書籍詳細

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P.4 掲載の参考文献

• 1) Pantelouris E. M.:Absence of thymus in a mouse mutant. Nature 217:370-371 (1968).

• 2) Rygaard, J & Povlsen, C. O.:Heterotransplantation of a human malignant tumour to nude mice. Act. Path. Microbiol. Scand. 77:758-760 (1969).

• 3) Rygaard. J & Povlsen, C. O (eds):Proceedings of the First International Workshop on Nude Mice. Gustav Fischer Stuttgart, 1973.

• 4) Nomura, T., Ohsawa, N, Tamaoki, N. & Fujiwara, K. (eds):Proceedings of the Second International Workshop on Nude Mice. Univ. of Tokyo Press, Tokyo, 1977.

• 5) Reed, N. D. (ed):Proceedings of the Third International Workshop on Nude Mice. Gustav Fischer, New York, 1979.

• 6) Sordat, B. (ed):Immune-Deficient Animals. Karger, Basel, 1984.

• 7) Rygaard, J., Brunner, N., Graem, N., & Spang-Thomsen, M.:Immune-Deficient Animals in Biomedical Research. Karger, Basel, 1987.

• 8) Wu B. Q. & Zheng J. (eds):Immune-Deficient Animals in Experimental Medicine. Karger, Basel, 1989.

• 9) Asano, S., Urabe, A., Sato, N., Kondo, Y., Ueyama, Y., Chiba, S., Ohsawa, N., & Kosaka, K.:Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood, 49:845-852 (1977).

• 10) Nomura, H., Imazeki, I., Oheda, M, Kubota, N., Tamura, M., Ono, M., Ueyama. Y., & Asano, S.:Purification and characterization of human granulocyte colony-stimulating factor (G-CSF). EMBO J. 5:871-876 (1986).
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P.9 掲載の参考文献

• 1) 吉田富三:「吉田肉腫 - 癌化学療法の基礎的研究」寧楽書房. 東京, 1949.

• 2) 市村宏子:ラット腹水肝癌を用いた癌化学療法のスクリーニング. 癌と化学療法2:605-610(1975)

• 3) Sugiura, K.:Effect of various compounds on the Ehrlich ascites carcinoma. Cancer Res. 13:431-441(1953)

• 4) Gellhorn, A. et al:Investigation of diverse systems for cancer chemotherapy screening. Cancer Res. 3 (Suppl.):125(1955)

• 5) Sugiura, K et al.:Effect of compounds on a spectrum of tumors. Cancer Chemother. Rep. 3(Part II):231-307(1972)

• 6) Leiter, J., Abott, B. J. and Schepartz, S. A.:Screening data from the Cancer Chemotherapy National Service Center Screening Laboratories. XXVIII. Cancer Res. (Suppl.) 9 (Part II):1626-1965(1965)

• 7) Goldin, A. et al.:A commentary. Experimental procedures and clinical predictability value. Cancer Chemother. Rep. 50:173-218(1966)

• 8) Goldin, A. et al.:Retrospective and prospective approaches to screening and comparative evaluation of analogs in the USA. In "Advances in Cancer Chemotherpy, The Proceedings of the 8th International Symposium of the Princess Takamatsu Cancer Research Fund, Tokyo, 1977", pp.179-198(1978), Japan Scientific Societies Press, Tokyo.

• 9) Schabel, F. M. Jr.:In vivo leukemic cell kill kinetics and "curability" in experimental systems. In "The Proliferation and Spread of Neoplastic Cells(A Collection of Papers Presented at the 21st Annual Symposium on Fundametal Cancer Research, 1967)," pp.379-408(1968), Williams and Wilkins, Baltimore.

• 10) Schabel, F. M. Jr.:Animal models as predictive systems. In "Cancer Chemotherapy Fundmental Concepts and Recent Advances," pp, 323-355(1975),Year Book Medical Publishers.

