書籍詳細

特別講演 I

P.7 掲載の参考文献

• 1) Critchley C:Studies on the mechanism of photoinhibition in higher plants. I. Effects of high light intensity on chloroplast activities in cucumber adapted to low light. Plant Physiol. 67:1161-1165, 1981.
  pubmed

• 2) Kyle DJ, Ohad I, Arntzen CJ:Membrane protein damage and repair:selective loss of a quinone-protein function in chloroplast membranes. Proc. Natl. Acad. Sci. USA 81:4070-4074, 1984.
  pubmed

• 3) 浅田浩二:植物の光酸素障害-その抑制と増幅-. 農薬学会誌 10:729-743, 1985.

• 4) Nakano Y, Asada K:Spinach chloroplasts scavenge hydrogen peroxide on illumination. Plant Cell Physiol. 21:1293-1307, 1980.

• 5) Autor AP (Edited):Biochemical Mechanisms of Paraquat Toxicity. Academic Press, New York, 1977.

• 6) Asada K, Takahashi M, Nakano Y, et al:Active oxygen in chloroplasts:suppression of singlet oxygen formation and scavenging of hydrogen peroxide. Oxygenases and Oxygen Metabolism. 255-266, edited by Nozaki M, Yamamoto S, Ishimura Y, et al, Academic Press, New York, 1982.

• 7) Mathews BW, Fenna RE, Bolognesi MC, et al:Structure of a bacteriochlorophyll a-protein from the green photosynthetic bacterium Prosthecochloris aesturarii. J. Mol. Biol, 131:259-285, 1979.

• 8) Takahashi M, Gross EL:Use of immobilized light-harvesting chlorophyll a/b protein to study the stoichiometry of its self-association. Biochemistry 17:806-810, 1978.

• 9) Takahashi M, Asada K:Dependence of oxygen affinity for Mehler reaction on photochemical activity of chloroplast thylakoids. Plant Cell Physiol. 23:1457-1461, 1982.

• 10) Asada K, Takahashi M, Hayakawa T:Photoproduction of superoxide in membranes of chloroplast thylakoids and intrachloroplast distribution of superoxide dismutase. Oxy Radicals and Their Scavenger Systems. Vol. 1, 240-245, edited by Cohen C, Greenwald A, Elsevier, Amsterdam, 1983.

• 11) Horton P:Interactions between electron transfer and carbon assimilation. Photosynthetic Mechanisms and the Environment. 135-187, edited by Barber J, Baker NR, Elsevier, Amsterdam, 1985.

• 12) Asada K, Takahashi M:Production and scavenging of active oxygen in photosynthesis. Photoinhibition. edited by Kyle DJ, Osmond CB, Arntzen CJ, Elsevier, Amsterdam, 1987. (in press)

• 13) Hayakawa T, Kanematsu S, Asada K:Purification and characterization of thylakoid-bound Mn-superoxide dismutase in spinach chloroplasts, Planta 166:111-116, 1985.
  pubmed

• 14) Takahashi M, Asada K:Superoxide anion permeability of phospholipid membranes and chloroplast thylakoids. Arch. Biochem. Biophys. 226:558-566, 1983.
  pubmed

• 15) Nakano Y, Asada K:Hydrogen peroxide is scavenged by ascorbate-specific peroxidase in spinach chloroplasts. Plant Cell Pysiol. 22:867-880, 1981.

• 16) Hossain MA, Nakano Y, Asada K:Monodehydroascorbate reductase in spinach chloroplasts and its participation in regeneration of ascorbate for scavenging hydrogen peroxide. Plant Cell Physiol. 25:385-395, 1984.

• 17) Hossain MA, Asada K:Monodehydroascorbate reductase from cucumber is a flavine adenine dinucleotide enzyme. J. Biol. Chem. 260:12920-12926, 1985.
  pubmed

• 18) Hossain MA, Asada K:Purification of dehydroascorbate reductase from spinach and its characterization as a thiol enzyme. Plant Cell Physiol. 25:85-92, 1984.

特別講演 II

P.23 掲載の参考文献

• 1) Henson PM, Johnston RB Jr:Tissue inlury in inflammation:oxidants, proteinases and cationic proteins. J. Clin. Invest. (in press)

• 2) Iyer GYN, Islam DMF, Quastel JH:Biochemical aspects of phagocytosis. Nature (Lond.) 192:535, 1961.

• 3) Baldrige CW, Gerard RW:The extra respiration of phagocytosis. Am. J. Physiol. 103:235, 1933.

• 4) Sbarra AJ, Karnovsky ML:The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes. J. Biol. Chem. 234:1355, 1959.
  pubmed

• 5) Karnovsky ML:The metabolism of leukocytes. Semin. Hematol. 5:156, 1968.

• 6) Klebanoff SJ, Hamon CB:Role of myeloperoxidase-mediated antimicrobial systems in intact leukocytes. J. Reticuloendothel. Soc. 12:170, 1972.
  pubmed

• 7) Babior BM, Kipnes RS, Curnutte JT:Biological defense mechanisms:the production by leukocytes of superoxide, a potential bactericidal agent. J. Clin, Invest. 52:741, 1973.
  pubmed

• 8) Johnston RB Jr, Keele BB Jr, Misra HP, Lehmeyer JE, et al:The role of superoxide anion generation in phagocytic bactericidal activity:studies with normal and chronic granulomatous disease leukocytes. J. Clin. Invest. 55:1357, 1975.
  pubmed

• 9) Weiss SJ, King GW, LoBuglio AF:Evidence for hydroxyl radical generation by human monocytes. J. Clin. Invest. 60:370, 1977.
  pubmed

• 10) Babior BM:The respiratory burst of phagocytes. J. Clin. Invest. 73:599, 1984.
  pubmed

• 11) Thomas EL:Myeloperoxidase, hydrogen peroxide, chloride antimicrobial system:nitrogenchlorine derivatives of bacterial components in bactericidal action against Escherichia coli. Infect. Immun. 23:522, 1979.
  pubmed

• 12) Goldstein IM, Roos D, Kaplan HB, Weissmann G,:Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis. J. Clin. Invest. 56:1155, 1975.
  pubmed

• 13) Henson PM:The immunologic release of constituents from neutrophil leukocytes. II. Mechanisms of release during phagocytosis, and adherence to nonphagocytosable surfaces. J. Immunol. 107:1547, 1971.
  pubmed

• 14) Johnston RB Jr, Lehmeyer JE:Elaboration of toxic oxygen by-products by neutrophils in a model of immune complex disease. J. Clin. Invest. 57:836, 1976.

• 15) Johnston RB Jr, Lehmeyer JE, Guthrie LA:Generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin G. J. Exp. Med. 143:1551, 1976.

• 16) Fantone JC, Ward PA:Role of oxygen-derived free radicals and metabolites in leukocytedependent inflammatory reactions. . Am. J. Pathol. 107:397, 1982.

• 17) Yamamoto K, Johnston RB Jr:Dissociation of phagocytosis from stimulation of the oxidative metabolic burst in macrophages. J. Exp. Med. 159:405, 1984.
  pubmed

• 18) Wright SD, Silverstein SC:Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from phagocytes. J. Exp. Med. 158:2016, 1983.
  pubmed

• 19) Lepay DA, Nathan CF, Steinman RM, Murray HW, et al:Murine Kupffer cells:mononuclear phagocytes deficient in the generation of reactive oxygen intermediates. J. Exp. Med. 161:1079, 1985.
  pubmed

• 20) Baehner RL, Nathan DG:Leukocyte oxidase:defective activity in chronic granulomatous disease. Science (Wash. D. C.) 155:835, 1967.

• 21) Quie PG, White JG, Holmes B, Good RA:In vitro bactericidal capacity of human polymorphonuclear leukocytes:diminished activity in chronic granulomatous disease of childhood. J. Clin. Invest. 46:668, 1967.
  pubmed

• 22) Johnston RB Jr, Newman SL:Chronic granulomatous disease. Pedintr. Clin. N. Amer. 24:365, 1977.

• 23) McCord JM, Fridovich I:Superoxide dismutase:an enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem. 244:6049, 1969.
  pubmed

• 24) Johnston RB Jr, Keele B, Webb L, Kessler D, et al.:Inhibition of phagocytic bactericidal activity by superoxide dismutase:a possible role for superoxide anion in the killing of phagocytized bacteria. J. Clin. Invest. 52:44a, 1973.

• 25) Baehner RL, Murmann SK, Davis J, Johnston RB Jr:The role of superoxide anion and hydrogen peroxide in phagocytosis-associated oxidative metabolic reactions. J. Clin. Invest. 56:571, 1975.

• 26) Sagone AL Jr, King GW, Metz EN:A comparison of the metabolic response to phagocytosis in human granulocytes and monocytes. J. Clin. Invest. 57:1352, 1976.
  pubmed

• 27) Sasada M, Johnston RB Jr:Macrophage microbicidal activity:correlation between phagocytosis-associated oxidative metabolism and the killing of candida by macrophages. J. Exp. Med 152:85, 1980.
  pubmed

• 28) Miller RM, Garbus J, Hornick RB:Lack of enhanced oxygen consumption by polymorphonuclear leukocytes on phagocytosis of virulent Salmonella typhi. Science (Wash. D. C.) 75:1010, 1972.

• 29) Sasada M, Kubo A, Nishimura T, Kakita T, et al:Candidacidal activity of monocyte-derived human macrophages:relationship between candida killing and oxygen radical generation by human macrophages. J. Leukocyte Biol. (in press)

• 30) Gabay JE, Heiple JM, Cohn ZA, Nathan CF:Subcellular location and properties of bactericidal factors from human neutrophils. J. Exp. Med. 164:1407, 1986.
  pubmed

• 31) Murray HW, Rubin BY, Rothermel CD:Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes:evidence that interferon-γis the activating lymphokine J. Clin. Invest. 72:1506, 1983.

• 32) Johnston RB Jr:Enhancement of phagocytosis-associated oxidative metabolism as a manifestation of macrophage activation. Lymphokines 3:33, 1981.

• 33) Johnston RB Jr, Godzik CA, Cohn ZA:Increased superoxide anion production by immunologically activated and chemically elicited macrophages. J. Exp. Med. 148:115, 1978.
  pubmed

• 34) Johnston RB Jr, Kitagawa S:Molecular basis for the enhanced respiratory burst of activated macrophages, Fed. Proc. 44:2927, 1985.
  pubmed

• 35) Nathan CF:Mechanisms of macrophage antimicrobial activity. Trans. R. Soc. Trop. Med. Hyg. 77:620, 1983.
  pubmed

• 36) Harris LK, Pabst MJ, Johnston RB Jr:Increased transglutaminase activity in elicited and activated macrophages:relationship to production of superoxide anion. J. Leukocyte Biol. 36:710, 1984.

• 37) Guthrie LA, McPhail LC, Henson PM, Johnston RB Jr:Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide:evidence for increased activity of the superoxide-producing enzyme. J. Exp. Med. 160:1656, 1984.
  pubmed

• 38) Weisbart RH, Kwan L, Golde DW, Gasson JC:Human GM-CSF primes neutrophils for enhanced oxidative metabolism in response to the major physological chemoattractants. Blood 69:18, 1987.

• 39) Finkel TH, Suzuki H, Guthrie LA, Forehand JR, et al:Priming of neutrophils and macrophages for enhanced release of superoxide anion by the calcim ionophore ionomycin:implications for activation of the respiratory burst. (Manuscript submitted)

• 40) Kitagawa S, Johnston RB Jr:Deactivation of the respiratory burst in activated macrophages:evidence for alteration of signal transduction. J. Immunol. 136:2605, 1986.
  pubmed

• 41) Ezekowitz RAB, Bampton M, Gordon S:Macrophage activation selectively enhances expression of Fc receptors for IgG2a. J. Exp. Med. 157:807, 1983.

• 42) Stahl P, Gordon S:Expression of a mannosyl-fucosyl receptor for endocytosis on cultured primary macrophages and their hybrids. J. Cell. Biol. 93:49, 1982.
  pubmed

• 43) Sasada M, Pabst MJ, Johnston RB Jr:Activation of mouse peritoneal macrophages by lipopolysaccharide alters the kinetic parameters of the superoxide-producing NADPH oxidase. J. Biol. Chem. 258:9631, 1983.
  pubmed

• 44) Tsunawaki S, Nathan CF:Enzymatic basis of macrophage activation:kinetic analysis of superoxide production in lysates of resident and activated mouse peritoneal macrophages and granulocytes. J. Biol. Chem. 259:4305, 1984.
  pubmed

• 45) Berton GM, Cassatella M, Cabrini G, Rossi F:Activation of mouse macrophages cause no change in expression and function of phorbol diesters' receptors, but is accompanied by alterations in the activity and kinetic parametes of NADPH oxidase. Immunology 54:371, 1985.

• 46) Kitagawa S, Johnston RB Jr:Relationship between membrane potential changes and superoxide-releasing capacity in resident and activated mouse peritoneal macrophages. J. Immunol. 135:3417, 1985,
  pubmed

• 47) Berridge MJ:Inositol trisphophate and diacylglycerol as second messengers. Biochem. J. 220:345, 1984.

• 48) Holian AJ, Stickle DF:Calcium regulation of phosphatidylinositol turnover in macrophage activation by formyl peptides. J. Cell. Physiol. 123:39, 1985.

• 49) DeTogni P, Della Bianca V, Grzeskowiak M, DiVirgilio F, et al:Mechanism of desensitization of neutrophil response to N-formyl-methionylleucylphenylalanine by slow rate of receptor occupany:studies on changes in Ca2+ concentration and phosphatidylinositol turnover. Biochem. Biophys. Acta 838:23, 1985.

• 50) Coggeshall KM, Cambier JC:B cell activation. VIII. Membrane immunoglobulins transduse signals via activation of phosphatidylinositol hydrolysis. J. Immunol. 133:3382, 1984.
  pubmed

• 51) Agwu DE, McPhail LC, Daniel LW, Bass DA, et al:Activation of phospholipase C in human neutrophils by phorbol myristate acetate. Fed. Proc. 45:4049A, 1986.

• 52) Channon JY, Leslie CC, Johnston RB Jr:Zymosan-stimulated production of phosphatidic acid by macrophages:relationship to release of superoxide anion and inhibition by agents that increase intracellular cyclic AMP. J. Leukocyte Biol. (in press)

• 53) Edwards CK III, Hedegaard HB, Zlotnik A, Gangadharam PR, et al:Chronic infection due to Mycobacterium intracellulare in mice:association with macrophage release of prostaglandin E2 and reversal by injection of indomethacin, muramyl dipeptide, or interferon-γ. J. Immunol. 136:1820, 1986.

• 54) Allison AC:Role of macrophage activation in the pathogenesis of chronic inflammation and its pharmacological control. Adv. Inflam. Res. 7:201, 1984.

• 55) Mason UG III, Greenberg LE, Yen SY, Kirkpatrick CH:Indomethacin-responsive mononuclear cell dysfunction in "atypical" mycobacteriosis. Cell. Immunol. 71:54, 1982.

• 56) Cummings NP, Pabst MJ, Johnston RB Jr:Activation of macrophages for enhanced release of superoxide anion and greater killing of Candida albicans by injection of muramyl dipeptide. J. Exp. Med. 152:1659, 1980.
  pubmed

• 57) Goldstein IM, Lind S, Hoffstein S, Weissmann G:Influence of local anesthetics upon human polymorphonuclear leukocyte function in vitro. J. Exp. Med. 146:483, 1977.
  pubmed

• 58) Peck SL, Johnston RB Jr, Horwitz LD:Reduced neutrophil superoxide anion release after prolonged infusions of lidocaine. J. Pharmacol. Exp. Ther. 235:418, 1985.
  pubmed

• 59) Lesnefsky EJ, VanBenthuysen K, McMurtry I, Johnston RB Jr, et al:Lidocaine reduces canine infarct size:protection from myocardial lipid peroxidation. Clin. Res. (in press)

指定講演

P.35 掲載の参考文献

• 1) Spudich J, Watt S:The regulation of rabbit skeletal muscle contraction. J. Biol. Chem, 246:4866-4871, 1971.
  pubmed

• 2) Gorwin H, Hartwig J:Isolation of actin-bindig Protein and villin from toad oocytes. Develop. Biol. 99:61-74, 1983.

• 3) Chaponier C, Yin H:The actin filament severing domain of gelsolin. J. Cell. Biol. 103:1473-1481, 1986.

• 4) Ito T, Zaner K, Stossel T:Non-ideality of volume flows and phase transitions of F-actin solutions in response to osmotic stress. Biophys. J. 51:745-753, 1987.

• 5) Edwards S, Evans K:Dynamics of highly entangled rod-like molecules. J. Chem. Soc. Frady Trans II 78:113-121, 1982.

