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書籍詳細

未契約
書籍名 免疫腫瘍学入門
出版社 癌と化学療法社
発行日 1981-09-30
著者
  • 小林博(編著)
ISBN
ページ数 394
版刷巻号 初版
分野
閲覧制限 未契約

本書はあらためて腫瘍免疫学としてではなく、癌研究を狙いとする免疫腫瘍学の立場に立ってみた。ここで敢て検索可能な免疫学の目を通して、「癌」をいかに考えていくかが本書の狙いである。(序文より)

目次

  • 表紙
  • 序文
  • 執筆者一覧
  • 目次
  • 1. 免疫腫瘍学の問題点
    • 癌特異抗原
    • Escape Mechanism
    • 癌の予防・治療への道
  • 2. 腫瘍抗原
    • 定義と分類
    • 抗原性の高低
    • 抗原性のheterogeneity
    • 抗原の証明法
    • 抗原の存在様式
  • 3. 分化関連抗原
    P.28閲覧
    • 癌胎児抗原
    • 不適性組織適合抗原
  • 4. 誘発抗原
    P.42閲覧
    • ウイルス誘発癌抗原
    • 物理作用誘発癌抗原
    • 化学物質誘発癌抗原
    • 自然発生癌抗原
  • 5. 動物の腫瘍特異抗原
    P.56閲覧
    • 可溶化の方法と精製
    • 生化学的性状
    • 免疫学的性状
  • 6. ヒトの腫瘍特異抗原
    P.71閲覧
    • 細胞性免疫反応による人癌抗原の検出
    • 体液性免疫反応による人癌抗原の検出
  • 7. 腫瘍特異抗原性の上昇
    P.82閲覧
    • 物理学的処理細胞の免疫原性
    • 化学物質処理細胞の免疫原性
    • ウイルス感染細胞の抗原性
    • 融合細胞の免疫原性
    • 腫瘍細胞を異物と混合した時のTAAの免疫原性
    • 免疫原性の高い腫瘍細胞を得る方法とその使用法
  • 8. 腫瘍細胞の異物化
    P.97閲覧
    • 化学物質による異物化
    • ウイルスによる異物化
    • 新しく獲得された異物抗原のTAA抗原性に果たす役割
  • 9. 発癌と免疫監視
    P.105閲覧
    • 免疫監視説
    • 発癌と胸腺
    • 免疫監視説の問題点
  • 10. 発癌要因と免疫抑制
    P.110閲覧
    • ウイルスと免疫抑制
    • 放射線と免疫抑制
    • 化学物質と免疫抑制
  • 11. 発癌と宿主要因
    P.123閲覧
    • ホルモンと免疫と発癌
    • 加令と免疫と発癌
    • 妊娠と免疫と発癌
  • 12. 腫瘍拒絶と細胞性免疫
    P.133閲覧
    • 細胞障害性T細胞
    • Antibody-dependent cell-mediatedcytotoxicity (ADCC)
    • 武装化マクロファージ
    • 活性化炎症細胞
    • Natural KilleT (NK)
    • 生体内腫瘍拒絶における細胞性免疫
    • 腫瘍に対する遅延型過敏症とそのin vitroにおける表現
  • 13. 腫瘍拒絶と液性抗体
    P.151閲覧
    • 抗腫瘍抗体
    • 腫瘍に対する液性免疫反応