• 11) Hagenbeek, A. et al.:Kinetics of minimal residual disease in a rat model for human acute myelocytic leukemia. In "Experimental Hematology Today", eds. S. J. Baum, G. D. Ledney and D. W. Van Bekkum., pp.215-222(1980),S. Karger, Basel.

• 12) Hagenbeek, A. et al.:Comparative evaluation of the L5222 and the BNML rat leukemia models and their relevance for human acute leukemia. Leukemia Res.1:75-253(1977)

• 13) Toolan, H. W.:Growth of human tumors in cortisone-treated laboratory animals:the possibility of obtaining permanently transplantable human tumors. Cancer Res. 13:389-394(953)

• 14) Rygaard, J. et al.:Heterotransplantation of a human malignant tumor in nude mice. Acta Pathol. Microbiol. Scand. 77:758-760 (1969)
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• 15) Ovejera, A. A.:The use of human tumor xenografts in large-scale drug screening. In "Rodent Tumor Models in Experimental Cancer Therapy," ed. R. F. Kallmann, pp.218-220(1987), Pergamon Press, New York.

• 16) Salmon, S. E. et al.:Quantitation of differential sensitivity of human tumor stem cells to anticancer drugs. N. Engl. J. Med. 298:1321-1327(1978)

• 17) 鶴尾 隆:米国国立癌研究所の抗癌剤スクリーニング. 癌と化学療法 14:2809-2815(1987)

• 18) Falzon, M. et al.:Metabolic activation and cytotoxicity of 4-ipomeanol in human non-small cell lung cancer lines. Cancer Res. 46:3484-3489(1989)

• 19) McLemore, T. et al.:4-Ipomeanol metabolism and P450 (A)gene expression in human lung cancer cell lines. Proc. AACR, 334(1988)

• 20) Kallmann, R. F.: "Rodent Tumor Models in Experimental Cancer Therapy," Pergamon Press, New York, 1987.

第一部 抗癌剤の新評価システム

P.13 掲載の参考文献

• 1) Povlsen, C. O. and Rygaard, J.:Effects of cyclophosphamide on a Burkitt's lymphoma serially grown in nude mice. Proc. 1st Int. Workshop on Nude Mice. 285-292(1974)

• 2) Povlsen, C. O., and Jacobsen, G. K.:Chemotherapy of a human malignant melanoma transplanted in the nude mouse. Cancer Res.35:2790-2796(1975)

• 3) Sharkey, F. E. and Fogh, J.:Considerations in the use of nude mice for cancer research. Cancer Metastasis Rev. 3:341-360(1984)

P.35 掲載の参考文献

• 1) Shibuya, M., Yokota, J. and Ueyama, Y.:Amplification and expression of a cellular oncogene (c-myc) in human gastric adenocarcinoma cells. Mol. Cell. Biol. 5:414-418(1985)

• 2) Yoshimura, S., Tamaoki, N., Ueyama, Y. and Hata, J.:Plasma protein production by human tumors xenotransplanted in nude mice. Cancer Res. 38:3474-3478(1978)

• 3) Yamasaki, H., Fukui, Y., Ueyama, Y., Tamaoki, N, Kawamoto, T., Taniguchi, S. and Shibuya, M.:Amplification of the structurally and functionally altered epidermal growth factor receptor gene(c-erbB) in human brain tumors. Mol. Cell. Biol. 8:1816-1820(1988)

P.47 掲載の参考文献

• 1) Laber, G., Schutze, E., Leskova, R, Kolb, R. and Georgopoulos, A.:A diffusion chamber technique for measuring concentrations of antibiotics in interstitial fluid. Infection 8:58-62(1980)

• 2) Georgopoulos, A., Schutze, E. and Laber, G.:Measurements of antimicrobial drug concentraions in renal interstitial fluid using the diffusion chamber technique. Infection 8:115-118(1980)

• 3) 杉山雄一:生理学的薬物速度論:基礎理論. 「医薬品開発のためのファーマコキネティックス実験法」(花野, 梅村, 伊賀編), pp.385-401(1985), ソフトサイエンス社, 東京.