• 6) Stossel T, Hartwig J:Phagocytosis and the contractile proteins of pulmonary macrophages. In Cell Motility Book B. 529-544, edited by Goldman R, Pollard T and Rosenbaum J, Cold Spring Harbor Laboratory, New York, 1976.

• 7) Niederman R, Amrein P, Hartwig J:Three-dimensional structure of actin filaments and of an actin gel made with actin-binding protein. J. Cell. Biol. 98:1400-1413, 1983.

• 8) Hartwig J, Shevin P:The archtecture of actin filaments and ultrastructual location of actin binding protein in the periphery of lung macrophages. J. Cell. Biol. 103:1007-1020, 1986.

P.44 掲載の参考文献

• 1) Tarao K, So K, Moroi T, et al:Detection of endotoxin in plasma and ascitic fluid of patients with cirrhosis:its clinical significance. Gastroenterology 73:539-542, 1977.
  pubmed

• 2) Utili R, Abernathy CO, Zimmerman HJ:Endotoxin effects on the liver. Life Sci. 20:553-568, 1977.
  pubmed

• 3) Nolan JP:Endotoxin, reticuloendothelial function and liver injury. Hepatology 1:458-465, 1981.
  pubmed

• 4) 芝山雄老, 斉藤雅文, 橋本和明, 他:エンドトキシンによる肝壊死の発生機序-肝循環障害の原因的役割について-. 肝臓 24:1242-1251, 1983.

• 5) Arai M, Okuno F, Hirano Y, et al:Protective effect of a calfextract on endotoxin-induced liver injury in rats. Cytoprotection and Cytobiology. 100-106, Vol. 4, Excerpta Medica, Tokyo, 1986.

• 6) Tottmar SOC, Petterson H, Kiessling K-H, et al:The subcellular distribution and properties of aldehyde dehydrogenase in rat liver. Biochem. J. 135:577-586, 1973,

• 7) Minakami S, Ringker RL, Singer TP, et al:Studies on the respiratory chain-linked dihydrodiphosphopyridine nucleotide dehydrogenase. I. Assay of the enzyme in particulate and in soluble preparations. J. Biol. Chem. 237:569-576, 1962.

• 8) King TE:Preparation of succinate dehydrogenase and reconstitution of succinate oxidase. In:Methods in enzymology, 322, Vol. X, edited by Estabrook RW and Pullman ME, Academic Press, New York, 1967.

• 9) Wharton DC, Tzagoloff A:Cytochrome oxidase from beef heart mitochondria. In:Methods in enzymology, 245, Vol. X, edited by Estabrook RW and Pullman ME, Academic Press, New York, 1967.

• 10) Beattie DS:Enzyme localization in the inner and outer membranes of rat liver mitochondria. Biochem. Biophys. Res. Co mmun. 31:901-907, 1968.

• 11) Lowry OH, Rosebrough NJ, Farr AI, et al:Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275, 1951.

• 12) 荒井正夫, 奥野府夫, 小林利次, 他:エンドトキシンによる血小板活性化の機序-特にactive oxygen speciesとの関連について-. 脈管学 26:1121-1125, 1986.

• 13) Fine DP:Activation of the classic and alternate complement pathway by endotoxin. J. Immunology 112:763-769, 1974.
  pubmed

• 14) Stuart MJ:Effect of endotoxin on arachidonic acid release and thromboxane B2 production by human platelets. Am. J. Hematology 11:159-164, 1981.

• 15) 上田 博:エンドトキシンのエネルギー代謝に及ぼす影響-特に肝ミトコンドリア機能と肝アデニンヌクレオタイドの動態について-. 日外会誌 81:581-593, 1980.

• 16) 松熊敏浩, 大和田勝男, 土屋正弘, 他:Solcoserylの各組織ミトコンドリアと細胞の呼吸能に対する作用. 薬理と治療 9:101-108, 1981.

• 17) 森 登, 国仲晃行, 村田敏郎:ソルコセリルの生化学的研究 第2報-ソルコセリルの呼吸阻害と脱水素酵素系におよぼす影響-. 基礎と臨床 8:11-17, 1974.

• 18) 井上昌一, 森 登, 国仲晃行, 他:ソルコセリルの生化学的研究 第1報-ソルコセリルの組織呼吸促進作用について-. 基礎と臨床 8:5-10, 1974.

• 19) 山田博保, 山下義昭, 橋本岩雄, 他:ソルコセリルの細胞増殖促進作用についてII. 電子伝達系に及ぼすソルコセリルの影響. 基礎と臨床 8:29-34, 1974.

• 20) Mela L, Miller LD, Bacalzo LV, et al:Role of intracellular variations of lysosomal enzyme activity and oxygen tension in mitochondrial impairment in endotoxemia and hemorrhage in the rat. Ann. Surg. 178:727-735, 1973.
  pubmed

P.52 掲載の参考文献

• 1) 高橋久雄, 石井裕正, 永田茂之, 他:実験的四塩化炭素肝障害における過酸化脂質および関連酵素の検討. Cyto-protection & biology. 27-33, 第2巻, 蟹書房, 東京, 1984.

• 2) 竹崎英一, 坪倉篤雄, 中西敏夫, 他:ガラクトース負荷試験の実験的検討-とくにICGRmaxとの比較検討-. 医学のあゆみ 125:1003-1005, 1983.

• 3) 竹崎英一, 中西敏夫, 梶山梧朗, 他:肝予備能検査法としてのガラクトース負荷試験の実験的検討-ICGRmaxとの比較検討-, 肝臓 24:1235-1241, 1983.

• 4) 竹崎英一, 坪倉篤雄, 中西敏夫, 他:負荷試験による肝予備力の解析. 臨床病理 32:577-583, 1984,

• 5) Ballard EJ:Galactokinase frome pig liver. Meth. Enaymol. 42:43-47, 1975.

• 6) 横尾和久, 高山佳子, 小沢高将, 他:ラット肝ミトコンドリア機能に及ぼす熱傷毒およびソルコセリルの影響. Cyto-protection & biology. 119-124, 第1巻, 蟹書房, 東京, 1983.

• 7) Keppler D, Decker K:Studies on the mechanism of galactosamine hepatitis:Accumulation of galactosamine-1-phosphate and its inhibition of VDP-glucose pyrophosphorylase. European J. Biochem. 10:219-225, 1969.

• 8) Farber JL, Samir K:The biochemical pathology of liver cell necrosis. Ame. J. Pathol. 81:237-249, 1975.

• 9) Liehr H, Grun M, Reutter W, et al:On the pathogenesis of galactosamine hepatitis. Virchows Arch B cell path. 26:331-344, 1978.

• 10) 末盛彰一, 竹崎英一, 松尾行雄, 他:障害肝におけるガラクトース負荷試験の実験的検討. 肝臓 27:36-42, 1986.

• 11) 末盛彰一, 竹崎英一, 川上広育, 他:ガラクトース負荷試験からみた再生肝におよぼすグルカゴンの効果. 肝臓 26:311-316, 1985.

• 12) 末盛彰一, 竹崎英一, 中西敏夫, 他:再生肝のガラクトース代謝についての実験的検討. 医学のあゆみ 133:393-394, 1985.
  Medical*Online

• 13) Vilstrup H:The galactose elimination capacity as a quantitative measure of liver function in acute carbon tetrachloride intoxication of rats. Europ. J. Clin. Invest. 8:317-319, 1978.
  pubmed

P.58 掲載の参考文献

• 1) Thayer WS, Rubin E:Molecular alterations in respiratory chain of rat liver after chronic ethanol consumption. J. Biol. Chem. 256:6090-6097, 1981.
  pubmed

• 2) Hamlyn AN, Brown AJ, Sherlock S:Casual blood-ethanol estimation in patients with chronic liver disease. Lancet 2:345, 1975.
  pubmed

• 3) Lieber CS:Metabolism of alcohol and associated hepatic effects. In Gastroenterology. 2957-2977, edited by Berk JE et al, W. B. Saunders, Philadelphia, 1985.

• 4) Scholz R, Hansen W, Thurman RG:Interaction of mixed-function oxidation with biosynthetic processes. I. Inhibition of gluconeogenesis in perfused rat liver by aminopyrine. Eur. J. Biochem. 38:64-72, 1973.
  pubmed

• 5) Sato N, Matsumura T, Schichiri M, et al:Hemoperfusion, rate of O2 consumption and the redox level of cytochrome C (+C1) in livers in situ of anesthetized rats measured by reflectance spectrophotometry. Biochem. Biophys. Acta 634:1-10, 1981.

• 6) Kamiike W, Watanabe F, Hashimoto T, et al:Change in cellular levels of ATP and its catabolites in ischemic rat liver. J Biochem. 91:1349-1356, 1982.

• 7) Thurman RG, Scholz R:Interaction of glycolysis and respiration in perfused rat liver. Eur. J. Biochem. 75:13-21, 1977.
  pubmed

• 8) Videla LA:Chemically induced antioxidant-sensitive respiration. F. E. B. S. Letters 178:119-121, 1984.

• 9) Christophersen BO:Effect of ethanol on mitochondrial oxidation. Biochem. Biophys. Acta 86:14-20, 1964.
  pubmed

• 10) Lelbach WK:Cirrhosis in the alcoholics and its relation to the volume of alcoholic abuse. Ann. N. Y. Acad. Sci. 252:85-92, 1975.

P.68 掲載の参考文献

• 1) Pringle JH:Notes on the arrest of hepatic hemorrhage due to trauma. Ann. Surg. 48:541, 1908.
  pubmed

• 2) 野浪敏明, 篠原正彦, 星野澄人, 他:肝循環動態に及ぼす肝流入血行遮断の影響. Cyto-protection & biology. 69-76, 第3巻, 蟹書房, 東京, 1985.

• 3) 中尾昭公, 野浪敏明, 原田明生, 他:門脈バイパス用カテーテル (アンスロン(R)) の作成と臨床治験成績. 臨床外科 39:383, 1984.

• 4) Mcmaster P, Medd R:Total hepatic ischemia in the Rhesus monkey. Brit. J. Surg. 64:819, 1977.
  pubmed

• 5) Barnett WO, Griffin JC, Morris L:Studies concerning hepatic pH changes and survival following temporary afferent vascular arrest to the liver. Surg. 43:572, 1958.

• 6) DiLuzio NR, Olcay I, Holper K, et al:The relationship of reticuloendothelial dysfunction and endotoxemia to survival after hepatic ischemia injury in the baboon. Cir. Shock 2:77, 1975.

• 7) Starzl TE, Kaupp HA, Brock DR, et al:Reconstructive problems in canine liver homotransplantation with special reference to the postoperative role of hepatic venous flow. Surg. Gynecol. Obstet. 111:733, 1960.

• 8) 星野澄人, 野浪敏明:急性門脈遮断時および解除後の全身血行動態と酸素需給動態に関する実験的研究. 日外会誌 86:738, 1985.

• 9) 篠原正彦, 中尾昭公:肝阻血の血液凝固線溶系に及ぼす影響に関する実験的研究. 日外会誌 86:544, 1985.

P.73 掲載の参考文献

• 1) Tomasi TB, Tan EM Jr, Salomon A, et al:Characteristics of an immune system common to certain external secretions. J. Exp. Med. 121:101-124, 1954.

• 2) Tomasi TB, Grey HM:Structure and function of immunoglobulin A. Prog. Allergy 16:81-218, 1972.
  pubmed

• 3) Delacroix DL, Hodgson HJF, Mcpherson A, et al:Selective transport of polymeric immunoglobulin A in bile. Quantitative relationships of monomeric and polymeric immunoglobulin A, immunoglobulin M, and other proteins in serum, bile, and saliva. J Clin. Invest. 70:230-241, 1982.

• 4) Russel WM, Brown AI, Mestecky J:Role of serum IgA:hepatobiliary transport of circulating antigen. J. Exp. Med. 153:968-976, 1981.

• 5) Peppard J, Orlans E, Payne AWR, et al:The elimination of circulating complexes containing polymeric IgA by excretion in the bile. Immunology 42:83-89, 1981.

• 6) Socken DJ, Simms ES, Nagy BR, et al:Secretory component-dependent hepatic transport of IgA antibody-antigen complexes. J. Immunol. 127:316-319, 1981.
  pubmed

• 7) Ohshio G, Furukawa F, Manabe T, et al:Relationship between secretory IgA, IgA containing (C3-fixing) circulating immune complexes and complement components (C3, C4) in patients with obstructive jaundice. Scand. J. Gastroenterol. 21:151-157, 1986.
  pubmed

• 8) Nagura H, Smith PD, Nakane PK, et al:IgA in human bile and liver. J. Immunol. 126:587-595, 1981.

• 9) Waldman RH, Mach JP, Stella MM, et al:Secretory IgA in human serum. J. Immunol.105:43-47, 1970.

• 10) Thompson RA, Carter R, Stokes RP, et al:Serum immunoglobulins, complement component levels and autoantibodies in liver disease. Clin. Exp. Immunol. 14:335-340, 1973.
  pubmed

• 11) Goldblum RM, Powell GK, Sidkle GV:Secretory IgA in the serum of infants with obstructive jaundice. J. Pediatr. 97:33-36, 1980.

• 12) Delacroix DL, Vaerman JP:Reassessment of levels of secretory IgA in pathological sera using quantitative radioimmunoassay. Clin. Exp. Immunol. 43:633-640, 1981.

• 13) Delacroix DL, Jonard P, Dive C, et al:Serum IgM-bound secretory component (sIgM) in liver diseases:comparative molecular state of the secretory component in serum and bile. J. Immunol. 129:133-138, 1982.

• 14) Delacroix DL, Reynaert M, Pauwels S, et al:High serum levels of secretory IgA in liver disease. Possible liver origin of the circulating secretory component. Dig. Dis. Sci. 27:333-340, 1982.
  pubmed

• 15) Hardwicke J, Rankin JG, Baker KJ, et al:The loss of protein in human and canine hepatic bile. Clin. Sci. 26:509-517, 1964.
  pubmed

• 16) Dive C, Heremans JF:Nature and origin of the proteins of bile. I. A comparative analysis of serum and bile proteins in man. Europ. J. Clin. Invest. 4:235-239, 1974.

• 17) Ohshio G, Furukawa F, Sekita K, et al:IgA containing circulating immune complexes and IgA anti-single stranded DNA antibodies in patients with obstructive jaundice. Clin.Exp. Immunol. 59:435-441, 1985.
  pubmed

• 18) Bailey MH:Endotoxin, bile salts and renal function in obstructive jaundice. Br. J. Surg. 63:774-778, 1976.

• 19) Drivans G, James O, Wardle N:Study of reticuloendothelial phagocytic capacity in patients with cholestasis. Br. Med. J. 26:1568-1569, 1976.

• 20) Katz S, Grosfeld JL, Gross K, et al:Impaired bacterial clearance and tripping in obstructive jaundice. Ann. Surg. 199:14-20, 1984.

P.84 掲載の参考文献

• 1) Collins GM, Bravo-Shugarman M, Terasaki PI:Kidney preservation for transplantation. Initial perfusion and 30 hours' ice storage. Lancet 2:1219-1222, 1969.
  pubmed

• 2) Dreikorn K, Horsch R, Rohl L:48-to 96-hour preservation of canine kidneys by initial perfusion and hypothermic storage using the Euro-Collins solution. Eur. Urol. 6:221-224, 1980.
  pubmed

• 3) Starzl TE, Iwatsuki S, Shaw BW:Transplantation of the human liver. In Maingot's abdominal operations. 1687-1722, 8th Ed, edited by Schwartz SI and Ellis H, Appeleton-Century-Crofts, Norwalk, 1985.

• 4) 藤森次勝, 門田守人, 梅下浩司, 他:肝保存に関する基礎的研究-虚血肝細胞障害における細胞外 Ca++ の意義. Cyto-protection & biology (土屋雅春編). 107-117, 第3巻, 蟹書房, 東京, 1985.

• 5) 梅下浩司, 門田守人, 藤森次勝, 他:肝保存に関する基礎的研究 (II)-保存液中のCa++の功罪. Cyto-protection & biology (長尾房大編). 83-89, 第4巻, 蟹書房, 東京, 1986.

• 6) Seglen PO:Preparation of isolated liver cells. In Methods in cell biology. 29-83, Vol. 3, edited by Prescott DM, Academic Press, New York, 1976.

• 7) 真杉文紀, 中村哲也:Sodium dodecylsulphate 可溶化による肝チオバルビツール酸値とビタミンE, 薬物によるその変動. ビタミン 51:21-29, 1977.
  Medical*Online

• 8) Tietze F:Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione:application to mammalian blood and other tissues. Anal. Biochem. 27:502-522, 1969.

• 9) Schanne FAX, Kane AB, Young EE, Farber JL:Calcium dependence of toxic cell death:a final common pathway. Science 206:700-702, 1979.

• 10) Smith MT, Thor H, Orrenius S:Toxic injury to isolated hepatocytes is not dependent on extracellular calcium. Science 213:1257-1259, 1981.

