. In Cell Membranes: Methods and Reviews (edited by Elson E, Frazier W and Claser L), Plenum Publishing Corp, New York, 1987, pp. 341-363.

• 2) Matrisian LM and Bowden GT: Stromelysin/ transin and tumor progression. Semin. Cancer Biol. 1:107-115, 1990.
  pubmed

• 3) Liotta LA, Steeg PS and Stetler-Stevensen WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64:327-336, 1991.

• 4) Wewer UM, Liotta LA, Jaye M, et al: Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin. Proc. Natl. Acad. Sci. USA 83:7137-7141, 1986.
  pubmed

• 5) Wewer UM, Taraboletti G, Liotta LA, et al: Role of laminin receptor in tumor cell migration. Cancer Res. 47:5691-5698, 1988.

• 6) Hynes RO: Integrins: A family of cell surface receptors. Cell 8:549-555, 1987.

• 7) Hynes RO: Integrins: Versatility, modulation, and spreading in cell adhesion. Cell 69:11-125, 1992.

• 8) Dedhar S and Saulnier R: Alteration in integrin expression on chemically transformed human cells: Specific enhancement of laminin and collagen receptor complex. J. Cell Biol. 110:481-489, 1990.
  pubmed

• 9) Koretz K, Schlag P, Boumsell L, et al: Expression of VLA-α2, VLA-α6 and VLA-β1 chains in normal mucosa and adenomas of colon, and in colon carcinomas and their liver metastasis. Am. J. Pathol. 138:741-750, 1991.

• 10) Torimura T, Ueno T, Tanikawa K, et al: Increased expression of laminin-binding integrins in hepatocellular carcinolna. Hepatology 20 (Suppl. ):276A, 1994.

P.111 掲載の参考文献

• 1) Kurose I, Fukumura D, Yonei Y, et al: Nitric oxide Inediates Kupffer cell-induced reduction of mitochondrial energization in syngenic hepatoma cells. Cancer Res. 53:2676-2682, 1993.

• 2) Decker K: Biological active products of stimulated liver macrophages (Kupffer cells). Eur. J. Biochem. 192:245-261, 1990.
  pubmed

• 3) Entman M L, Youker K, Shoji T, et al.: Neutrophil induced oxidative injury of cardiac myocytes. A compartmented system requiring CD11b/CD18-ICAM-1 adherence. J. Clin. Invest. 90:1335-1345, 1992.
  pubmed

• 4) Goodrum K J, McCormick L L, Schneider B: Group B streptococcus-induced nitric oxideproduction in murine macrophages is CR3 (CD11b/CD18) dependent. Infection Immunity 62:3102-3107, 1994.

• 5) Takada A, Takase S and Tsutsumi M: Alcohol and hepatic carcinogenesis. In Alcohol, Immunity, and Cancer, CRC Press, 1993, pp. 151-173.

• 6) DeCarli L M and Lieber C S: Fatty liver intherat after prolonged intake of ethanol with a nutritionally adequate new liquid diet. J. Nutr. 91:331-336, 1967.

• 7) Bartholomew B: A rapid method for the assey of nitrate in urine using the nitrate reductase enzyme of Escherichia coli. Food Chem. Toxicol. 22:541-543, 1984.

• 8) Yamada T, Sartor RB, Marshall S, et al: Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats. Gastroenterology 104:759-771, 1993.

• 9) Eberhard M and Erne P: Kinetics of calcium binding to flio-3 determined by stopped-flow fluorescence. Biochem. Biophys. Res. Commun. 163:309-314, 1989.

• 10) Merrit JE, McCarthy SA, Davies MPA, et al: Use of fluo-3 to measure cytosolic Ca2+ in platelets and neutrophils. Biochem. J. 269:513-519, 1992.

• 11) Moncada S: The L-arginine: nitric oxide pathway. Acta Physiol. Scand. 145:201 227, 1992.

• 12) Earnst D L, Edward R A, Carolyns J, et al: Ethanol and diet-induced alterations in Kupffer cell function. Alcohol Alcohol. 28:73-83, 1993.

• 13) Fukui H, Kitano H, Tsujii T, et al: Effect of alcohol on the functions of Kupffer cells and splenic macrophages in rats. Alcohol Alcohol. 28:53-57, 1993.

• 14) Spolarics Z, Spitzer J J, Wang J F, et al: Alcohol administration attenuates LPS induced expression of inducible nitric oxide synthase in Kupffer and hepatic endothelial cells. Biochem. Biophys. Res. Commun. 197:606-611, 1993.
  pubmed

• 15) Hijioka T, Goto M, Lemasters J J, et al: Effect of short-term ethanol treatment on voltage-dependent calcium channels in Kupffer cells. Hepatology 18:400-405, 1993.
  pubmed

P.116 掲載の参考文献

• 1) Volpes R, Van den Oord JJ, Desmet VJ: Hepatic expression of intercellular adhesion molecule-1 (ICAM-1) in viral hepatitis B. Hepatology 12:148-154, 1990.
  pubmed

• 2) 持田 智, 藤原研司: 肝炎劇症化と肝類洞壁細胞. BIOclinica 9:238-242, 1994.