    • 液性免疫の細胞性免疫に及ぼす作用
    • 腫瘍が液性免疫の攻撃から逃れる機序
    • 抗腫瘍自然抗体
  • 14. 腫瘍免疫と組織適合抗原遺伝子
    P.161閲覧
    • 組織適合抗原の遺伝子支配
    • 腫瘍関連抗原の遺伝子支配
    • 免疫担当細胞表面抗原及びレセプターの遺伝子支配
    • 抗原認識過程における組織適合抗原の役割
  • 15. 腫瘍免疫とIr遺伝子
    P.171閲覧
    • 免疫応答の遺伝子支配
    • 発癌の遺伝子支配
    • 腫瘍の免疫学的移植抵抗性の遺伝子支配
    • 人癌の遺伝子支配
  • 16. 腫瘍免疫と細胞工学
    P.182閲覧
    • 細胞融合
    • 雑種細胞における遺伝子発現
    • ハイブリドーマ
    • 細胞内物質移入
  • 17. 癌細胞の免疫学的逃避
    P.195閲覧
    • 癌細胞膜面の抗原表現阻止物質
    • 癌増殖の免疫学的促進
    • 阻止因子の誘出
  • 18. 担癌体の免疫抑制
    P.205閲覧
    • 担癌生体における免疫抑制血清因子
    • 担癌体における免疫抑制細胞の役割
    • 担癌時期と免疫能
  • 19. 癌と免疫異常症
    P.217閲覧
    • 癌と免疫異常症の合併
    • 動物の免疫異常症とこれに癌の合併する機序
    • 人間の免疫異常症とこれに癌の合併する機序
    • 免疫異常症と癌における遺伝的因子の関与
  • 20. 人癌の免疫学的診断
    P.233閲覧
    • 免疫診断のための要因
    • 癌胎児性蛋白
    • 腫瘍関連抗原と臓器特異抗原
  • 21. 癌患者の免疫能
    P.247閲覧
    • 免疫能測定の意義
    • 細胞性免疫能の測定方法
    • 血清成分による免疫能測定
    • 生体内での測定法
  • 22. 癌の免疫療法の概念
    P.262閲覧
    • 癌の免疫療法の分類
    • 特異的活動免疫療法
    • 非特異的活動免疫療法
    • 受動免疫療法
  • 23. 癌の免疫療法の実際
    P.279閲覧
    • 免疫療法の歴史
    • 免疫療法の現況
    • 免疫療法の実際
    • 効果判定と評価
  • 24. 癌の免疫外科
    P.289閲覧
    • 外科手術と患者の免疫能
    • 癌の転移と免疫
    • リンパ節郭清と免疫
    • 凍結外科・温熱療法と免疫
    • 外科手術と免疫化学療法
  • 25. 癌の免疫放射線療法
    P.298閲覧
    • 癌細胞の放射線感受性
    • 放射線による免疫療法
    • 放射線照射と生体免疫
  • 26. 癌の免疫化学療法
    P.304閲覧
    • 制癌剤の生体免疫に及ぼす影響
    • 免疫化学療法の基礎
    • 免疫化学療法の臨床
    • 抗体結合制癌剤を用いる免疫化学療法
  • 27. 癌の免疫学的予防
    P.316閲覧
    • 非特異免疫による発癌予防
    • 特異免疫による発癌予防
  • 28. 免疫腫瘍学への将来の期待
    P.322閲覧
    • まとめ
  • 文献
    P.329閲覧
  • 索引
    P.374閲覧
  • 奥付