• 4) 宮村, 金沢:薄層カップ法による体液中ペニシリン及びストレプトマイシンの濃度測定法. J. Antibiot. 3:411-416(1950)

• 5) 増池健年, 大嶽純一, 武本宣教:高速液体クロマトグラフィーによる生体試料中のアドリアマイシンとその代謝物の定量 (第1報) 直接注入法による血清, 血漿の分析. 薬学雑誌 104:614-619(1984)

• 6) Bender, R. A., Castle, M. C, Margileth, D. A. and Oliverio, V. T.:The pharmacokinetics of [3H] vincristine in man. Clin. Parmacol. Ther. 22:430-438(1977)

• 7) Nakamura, K., Asami, M., Kawada, K. and Sasahara, K.:Quantitative datermination of ACNU (3-[(4-amino-2-methyl-5-pyrimidinyl)methyl] -1-(2-chloroethyl)-1-nitrosourea hydrochloride), a new water-soluble antitumor nitrosourea, in biological fluids and tissues of patients by high-performance liquid chromatography. I. Analytical method and pharmacokinetics. Ann. Rep Sankyo Res. Lab. 29:66-74(1977)

• 8) Wanger, T., Heydrich, D., Jork, T., Veelcker, G. and Hohorst H.J.:Comparative study on pharmacokinetics of activated ifosfamide by a modified fluorometrics test. J. Cancer Res. Clin. Oncol. 100:95-104(1981)

• 9) Lu, K., Yap, H-Y. and Loo, T. L.:Clinical pharmacokinetics of vinblastine by continuous intravenous infusion. Cancer Res. 43:1405-1408(1983)

• 10) 藤田 浩:制癌剤の体内分布-測定法 (第1部). 癌と化学療法 1:497-503(1974)

• 11) Bertino, J. R. and Fischer, G. A.:Techniques for study of resistance of folic acid antagonists. Methods Med. Res. 10:297-307(1964)

• 12) Fujita, H.:Comparative studies on the blood level, tissue distribution, excretion and inactivation of anticancer drugs. Jpn. J. Clin, 1:151-162(1972)

• 13) Brenner, D. E., Galloway, S., Cooper, J., Noone, R. and Hande, K. R.:Improved high-performance liquid chromatography assay of doxorubicin:Detection of circulating aglycons in human plasma and comparison with thin-layer chromatography. Cancer Chemother. Pharmacol. 14:39-145(1985)

• 14) Himmelstein, K. J., Patton, T. F., Belt, R. J. Taylor, S., Repta, A. J. and Sternson, L. A.:Clinical kinetics of intact cisplatin and some related species, Clin. Pharmatol. Ther. 29:658-664(1981)

• 15) Shimoyama, M.:Cytocidal action of anti-cancer agents:evaluation of the sensitivity of cultured animal and human cancer cells. In "Comparative Leukemia Research 1973, Leukemogenesis," eds. Y. Ito and R. M. Dutcher. pp.711-722(1975),University of Tokyo Press, Tokyo.

• 16) Kudo, K.:Analysis of the clinical results of chemotherapies for metastatic breast cancer, with special reference to "massive-dose cyclic" schedules. In "Current Chemotherapy and Infectious Disease" (Proc, 11th ICC and ICAAC),pp.1665-1667(1980). American Society of Microbiology, Washington, D. C.