• 11) Fariss MW, Pascoe GA, Reed DJ:Vitamin E reversal of the effect of extracellular calcium on chemically induced toxicity in hepatocytes, Science 227:751-754, 1985.
  pubmed

• 12) Chance B, Boveris A, Nakase Y, Sies H:Hydroperoxide metabolism:an overview. In Function of Glutathione in Liver and Kidney. 95-105, edited by Sies H and Wendel A, Springer Verlag, New York, 1978.

• 13) Younes M, Siegers CP:Lipid peroxidation as consequence of glutathione depletion in rat and mouse liver. Res. Commun. Chem. Pharmacol. 27:119-128, 1980.
  pubmed

• 14) Fariss MW, Olafsdottir K, Reed DJ:Extracellular calcium protects isolated rat hepatocytes from injury. Biochem, Biophys. Res. Commun. 121:102-110, 1984.
  pubmed

• 15) Graf P, Sies H:Hepatic glutathione release upon decreases of extracellular calcium concentration. Biochem. Pharmacol. 35:2832-2833,1986.
  pubmed

P.89 掲載の参考文献

• 1) 木村郁子, 木村正康:幼牛血液抽出剤のマウス門脈平滑筋のCaスパイクに及ぼす効果. Cyto-protection & biology. 77-81, 第4巻, 蟹書房, 東京, 1986.

• 2) Bulbring E, Tomita T:Suppression of spontaneous spike generation by catecholamines in the smooth muscle of the guinea-pig taenia coli. Proc. roy. Soc. B. 172:103-119, 1969.

• 3) Kimura I, Kimura M, Yoshimura Y:Quantitization of Ca spike frequency in a single sucrose gap and mechanical relaxation induced by Ca antagonists, isoproterenol and papaverine. Arch. intern. Pharmacodyn. 252:40-52, 1981.

• 4) 木村正康, 木村郁子:正常及び糖尿病態マウスの門脈平滑筋による自発性スパイクと収縮に及ぼす Papaverine, Ca2+拮抗薬, 胆汁酸の抑制作用様式. 医科学応用研究財団研究報告Vol.2 (医科学応用研究財団編). 86-95, 名古屋, 1983.

• 5) GO Carrier, CV Jackson, NL Scarborough:Influence of diabetes mellitus and aging on adrenergic responses of innervated and noninnervated vascular smooth muscle. Vascular Neuroeffector Mechanisms (4th International Symposium) 125-137, edited by JA Bevan et al, Raven Press, New York, 1983.

• 6) JV Levy:Prostacyclin production by aortic tissue from rats with experimental diabetes mellitus and diabetes insipidus. Vascular Neuroeffector Mechanisms (4th International Symposium) 383-388, edited by JA Bevan et al, Raven Press, New York, 1983.

P.98 掲載の参考文献

• 1) Atkinson DE:The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry 7:4030-4034, 1968.

• 2) 荒川哲男, 中村肇, 蝶野慎治, 他:ラット胃粘膜prostaglandin E2に関する研究 (第1報) -測定法の確立と非ステロイド系抗炎症剤による影響について-. 日消誌 77:1052-1059, 1980.

• 3) 稲川寿夫, 大木史郎, 沢田正文, 他:Radio immunoassay法によるProstaglandinの分離定量に関する検討. 薬学雑誌 92:1187-1194, 1972.

• 4) Lacy PE, Kostianovsky M:Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16:35-39, 1967.
  pubmed

• 5) Popper HL, Necheles H, Russel KC:Transition of pancreatic oedema into pancreatic necrosis, Surg. Gynecol. Obstet. 87:79-82, 1948.

• 6) Papp M, Varga B, Acs Z:Pharmacological effects on pancreatic blood flow. Arch. Int. Pharmacol. 161:61-67, 1966.

• 7) Chou CC, Frohlich ED, Texter Jr EC:A comparative study of the effects of bradykinin, Kallidin II, and eledoisin on segmental superior mesenteric resistance. J. Physiol. 176:1-11, 1965.

• 8) Kinami Y, Mura T, Sugii M, et al:Function of pancreatic endocrine cells in experimental acute pancreatitis. World J. Surg. 6:471-477, 1982.
  pubmed

• 9) Edelman K, Valenzuela JE:Effect of intravenous lipid on human pancreatic secretion. Gastroenterology 85:1063-1066, 1983.
  pubmed

• 10) Ozawa K, Kitamura O, Ohsawa T, et al:Mitochondrial vulnerability and lipid metabolism. J. Biochemistry 66:361-367, 1969.

• 11) Robert A, Nezamis JE, Lancaster C, et al:Cytoprotection by prostaglandins in rat. Gastroenterology 77:761-767, 1979.

• 12) 横尾和久, 高山佳子, 小沢高将, 他:ラット肝のミトコンドリア機能に及ぼす熱傷毒およびソルコセリルの影響. Cyto-protection & biology. 119-124, 第1巻, 蟹書房, 東京, 1983.

P.107 掲載の参考文献

• 1) 立入 弘:診療放射線技術. 369-403, 第3版, 下巻, 南江堂, 東京, 1978.

• 2) Emilia F, Edmond PM, Edward A, et al:"Kinetics of cell proliferation of an Experimental Tumor" Cancer Research 27:Part1, 1122-1131, 1967.

• 3) 井上昌一, 森 登, 国仲景行, 他:ソルコセリルの生化学的研究 (第1報) -ソルコセリルの組織呼吸促進作用について-. 基礎と臨床 8 (13):4013-4018, 1974.

• 4) 森 登, 国仲晃行, 村田敏郎:ソルコセリルの生化学的研究 (第2報) -ソルコセリルの呼吸阻害と脱水素酵素系に及ぼす影響-. 基礎と臨床 8 (13):4019-4025, 1974.

• 5) 添田百枝, 青梅美恵子, 大友道子:60CoおよびX線照射による白血球減少に対するSolcoserylの治療研究. 日本医学放射線学会雑誌 25 (2):51-55, 1965.

• 6) 高梨理由, 石墨公子, 新井 正:ソルコセリルの培養細胞に及ぼす効果. 組織培養 2 (6):203-206, 1976.

• 7) 額田純一郎, 岩本 忍, 作田正義:マウス脾臓NK活性に及ぼすソルコセリルの影響. Cytoprotection & biology. 71-78, 第2巻, 蟹書房, 東京, 1984.

P.115 掲載の参考文献

• 1) Dinarello CA, et al:Molecular basis of fever in humans. Am. J. Med. 72:799-819, 1982.
  pubmed

• 2) Kampschmidt RF, et al:Stimulation of antimicrobial activity in the rat with leukocytic endogenous mediator. J. Ret. Soc. 17:162-169, 1975.

• 3) Ozaki Y, et al:Enhanced resistance of mice to bacterial infection induced by recombinant human interleukin 1α. Infect. Immun. 55:1436-1440, 1987.

• 4) Furutani Y, et al:The production of human interleukin 1 by recombinant DNA technology. Proc. Jpn. Soc. Immunol. 15:380, 1985. (in Japanese)

• 5) Hanson DF, et al:Demonstration of interleukin-1 activity in apparently homogenous specimens of the pI 5 form of rabbit endogenous pyrogen. Infect. Immun. 45:483-490, 1984.
  pubmed

• 6) Miller LC, et al:Estimation of ED50 and its error by means of logarithmic-probit graph paper. Proc. Soc. Exp. Biol. Med. 57:261-264, 1944.

P.123 掲載の参考文献

• 1) Prescott SM, Zimmerman GA, McIntyre TM:Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-n-glycero-3-phosphochline) when stimulated with thrombin. Proc. Natl. Acad. Sci. USA 81:3534-3538, 1984.

• 2) Sporn LA, Marder VJ, Wagner DD:von Willebrand Factor released from Weibel-Palade bodies binds more avidly to extracellular matrix than that secreted constitutively. Blood 69:1531-1534, 1987.
  pubmed

• 3) Doyle MJ, Mosher DF, Jaffe EA:Endothelial cells synthesis and secrete thrombospondin. J. Cell. Biol. 87:306a, 1980.

• 4) Maruyama I:The regulation of blood coagulation by the endothelium. Acta Haemat. Jpn. 49:146-153, 1986.

• 5) Rodgers GM, Shuman MA:Prothrombin is activated on vascular endothelial cells by factor Xa and calcium. Proc. Natl. Acad. Sci, USA 80:7001-7005, 1983.
  pubmed

• 6) Esmon CT, Owen WG:Identifiction of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc. Natl. Acad. Sci. USA 78:2249-2254, 1981.

• 7) Esmon NL, Owen WG, Esmon CT:Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C, J. Biol. Chem. 257:859-864, 1982.
  pubmed

• 8) Esmon CT, Esmon NL, Harris KW:Complex formation of between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J. Biol. Chem. 257:7944-7947, 1982.
  pubmed

• 9) Salem HH, Maruyama I, Ishii H, Majerus PW:Isolation and characterization of thrombomodulin from human placenta. J. Biol. Chem. 259:12246-12251, 1984.
  pubmed

• 10) Maruyama I, Salem HH, Ishii H, Majerus PW:Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin. J. Clin. Invest. 75:987-991, 1985.
  pubmed

• 11) Stern D, Nauroth P, Marcum J, et al:Interaction of antithrombin III with bovine aoryic segments. Role of heparin in binding and enhanced anticoagulant activity. J. Clin. Invest. 75:272-279, 1985,

• 12) Baker JB, Low DA, Simmer RL, Cuningham DD:Protease-Nexin:acellular component that links thrombin and plasminogen activator and mediates their binding to cells. Cell 21:37-45, 1980.

• 13) Loskutoff DJ:Effect of thrombin on fibrinolytic activity of cultured bivine endothelial cells. J. Clin. Invest. 64:329-332, 1979.

• 14) Suzuki K, Stenflo J, Dahlback B, Teodorsson G:Inactivation of human coagulation factor V by activated protein C. J. Biol. Chem. 258:1914-1920, 1983.

• 15) Kane WH, Majerus PW:Purification and characterization of human coagulation factor V. J. Biol. Chem. 256:1002-1007, 1981.
  pubmed

• 16) Miletich JP, Broze GJ, Majerus PW:The synthesis of sulfated dextran beads for isolation of human plasma coagulation factors II, IX and X. Anal. Biochem. 105:304-310, 1980.

• 17) Imamoto T, Terashita Z, Tanabe M, Nishikawa K, Hirata M:Protective effect of a novel thromboxane synthetase inhibitor, CV-4151, on myocardial damage due to coronary occlusion and reperfusion in heats of anesthetized dogs. J. Cardiovasc. Pharmacol. 8:832-839, 1986.

• 18) Jaffe EA, Nachman RL, Becker CG, Minick CR:Culture of human endothelial cells derived from umbilical vein. J. Clin. Invest. 32:2754-2756, 1973.

• 19) 徳永蔵, 他:陽圧環境下における培養血管内皮細胞および平滑筋細胞の増殖と機能. 動脈硬化 12:771-773, 1984.

• 20) Bevilacqa MP, Pober JS, Wheeler ME, et al:Interleukin-1 actition of vascular endothelium. Effect on procoagulant activity and leukocyte adhesion. Am. J. Pathol. 121:393-403, 1985.

• 21) Stern DM, Bank I, Nawroth PP, et al:Self-regulation of procoagulant events on the endothelial cell surface. J. Exp. Med. 162:1223-1235, 1985.

P.130 掲載の参考文献

• 1) Nakao H, Arakawa M:Antileukemic agent. I. Some 2, 5-disubstituted p-benzoquinones. Chem. Pharm. Bull 20:1962-1967, 1972.

• 2) 栗田宗次, 西村 穣, 小川一誠, 他:悪性腫瘍に対するcarbazilquinoneの臨床成績. 日本癌治療学会誌 8:13-21, 1973.

• 3) 中里博昭, 市橋秀仁, 近藤達平:胃癌・大腸癌の治癒切除症例に対するエスキノンおよびクレスチンの交代補助免疫化学療法効果に関する臨床比較対照試験成績. 癌と化学療法 13:308-318, 1986.

• 4) 中村 徹, 巽 紘一, 深井百代, 他:白血病細胞における carbazilquinone の作用機序. 日本血液学会雑誌 37:1-8, 1974.

• 5) Kanamaru R, Asamura M, Sato H, et al:Comparative studies of effects of carbazilquinone and mitomycin C on DNA and protein synthesis of Yoshida sarcoma and Yoshida hepatomas. Sci. Rep. Res. Inst. Tohoku Univ. 22:18-24, 1975.
  pubmed

• 6) Maehara Y, Anai H, Kusumoto H, et al:Carboquone alters the protein synthesis of Chinese hamster V79 cell. Oncology 44:253-256, 1987.
  pubmed

• 7) Weisenthal LM, Marsden JA, Patricia LD, et al:A novel dye exclusion method for testing in vitro chemosensitivity of human tumors. Cancer Res. 43:749-757, 1983.

• 8) Laemmli UK, Favre M:Maturation of the head of bacteriophage T4:I. DNA packaging events. J. Mol. Biol. 80:575-599, 1973.
  pubmed

• 9) Chamberlain Jp:Flourographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. Anal. Biochem. 98:132-135, 1979.
  pubmed

• 10) O'Farrell PH:High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem. 250:4007-4021, 1975.
  pubmed

• 11) O'Farrell PZ, Goodman HM, O'Farrell PH, et al:High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell 12:1133-1142, 1977.

• 12) Arakawa M, Aoki T, Nakao H, Effect of carbazilquinone on lymphoid leukemia L-1210. Gann 61:485-493, 1970.
  pubmed

• 13) Arakawa M, Nakao H, Aoki T:Effect of carbazilquinone on transplantable and primary tumors in mice. Gann 61:535-539, 1970.
  pubmed

• 14) Mickey DD:Combined therapeutic effects of an immunomodulator, PSK, and chemotherapy with carboquone on rat bladder carcinoma. Cancer Chemother. Pharmacol. 15:54-58, 1985.
  pubmed

• 15) Bravo R, Celis JE:Up-dated catalogue of HeLa cell proteins:percentage and characteristics of the major cell polypeptides labeled with a mixture of 16 14C-labeled amino acids. Clin. Chem. 28:766-781, 1982.
  pubmed

• 16) Mivechi NF, Li GC:Themotolerance and profile of protein synthesis in murine bone marrow cells after heat shock. Cancer Res. 45:3843-3849, 1985.

• 17) Li GC, Shrieve DC:Thermal tolerance and specific protein synthesis in Chinese hamster fibroblasts exposed to prolonged hypoxia. Exp. Cell Res. 142:464-468, 1982.
  pubmed

P.142 掲載の参考文献

• 1) Neuwelt EA, Balaban E, Diehl J, et al:Successful treatment of primary central nervous system lymphomas with chemotherapy after osmotic blood-brain barrier opening. Neurosurgery 12:662-671, 1983.
  pubmed

• 2) Neuwelt EA:Therapeutic potential for blood-brain barrier modification in malignant brain tumor. Prog. Exp. Tumor Res. 28:51-66, 1984.
  pubmed

• 3) Neuwelt EA, Howieson J, Frenkel EP, et al:Therapeutic efficacy of multiagent chemotherapy with drug delivery enhancement by blood-brain barrier modification in glioblastoma. Neurosurgery 19:573-582, 1986.

• 4) Tomiwa K, Hazawa F, Mikawa H:Reversible osmotic opening of the blood-brain barrier:prevention of tissue damage with filtration of the perfusate. Acta Pathol. Jpn. 32 (3):427-435, 1982.

• 5) Inoue T, Nagara H, Kondo A, et al:Effects of intracarotid hyperosmolar mannitol in triethyltin (TET)-induced rat brain edema-preservation of blood-brain barrier (BBB) in TET edema. Brain Research 414:309-313, 1987.

• 6) Inoue T, Fukui M, Nishio S, et al:Hyperosmotic blood-brain barrier disruption in brains of rats with an intracerebrally transplanted RG-C6 tumor. J. Neurosurg. 66:256-263, 1987.
  pubmed

• 7) Marunaka T, Umeno Y, Yoshida K, et al:High-pressure liquid chromatographic determination of ftorafur(1-(tetrahydro-2-furanyl)-5-fluorouracil) and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus ftorafur. J Pharmaceut. Sci. 69:1296-1300, 1980.

• 8) Kondo A, Inoue T, Nagara H, et al:Neurotoxicity of adriamycin passed through the transiently disrupted blood-brain barrier by mannitol in the rat brain. Brain Research 412:73-83, 1987.
  pubmed

• 9) Neuwelt EA, Barnett PA, Bigner DD, et a:Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent:the factor of the blood-brain barrier. Proc. Natl. Acad. Sci. USA 79:4420-4423, 1982.

• 10) Nakagawa H, Groothuis D, Blasberg RG:The effect of graded hypertonic intracarotid infusions on drug delivery to experimental RG-2 gliomas. Neurology (Cleveland) 34:1571-1581, 1984.