参考文献

2. 腫瘍抗原

P.7 掲載の参考文献

  • 1) 日本免疫学会(編) :免疫実験操作法, A. 日本免疫学会, 1978.
  • 2) 日本免疫学会(編) :免疫実験操作法, B. 日本免疫学会, 1978.
  • 3) Gaylord, H. R. and Clows, G. H. A.:Spontaneous regression of cancer. Gynec. Obstet, 2:633-639, 1903.
  • 4) Aberev, G. I., Perova, S. D., Khramkova, N. I., Postnikova, Z. A. and Irlin, I. S.:Production of embryonal α-globulin by transplantable mouse hepatomas. Transplantation, 1:174-180, 1963.
  • 5) Klein, G., Sjogren, H. O. and Klein, E.:Demonstration of host resistance against sarcomas induced by implantation of cellophane films in isologous recipients. Cancer Res, 23:84-92, 1963.
  • 6) Old, L. J., Boyse, E. A. and Stockert, E.:Antigenic properties of experimental leukemias. J. Natl. Cancer Inst., 31:977-986, 1963.
  • 8) Tatarinov, J.:Detection of embryospecific α-globulin in the blood of patients with primary liver tumors. Vopn. Med. Klin., 10:90-91, 1964.
  • 9) Everson, R. C. and Cole, W. H.:Spontaneous regression of cancer. Saunders Company, Philadelphia, 1966.
  • 10) Rosenau, W. and Morton, D. L.:Tumor-specific inhibition of growth of methylcholanthrene-induced sarcomas in vivo and in vitro by sensitized isologous lymphoid cells. J. Natl. Cancer Inst., 36:825-836, 1966.
  • 11) Takeda, K., Kikuchi, Y., Yamawaki, S., Ueda, T. and Yoshiki, T.:Treatment of artificial metastases of methylcholanthrene-induced rat sarcomas by autoimmunization of the autochthonous hosts. Cancer Res., 28:2149-2154, 1968.
  • 12) Takemoto, K. K., Ting, R. C. Y., Ozer, H. L. and Fabish, P.:Establishment of a cell line from an inbred mouse strain for transformation studies:Simian virus 40 transformation and tumor production. J. Natl. Cancer Inst., 41:1401-1409, 1969.
  • 13) Coggin, J. H., Ambrose, K. R. and Anderson, N. G.:Fetal antigen capable of inducing transplantation immunity against SV40 hamster tumor cells. J. Immunol., 105:525-529, 1970.
  • 14) Taylor, R. B., Duffus, W. P. H., Raff, M. C. and de Petris, S.:Redestribution and pinocytosis of limphocytes surface immunoglobulin molecules induced by anti-immunoglobulin antibody. Nature New Biol., 223:317-321, 1971.
  • 16) Bartlet, G. L.:Effect of host immunity on the antigenic strength of primary tumors. J. Natl. Cancer Inst., 49:493-504, 1972.
  • 19) Kobayashi, H., Kuzumaki, N., Gotohda, E., Takeichi, N., Sendo, F., Hosokawa, M. and Kodama, T.:Specific antigenicity of tumors and immunological tolerance in the rat induced by Friend, Gross and Rauscher viruses. Cancer Res., 33:1598-1603, 1973.
  • 20) Kodama, T., Gotohda, E. and Kobayashi H.:Immunoelectron microscopic studies on surface antigens of rat tumor cells infected with Friend virus. Gann, 64:475-479, 1973.
  • 21) Kodama, T., Takeichi, N., Gotohda, E. and Kobayashi, H.:Electron microscopic studies on sialoglycoprotein layer of rat Friend tumor cells. Gann, 64:613-616, 1973.
  • 22) Ishidate, M.:Antigenic spicificity of different cell lines of rat ascites hepatoma originating in the same individual. Gan Monograph of Cancer Res., 16:195-210, 1974.
  • 27) Simmons, R. L. and Rios, A.:Comparative immunotherapeutic effect of concanavalin A and neuraminidase-treated cancer cells. Transplantation. Proc., 7:247-251, 1975.
  • 31) Heppner, G. H., Dexter, D. L. and Miller, F. R.:Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor. Cancer Res., 38:3758-3763, 1978.
  • 32) Stackpole, C. W. and Jacobson, J. B.:Antigenic modulation. In The Handbook of Cancer Immunology, ed. by Waters, H., Garland STPM Press, New York & London, Vol. 2:55-159, 1978.
  • 34) Kodama, T.:Lateral mobility and stabilized expression of tumorassociated surface antigen in xenogenized tumor cells. In GANN Monogr. Cancer Res., ed. by Kobayashi, H., Japan Scientific Societies Press, Tokyo, No. 23:57-63, 1979.