• 17) Lawrence, J. R., Steele, W. H., Stuart, J. F. B., McNeill, C. A., McVie, J. G. and Whiting, B.:Dose dependent methotrexate elimination following bolus intravenous injection. Eur. J. Clin. Pharmacol. 17:371-374(1980)

• 18) Boerrigter, G. H., Heinerman, E. C. M., Braakhuis, B. J. M. and Snow, G. B.:Chemosensitivity of human head and neck cancer xenografts in the clonogenic assay and in nude mice. Br. J. Cancer 54:53-59(1986)

• 19) Braakhuis, B. J. M, Leyva, A., Schoevers, E. J., Boerrigter, G. H., Schornagel, J. H. and Snow, G. B.:Lack of effect of methotrexate on human head and neck tumors transplanted in athymic nude mice. Acta Otolaryngol. 99:208-213(1985)

P.57 掲載の参考文献

• 1) 田口鐵男:胃がんの術後補助化学療法の現況. 癌と化学療法 16:2169-2172(1989)

• 2) 小川一誠:進行胃癌の化学療法. 癌と化学療法 16:2161-2168(1989)

• 3) Ramming, K. P. and Haskell, C. M.:Stomach cancer. In "Cancer Treatment", ed. C. M. Haskell, pp.257-271(1985), W. B. Saunders Co., Philadelphia.

• 4) 小川一誠:進行食道癌・胃癌化学療法の現況. 癌と化学療法 9:2097-2103(1982)

P.65 掲載の参考文献

• 1) Sarna, G. P., Holmes, E. C., Petrovich, Z. and Figlin, R. A.:Lung cancer, In "Cancer Treatment(2nd ed)," ed. C. M. Haskell, pp.180-211(1985). W. B. Saunders Co. Philadelphia.

• 2) 富永祐民, 広瀬かおる, 黒石哲生:日本におけるがん死亡の将来予測. 癌と化学療法 16:101-111(1989)

• 3) 西条長宏:非切除肺癌の集学的治療. 臨床科学 19:1230-1239(1983)

• 4) Ota, K. and Nishimura, M:Present status of lung cancer chemotherapy in Japan. In "New Anticancer Drugs (Recent Result Cancer Res. vol. 70) 1), eds. S. K. Carter and Y. Sakurai, pp.167-177(1980). Springer-Verlag, Berlin, Heiderberg.

• 5) Saijo, N. and Niitani. H.:Experimental and clinical effect of ACNU in Japan, with emphasis on small-cell carcinoma of the lung. Cancer Chemother. Pharmacol. 4:165-171(1980)

• 6) Hansen, H. H.:Management of small cell anaplastic carcinoma. In "Lung Cancer 1980 (II World Conference)," pp.113-132(1980), Excerpta Medica, Amsterdam.

• 7) Selawry, O. S.:Monochemotherapy of bronchogenic carcinoma with special reference to cell type. Cancer Chemother. Rep. 4:177-188(1973)

• 8) Joss, R. A., Cavalli, F. Goldhirsch, A, and Brunner, K.:New drugs in small cell lung cancer. Cancer Treat. Rev. 13:157 176(1986)

• 9) Bakowski, M. T and Crouch,J. C.:Chemotherapy of non-small cell lung cancer:a reappraisal and a look to the future. Cancer Treat. Rev. 10:159-172(1983)

• 10) 藤田次郎, 西条長宏:Non-small cell carcinomaに対するPhase II study.治療 67:1059-1067(1985)

P.71 掲載の参考文献

• 1) Haskell, C. M., Giuliano, A. E., Thompson, R. W. and Zarem, H, A.:Breast cancer. In: "Cancer Treatment (2nd ed.)" ed. C. M. Haskell, pp.137-180(1985), W. B. Saunders Co. Philadelphia.