• 3) Yamada S, Ogata I, Hirata K, et al: Intravascular coagulation in the development of massive hepatic necrosis induced by Corynebacterium parvum and endotoxin in rats. Scand. J. Gastroenterology 24:293-298, 1989.

• 4) Mochida S, Ogata I, Hirata K, et al: Provocation of massive hepatic necrosis by endotoxin after partial hepatectomy in rats. Gastroenterology 99:771-777, 1990.
  pubmed

• 5) 持田 智, 新井雅裕, 大野明彦・他: 劇症肝炎とラット肝不全モデルの相異似性. 肝臓 36:328-330, 1995.

• 6) Arai M, Mocida S, Ohno A, et al: Sinusoidal endothelial cell damage by activated macrophages in rat liver necrosis. Gastroenterology 104:1466-1471, 1993.

• 7) Arai M, Mochida S, Ohno A, et al: Coagulability in rat hepatic sinusoid evaluated by macrophage tissue factor and endothelial cell thrombomodulin. Thromb. Res. 80:113-123, 1995.
  pubmed

• 8) Arai M, Mocida S, Ohno A, et al: Coagulability in the sinusoids of orthotopically transplanted liver in rats, Transplant. Proc. 26:913-915, 1994.

• 9) Mochida S, Ohno A, Arai M, et al: The role of adhesion molecules in the development of massive hepatic necrosis in rats. Hepatology. (in press)

• 10) Ohno A, Mochida S, Arai M, et al: ICAM-1 expression in hepatocytes following dissociation of cell-to-cell contact in rats. Biochem. Biophys. Res. Commum. 214:1225-1231, 1995.

P.120 掲載の参考文献

• 1) Arii S, Monden K, Adachi Y, et al: Pathogenic role of Kupffer cell activation in the reperfusion injury of cold-preserved liver. Transplantation 58:1072-1077, 1994.
  pubmed

• 2) Knook DL, Blansjaar N and Sleyster ECh: Isolation and characterization of Kupffer and endothelial cells from the rat liver. Exp. Cell. Res. 109:317-329, 1977.

• 3) Tamatani T and Miyasaka M: ldentification of monoclonal antibodies reactive with the rat homolog of ICAM-1, and evidence for a differential involvement of ICAM-1 in the adherence of resting versus activated lymphocytes to high endothelial cells. Int. Immunol. 2:165-171, 1990.

• 4) 門田一宣, 有井滋樹, 足立幸人・他: 肝冷却保存再灌流障害におけるKupffer細胞の関与について. 肝類洞壁細胞研究の進歩 (谷川久一・編), 第6巻, 国際医書出版, 東京, 1994, pp. 189-192.

• 5) Bevilacqua MP, Pober JS and Mendrick DL: Identification of all inducible endothelial-leukocyte adhesion molecule. Proc. Natl. Acad. Sci. USA 84:9238-9242, 1987
  pubmed

• 6) Monden K, Arii S, Ishiguro S, et al: Involvement of ICAM-1 expression on sinusoidal endothelial cell and neutrophil adherence in the reperfusion injury of cold-preserved livers. Transplant. Proc. 27:759-761, 1995.
  pubmed

P.124 掲載の参考文献

• 1) Furukawa H, Todo S, Imventarza O, et al: Effect of cold ischemia time on the early outcome of human hepatic allografts preserved with UW solution. Transplantation 51:1000-1004, 1991.
  pubmed

• 2) Takei Y, Marzi I, Gao W, et al: Leukocyte adhesion and cell death following orthotopic liver transplantation in the rat. Transiplantation 51:959-965, 1991.
  pubmed

• 3) Zimmermann FA, Butcher GW, Davies HS, et al: Techniques of orthotopic liver transplantation in the rat and some studies of the immunologic response to fully allogenic liver graft. Transplant. Proc. 1:571-577, 1979.
  pubmed

• 4) Hsu S, Raine L, Fanger H: Use of avidinbiotin-peroxidase complex (ABC) in immunoperoxidase techniques: acomparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem. 29:577-580, 1981.

• 5) Adams DH, Hubscher SG, Shaw J, et al: Intercellular adhesion molecule 1 on liver allografts during rejection. Lancet 2:1122-1125, 1989.
  pubmed

• 6) Goto M, Takei Y, Kawano S, et al: Tumor necrosis factor and endotoxin in the pathogenesis of liver and pulmonary injuries after orthotopic liver transplantation in the rat. Hepatolgy 16:487-493, 1993.

• 7) Sugama Y, Tiruppathi C, Janakidevi K, et al: Thrombin-induced expression of endothelial p-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion. J. Cell. Biol. 119:935-944, 1992.

• 8) Himmelreich G, Kierzek B, Neuhaus P, et al: Coagulation changes and the influence of the early perfusate in the course of orthotopic liver transplantation (OLT) when aprotinin isused intra-operatively. Blood Coagul. Fibrinolysis 2:51 58, 1991.