3. 分化関連抗原

P.28 掲載の参考文献

  • 1) 西 信三, 平井秀松:CEA (Carcinoembryonic antigen) の測定法. 臨床病理臨時特集 25:55-68, 1976.
  • 2) 佐藤清美:アイソザイムのガン胎児性変異, 特にグリコーゲンホスホリラーゼについて. 生化学, 49:1091-1119, 1977.
  • 3) 平井秀松:抗体抗原, Carcino-embryonic antigen. 総合臨床, 27:2437-2446, 1978.
  • 4) 東野一彌, 波田寿一:癌とアルカリホスファターゼ. 代謝, 16:215-223, 1979.
  • 5) 新津洋司郎:腫瘍マーカーIsoferritin. 臨床科学, 16:857-862, 1980.
  • 6) 西 信三:Alpha-fetoprotein (AFP) , 基礎の立場から. 臨床科学, 16:793-800, 1980.
  • 7) 平井秀松:癌胎児共通表現形質. 代謝, 17, 8月臨時増刊:211-228, 1980.
  • 8) Bodmer, W. F.:A new model for allelism at histocompatibility and other complex loci.:Polymorphism for control of gene expression. Transplant. Proc., 5:1471-1475, 1973.
  • 9) Martin, W. J., Esber, E., Cotton, W. G. and Rice, J. M.:Derepression of alloantigens in malignancy:Evidence for tumor susceptibility alloantigens and for possible self-reactivity of lymphoid cells active in the microcytotoxicity assay. Br. J. Cancer, 28:(Suppl. I) :48-61, 1973.
  • 22) Imamura, M., Gipson, T. G., Bensky, N., Justice, R. and Martin, W. J.:Lung tumor reactive cytotoxic lymphocytes generated in mixed lymphocyte culture between C3HfeB/HeN (H-2kb) and C3H/HeN(H-2k) strain mice. J. Immunol., 123:1863-1866, 1979.
  • 27) Finke, J. H., Fyfe, D. A., Del Villano, B. C., Butler, G. H. and Ponzio, N. H.:Characterization of "foreign" alloantigen-like specificities on a murine lymphoma cell lines. Transplant. Proc., 12:53-58, 1980.
  • 28) Greene, M. I. and Perry, L. L.:The relationship of alloreactivity to syngeneic tumor immunity. Transplant. Proc., 12:80-86, 1980.
  • 30) McAlack, R. F.:Normal HLA phenothypes and neo-HLA-like antigens on cultured human neuroblastoma. Transplant. Proc., 12:107-113, 1980.
  • 31) Schimidt, W. and Festenstein, H.:Serological and immunochemical studies of allospecificities on K36, a syngeneic lymphoma of AKR. J. Immunogenet. 7:7-17, 1980.

4. 誘発抗原

P.42 掲載の参考文献

  • 1) 中村恭二:ラットのメチルコラントレン肉腫の抗原共通性. 癌の免疫病理, 3:28-35, 1967.
  • 2) 菊地浩吉:癌組織におけるリンパ系反応, 人癌と免疫 (藤井源七郎編) . ライフサイエンス社, pp. 67-73, 1976.
  • 3) Foley, E. J.:Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin. Cancer Res., 13:835-843, 1953.
  • 6) Sjogren, H. O.:Transplantation methods as a tool for detection of tumor specific antigens. Progr. Expr. Tumor Res., 6:289-322, 1965.
  • 9) Reiner, J. and Southam, C. M.:Evidence of common antigenic properties in chemically induced sarcomas of mice. Cancer Res., 27:1243-1247, 1967.
  • 11) Zbar, B., Wepsic, H. T., Rapp, H. J., Borsos, T., Kronman, B. S. and Churchill, W. H.:Antigenic specificity of hepatomas induced in strain-2 guinea pigs by diethylnitrosoamine. J. Natl. Cancer Inst., 43:833-842, 1969.
  • 12) Outzen, H. C., Andrews, E. J., Basombrio, M. A., Litwin, S., and Prehn, R. T.:Attempted induction of tumor antigen in carcinogen-treated cells. J. Natl. Cancer Inst., 49:1295-1302, 1972.
  • 23) Hellstrom, I. and Hellstrom, K. E.:Cyclophosphamide delays 3-methyl-cholanthrene sarcoma induction in mice. Nature, 275:129-130, 1978.