• 11) Hiesiger EM, Voorhies RM, Basler GA, et al:Opening the blood-brain and blood-tumor barriers in experimental rat brain tumors:the effect of intracarotid hyperosmolar mannitol on capillary permeability and blood flow. Ann. Neurol. 19:50-59, 1986.

• 12) Groothuis DR, Fischer JM, Lapin G, et al:Permeability of different experimental brain tumor models to horseradish peroxidase. J. Neuropathol. Exp. Neurol. 41:164-185, 1982.
  pubmed

• 13) Nishio S, Ohta M, Abe M, et al:Microvascular abnormalities in ethylnitrosourea (ENU)-induced rat brain tumors:structural basis for altered blood-brain barrier function. Acta Neuropathol. (Berl) 59:1-10, 1983.
  pubmed

• 14) Stewart PA, Hayakawa K, Hayakawa E, et al:A quantitative study of blood-brain barrier permeability ultrastructure in a new rat glioma model. Acta Neuropathol. (Berl) 67:96-102, 1985.

• 15) Vick NA, Bigner DD:Microvascular abnormalities in virally-induced canine brain tumors:structural bases for altered blood-brain barrier function. J. Neurol. Sci. 17:29-39, 1972.
  pubmed

• 16) Panther LA, Baumbach GL, Bigner DD, et al:Vasoactive drugs produce selective changes in flow to experimental brain tumors. Ann. Neurol. 18:712-715, 1985.
  pubmed

• 17) Yamada K, Hayakawa T, Ushio Y, et al:Regional blood flow and capillary permeability in the ethylnitrosourea-induced rat glioma. J. Neurosurg. 55:922-928, 1981.
  pubmed

• 18) Tomiwa K, Hazawa F, Mikawa H:Neurotoxicity of vincristine after the osmotic opening of the blood-brain barrier. Neuropathol and App. Neurobiol. 9:345-354, 1983.

• 19) Bigotte L, Olsson Y:Toxic effects of adriamycin on the central nervous system. Acta Neuropathol. 61:291-299, 1983.
  pubmed

• 20) Cho ES:Toxic effects of adriamycin on the ganglia of the peripheral nervous system:a neuropathological study. J. Neuropathol. Exp. Neurol. 36:907-915, 1977.
  pubmed

P.151 掲載の参考文献

• 1) O'Brien MD, Waltz AG:Transorbital approach for occluding the middle cerebral artery without craniectomy. Stroke 4:201-206, 1973.
  pubmed

• 2) Hoff JT:Cerebral protection. J. Neurosurg. 65:579-591, 1986.
  pubmed

• 3) Ishiguri H, Kuchiwaki H, Takada S, et al:Distribution and movement of tissue water in 6-ANA-induced brain edema. Proceedings of the Third Symposium on Cytoprotection. 43-51, edited by Tsuchiya M, Excerpta Medica, Tokyo, 1986.

• 4) 河野輝昭, 堤 圭介, 三宅仁志, 他:虚血性脳浮腫に対する幼牛血液抽出剤の効果. Cyto-protection & biology. 117-126, 第4巻, 蟹書房, 東京, 1986.

• 5) Heiss WD, Hayakawa T, Waltz AG:Cortical neuronal function during ischemia. Arch. Neurol. 33:813-820, 1976.
  pubmed

• 6) Tamura A, Asano T, Sano K:Correlation between rCBF and histological changes following temporary middle cerebral artery occlusion. Stroke 11:487-493, 1980.
  pubmed

• 7) Traupe H, Kruse E, Heiss WD:Reperfusion of focal ischemia of varying duration:Postoischemic hyper-and hypo-perfusion. Stroke 13:615-622, 1982.
  pubmed

• 8) Bose B, Osterholm JL, Payne JB, et al:Preservation of neuronal function during prolonged focal cerebral ischemia by ventriculocisternal perfusion with oxygenated fluorocarbon emulsion, Neurosurgery 18:270-276, 1986.
  pubmed

• 9) 溝井和夫, 安孫子尚, 鈴木二郎, 他:虚血脳の可塑性に関する実験的検討-虚血程度とその持続時間-. 脳神経 38:877-884, 1986.

• 10) 楠田賢治, 佐渡島省三, 藤井健一郎, 他:実験的脳虚血および血流再開時の局所脳血流と脳波. 脳卒中 8:370-378, 1986.

• 11) Ashburn MA, Mitchell LB, Dean DF, et al:The power spectrum analyser as an indicator of cerebral ischaemia during carotid endarterectomy. Anaesth Intens Care 13:378-391, 1985.

• 12) Jones TH, Morawetz RB, Crowell RM, et al:Thresholds of focal cerebral ischemia in awake monkeys. J. Neurosurg. 54:773-782, 1981.
  pubmed

• 13) Morawetz RB, Degirolami U, Ojemann RG, et al:Cerebral blood flow determined by hydrogen clearance during middle cerebral artery occlusion in unanesthetized monkeys. Stroke 9:143-149, 1978.
  pubmed

• 14) Ames III A, Wright RL, Kowada M, et al:Cerebral ischemia. II. The no-reflow phenomenon. Amer. J. Path. 52:437-453, 1968.

• 15) Crowell RM, Olsson Y:Impaired microvascular filling after focal cerebral ischemia in monkeys. J. Neurosurg. 36:303-309, 1972.
  pubmed

• 16) Astrup J, Siesjo BK, Symon L:Tresholds in cerebral ischemia-The ischemic penumbra. Stroke 12:723-725, 1981.

• 17) 井上昌一, 森 登, 国仲晃行, 他:ソルコセリルの生化学的研究 (第1報) -ソルコセリルの組織呼吸促進作用について-. 基礎と臨床 8:4013-4018, 1974.
  Medical*Online

• 18) 松熊敏浩, 大和田勝男, 土居正弘, 他:Solcoserylの各組織ミトコンドリアと細胞の呼吸能に対する作用. 薬理と治療 9:895-902, 1981.

P.159 掲載の参考文献

• 1) Demopoulos HB, Flamm ES, Pietronigro DD, et al:The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol. Scand. 492 (Suppl):91-119, 1980.
  pubmed

• 2) Siesjo BK:Cell damage in the brain.:a speculative synthesis. J. Cereb. Blood Flow Metabol. 1:155-185, 1981.

• 3) Itoh T, Kawakami M, Yamauchi Y, et al:Effect of allopurinol on ischemic and reperfusion-induced cerebral injury in SHRs. Stroke 17:1284-1287, 1986.

• 4) Michel DT, Gene CP, Alfred SC:Protective action by methylprednisolone, allopurinol and indomethacin aganist stroke-induced damage to adenylate cyclase in gerbil cerebral cortex, Stroke 15:329-335, 1984.

• 5) Robert I, Dauid P, Benjamin SA, et al:An assesment of the possible protective effect of allopurinol in acute stroke. J. Neurol. Neurosurg. Psychiatry 49:585-587, 1986.

• 6) 中尾 真, 中尾順子, 金沢 徹:陽イオン輸送系. 生化学実験講座 (日本生化学会編). 277-290, 14巻, 東京化学同人, 東京, 1977.

• 7) 八木國夫 :過酸化脂質の測定. 臨床検査 23:115-120, 1979.

• 8) 栗原正紀, 河野輝昭, 森 和夫, 他:虚血性脳浮腫と細胞膜障害-脳微小血管Na+-K+ATPase活性変動より-. 脳虚血とフリーラジカル (佐野圭司, 他監修). 200-205, にゅーろん杜, 東京, 1983.

• 9) 島 健, 山本光生, 岡田芳和, 他:SHR両側頸動脈結紮による脳虚血. 脳神経 31:1235-1243, 1979.

• 10) MacMillan V:Cerebral Na+-K+ ATPase activity during exposure to and recovery from acute ischemia. J. Cereb. Blood Flow Metabol. 2:457-465, 1982.

• 11) 浅野孝雄, 城下博夫, 後藤 修, 他:虚血性脳浮腫発生機序-脳微小血管Na+, K+-ATPaseの役割と, AVSの抗浮腫作用を中心として-. 脳外 13:1147-1149, 1985.

• 12) 片山泰朗, 赫 彰郎, 永積 惇, 他:完全虚血脳に発生する脳浮腫の成因に関する研究. 脈管学 24:1271-1274, 1984.

• 13) 山本光生, 島 健, 魚住 徹, 他:脳虚血における過酸化脂質の生成-不可逆的細胞障害への関与について-. 脳虚血と細胞障害 (佐野圭司, 他監修). 59-65, にゅーろん社, 東京, 1980.

• 14) 木畑正義, 清水能人, 三宅寛治, 他:脳卒中発作時の血中α-トコフェロールおよびTBA反応物質について. 医学のあゆみ 101:591-592, 1977.

• 15) 各務満喜子, 岩城保仁, 川本道夫, 他:脳血管障害急性期における血清過酸化脂質と血清総ビタミンEおよびHDL-Eの関係. 過酸化脂質研究 2:115-118, 1978.

• 16) 伊東 亨, 川上正人:実験的虚血SHRにおける allopurinol の作用と Malondialdehyde におよぼす影響. 第12回日本脳卒中学会総会抄録集, 60, 1987.

• 17) 吉田伸一, 伊能 睿, 浅野孝雄, 他:実験的脳虚血における膜脂質の崩壊-血流再開後の組織損傷と過酸化反応-. 脳虚血と細胞障害 (佐野圭司, 他監修). 39-50, にゅーろん社, 東京, 1980.

• 18) 窪田 惺, 朝倉哲彦, 喜多村孝一:急性頭蓋内圧亢進時における脳血流量, 頭蓋内圧, 全身血圧および脳波におよぼすソルコセリルの影響. 脳外 4:163-173, 1976.

• 19) 浜中敏議,吉川隆春, 石井 誠, 他:幼牛の血液より得られた組織呼吸賦活物質SS-094の薬理 (15) -脳循環に及ぼす影響-. 基礎と臨床 8:4115-4123, 1974.
  Medical*Online

• 20) 倉本進賢, 渡辺光夫, 大仲良一, 他:Solcoserylの脳深部の局所血流に及ぼす影響について. 新薬と臨牀 18:696-700, 1969.

• 21) 山田 欽, 大沢温臣, 田中信夫, 他:ソルコセリルによる脳血管障害の治療. 新薬と臨牀 23:387-395, 1974.
  Medical*Online

• 22) SOLCOSERYL脳血管障害臨床研究会:脳血管障害に対するSolcoserylの二重盲検法による薬効評価. 基礎と臨床 12:311-343, 1978.
  Medical*Online

P.166 掲載の参考文献

• 1) Nakahara M:Polypeptide and Kinin Forming Activity of Deproteinised Calf Blood Extract. Arzneim.-Forsch. 16:371-373, 1966.

• 2) 小林 悟, 中村裕義, 金久保好男, 他:SS-094 の RBC-Filtrability に及ぼす影響. Cyto-protection & biology. 125-129, 第1巻, 蟹書房, 東京, 1983.

• 3) 内海耕慥, 高橋聖一, 山本博文:多核白血球のO2-生成に対するソルコセリルの作用. Cyto-protection & biology. 131-139, 第1巻, 蟹書房, 東京, 1983.

• 4) 近藤祥昭, 三島邦基, 菊地武志, 他:胃潰瘍に対する Solcoserylの効果の検討-Double blind contralled studyによる-. 基礎と臨床 7 (6):1421-1425, 1973.

• 5) 吉永和恵, 山田全一, 矢代昭夫, 他:潰瘍性皮膚疾患に対する Solcoseryl注の臨床成績-Double blind contralled study による-. 基礎と臨床 8 (13):4299-4311, 1974.

• 6) 伊東 亨, 川島 祐, 小野良樹, 他:二十盲検法によるソルコセリル注の脳動脈硬化症に対する臨床効果. 基礎と臨床 8 (13):4265-4287, 1974.

• 7) 渡辺 孝:循環遮断法における幼牛血液抽出物の脳保護作用. 日本低体温研究会3 (1):27-31, 1983.

• 8) 石栗 仁, 口脇博治, 太田昌幸, 他:6-ANN (6-aminonicotinamide) 脳浮腫モデルにおける総水分含有量および自由水の変動と形態学的変化. Cyto-protection & biology. 25-34, 第3巻, 蟹書房, 東京, 1985.

• 9) Quadbeck G, Claver B, Minet G, et al:Einfluβ von Stimulantien und Anti-depressiva auf das Hoehen-EEG der Ratte. Arzneim-Forsch. 14:563-565, 1965.

• 10) 龍 浩志, 植村研一, 中島正二, 他:実験的脳損傷に対するソルコセリルの影響-脳ミトコンドリアの形態学的検討-. 基礎と臨床 17 (2):465-471, 1983.
  Medical*Online

• 11) Kogure K, Watson BD, Busto R, et al:Potentiation of lipid peroxydes by ischemia in rat brain. Neurochem. Res. 7 (4):437-454, 1982.

• 12) McGee-Russel SM, Brown AW, Brierley JB:A combined light and electron microscopy study of early anoxic-ischemic cell change in rat brain. Brain Res. 20:193-200, 1970.

• 13) Duchen LW:Hypoxic neuronal damage, Greenfield's Neuropathology. 8-11, 4th Ed, edited by Adams JH, Corsellis JAN, Duchen LW, Edward Arnold, London, 1984.

• 14) Brown AW, Brierley JB:Anoxic-ischemic cell change in rat brain light microscopic and fine-structural observations. J. Neurol. Sci. 16:59-84, 1972.
  pubmed

• 15) Kirino T:Delayed neuronal death in the Gerbil hippocampus following ischemia. Brain Res. 239:57-69, 1982.

• 16) 小林督志:Ischemia の大脳皮質 energy metabolites および cyclic nucleotides に及ぼす影響. Neurol. Med. Chir. (Tokyo) 18 (Part II):21-28, 1978.

• 17) Yoshida S, Inoh S, Asano T, et al:Effect of transient ischemia on free fatty acids and phospholipids in the gerbil brain. J. Neurosurg. 53:323-331, 1980.

• 18) Gaudet RJ, Akam I, Levine L:Accumulation of cyclooxygenase products of achachidonic acid metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlsion. J. Neurochem. 35 (3):653-658, 1980.

• 19) 伊藤梅男, 大野喜久郎, 富田博樹, 他:Mongolian gerbil における一時的脳虚血後の脳障害に関する研究. Neurol. Med. Chir. (Tokyo) 16:313-322, 1976.

• 20) 伊藤梅男, 大野喜久郎, 山口武兼, 他:実験的脳虚血モデルとしての Mongolian gerbil について. 脳卒中 2:95-97, 1980.

P.175 掲載の参考文献

• 1) Kawamura T, Ishimori A, Koizumi F, et al:Aspirin-induced ulcer in puromycin-treated rats. In Experimental Ulcer. 59-64, edited by Tsuchiya M, Oda M and Okazaki I, Yurinsha Co. Ltd., 1984.

• 2) Robert A:Cytoprotection by prostaglandins. Gastroenterology 77:761-767, 1973.

• 3) 川村 武, 大川淳雄, 坂牛省二, 他:アスピリン実験潰瘍におけるマーズレンSの効果-粘膜内 PGE2 との関連において-. 基礎と臨床 19:255-259, 1985.

• 4) 荒川哲男, 中村 肇, 蝶野慎治, 他:ラット胃粘膜 prostaglandin E2 に関する研究 (第一報) -測定法の確立と非ステロイド系抗炎症剤による影響について-. 日消誌 77:1052-1059, 1980.

• 5) Sewing KF, Hannemann H:Calcium channel antagonists verapamil and gallopamil are powerful inhibitor of acid secretion in isolated and enriched gunea pig parietal cells. Pharmacology 27:9-14, 1983.

• 6) McCord JM:The pathophysiology of superoxide:Roles in inflamation and ischemia. Can. J. Physiol. Pharmacol. 60:1341-1351, 1985.

• 7) Parks DA, Bulkly GB, Granger DN, et al:Ishemic injury in the cat small intestine:Role of superoxide radicals. Gastroenterology 82:9-15, 1982.

• 8) Cochran TA, Stefanko J, Moore C, et al:Cytotoxic-free radicals in stress ulceration. Esophagus, Stomach and Gastroentestinal Hormons 33:159-161, 1982.

• 9) 吉川敏一:消化管と虚血. 虚血と細胞障害-活性酸素. フリーラジカル. 215-226, 早石 修, 八木国夫, 五島雄一郎監修, 医歯薬出版, 東京, 1980.

• 10) 宮川晴雄, 吉川敏一, 谷川 徹:水浸拘束ストレス潰瘍におけるフリーラジカルの関与. 日消誌 84:131, 1987.

• 11) Sevanian A, Muakkassah-kelly SF, Montestrugue S:The influence of phospholipase A2 and glutathione peroxidase on the elumination of membrane lipid peroxides. Arch. Biochem. Biophys. 223:441-452, 1983.