• 2) 富永祐民, 広瀬かおる, 黒石哲生:日本におけるがん死亡の将来予測. 癌と化学療法 16:101-111(1989)

• 3) 泉雄 勝:再発乳癌の病態. 癌と化学療法 12:412-420(1985)

• 4) 寺沢敏夫, 小山博記, 和田富雄, 西沢征夫, 芝 英一, 梶田明義:再発乳癌の治療概論. 癌と化学療法 12:428-438(1985)

P.77 掲載の参考文献

• 1) Kornblith, P, L. and Walker, M.:Chemotherapy for malignant gliomas. J. Neurosurg. 68:1-17(1988)

• 2) 生塩之敬, 早川 徹, 最上平太郎:グリオーマの化学療法. 癌と化学療法 4:497-505(1977)

• 3) 星野孝夫:脳腫瘍の化学療法. 脳と神経 28:739-750(1976)

• 4) Hirano, A., Matsui, T.:Vascular structures in brain tumors. Hum. Pathol. 6:611-621(1975)

• 5) 小林知雄:血液脳関門と脳腫瘍の化学療法. 癌と化学療法 8:655-663(1981)

P.91 掲載の参考文献

• 1) 加藤孝子, 石毛英男, 小林 治・他:難治性絨毛癌に対する合理的化学療法の検討. 癌と化学療法 9:815-821(1982)

• 2) Goldstein, D. P., Winig, P. C. and Shirley, R. L.:Actinomycin D as initial therapy of gestational trophoblastic disease. A reevaluation. Obstet. Gynecol. 39:341-345(1972)

• 3) Sung, H. C., Wu, P. C. and Yang, H. Y.:Reevaluation of 5-fluorouracil as a single therapeutic agent for gestational trophoblastic neoplasms. Am. J. Obstet. Gynecol. 150:69-75(1984)

• 4) 井出上昭久, 桑原 仁:Actinomycin Dの絨毛性腫瘍における使用経験. 産婦人科の実際 19:432-436(1970)

• 5) Hertz, R., Lewis, J. and Lipsett, M. B.:Five years' experience with the chemotherapy of metastatic choriocarcinoma and related trophoblastic tumors in women. Am. J. Obstet. Gynecol. 82:631-640(1961)

• 6) 塩野義製薬の臨床文献集より

• 7) Song, H. Z, Xia, Z., Wu, B. et al.:20 years' experience in chemotherapy of choriocarcinoma and malignant mole. Chinese Med. J. 92:677-687(1979)

• 8) Bonadonna, G., Monfardini, S., DeLena, M. et al.:Clinical evaluation of adriamycin, a new antitumor antibiotic. Br. Med. J. 3:503-506(1969)

• 9) 竹内正七, 金沢浩二:シスプラチンの臨床的意義をめぐって. 臨床応用への試み, 絨毛癌. Prog. Med. 6:2585-2588(1986)

• 10) Ueyama, Y., Morita, K., Yokoyama, M. et al.:Establishment and maintenance of human malignant tumors serially transplanted to nude mice. In "Proc. 2nd Int. Workshop on Nude Mice", eds. T. Nomura, N. Ohsawa, N. Tamaoki, K. Fujiwara. pp.365-374(1977), Univ. of Tokyo Press, Tokyo.

• 11) 富永 健:進行・再発大腸癌の化学療法. 癌と化学療法 13:2298-2306(1986)

• 12) 古江 尚:膵癌. 「癌化字療法の基礎と臨床」 (古江 尚, 太田和雄, 田口鐵男, 仁井谷久暢, 藤田 浩, 塚越 茂編) pp.469-471(1986), 癌と化学療法社, 東京.

P.98 掲載の参考文献

• 1) Berger, D. P., Fiebig, H. H., Winterhalter, B. R., Wallbrecher, E. and Henss, H.:Preclinical phase II study of ifosfamide in human tumour xenografts in vivo. Cancer Chemother, Pharmacol. 26(Suppl.):7-11(1990)

• 2) 久保田哲朗, 中田宗彦, 花谷勇治, 露木 建, 浅沼史樹, 石引久弥, 阿部令彦:ヌードマウス可移植性ヒト癌における制癌剤感受性を決定する因子について. 最新医学 37:1438-1442(1982)

• 3) Mattern, J., Wayss, K. and Volm, M.:Effect of five antineoplastic agents on tumor xenografts with different growth rates. JNCI 72:1335-1339(1984)