5. 動物の腫瘍特異抗原

P.56 掲載の参考文献

  • 1) 名取 孝, 相沢幹:腫瘍特異的移植抗原の物性に関する研究の概況. 医学のあゆみ, 105:861, 1978.
  • 2) 山岸久一, Pellis N. R. and Kahan B. D.:メチールコラントレン誘発腫瘍抗原(TSTA) の解析. isoelectric focusingによるtumor-facilitating antigenとtumor-protective antigenの分画, 医学のあゆみ. 109:432-434 1979.
  • 14) Natori, T., Law, L. W. and Appella, E.:Biological and biochemical properties of Nonidet P40-solubilized and partially purified tumor-specific antigens of transplantation type from plasma membranes of a methylcholanthrene-induced sarcoma. Cancer Res., 37:3406, 1977.
  • 18) Luborsky, S. W., Chang, C. et al.:Comparative behavior of simian virus 40 T-antigen and of tumor specific surface and transplantation antigens during partial purification. Cancer Res., 38:2367, 1978.
  • 19) Natori, T., Law, L. W and Appella, E.:Immunocheimcal eviedence of a tumor-specific surface antigen obtained by detergent solubilization of the membranes of a chemically induced sarcoma, Meth-A. Cancer Res., 38:359, 1978.

6. ヒトの腫瘍特異抗原

P.71 掲載の参考文献

  • 1) 山村雄一, 桜井欽夫, 木村禧代二 (監修) :人癌と免疫. (藤井源七郎他編) ライフサイエンス, 1976.
  • 2) 珠玖洋, 高橋利忠:ヒトの癌細胞抗原. 代謝, 15:157-160, 1978.
  • 4) Waters, H. (ed.) :The Handbook of Cancer Immunology. Garland STPM press, New York and London, 1978.

7. 腫瘍特異抗原性の上昇

P.82 掲載の参考文献

  • 2) Lin, J. S. L., Huber, N. and Murphy, W. H.:Immunization of C58 mice to line Ib leukemia. Cancer Res., 29:2157, 1969.
  • 4) Braun, W., Plescia, O. L., Paskova, J. and Wehl D.:Basic proterins and synthetic polynucleotides as modifiers of immunogenicity of syngeneic tumor cells. Israel J. Med. Sci., 7:72, 1971.
  • 5) Prager, M. D. Baechtel, F. S., Ribble, R. J., Ludden, C. M. and Mehta, J. M.:Immunological stimulation with modified lymphoma cells in a minimally responsine tumorhost system. Cancer Res., 34:3203, 1974.
  • 6) Frost, P. and Sanderson, C. J.:Tumor immunoprophyloxis in mice using glhtaraldehyde-treated syngeneic tumor cells. Cancer Res., 35:2646, 1975.
  • 9) Prager, M. D. and Gordon, W. C.:Enhanced response to chemoimmunotherapy and immunoprophyloxis using tumor associated antigens with a lipophilic agent. Cancer Res., 38:2052, 1978.
  • 11) Takatsu, K., Tominaga, A. and Late Kitagawa, M.:Induction of antitumor activity in mice presansitized with Mycobacterium by immunization with tuberculin-coated tumor. Gann, 69:597, 1978.
  • 12) Takeichi, N., Austin, F. C., Oikawa, T. and Boone, C. W.:Augmented immunogenicity of tumor cell membranes produced by infection with influenza virus as compared to Moloney sarcoma virus. Cancer Res., 38:4580, 1978.
  • 14) Bartelett, G. L. and Kreider, J. W.:Active, tumor-specific immunotherapy of LSTRA murine leukemia using irradiated cells and corynebacterium parvum. Proc., AACR and ASCO, 20:189, 1979.
  • 15) Kim, K. S.:Tumor-specific immunity induced by somatic hybrids, II. Elicitation of enhanced immunity against the parent plasmacytoma. J. Immunol, 123:739, 1979.
  • 17) Moriuchi, T. and Kobayashi, H.:Role of virus-associated antigen on xenogenized tumor cell surface in production of antibody against tumor-associated antigen. GANN Monogr. Cancer Res., 23:65, 1979.
  • 18) Oikawa, T., Gotohda, E., Austin, F. C., Takeichi, N. and Boone, C. W.:Temperature-dependent alteration in immunogenicity of tumor-associated transplantation antigen monitored via paraformaldehyde fixation. Cancer Res., 39:3519, 1979.
  • 19) Prager, M. D. and Gordon, W. C.:Immunoprophylaxis and therapy with lipid conjugated lymphoma cells. GANN Monogr. Cancer Res., 23:143, 1979.
  • 20) Schapira, D. V., McCune, C. S. and Hensham, E. C.:Treatment of advanced renal cell carcinoma with specific immunotherapy of autologous tumor cells and C. parvum. Proc. AACR and ASCO, 20:348, 1979.
  • 21) Skornick, Y. and Schinitzky, M.:Effective tumor immunization induce by cells of elevated membrane microviscosity. Abstract of Meeting on Immunological Aspects of Experimental and clinical cancer, Tel Avin, Israel. p. 153, 1979.
  • 24) Kasai, M., Irie, R. F., Holmes, E. C. and Irie, K.:Increased cytotoxic sensitivity of mumps virus-infected melanoma cells to antibody from melanoma patients. Proc. AACR and ASCO, 21:220, 1980.
  • 25) Mizushima, Y., Sendo, F., Takeichi, N., Hosokawa, M. and Kobayashi, H.:Enhancement of antitnmor transplantation resistance in rats by the antileukemia drug busulfan. Submitted to Cancer Res.
  • 26) Mizushima, M., Sendo, F., Miyake, T. and Kobayashi, H.:Augmentation of specific cell-mediated immune responses to tumor cells in tumor bearing rats pretreated with the antileukemia drug busulfan. Submitted to J. Natl. Cancer Inst.