• 12) Wills ED:Mechanisms of lipid peroxide formation in animal tissues. Biochem. J. 99:667-676, 1966.
  pubmed

• 13) Yoshikawa T, Miyagawa H, Yoshida N, et al:Increase in lipid peroxidation in rat gastric mucosal lesions induced by water-immersion restraint stress. J. Clin. Biochem. Nutr. 1:271-277, 1986.

• 14) Higuchi Y:Lipid peroxide and α-tochopherol in rat streptozotocin-induced diabetes mellitus. Acta Med. Okuyama. 36:165-175, 1982.

• 15) 福沢健治:脂質過酸化反応とビタミンE. ビタミン 52:518-520, 1978.
  Medical*Online

• 16) Dillard CJ, Kunert KJ, Tappel AL:Effect of vitamin E, ascorbic acid and mannitol on alloxan-induced lipid peroxidation in rats. Arch. Biochem.Biophys. 216:204-212, 1982.
  pubmed

• 17) Taniguchi M, IIara T:Effects of riboflavin and selenium deficiencies on glutathione and its relating enzymme activities with respect to lipid peroxide content of rat livers. J Nutr. Sci. Vitaminol. 29:283-292, 1983.

• 18) Taniguchi M:Effects of riboflavin deficiency on lipid peroxidation of rat liver microsomes. J. Nutr. Sci. Vitaminol. 26:401-413, 1980.
  pubmed

• 19) Takagi K, Okabe S:The effects of drugs on the production and recovery processes of the stress ulcer. Jap. J. Pharmac. 18:9-18, 1968.

• 20) 八木国夫:血清過酸化脂質の測定とその臨床的意義. 臨床病理 29:221-225, 1981.

• 21) Ohkawa H, Ohishi N, Yagi K:Assay for lipid peroxides in animal tissues by thiobarbitric acid reaction. Anal. Biochem. 95:351-358, 1979.

• 22) 大石誠子:ビタミンB2の定量法. ビタミン 57:147-152, 1983.
  Medical*Online

• 23) Beutler E:The correction of glutathione reductase deficiency by riboflavin administration. J. Clin. Invest. 48:7a, 1976.

• 24) 北島政樹, 上田光久, 相馬 智:胃・十二指腸潰瘍の病態生理からみた粘膜血流と防御因子. 胃と腸 17:747-756, 1982.

• 25) Capel ID, Dorrell HM, Smallwood AE:The influence of cold-restraint stress on some components of the antioxidant defence system in the tissues of rats of various ages. J. Toxic. Envir. Health 11:425, 1983.

• 26) 伊藤 誠, Guth PH:虚血性胃粘膜病変の成因にあずかるoxygen-derived free radicalの意義-. Therapeutic Research 2:1196-1200, 1985.

• 27) 荻野景規, 岡 紳繭, 松田和也, 他:ラット胃粘膜障害における superoxide dismutaseに関する研究 (第一報) -阻害剤ジエチルジチオカルバメートの影響について-. 日消誌 84:205-209, 1987.

• 28) Pappenheimer AM, Victor J:"Ceroid" pigment in human tissues. Amer. J. Patho. 22:395-413, 1945.

• 29) 村山繁雄, 桜井賢二, 樫田光夫, 他:高度の後索変性と brown bowel syndrome を呈し, vitamin E 欠乏の関与が疑われる一剖検例. 日内学誌 71:1484, 1982.

• 30) 大熊 稔:プロスタサイクリンとビタミンE. ビタミン 55:119-120, 1981.
  Medical*Online

• 31) 加賀綾子:高度酸素暴露の生化学並びに組織学的研究-過酸化脂質を中心として-. 北海道医学雑誌 56:159-175, 1981.

• 32) 杉原一正:リボフラビン欠乏ラットの口腔粘膜病変に関する生化学的並びに電子顕微鏡学的研究. 歯基礎誌 18:329-348, 1976.

P.183 掲載の参考文献

• 1) 平山洋三, 丹羽寛文, 赤塚宣治, 他:水浸拘束潰瘍の発生における胃粘膜血流動態の検討. Gastroenterol. Endosco. 26:492-502, 1984.

• 2) 鎌田武信, 佐藤信紘, 川野 淳, 他:急性胃病変の成因に関する検討. 1. 胃粘膜エネルギー代謝の特異性. 日消誌 74:321-327, 1977.

• 3) Perry MA, Wadhwa S, Parks DA, et al:Role of oxygen radicals in ischemia-induced lesions in the cat stomach. Gastroenterology 90:362-367, 1986.
  pubmed

• 4) 岡 紳爾, 荻野景規, 安武隆二郎, 他:急性胃粘膜病変における活性酸素の役割-鉄キレート剤の効果-. 炎症 7:269-273, 1987.
  Medical*Online

• 5) Yoshikawa T, Miyagawa H, Yoshida N, et al:Increase in lipid peroxidation in rat gastric mucosal lesions induced by water-immersion restraint stress. J. Clin. Biochem. Nutr. 1:271-277, 1986.

• 6) 荻野景規:SOD からみた胃粘膜防御機構. 胃粘膜防御機構の重層構造 (竹本忠良編). 145-152, 第1版, メディカルトリビューン, 東京, 1987.

• 7) 荻野景規,岡 紳爾, 松浦伸二郎, 他:胃粘膜防御機構と SOD. Free Radicals in Clinical Medicine フリーラジカルの臨床 (大柳善康, 吉川敏一編). 127-131, 第1版, 日本医学館, 東京, 1987.

• 8) 荻野景規 岡 紳爾, 坂井田功, 他:Copper, zinc-superoxide dismutase (Cu, Zn-SOD) モノクローナル抗体の作製と諸性質. 炎症 7:259-262, 1987.
  Medical*Online

• 9) 荻野景規 岡 紳爾, 松浦伸二郎, 他:ヒト胃粘膜における Cu, Zn-SODの局在-モノクローナル抗体を用いて-. 日消誌 84:312, 1987.

• 10) Thaete LG, Crouch RK, Schulte BA, et al:Immunolocalization of copper-zinc superoxide dismutase. II rat. J. Histochem. Cytochem. 33:803-808, 1985.

• 11) 荻野景規, 岡 紳爾, 松田和也, 他 :ラット胃粘膜障害における superoxide dismutase に関する研究 (第1報)-阻害剤ジエチルジチオカルバメートの影響について-. 日消誌 84:205-209, 1987.

• 12) Ogino K, Oka S, Mazuura S, et al:Effect of diethyldithiocarbamate on ulcerogenicity in rat stomach. Biochem. Int. 1987. (in press)

• 13) Oyanagui Y:Reevaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal Biochem. 142:290-296, 1984.
  pubmed

• 14) Aukland K, Bower BF, Berliner RW:Measurements of local blood flow with hydrogen gas. Circ. Res. 14:164-187, 1964.
  pubmed

• 15) 荒川哲男, 中村 肇, 蝶野慎治, 他:ラット胃粘膜 prostaglandin E2に関する研究 (第1報) -測定法の確立と非ステロイド系抗炎症剤による影響について. 日消誌 77:1052-1059, 1980.

• 16) Shay H, Sun DCH:Etiology and pathology of gastric and duodenal ulcer. In Gastroenterology. 420-465, vol. 1, edited by Bockus HL, Saunders Co, Philadelphia, 1964.

• 17) Fridovich J:The biology of oxygen radicals. Science 201:875-880, 1978.

• 18) Yoshikawa T, Tanaka H, Kondo M:The increase of lipid peroxidation in rat adjuvant anthrites and its inhibition by superoxide dismutase. Biochem. Med. 33:320-326, 1985.
  pubmed

• 19) McCord JM:Free radicals and infammation:protection of synovial fluid by superoxide dismutase. Science 185:529-531, 1974.

• 20) Oyanagui Y:Physiological regulation of vascular permeability by endogeneous glucocorticoids and active oxygen. Inflammation 7:81-89, 1983.
  pubmed

• 21) Collins GGS:Inhibition of dopamine-β-oxidase by diethyldithiocarbamate. J. Pharm. Pharmacol. 17:526-527, 1965.

• 22) 中村正彦, 大家友二, 森下鉄夫, 他:胃粘膜微小循環系の構造とその調節機構-とくに自律神経性統御との関連. 脈管学 24:11-18, 1984.

• 23) Fujita T, Fujimoto Y, Tanioka H:Antioxidan-effects on prostaglandin synthesis in rabbit kidney medulla slices. Experimentia 38:1472, 1982.

P.191 掲載の参考文献

• 1) Kenneth R, et al:Accelerated phospholipid degradation and associated membrane dysfunction in irreversible, Ischemic liver cell injury. The journal of biological chemistry 253:4809-4817, 1978.

• 2) Kenneth R, et al:Prevention by chlorpromazine of ischemic liver cell death. Am. J. Path. 88:539-553, 1977.

• 3) Weisiger RA, et al:Oxygen racdials and ischemic tissue injury. Gastroenterology 90:494-496, 1986.
  pubmed

• 4) Parks DA, et al:Role of oxygen free radicals in shock, ischemia, and organ preservation. Surgery 94:428-432, 1983.
  pubmed

• 5) 内海耕慥, 他:多形核白血球のO2-生成に対するソルコセリルの作用. Cyto-protection & biology. (三宅健夫監修) 131-137, 第1巻, 蟹書房, 東京, 1983.

• 6) Baker HC:Ischemic necrosis in the rat liver. J. path bact LXXI:135-143, 1956.

• 7) 加藤真之:血清アルコール脱水素酵素活性の臨床的意義に関する実験的研究-とくに肝小葉 Zone 3の肝障害の生化学的指標として-. 日消誌 82 (9):2074-2081, 1985.

• 8) Ohkawa H, et al:Assay for lipid peroxides in animal tissues by thiobarbitaric acid reaction. Anal. Biochem. 95:351-358, 1979.

• 9) 土屋雅春:微小循環. 中学医学双書. 中学医学社, 東京, 1965.

• 10) Arthur MJP, et al:Oxygen-derived free radicals promote hepatic injury in the rat. Gastroenterology 89:1114-1122, 1985.

• 11) 宍戸輝男:微小循環障害部血液内容の変化. 脈管学 9:125, 1969.

P.199 掲載の参考文献

• 1) 内海耕慥, 高橋聖一, 山本博文, 他 :多核白血球のO2- 生成に対するソルコセリルの作用. Cyto-protection & biology. 131-139, 第1巻, 蟹書房, 東京, 1983.

• 2) 高橋久雄, 石井裕正, 永田茂之, 他:実験的四塩化炭素肝障害における過酸化脂質および関連酵素の検討. Cyto-protection & biology. 27-33, 第2巻, 蟹書房, 東京, 1984.

• 3) Nordstrom G, Seeman T, Hasselgren P, et al:Beneficial effect of allopurinol in liver ischemia. Surgery 97:679-684, 1985.
  pubmed

• 4) 小川 龍, 守田敏洋, 国元文生:ショックと過酸化反応. ICUとCCU 9:103-110, 1985.

• 5) 中野 稔, 松浦輝男, 二木鋭雄:スーパーオキシド. 47-57, 医歯薬出版, 東京, 1984.

• 6) 丹羽靱負:活性酸素と抑制剤. Medicina 22:1234-1236, 1985.

P.206 掲載の参考文献

• 1) Theofilopoulos An, Dixon FJ:Etiopathogenesis of murine SLE. Immunol. Rev. 55:179-216, 1981.
  pubmed

• 2) Morse HC, Davidson WF, Yetter RA, et al:Abnormalities induced by the mutant gene lpr. J. Immunol. 129:2612-2615, 1982.

• 3) Wofsy D, Hardy RR, Seaman WE:The proliferation in autoimmune MRL/lpr mice lack L3T4, an antigen on" helper" T cell that is involved in the response of class II major histocompatibility antigen. J. Immunol. 132:2686-2689, 1984.
  pubmed

• 4) Kelley VE, Strom TB:Increase in macrophage Ia expression in autoimmune mice. J. Immunol. 129:923-925, 1982.

• 5) Kofler R, Schreider RD, Dixon FJ, et al:Macrophage I-A/1-E expression and macrophage-stimulating lymphokines in murine lupus. Cell. Immunol. 87:92-100, 1984.

• 6) Johnston RB, Godzik CA, Cohn ZA:Increased superoxide anion production by immunologically and chemically elicited macrophages. J. Exp. Med. 148:115-127, 1987.

• 7) Weiss SJ, LoBuglio AF:Biology of disease:Phagocyte-generated oxygen metabolites and celluler injury. Lab. Invest. 47:5-18, 1982.

• 8) Ohkawa H, Ohishi N, Yagi K:Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:351-358, 1979.
  pubmed

• 9) Johnston RBJr:Measurement of O secreted by monocytes and macrophages. Methods in Enzymol. 105:365-369, 1984.

• 10) Rokutan K, Kawai K, Asada K:Inactivation of 2-oxoglutarate dehydrogenase in rat liver mitochondria by its substrate and t-butyl hydroperoxide. J. Biochem. 102:415-422, 1987.

• 11) Rio LA, Ortega MG, Lopes AL, et al:A more sensitive modification of the catalase assay with the Clerk oxygen electrode. Anal. Biochem. 80:409-415, 1977.

• 12) McCord JM, Fridovich I:Superoxide dismutase:Enzymatic function for erythrocuprein (hemocuprein). J. Biol. Chem. 244:6049-6055, 1969.

• 13) Holmes B, Park BH, Malawista SE, et al:Chronic granulomatous disease in female:A deficiency in leukocyte glutathione peroxidase. New Eng. J. Med. 283:217-221, 1970.

• 14) Roos D, Weenig RS, Wyss SR, et al:Protection of human neutrophils by endogeneous catalase. J. Clin. Invest. 65:1515-1522, 1980.

• 15) Baker SS, Cohen HJ:Altered oxidative metabolism in selenium-deficent rat granulocytes. J. Immunol. 130:2856-2860, 1983.

P.215 掲載の参考文献

• 1) Prince RC, Gunson D:Superoxide production by neutrophils. Trends Biochem. Sci. March:86-87, 1987.

• 2) Tauber AI:Protein kinase C and the human neutrophil NADPH-oxidase. Blood 69:711-720, 1987.
  pubmed

• 3) Utsumi K, Okimasu E, Miyahara M:Selective interaction of cytoskeletal protein with liposomes. FEBS Lett. 141:176-180, 1982.
  pubmed

• 4) Nakagawara A, Shibata K, Minakami S, et al:Action of cytocharasin E on polymorphonuclear leukocytes of guinea pig Peritoneal exudates. Exp. Cell Res. 101:225-234, 1976.

• 5) Utsumi K, Sugiyama K, Miyahara M, et al:Effect of concanavalin A on membrane potential of polymorphonuclear leukocytes monitored by fluorescent dye. Cell Struct. Funct. 2:203-209, 1977.

• 6) Kikkawa U, Takai Y, Nishizuka Y, et al:Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties. J. Biol. Chem. 257:13341-13348, 1982.
  pubmed

• 7) Boni LT, Rando RR:The nature of protein kinase C activated by physically defined phos-pholipid vesicles and diacylglycerols. J. Biol. Chem. 260:10819-10825, 1985.

• 8) 井上豊治, 土居真人, 内海耕慥, 他:水銀化合物による細胞膜傷害と Cepharanthine の阻止作用. 医学と生物学 95:305-309, 1977.

• 9) 宮原正信, 高橋正彦, 内海耕慥, 他:酸素欠乏によるミトコンドリア機能の傷害と薬物によるその改善. Cyto-protection & biology. 143-149, 第3巻, 蟹書房, 東京, 1985.

• 10) Mori T, Takai Y, Nishizuka Y, et al:Inhibitory action of chlorpromazine, dibucain, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase. J. Biol. Chem. 255:8378-8380, 1980.

• 11) Weiss B, Prozialeck W, Wallace TL, et al:Pharmacological regulation of calmodulin. Ann. NY Acad. Sci. 356:319-345, 1980.
  pubmed

• 12) Chandler D, Meusel G, Stapleton C, et al:FMLP-induced enzyme release from neutrophils:a role for intracellular calcium. Am. J. Physiol. 245:C196-C202, 1983.
  pubmed

• 13) Castagna M, Takai Y, Nishizuka Y, et al:Direct activation of calcium-activated, phspholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem. 257:7847-7851, 1982.
  pubmed

• 14) Hidaka H, Inagaki M, Sasaki Y, et al:Isoquinorinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23:5036-5041, 1984.
  pubmed

• 15) Keeffe EB, Blankenship NM, Scharschmit BF:Alteration of rat liver plasma membrane fluidity and ATPase activity by chlorpromazine hydrochloride and its metabolites. Gastroenterology 79:222-231, 1980.