• 4) 藤田史子:ヌードマウス移植ヒト消化器癌および乳癌株の抗癌剤感受性に関与する因子の解析. 日癌治会誌 22:2331-2346(1987)

P.105 掲載の参考文献

• 1) Ozawa, S., Sugiyama, Y., Mitsuhashi, Y., Kobayashi, T. and Inaba, M.:Cell killing action of cell cycle phase non-specific antitumor agents is dependent on concentration-time product. Cancer Chemother. Phamacol. 21:185-190(1988)

• 2) 下山正徳, 木村禧代二:化学療法. 「人癌細胞の培養」 (大星章一, 管野晴夫編) pp.3823-3828(1975), 朝倉書店, 東京.

• 3) Ozawa, S., Sugiyama, Y., Mitsuhashi, J. and Inaba, M.:Kinetic analysis of cell killing effect induced by cytosine arabinoside and cisplatin in relation to cell cycle phase specificity in human colon cancer and Chinese hamster cells. Cancer Res. 49:3823-3828(1989)

• 4) 久保田哲朗:未発表データ

• 5) Wagner, T., Heydrich, D., Jork, T., Veelcker, G. and Hohorst, H. J.:Comparative study on human pharmacokinetics of activated ifosfamide and cyclophosphamide by a modified fluorometric test. J. Cancer Res. Clin. Oncol. 100:95-104(1981)

• 6) Nakamura, K., Asami, M., Kawada, K. and Sasahara, K.:Quantitative determination of ACNU (3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride), a new water-soluble antitumor nitrosourea, in biological fluids and tissues of patients by high-performance liquid chromatography. I, Analytical method and pharmacokinetics. Ann. Rep. Sankyo Res. Lab. 29:66-74(1977)

• 7) Himmelstein, K. J., Patton, T. F., Belt, R. J., Taylor, S., Repta, A. J. and Sternson, L. A.:Clinical kinetics of intact cisplatin and some related species. Clin. Pharmacol. Ther. 29:658-664(1981)

• 8) Brenner, D. E., Galloway, S., Cooper, J., Noone, R. and Hande, K. R.:Improved high-performance liquid chromatography assay of doxorubicin:Detection of circulating aglycons in human plasma and comparison with thin-layer chromatography. Cancer Chemother. Pharmacol. 14:139-145(1985)

P.123 掲載の参考文献

• 1) Povlsen, C. O. and Rygaard. J.:Effects of cyclophosphamide (Endoxan) on a Burkitt lymphoma serially grown in nude mice. In "Proc. 1st Int. Workshop on Nude Mice", eds. J. Rygaard and C. O. Povlsen, pp.285-292(1974), Gustav Fischer Verlag, Stuttgart.

• 2) Tomayko, M. M. and Reynolds, C. P.:Determination of subcutaneous tumor size in athymic (nude)mice. Cancer Chemother. Pharmacol. 24:148-154(1989)

• 3) 藤田史子, 藤田昌英, 木本安彦, 下妻晃二郎, 田口鐵男:ヌードマウス移植ヒト消化器癌および乳癌の各種抗癌剤に対する感受性. 癌と化学療法 12:353-361(1985)

• 4) Ovejera, A. A., Houchens, D. P. and Barker, A. D.:Chemotherapy of human tumor xenografts in genetically athymic mice. Ann. Clin. Lab. Sci. 8:50-56(1978)

• 5) Shorthouse, A. J., Jones, J. M., Steel, G. G. and Peckham, M. J.:Experimental combination and single-agent chemotherapy in human lung-tumour xenografts. Br. J. Cancer 46:35-44(1982)

• 6) Arai, T., Okamoto, K., Terao, K., Tokita, H., Sekimoto, K., Fukushima, T. and Tanaka, N.:Effectiveness of antitumor agents against human tumors in nude mice. In "Proc. 2nd Int. Workshop on Nude Mice", eds. T. Nomura, N. Ohsawa, N. Tamaoki and K. Fujiwara, pp.461-474(1977), University of Tokyo Press, Tokyo.