• 16) Smolen JE, Korchak HM, Weissmann G:Increased levels of cyclic adenosine-3', 5'-monophosphate in human polymorphonuclear leukocytes after surface stimulation. J. Clin. Invest. 65:1077-1085, 1980.
  pubmed

• 17) Fujita I, Irita K, Minakami S:Diacylglycerol, 1-oleoyl-2-acetyl-glycerol, stimulates superoxide-generation from human neutrophils. Biochenm. Biophys. Res. Commun. 120:318-324, 1984.
  pubmed

• 18) 日高弘義, 中 充子:プロテインキナーゼCの分子薬理. 蛋白質 核酸 酵素 31:534-548, 1986.

• 19) Grinstein S, Goetz-Smith JD, Mellors A, et al:Protein phosphorylation during activation of Na+/H+exchange by phorbol esters and by osmotic shrinking. J. Biol. Chem. 261:8009-8016, 1986.

P.221 掲載の参考文献

• 1) Miyachi Y:Reactive oxygen species in photodermatology. In The Biological Role of Reactive Oxygen Species in Skin. 37-41, edited by Hayaishi O, Imamura S and Miyachi Y, University of Tokyo Press, Tokyo, 1987.

• 2) Miyachi Y, Imamura S, Niwa Y, et al:Mechanisms of contact photosensitivity in mice. VI. Oxygen intermediates are involved in contact photosensitization, but not in ordinary contact sensitization. J. Invest. Dermatol. 86:26-28, 1986.

• 3) Toda K, Miyachi Y, Nesumi N, et al:UVB/PUVA-induced suppression of human natural killer activity is reduced by superoxide dismutase and/or interleukin 2 in vitro. J. Invest. Dermatol. 86:519-522, 1986.
  pubmed

• 4) Miyachi Y, Horio T, Imamura S:Sunburn cell formation is prevented by scavenging oxygen intermediates. Clin. Exp. Dermatol. 8:305-310, 1983.
  pubmed

• 5) Toda K, Miyachi Y, Imamura S, et al:Decreased NK activity of nude mice receiving longterm ultraviolet irradiation:In relation to tumor induction. J. Clin. Lab. Immunol. 20:129-131, 1986.
  pubmed

• 6) Olson RL, Gaylor J, Everett MA:Ultraviolet-induced individual cell keratinization. J. Cut Pathol.1:120-125, 1974.

• 7) Danno K, Takigawa M, Horio T:Relationship of the cell cycle to sunburn cell formation. Photochem. Photobiol. 34:203-206, 1981.
  pubmed

• 8) Johnson BE:Ultraviolet radiation and lysosomes in skin. Nature 219:1258-1259, 1968.
  pubmed

• 9) Honigsman H, Wolff K, Konrad K:Epidermal lysosomes and ultraviolet. J. Invest. Dermatol. 63:337-342, 1974.

• 10) Meffert H, Diezel W, Sonnichsen N:Stable lipid peroxidation products in human skin:Detection, ultraviolet light-induced increase, pathogenic importance. Experientia 32:1397-1398, 1976.
  pubmed

• 11) Kim YP, Lee SC:Superoxide dismutase activities in the human skin. In The Biological Role of Reactive Oxygen Species in Skin. 225-230, edited by Hayaishi O, Imamura S and Miyachi Y, University of Tokyo Press, Tokyo, 1987.

• 12) Ohkuma N, Iizuka H, Mizuno T, et al:Superoxide dismutase in epidermis:Its relation to keratinocyte proliferation. In The Biological Role of Reactive Oxygen Species in Skin. 231-237, edited by Hayaishi O, Imamura S and Miyachi Y, University of Tokyo Press, Tokyo, 1987.

• 13) Ogura R, Sugyama M, Sakanashi T, et al:Role of oxygen in lipid peroxide of skin exposed to ultraviolet. In The Biological Role of Reactive Oxygen Species in Skin. 55-63, edited by Hayaishi O, Imamura S and Miyachi Y, University of Tokyo Press, Tokyo, 1987.

• 14) Miyachi Y, Imamura S, Niwa Y:Decreased skin superoxide dismutase activity by a single exposure of ultraviolet is reduced by liposomal superoxide dismutase pretreatment. J. Invest. Dermatol. 89:111-112, 1987.
  pubmed

• 15) Sugiura K, Ueda H, Hirano K, et al:Studies on superoxide dismutase in human skin (2). Contents of superoxide dismutase and lipidperoxide in normal human skin. Jpn. J. Dermatol. 95:1541-1545, 1985.

• 16) Miyachi Y, Uchida K, Komura J, et al:Auto-oxidative damage in cement dermatitis. Arch.
  pubmed

• 17) Niwa Y, Kanoh T, Sakane T, et al:Detection of enhanced lipidperoxide levels in patients with inflammatory skin diseases. J. Clin. Biochem. Nutr 2:245-251, 1987.

• 18) Michelson AM, Jadot G, Puget K:Mechanism of anti-inflammatory activity of superoxide dismutase. In The Biological Role of Reactive Oxygen Species in Skin. 199-210, edited by Hayaishi O, Imamura S and Miyachi Y, University of Tokyo Press, Tokyo, 1987

P.232 掲載の参考文献

• 1) 山本英昭, 中村紀夫, 坂口友次朗, 他:実験的ストレス潰瘍の胃粘膜血流に及ぼすカテコールアミンの影響. Cyto-protection & biology. 201-210, 第4巻, 蟹書房, 東京, 1987.

• 2) Iriyama K, Yoshiura M, Iwamoto T, et al:Determination of catecholamines in rat gastric wall:reserved-phase high-performance liquid chromatography with electrochemical detection. Jikeikai Med. J. 31:119-125, 1984.

• 3) 木村 宏:組織細胞化学, 111-122, 学際企画, 東京, 1984.

• 4) 織田正也, 中村正彦, 米井嘉一, 他:胃微小循環研究の動向・消化器血流の研究 2-胃粘膜血流の調節因子をめぐって-. 消化器血流研究会編, 94-142, 三松堂, 東京, 1985.

• 5) 永津俊治:カテコールアミン代謝と関連酵素- in vivo での代謝速度と酵素活性測定法-. 蛋白質核酸酵素26:1307-1320, 1981.

• 6) Silbernagl S, Despopoulos A:Taschenatlas der Physiologie. Thieme, Munchen, 1979.

• 7) Regis RV, Susan AM, Robert JE, et al:Diminished sympathetic responsiveness in nephrectomize rats-role of the renin angiotensin system. CLIN. AND EXPER.-THEORY AND PRACTICE A6(5):993-1009, 1984.

P.241 掲載の参考文献

• 1) Robert A, Lancaster C, Hanchar AJ, et al:Mild irritants prevent gastric necrosis through prostaglandin formation:histological study. Gastroenterology 74:1086, 1978.

• 2) Robert A, Nezamis JE, Lancaster C, et al:Mild irritants prevent gastric necrosis through adaptive cytoprotection" mediated by prostaglandins. Am. J. Physiol. 245:G113-G121, 1983.
  pubmed

• 3) Kobayashi K, Arakawa T, Nakamura H:Adaptive cytoprotection by prostaglandins. Advances in Prostaglandin, Thromboxane, and Leucotriene Reseach 15:651-653, 1985.

• 4) 工藤 猛:stress 潰瘍発生における胃粘膜下血流量におよぼす自律神経ならびに Catecholamines の影響に関する実験時研究. 日消誌 81:987-995, 1984.

• 5) Robert A, Nezamis JE, Lancaster C, et al:Cytoprotection by prostaglandins in rats:prevention of gastric necrosis produced by alcohol, HCI, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 77:433-443, 1979.

• 6) Sewell RB:Prostaglandins role in gastric mucosal cytoprotection. Medical Journal of Australia 142:10-13, 1985.

• 7) 大久保剛, 織畑道宏, 渡部洋三, 他:水浸拘束ストレス潰瘍に対する Sofalcon ならびにPGE2, I2の効果-主として胃粘膜下血流面からの検討-. Cyto-protection & biology. 163-171, 第4巻, 蟹書房, 東京, 1986.

• 8) 村松 信, 田中 誠, 諏訪俊男, 他:Effect of 2'-carboxymethoxy-4, 4'-bis (3-methyl-2-buthenyloxy) chalcone (Su-88) on prostaglandin metabolism in dog gastric mucosa. Biochem. Pharmacol. 33:2629-2633, 1984.

• 9) Konturek SJ, Radecki T, Brzozowski T:Antiulcer and cytoprotective effect of solon, a synthetic flavonoid derivative of sopharadin:role of endogenous prostglandins. Eur. J. Pharmacol. 25:185-192, 1986.

• 10) Leung FW, Robert A, Guth PH:Gastric mucosal blood flow in rats after administration of 16-16-dimethyl PGE2 at cytoprotective dose. Gastroenterology 88:1948, 1985.

P.250 掲載の参考文献

• 1) Palner DE, et al:Sources of upper gastrointestinal hemorrhage in cirrhotic patients with esophageal varices. N. Engl. J. Med. 248:1057, 1953.

• 2) Schnitker MA, et al:A histologic study of the liver in patients affected with peptic ulcer. An. J. Dig. Dis. 1:537, 1934.

• 3) 川井啓市, 他:肝と消化管. Medicina 11:56, 1974.

• 4) Waldram R, et al:Emergency endoscopy after gastrointestinal hemorrhage in 50 patients with portal hypertension. Br. Med. J. 12:94, 1974,

• 5) 宮地 徹, 他:肝硬変及び肝癌にみられた胃潰瘍の5例. 病理学雑誌 1:774, 1942.

• 6) Swisher WP, et al:Massive hemorrhage in patients with both esophageal varices and duodenal ulcer. Gastroenterology, 26:868, 1954.

• 7) 加藤抱一:門脈圧亢進例における胃酸分泌. 日消誌76:1427, 1979.

• 8) 宮本二郎, 他:食道静脈瘤患者における胃血行動態に関する内視鏡的検討. Gastroenterological Endoscopy 23:497, 1981.

• 9) 坂崎庄平, 他:肝硬変ラットにおける消化性潰瘍の成因に関する検討-ことに粘膜血流-. 日消誌 79:601, 1982.

• 10) 勝見康平, 他:胃粘膜血流, 胃分泌相関からみた消化性潰瘍の成因に関する研究. -肝硬変ラットによる検討-. 日消誌78:394, 1981.

• 11) Kitano S, et al:Mucosal blood flow and modified vascular responses to norepinephrine in the stomach of rats with liver cirrhosis. Eur. Surg. Res. 14:222, 1982.

• 12) Takagi K, Okabe S:The effects of drugs on the production and recovery process of the stress ulcer in rats. Jap. J. Pharmacol. 18:9-18, 1968.
  pubmed

• 13) Grosfeld JL, et al:Effect of stress and aspirin on extrahepatic portal hypertension in rats. J. Pediatric Surg. 10:609, 1975.

• 14) 今野喜郎, 他:水素ガスクリアランス法による胃粘膜血流測定の工夫-胃痩を用いた電極固定法-. 日消誌80:237, 1983.

• 15) Kety SS:The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol. Rev. 3:1, 1951.

• 16) Ostrow JD, et al:Gastric secretion in human hepatic cirrhosis. Gastroenterology 38:303, 1960.
  pubmed

• 17) Orloff MJ, et al:Gastric secretion and peptic ulcer following Portacaval shunt in man. Ann. Surg. 170:515, 1969.
  pubmed

• 18) Ratnoff OD, et al:The natural history of Laennecs cirrhosis. Medicine 21:207, 1942.

P.258 掲載の参考文献

• 1) 小島一馬, 守田則一, 塩飽徳行, 他:下腸管膜動脈再建術後に発症した虚血性大腸炎の1例-発症前後に於ける内視鏡下の粘膜血流の変化について-. 第39回日本消化器内視鏡学会九州地方会, 昭和60年:日本内視鏡学会誌 26:114, 1986.

• 2) 井上幹夫, 小島一馬, 守田則一, 他:虚血性大腸炎発症前後における大腸粘膜の血流動態. 厚生省炎症性腸疾患調査研究班第2回総会 (昭和61年1月)

• 3) 塩飽徳行, 守田則一, 小島一馬, 他:虚血性大腸炎発症前後に於ける大腸粘膜の経時的観察. 日本消化器病学会誌. 83:472, 1986.

• 4) 塩飽徳行, 守田則一, 小島一馬, 他:虚血性大腸炎の内視鏡的経過と粘膜血流について. 第41回日本消化器内視鏡学会九州地方会, 昭和61年6月(大分)

• 5) Stosseck K, Lubbers DW, Cottin N :Determination of local blood flow (microflow) by electrochemically generated hydrogen. Contruction and application of the measuring probe. Pflugers Arch. 348:225-238, 1974.

• 6) Stosseck K, Lubbers DW:Determination of microflow of the cerebral cortex by means of electrochemically generated hydrogen. In Brain and blood flow. 80-84, edited by R. W. Ross Russell, Pitman Medical Publishing, London, 1970.

• 7) Aukland K, Bower BF, Berlin RW:Measurement of local blood flow with hydrogen gas. Circulation Res. 14:164-187, 1964.

• 8) Boley SJ, Schwartz S, Lash J, Sternhill V:Reversible vascular occlusion of the colon. Surg. Gynec. Obst.116:53-60, 1963.

• 9) Marston A, Phelis MT, Thomas MT, Morson BC:Ischemic colitis. Gut 7:1-15, 1966.

• 10) Hagihara PF, Ernst CB, Griffen WO Jr:Incidence of Ischemic colitis following abdominal aortic reconstruction. Surg. Gynecol. Obstet. 149:571-573, 1979.
  pubmed

• 11) Launer DP, Miscall BG, Beil AR Jr:Colorectal infarction following resection of abdominal aortic aneurysms. Dis Colon Rectum. 21:613-617, 1978.
  pubmed

• 12) Ernst CB, Hagihara PF, Daugherty ME, Satchello CR, Griffen WO Jr:Ischemic colitis incidence following abdominal aortic reconstruction:a prospective study. Surgery 80:417-421,

• 13) Dalinka MK, Gohel VK, Schaffer B, Hemberg J:Gastrointestinal complications of aortic bypass surgery. Clin. Radiol. 27:255-259, 1976.

• 14) Goldshmidt Z, Durst AL, Romanoff H:Necrosis of the colon following elective resection of abdominal aortic aneurysms. Vasc. Sur. 9:141-146, 1975.

• 15) 宮本二郎, 高瀬靖広, 竹島 徹, 他:胃かいよう患者における胃血行動態. Gastroenterol. Endosc. 23:781-791, 1981.

• 16) 野村幸治:虚血性大腸炎に関する臨床的, 実験的研究I. 虚血性大腸炎の臨床的研究-その臨床像と手術適応について. Gastroenterol. Endosc. 5:632-640, 1984.

• 17) Hobson RW, Wright CB, Rich NM, Collins GJ Jr:Assessment of colonic ischemia during aortic surgery by Doppler ultrasound. J. Surg. Res. 20:231-235, 1976.
  pubmed

• 18) Milton WK, Scott AH, Collin R, et al:Ischemic colitis after aortic aneurysmectomy. Am. J. Surgery 145:392-394, 1983.

• 19) Boley SJ, Agrawal GP, Warren AR, et al:Patho-physiologic effects of bowel distention on intestinal blood flow. Am. J. Srug. 117:228-234, 1969.

• 20) Gatch WD, Culbertson CG:Circulatory disturbances caused by intestinal obstruction. Ann. Surg. 102:619-635, 1935.
  pubmed

• 21) Granger DN, Richardson PDI, Kvietys PR:Intestinal blood flow. Gastroenterology 78:837-863, 1980.

• 22) Ruf W, Suehiro GT, Suehiro A, et al:Intestinal blood flow at various intraluminal pressures in the piglet with closed abdomen. Ann. Surg. 191:157-163. 1980.
  pubmed

• 23) 野村幸治, 藤田 潔, 針間喬, 他:虚血性大腸炎の成因に関する実験的検討-大腸粘膜血流測定による検討-. Gastroenterol. Endosc. 25:531-535, 1983.

P.268 掲載の参考文献

• 1) 浅田修二, 白木正裕, 平田一郎, 他:胃粘液の画像解析-リン脂質を含めて.胃と腸 21:1173-1181, 1986.

• 2) 浅田修二:画像処理装置 (VIP) による胃粘液の検討. 大阪医大誌 46:62-76, 1987.

• 3) 今井定悟, 山本久夫, 斉藤千春:非ステロイド性消炎剤インドメサシン. 住友化学 特集号-I:87-100, 1967.

• 4) Miller TA:Protective effect of prostaglandins against gastric mucosal damage:Current knowledge and proposed mechanisms. Am. J. Physiology 245:G601-G623, 1983.

• 5) 小林絢三, 荒川哲男, 中村 肇:胃粘膜防御機構におけるプロスタグランディンの役割. 胃と腸 19:527-533, 1984.

• 6) Hollander F:The two-component mucous barrier. Arch. Int. Med. 93:107-120, 1954.

• 7) 蝶野愼治, 山田博明, 荒川哲男, 他:薬剤性消化管病変における内因性prostaglandinの意義について-aspirin と indomethacin との比較-. 日消誌 78:2295-2301, 1981.

• 8) Azuumi Y, Ohara S, Ishihara K, et al:Correlation of quantitative change of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats. Gut 21:533-536, 1980.
  pubmed

• 9) Menguy R, Desbaillets L:Role of inhibition of gastric mucous secretion ih the phenomenon of gastric mucosal injury by indomethacin. Am. J. Dig. Dis. 12:862-866, 1967.

• 10) Nicoloff DM:Indomethacin. Arch. Surg. 97:809-815, 1968.
  pubmed

• 11) Narumi S, Kanno M:Effect of the non-steroidal antiphlegistics on the gastric mucosal barrier and hexosamine content in rats. Japan. J. Pharmacol. 22:675-684, 1972.

• 12) Davenport HW:Salicylate damage to gastric mucosal barrier. N. Engl. J. Med. 276:1307-1312, 1967.

• 13) Ivey KJ, Morrison S, Grey C:Effect of oral and intravenous salicylates on the gastric mucosal barrier. Aust. NZ. J. Med. 1:300-301, 1971.

• 14) Bowen BK, Krause WJ, Ivey KJ:Effect of sodium bicarbonate on aspirin-induced damage and potential difference changes in human gastric mucosa. Br. Med. J. 2:1052-1055, 1977.
  pubmed

• 15) 大江慶治, 白川敏夫, 三好秋馬, 他:水素イオンの back diffusion と消化性潰瘍 第9報. タウロコール酸の胃粘膜関門障害作用の機序に関するモルモット胃粘膜 in vitro 実験系による研究. 内科宝函 27:225-231, 1980.

• 16) Douthwaite AH, Lintott CAM:Gastroscopic observations of the effect of aspirin and certain other substance on the stomach. Lancet 2:1222-1225, 1938.

• 17) Ivey KJ, Roth JLA:Drug and chemical-induced injuries of the stomach. Gastroenterology. 975-1003, 4th Ed, edited by Bockus HL, W. B. Saunders Comp., Phil & London, 1985.

• 18) Murray HS, Strottman MP, Cooke AR:Effect of several drugs on gastric potential difference in man. Br. Med. J. 1:19-21, 1974.

• 19) Takeuchi K, Nobuhara Y:Inhibition of gastric motor activity by 16, 16-dimethyl prostaglandin E2:A possible explanation of cytoprotection. Dig Dis. Sci. 30:1181-1188, 1985.
  pubmed

• 20) 中原 朗, 島倉秀也, 福富久之, 他:薬剤性胃粘膜障害-内視鏡下観察法とインドメタシン潰瘍-. Therapeutic Research 4:500-507, 1986.
  Medical*Online

P.277 掲載の参考文献

• 1) Shay H, Sun DCH:Etiology and pathology of gastric and duodenal ulcer. In:Gastroenterology. 420, Vol. 1, edited by HL Bochus, Saunders Co., 1953.

• 2) Granger DN, Rutili G, McCord JN:Superoxide radicals in feline intestinal ischemia. Gastroenterology 81:22-29, 1981.

• 3) Peskar BM, Lange K, Hoppe U, et al:Ethanol stimulates formation of leukotriene C4 in rat gastric mucosa. Prostaglandins 31:283-293, 1986.
  pubmed

• 4) Guth Ph, Paulsen G, Nagata H:Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat:Effect of prostaglandin cytoprotection. Gastroenterology 87:1083-1090, 1984.
  pubmed

• 5) Jentjents T, Smith HL, Strous GJ:16, 16-dimethyl prostaglandin E2 stimulates galactose and glucosamine but not serine incorporation in rat gastric mucous cells. Gastroenterolog. 87:409-416, 1984.

• 6) Robert A, Nezamis JE, Phillips Jp:Inhibition of gastric secretion by prostaglandins. Am. J. Dig. Dis. 12:1073-1076, 1967.
  pubmed

• 7) Robert A, Nezamis JE, Lancaster C, et al:Cytoprotection by prostaglandins in rats. Gastroenterolog 77:433-443, 1979.

• 8) Robert A, Nezamis JE, Lancaster Jp, et al:Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins. Am. J. Physiol. 245:113-121, 1983.

• 9) 荒川哲男, 中村 肇, 蝶野慎治, 他:ラット胃粘膜 prostaglandin E2に関する研究 (第1報). 日消誌 77:1052-1059, 1980.

• 10) Goto H, Nakazawa S, Ozawa T:Decreased levels of prostaglandins I2 and E2 in acute gastric mucosal lesions induced by hypoxia. Biochem. Int. 14:311-317, 1987.
  pubmed

• 11) Zipser RD, Nast CC, Lee M:In vivo production of leukotriene B4 and C4 in rabbit colitis. Gastroenterology 92:33-39, 1987.

• 12) Kinoshita T, Nimura Y, Shionoya K, et al:Predominance of prostaglandin D2 and I2 in the rat gastric mucosa-Analysis by high performance liquid chromatogrphy-. Biochem. Int. 14:303-309, 1987.

• 13) Powell SW:Rapid extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica. Methods Enzymol. 86:467-477, 1982.

• 14) Vane JR:Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol. 231:232-235, 1971.
  pubmed

• 15) Takeuchi K, Ueki S, Okabe S:Motility in the pathogenesis of indomethacin-induced gastric lesions in rats. Dig. Dis. Sci. 31:1114-1122, 1986.
  pubmed

P.285 掲載の参考文献

• 1) Eastwood GL:Gastrointestinal epitherial renewal. Gastroenterology 72:962-975, 1975.

• 2) Hawkey CJ, Rampton DS:Prostaglandins and gastrointestinal mucosa:Are they important in its function, diseads, or treatmet? Gastroenterology 89:1162-1188, 1985.
  pubmed

• 3) Matuoka K, Tanaka M, Mitsui Y, et al:Cultured rabbit gastric epitherial cells producing prostaglandin I2. Gastroenterology 84:498-505, 1983.

• 4) Lovgren O, et al:Side effects of indomesacin. Brit. Med. J. 1:118, 1964.

• 5) Lockard Jr OO, Ivey KJ, Butt JH, et al:Tha prevarence of duodenal lesion in patient with rheumatic disease on chronic aspirin therapy. Gastrointest Endosc. 26:5-7, 1980.

• 6) Kuwayama H, Eastwood GL, Miyake S, et al:Adaptation of gastric mucosa to repeated indomesacin administration. Gastroenterology 90:1506, 1986.

• 7) 桑山 肇:インドメサシンによる消化管粘膜障害. Progress of Digestive Endoscopy 28:8-23, 1986.

• 8) Graham DY, Smith JL, Dobbs SM:Gastric adaptation occurs with administration in man. Dig. Dis. Sci. 28:1-6, 1983.
  pubmed

• 9) St John DJB, Teomans ND, McDermott FT, et al:Adaptation of the gastric mucosa repeated administration of aspirin in the rat. Am. J. Dig. Dis. 18:881-886, 1973.

• 10) Thomas DR, PhilPott GW, Jaffe BM:The relationship between concentration of prostagrandin and rates of cell proliferation. Exp. Cell. Res. 84:40-46, 1974.

• 11) Claesson HE, Lindgen JA, Hammarstrom S:Endogeneous prostagrandin E2 production inhibits proliferation of polyoma virus-transformed 3T3 cells;corelation with cellular level of cyclicAMP. Advan. Prost. Thrombs. Res. 6:541-544, 1980.

P.296 掲載の参考文献

• 1) 永松悠二, 八木田真光, 三浦良史, 他:ラット胃粘膜関門障害時における胃粘膜血流並びに水素イオン透過性の変動について. 日消会誌 83:566, 1986.

• 2) 永松悠二, 八木田真光, 三浦良史, 他:エタノールによる胃粘膜関門障害時における胃粘膜水素イオン透過性と粘膜血流の相関について. ペプシン研究会議事録 33:136-144, 1986.

• 3) Robert A, Schultz JR, Nezamis JE, et al:Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2 and 16, 16-dimethyl PGE2. Gastroenterology 70:359-370, 1976.

• 4) Robert A, Nezamis JE, Lancaster C, et al:Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alchohol, HCI, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77:433-443, 1979.

• 5) Robert A:Advances in Prostaglandins and Thromboxane Research. vol. 8. 1533-1541, edited by Samuelsson B, Ramwell PW and Paoletti R, Raven Press, New York, 1980.

• 6) Flemstrom G, Garner A:Gastroduodenal HCO3 transport:characteristics and proposed role in acidity regulation and mucosal protection. Am. J. physiol. 242:G 183-G 193, 1982.

• 7) Allen A:Structure and function of gastric mucus. In Physiology of the Gastrointestinal Tract. 617-639, edited by Johnson LR, Raven Press, New York, 1981.

• 8) Bolton Jp, Palmer D, Cohen MM:Stimulation of mucus and nonparietal cell secretion by the E2 prostaglandins. Am. J. Dig. Dis, 23:359-364, 1978.
  pubmed

• 9) Williams SE, Turnberg LA:Demonstration of a pH gradient across mucus adherent to rabbit gastric mucosa:evidence for a tmucus-bicarbonate:barrier. Gut 22:94-96, 1981.

P.303 掲載の参考文献

• 1) Yajima H, Akaji K, Fujii N, et al:Synthesis of a heptacosapeptide amide corresponding to the entire amino acid sequence of gastric gastrin releasing peptide. Chem. Pharm. Bull. 28:2276-2278, 1980.

• 2) 記井英治, 真辺忠夫, 戸部隆吉:GRP の膵に対する作用について (第1報:膵外分におよぼす影響と機序). 日消病会誌 83:204-213, 1986.

• 3) 中村紀夫, 桜井健彦, 長州尭雄, 他:急性胃病変と慢性胃潰瘍の病理. 胃と腸14:1473-1479, 1979.

• 4) Manabe T, Suzuki T, Honjo I, et al:Changes of upper gastrointestinal blood flow after hemorrhage in rabbits. Surgery 81:446-452, 1977.
  pubmed

• 5) Hottenrott C, Seufert RM, Becher H:The role of ischemia in the pathogenesis of stress induced gastric lesions in piglets. Surg. Gynecol. Obstet. 146:217-220, 1978.

• 6) Menguy R, Desbaillets L, Masters YF:Mechanism of stress ulcer:Influence of hypovolemic shock on energy metabolism in the gastric mucosa. Gastroenterology 66:46-55, 1974,
  pubmed

• 7) Moncada S, Glyglewski R, Bunting S, et al:An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263:663-665, 1976.

• 8) Konturek SJ, Radecki T, Brzozowski T, et al:Gastric cytoprotection by prostaglandins, ranitidine, and probanthine in rats. Scand. J. Gastroenterol. 16:7-12, 1981.
  pubmed

• 9) Konturek SJ, Piastucki I, Brzozowski T, et al:Role of prostaglandins in the formation of aspirin-induced gastric ulcers. Gastroenterology 80:4-9, 1981.
  pubmed

• 10) Robert A, Hanchar AJ, Lancaster C, et al:Antisecretary and cytoprotective effects of prostacyclin (PGI2). Fed. Proc. 37:460, 1978.

• 11) Gerkens JF, Gerber JG, Shand DG, et al:Effect of PGI2, PGE2, and 6-keto PGF1α on canine gastric blood flow and acid secretion. Prostaglandins 16:815-823, 1978.

• 12) Gaskill HV, Sirinek KR, Levine BA:Prostacyclin-mediated gastric cytoprotection is dependent on mucosal blood flow. Surgery 92:220-225, 1982.
  pubmed

• 13) Gaskill HV, Sirinek KR, Levine BA:Prostacyclin selectively enhances blood flow in area of the GI tract prone to stress ulceration. J. Trauma. 24:397-402, 1984.

• 14) Lippton HL, Chapnick BM, Hyman AL, et al:Inhibition of vasoconstrictor responses by prostacyclin (PGI2) in the feline mesenteric vascular bed. Arch. Int. Pharnzacodyn. 241:214-223, 1979.

• 15) Carmichael HA, Nelson LM, Russel RI:Cimetidine and prostaglandin:Evidence for different modes of action on the rat gastric mucosa. Gastroenterology 74:1229-1232, 1978.
  pubmed

• 16) Levine BA, Sirinek KR, Mcleod CG, et al:The role of cimetidine in the prevention of stress induced gastric mucosal injury. Surg. Gynecol. Obstet. 148:399-402, 1979.
  pubmed

• 17) Bugajski J, Hano J, Danek L:Effect of metiamide, a histamine H2-receptor antagonist, on the development of gastric stress ulcers and acid secretion, Europen J. Pharmacol. 36:237-240, 1976.

P.313 掲載の参考文献

• 1) 金山知新 :閉塞性黄疸患者に出現する急性胃・十二指腸潰瘍の臨床ならびに実験的研究. 日外会誌 74:133-147, 1973.

• 2) Silen W, Hein MF, Albo RJ, et al:Influence of liver upon canine gastric secretion. Surgery 54:29-36, 1963.
  pubmed

• 3) 日野輝夫:閉塞性黄疸に関連したストレス潰瘍発生の実験的研究. 岐阜医紀 30:838-884, 1982.

• 4) 児玉 治:急性十二指腸潰瘍の発生機序と外因性セクレチンの及ぼす影響に関する実験的研究. 広島大学医学雑誌 29:151-189, 1981.

• 5) 沖永功太:閉塞性黄疸に併発する急性胃潰瘍の実験的研究-胃粘膜血流と胃粘膜関門の検討を中心に-. 日外会誌 77:1325-1341, 1976.

• 6) 城所 仂, 渡部洋三, 工藤 猛:水素ガスクリアランス式組織血流計による意識下ラットの胃粘膜下血流量に関する研究. 外科治療 44:698, 1981.

• 7) Harada K, Mizumoto S, Misumi A, et al:Studies of the mechanisms of gastric bleedings under obstructive jaundice-role of biogenic amines-. Gastroenterol. Jpn. 18:71-78, 1983.
  pubmed

• 8) Takagi K, Okabe S:The effects of drugs on the production and recovery process of the stress ulcer. Jpn. J. Pharmacol. 18:9-18, 1968.
  pubmed

• 9) 佐藤寿雄, 佐々木巌, 亀山仁一, 他 :閉塞性黄疸と術後急性潰瘍. 消化器外科 5:1993-1998, 1982.

• 10) 加来 博:胃粘膜上皮の動態とその解析-3H-thymidineオートラジオグラフィーによる研究. Arch. histol. jap). 27:223-246, 1966.

• 11) 小宮山清洋:胃における粘液蛋白の生成ならびに分泌に関する研究. 信州医誌 29:279-290, 1981,

• 12) Menguy R:Mechanism of stress ulcer-influence of sodium taurocholate on gastric mucosal energy metabolism during hemorrhagic shock and on mitochondrial respiration and ATPase in gastric mucosa-. Am. J. Dig. Dis. 21:1001-1007, 1976.
  pubmed

• 13) Tanaka K, et al:Effect of bile acid and salicylate on isolated surface and glandular cells of rabbit stomach. Surgery 93:660-663, 1983.
  pubmed

P.321 掲載の参考文献

• 1) Ostrow JD, Timmerman RJ, Gray SJ:Gastric secretion in human hepatic cirrhosis. Gastroenterology 38:303-313, 1960.
  pubmed

• 2) Mazzacca G, Budillon G, De Marco F, et al:Serum gastrin in patients with cirrhosis of the liver. Digestion 11:232-239, 1974.
  pubmed

• 3) 坂上 博:肝障害時の胃液分泌に関する研究 第二編 肝硬変の胃液分泌. 愛媛医学 2:120-127, 1983.

• 4) シンポジウムII. 肝疾患と消化管病変 (食道静脈瘤はのぞく) 司会=市田文弘, 木原彊. Gastroenterological Endoscopy 28:1129-1154, 1986.

• 5) 西本幸弘:肝癌, 肝硬変, その他の肝疾患における胃・十二指腸の潰瘍性疾患の合併についての研究. 最新医学 14:1482-1500, 1959.

• 6) Solis-Herruzo JA, Pardo-Rueda J:Functional study of the gastric mucosal barrier in hepatic cirrhosis. Acta Hepato-Gastroenterol. 23:351-359, 1976.

• 7) 日高令一郎:肝硬変症時の胃粘膜血流動態の検討-特に食道静脈瘤硬化療法前後での比較と胃粘膜病変との関連について-. Gastroenterological Endoscopy 27:1929-1939, 1985.

• 8) 蓮見昭武, 青木春夫, 坂本賢也, 他:肝硬変症・門脈圧亢進症症例における内視鏡下胃壁組織血流動態に関する検討-特に胃壁粘膜・粘膜下血流量の同時測定成績よりみた食道・胃静脈瘤の発生要因について-. 第17回日本門脈圧亢進症研究会プロシーディングス, 1984.