• 7) Freireich, E J., Gehan, E. A., Rall, D. P., Schmidt, L. H. and Skipper, H. E.:Quantitative comparison of toxicity of anticancer agents in mouse, cat, hamster, dog, monkey and man. Cancer Chemother. Rep. 50:219-244, (1966)

• 8) Bailey, M. J., Gazet, J. C., Smith, I. E. and Steel, G. G.:Chemotherapy of human breastcarcinoma xenografts. Br. J. Cancer. 42:530-536, (1980)
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• 9) Povlsen, C. O.:Growth of human tumors in nude mice and chemotherapy studies in this model. In "Proc. Sym. The Use of Athymic (Nude)Mice in Cancer Res", eds. D. P. Houchens and A. A. Ovejera, pp.187-194(1978). Gustav Fischer, New York.

• 10) Osieka, R. and Johnson, R. K.:Evaluation of chemical agents in phase I clinical trial and earlier stages of development against xenografts on human colon carcinoma. eds. D. P. Houchens and A. A. Ovejera, pp.217-223(1978), Gustav Fischer, New York.

• 11) Ovejera, A. A., Houchens. D. P. and Barker, A. D.:Sensitivity of a human tumor xenograft in nude(athymic)mice to various clinically-active drugs. In "Proc. 2nd Int. Workshop on Nude Mice", eds. T. Nomura, N. Ohsawa, N. Tamaoki and K. Fujiwara, pp.451-460(1977), University of Tokyo Press, Tokyo.

• 12) Fujita, M., Fujita, F. and Taguchi, T.:Chemosensitivity of human gastrointestinal and breast cancer xenografts in nude mice and predictability to clinical response of anticancer agents. In "Immune-Deficient Animals", ed. B. Sordat, pp.311-315(1984), Karger, Basel.

• 13) Houchens, D. P., Ovejera, A. A. and Barker, A. D.:The therapy of human tumors in athymic (nude)mice. In "Proc. Sym. The Use of Athymic (Nude)Mice in Cancer Research", eds. D. P. Houchens and A. A. Ovejera, pp.267-280(1978). Gustav Fischer, New York.

• 14) Giovanella, B, C., Stehlin, J. S. and Shepard, R. C.:Experimental chemotherapy of human breast carcinomas heterotransplanted in nude mice. In "Proc. 2nd Int. Workshop on Nude Mice", eds. T. Nomura, N. Ohsawa, N. Tamaoki and K. Fujiwara, pp.475-481(1977), University of Tokyo Press, Tokyo.

• 15) Giuliani, F. C., Zirvi, K. A. and Kaplan, N. O.:Therapeutic response of human tumor xenografts in athymic mice to doxorubicin. Cancer Res. 41:325-335(1981)

• 16) Shorthouse, A. J., Peckham, M. J., Smyth, J. F. and Steel, G. G.:The therapeutic response of bronchial carcinoma xenografts:A direct patient-xenograft comparison. Br. J. Cancer 41 (Suppl) IV:142-145(1980)

• 17) Steel, G. G., Courtenay, V. D. and Peckham, M. J.:The response to chemotherapy of a variety of human tumour xenografts. Br. J. Cancer 47:1-13(1983)

• 18) Fodstad, Φ., Aass, N. and Pihl, A.:Response to chemotherapy of human, malignant melanoma xenografts in athymic, nude mice. Int. J. Cancer 25:453-458(1980)

• 19) Taetle, R., Rosen, F., Abramson, I., Venditti, J. and Howell, S.:Use of nude mouse xenografts as preclinical drug screens:In vivo activity of established chemotherapeutic agents against melanoma and ovarian carcinoma xenografts. Cancer Treat. Rep. 71:297-304(1987)

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第二部 抗癌剤評価に用いるヌードマウスとヒト腫瘍株

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(付1) 腫瘍の移植方法

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