• 9) Davenport IIW:Destruction of the gastric mucosal barrier by detergents and urea. Gastroenterology 54:175-181, 1968.

• 10) Black RB, Roberts G, Rhodes J:The effect of healing on bile reflux in gastric ulcer. Gut 12:552-558, 1971.
  pubmed

• 11) Tympner F, Domschke W, Demling L:Duodenogastric reflux in gastric ulcer patients in relation to intestinal metaplasia of the gastric mucosa. Acta Hepato-Gastroenterol. 23:360-364, 1976.

• 12) 里見隆彦 :幽門機能と慢性胃炎-十二指腸球部および幽門輪変形と逆流胆汁酸濃度との関連において-. 日消誌 79:1090-1097, 1982.

• 13) Keane FB, Dimagno EP :Duodenogastric reflux in humans:Its relationship to fasting antroduodenal motility and gastric, pancreatic, and biliary secretion. Gastroenterology 81:726-731, 1981.
  pubmed

• 14) 周山秀昭:肝硬変患者におけるradioisotope法による胃排出能の検討. 日消誌 81:2507-2515, 1984.

• 15) Robert A, Nezamis JE, Lancaster C, et al:Cytoprotection by prostaglandins in rats. Gastroenterology 77:433-443, 1979,
  pubmed

• 16) Cohen MM, McCready DR, Clark L, et al:Protection against aspirin-induced antral and duodenal damage with Enprostil-A double-blind endoscopic study. Gastroenterology 88:382-386, 1985.
  pubmed

• 17) Mann NS:Bile-induced acute erosive gastritis. Its prevention by antacid, cholestyramine, and prostaglandin E2. Am. J Dig. Dis. 21:89-92, 1976.
  pubmed

• 18) Muller-lissner St A, Fimmel CJ, Blum AL:Failure of 16, 16-Dimetyhl-PGE2 to protect the human stomach from taurocholate induced damage. Hepato-Gastroenterol. 30:107-117, 1983.

P.329 掲載の参考文献

• 1) 亀山仁一, 仁科盛之, 八木 聡, 他:胃粘膜血流からみた腎不全時における急性潰瘍の予防効果について. Cyto-protection & biology. 173-179, 第4巻, 蟹書房, 東京, 1987.

• 2) 仁科盛之, 亀山仁一, 八木 聡, 他:急性腎不全時における迷切の胃粘膜におよぼす影響. Prog. Med. 7:439-444, 1987.
  Medical*Online

• 3) Takagi K, Okabe S:The effect of drugs on the production and recovery process of the stress ulcer. Jap. J. Pharmac. 18:9-18, 1968.

• 4) 宮川英喜, 亀山仁一, 佐々木巌, 他:急性潰瘍に対する実験的研究-閉塞性黄疸と迷切の影響を含めて. 日外会誌 84:113-118, 1983.

• 5) 今野喜郎, 亀山仁一, 佐々木巌, 他:水素ガスクリアランス法による胃粘膜血流量測定の一工夫-胃痩を用いた電極固定法-. 日消誌 80:237, 1983.

• 6) 岡田昌之, 村上征夫, 宮原 透, 他:Stress 潰瘍発生過程における胃粘膜血流と胃酸分泌について-特にソルコセリルの薬剤効果を中心に. Cyto-protection & biology. 11-26, 第1巻, 蟹書房, 東京, 1983.

• 7) 工藤 猛, 渡部洋三, 佐々木浩, 他 :水浸拘束ストレス潰瘍発生における胃血流量と胃粘液分泌に関する研究. Cyto-protection & biology. 97-105, 第2巻, 蟹書房, 東京, 1984.

• 8) 杉山 貢, 渡辺桂一, 山本俊郎, 他 :胃粘膜防御機構からみた実験潰瘍に対する迷切とHistamine H2-receptor Antagonist の効果. ヒスタミンレセプター研究会議事録 5:154-161, 1986.

• 9) 長町幸雄 :消化性潰瘍に対するソルコセリルの適用とその基礎的根拠. Cyto-protection & biology. 1-9, 第1巻, 蟹書房, 東京, 1983.

• 10) 中村紀夫, 坂口友次郎, 長洲尭雄, 他 :胃粘膜防御因子に対するソルコセリルの影響. Cyto-protection & biology. 45-53, 第1巻, 蟹書房, 東京, 1983.

• 11) 藤井一元, 向井勝紀 :胃粘膜防御機構における内因性PGの役割. Cyto-protection & biology. 175-182, 第2巻, 蟹書房, 東京, 1984.

• 12) 守田則一, 国崎 真, 井原裕二, 他 :胃粘膜血流よりみた消化性潰瘍の基礎的研究-抗潰瘍剤の成犬胃粘膜血流に及ぼす影響. Cyto-protection & biology. 163-170, 第3巻, 蟹書房, 東京, 1985.

• 13) 伊藤幹雄, 田中敏彦, 鈴木良雄 :ラット酢酸潰瘍の治癒過程における胃粘液糖蛋白質量の変動に対する抗潰瘍剤の効果. Cyto-protection & biology. 249-255, 第3巻, 蟹書房, 東京, 1985.

• 14) 石田敬幸, 三重野寛, 門川康彦, 他 :ラットの胃粘膜関門に及ぼす幼牛血液抽出剤の影響. Cyto-protection & biology. 231-235, 第4巻, 蟹書房, 東京, 1987.

• 15) 北島政樹, 木内立男, 鳥居治文, 他 :ストレス潰瘍と胃粘膜ムコ物質-Cimetidine および迷切術を中心に. ヒスタミンレセプター研究会議事録 4:20-32, 1985.

• 16) 尾野光市, 勝見正治, 河野暢之, 他 :腎障害ラットの胃粘膜障害と胃粘膜内プロスタグランディン E2. Cyto-protection & biology. 245-251, 第4巻, 蟹書房, 東京, 1987.

P.335 掲載の参考文献

• 1) 石田康男, 高橋愛樹, 鈴木快輔, 他 :粘膜内粘液と潰瘍. Cyto-protection & biology. 209-215, 第3巻, 蟹書房, 東京, 1985.

• 2) 石田康男, 高橋愛樹, 鈴木快輔, 他 :胃粘膜内粘液の局在と潰瘍発生過程における変化. Cyto-protection & biology. 223-230, 第4巻, 蟹書房, 東京, 1986.

• 3) 村上 学, 他 :テプレノンと胃粘膜糖蛋白質. 胃潰瘍治療剤の新展開 (竹本忠良編). 3-11, 第1版, メディカルトリビューン, 東京, 1986.

• 4) 浅田修二, 岡 博行, 大柴三郎, 他:テプレノンと臨床-胃粘液について- (竹本忠良編). 86-92, 第1版, メディカルトリビューン, 東京, 1986.

• 5) 青木照明 :迷走神経切離術の理論と実績. 消化性潰瘍の病態生理と治療に対するその反応 (消化器臨床生理研究会編). 15-24, 第9版, 医事出版社, 東京, 1986.

• 6) 島津久明, 森岡恭彦, 他 :消化性潰瘍の手術適応と標準術式. 消化器外科 3:285-292, 1985.

• 7) 佐々木善二, 川井啓市 :胃粘膜増殖細胞. 被蓋上皮細胞回転に対するテプレノンの作用 (竹本忠良編). 70-76, 第1版, メディカルトリビューン, 東京, 1986.

P.344 掲載の参考文献

• 1) 北島政樹, 上田光久, 相馬 智 :粘膜血流を中心として. 消化管粘膜の防御機構 (川井啓市編). 144-152, 医学図書出版, 1982.

• 2) Kitajima M, Kiuchi T, Seki M, et al:Gastric mucosal lesions following thermal injury:Relationship to gastric microcirculation and quantitative changes of gastric mucosubstances in the rat. Gastric Mucus and Mucus Secreting cells. 184-192, edited by Keiichi Kawai, Excerpta Medica, Tokyo, 1985.

• 3) 小林絢三, 荒川哲男, 中村 肇 :胃粘膜防御機構とプロスタグランディン. 胃と腸 19:527-533, 1984.

• 4) Symon L, Pasztor E, Dorsh NW :Physical responses of local areas of the cerebral circulations in experimental primates determined by the method of hydrogen clearance. Stroke 4:632-642, 1973.

• 5) Kety SS, Schmidt CF:The nitrous oxide method for the quantitative determination of cerebral blood flow in man:Theory, procedure and normal value. J. Clin. Invest. 27:476-483, 1948.
  pubmed

• 6) Shore PA, Burkhalter A, Cohn VH:Amethod for the fluorometric assay of histamine in tissues. J. Pharmacol. Exp. Ther. 127:182-186, 1959.

• 7) Juhlin L, Shelly WB:Detection of histamine by new fluorescent o-phthalaldehyde stain. J. Histochem. Cytochem. 14:525-528, 1966.

• 8) Falck B, Hillap G:Fluorescence of catecholamines and related compounds condenced with formaldehyde. J. Histochem. Cytochem. 10:348-354, 1962.

• 9) 藤原元始 :蛍光法による Catecholamine および Serotonin の組織化学的検出 (その方法と応用). 最新医学22. 100-119, 1967.

• 10) 三好秋馬 :無酸症発現に関する臨床病理学的研究. 日消誌 59:585-593, 1962.

• 11) Guth PH, Hall P:Microcirculation and mast cell changes in restraint induced gastric ulcer. Gastroenterology 50:562-570, 1966.

• 12) 戸部隆吉 :ヒト消化管における活性アミン (セロトニン, ヒスタミン) の分布と遊離.医学のあゆみ 84:687-692, 1973.

• 13) Erspamer V, Asero B:Identification of enteramine, as 5-hydroxytryptamine. Nature 109:800, 1952.

P.355 掲載の参考文献

• 1) 岡部 進, 竹内孝治, 高木敬次郎:実験潰瘍-病態モデルとその病因- (梅原千治, 高木敬次郎, 長尾房大, 松尾裕編). 25-33. 日本メディカルセンター, 東京, 1976.

• 2) Inayama S, Shibata T, Ohtsuki J, et al:A new microanalytical method for determination of hydroxyproline in connective tissue. Keio J. Med. 27:43-46, 1978.
  pubmed

• 3) 堀 久枝, 永井 裕 :コラーゲン代謝と疾患 (永井 裕, 藤本大三郎編). 86-109, 講談社, 東京, 1983.

• 4) 土屋雅春, 織田正也, 中村正彦, 他 :ラット胃粘膜微小循環の自律神経統禦について-特に実験的ストレス潰瘍発生機構に関連して-. 日消誌 78:1000-1014, 1981.

• 5) 岡崎 勲, 丸山勝也, 柏崎一男, 他 :内的・外的傷害因子に対する胃粘膜結合組織の反応. 日消誌 81:829-834, 1984.

• 6) Riley WB Jr, Peacock EE Jr:Identification, distribution, and significance of a collagenolytic enzyme in human tissues. Proc. Soc. Exp. Biol. Med. 124:207-210, 1967.
  pubmed

• 7) 長谷部哲理, 原沢 茂, 三輪 剛, 他 :犬酢酸潰瘍の治癒過程における組織中コラーゲンおよびコラゲナーゼの経時的変動-Solcoseryl および Vitamin C と鉄剤の効果-. Cyto-protection & biology (長尾房大編). 259-269, 第4巻, 蟹書房, 東京, 1987.

• 8) 岡崎 勲, 丸山勝也, 柏崎一男 :組織修復と動物性コラゲナーゼ. 最新医学 37:240-246, 1982.
  Medical*Online

• 9) 工藤 猛, 渡部洋三, 佐々木浩, 他 :水浸拘束ストレス潰瘍発生における胃血流量と胃粘液分泌に関する研究. Cyto-protection & biology (相馬智編). 97-105, 第2巻, 蟹書房, 東京, 1984.

P.363 掲載の参考文献

• 1) Azuumi Y, Ohara S, Ishihara K, et al:Correlation of quantitative changes of gastric mucosal glycoproteins with aspirin-induced gastric damage in rats. Gut 21:533-536, 1980.
  pubmed

• 2) Neuhaus OW, Letzring M :Determination of hexosamines in conjugation with electrophoresis on starch. Anal. Chem. 29:1230-1233, 1957,

• 3) Kimura K, Takemoto T:An endoscopic recognition of the atrophic border and its significance in chronic gastritis. Endoscopy 3:87-97, 1969

• 4) 川井啓市 :慢性胃炎および胃下垂症. 最新医学 21:960-973, 1966.

• 5) Allen A:Structure of gastro-intestinal mucus glycoproteins and the viscous and gelforming properties of mucus. Brit. Med. Bull. 34:28-33, 1978.
  pubmed

• 6) Carlstedt I, Sheehan JK, Corfield AP, et al:Mucous glycoproteins :A gel of a problem. Essays in Biochemistry 20 :41-76, 1985.

• 7) 桶谷 清, 村上 学, 藤崎秀明, 他:ヘキソサミンを指標とした粘液糖蛋白質の簡易比色定量法-消化管粘膜からの生検試料に関して. 医学のあゆみ 131:745-749, 1984.
  Medical*Online

• 8) 筧 正雄, 岡部治弥, 小原 進, 他:ラットにおける胃粘膜高分子糖タンパク質の分布と絶食負荷による変動. 日消誌 79:181-186, 1982.

• 9) Ohara S, Ishihara K, Kakei M, et al:Distribution of mucosal macro-molecular glycoproteins in rat stomach. Comp. Biochem. Physiol, B. 72:309-311, 1982.

• 10) 浅田修二, 白木正裕, 大柴三郎 :粘液. 胃のサイトプロテクションとその周辺 (竹本忠良・小林絢三編). 27-36, 医歯薬出版, 1986.

• 11) 斎藤 満, 竹内 憲, 竹本忠良:粘膜血流とpotential difference. 胃粘膜の防御機構 (竹本忠良・小林絢三編). 64-74, 医歯薬出版, 1985.

• 12) 宮本二郎, 高瀬靖広, 竹島 徹, 他:胃潰瘍患者における胃血行動態. Gastroenterological Endoscopy 23:781-791, 1981.

• 13) 上地六男, 横山 泉 :血流および酸素分圧からみた粘膜防御機構. 胃粘膜血流の基礎と臨床. 167-173, 羊土社, 1983.

• 14) 松川フレディ, 松永元良, 常岡健二 :胃粘膜血流. 胃粘膜PDおよびpHとの相関-薬剤の影響. 胃粘膜血流の基礎と臨床. 185-193, 羊土社, 1983.

• 15) 平松 新, 水野孝子, 鮫島美子 :差温式熱電対法および水素ガスクリアランス法による胃粘膜血流測定-胃潰瘍ならびに肝硬変症について. 胃粘膜血流の基礎と臨床. 175-184, 羊土社, 1983.

• 16) 鎌田武信, 佐藤信紘, 川野 淳, 他 :急性胃粘膜病変の成因に関する検討 (第3報). 臓器反射スペクトル解析による頭部外傷, 熱傷後の胃粘膜血流動態に関する研究. 日消誌 78:2302-2307, 1981.

• 17) 渡辺嘉久, 小林礼子, 吉越富士雄, 他:酸分泌抑制時の粘液分泌動態. 胃粘膜の防御機構 (竹本忠良・小林絢三編). 24-31, 医歯薬出版, 1985.

• 18) 赤坂裕三, 窪田吉克, 奥田順一, 他 :腺境界と胃病変-腺境界の識別法と腺境界の局在に関連する諸因子を中心に-. 胃と腸 15:155-165, 1980.

• 19) 木村 健:萎縮性胃炎の経年的推移. 日消誌 70:307-315, 1973.

• 20) 郡 大裕, 鈴木邦夫, 加藤卓次, 他 :一般健康住民の胃粘膜変化. Gastroenterological Endoscopy 27:715-725, 1985.

• 21) 上地六男, 新見晶子, 川村雅枝, 他 :消化性潰瘍と粘液物質-mucous-bicarbonate barrier-. Progress of Digestive Endoscopy 23:37-42, 1983.

• 22) 岡 博行 :胃潰瘍における抗潰瘍剤投与下の胃粘膜糖タンパクの変動-hexosamineを指標として-. 大阪医大誌 44:413-421, 1985.

• 23) 原田容治, 斎藤利彦 :胃潰瘍および胃癌における粘膜内hexosamine の変動. Progress of Digestive Endoscopy 24:47-51, 1984.

• 24) 鎌田武信, 佐藤信紘 :臓器反射スペクトル法による粘膜血流測定. 胃粘膜血流の基礎と臨床. 133-143, 羊土社, 1983.

• 25) 北島政樹, 鳥居治文, 依田一郎, 他 :急性胃粘膜病変と粘膜血流. 胃粘膜の防御機構 (竹本忠良・小林絢三編). 75-89, 医歯薬出版, 1985.