8. 腫瘍細胞の異物化

P.97 掲載の参考文献

  • 2) Kobayashi, H., Sendo, F., Kaji, H., Shirai, T., Saito, H., Takeichi, N., Hosokawa, M. and Kodama, T.:Modification in growth of transplantable rat tumors exposed to Friend virus. J. Natl. Cancer Inst., 42:413, 1969.
  • 5) Basombrio, M. A.:Antigenic conversion of established tumors with the Moloney sarcoma virus. Proc. AACR and ASCO, 13:74, 1972.
  • 6) Yamada, K. and Hatano, M.:Lowered transplantability of cultured tumor cells by persistent infection with paramyxovirus (HVJ) , Gann, 63:647, 1972.
  • 9) Itaya, T., Moriuchi, T., Kodama, T. and Kobayashi, H.:Regression mechanism of xenogenized tumor cells in the view point of humoral immunity. Proc. Cancer Ass., 37:85, 1978.
  • 10) Kodama, T., Kato, H., Gotohda, E., Kobayashi, H. and Sendo, F.:Regression of established tumors in rats by injection of diethylaminoethyl-dextran and Friend murine Leukemia virus., J. Natl. Cancer Inst., 61:403, 1978.
  • 13) Takeichi, N, Austin, F. C., Oikawa, T. and Boone, C. W.:Augmented immunogenicity of tumor cell membranes produced by infection with influenza-virus, Cancer Res., 38:4580, 1978.
  • 16) Takeyama, H., Kawashima, K., Yamada, K. and Ito, Y.:Induction of tumor resistence in mice by L1210 leukemia cells persistently infected with HVJ (Sendai virus) , Gann., 70:493-501, 1979.
  • 17) Yamaguchi, H., Moriuchi, T., Kasai, M., Hosokawa, M., Kodama, T. and Kobayashi, H.:Relationship between immunogenicity and amounts of virus associated antigen in xenogenized tumor cells. Pro. Cancer Ass., 37:73, 1979.
  • 18) Baldwin, R. W.:Personal communication.

9. 発癌と免疫監視

P.105 掲載の参考文献

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10. 発癌要因と免疫抑制

P.110 掲載の参考文献

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11. 発癌と宿主要因

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12. 腫瘍拒絶と細胞性免疫

P.133 掲載の参考文献

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13. 腫瘍拒絶と液性抗体

P.151 掲載の参考文献

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14. 腫瘍免疫と組織適合抗原遺伝子

P.161 掲載の参考文献

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15. 腫瘍免疫とIr遺伝子

P.171 掲載の参考文献

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16. 腫瘍免疫と細胞工学

P.182 掲載の参考文献

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  • 42) Saxton, R. E., Burk, M. W., Irie, R. F. and Morton, D. L.:Melanoma cell surface antigens:Isolation by monoclonal antibody affinity chromatography. AACR proc. 22:299, 1981.

17. 癌細胞の免疫学的逃避

P.195 掲載の参考文献

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18. 担癌体の免疫抑制

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19. 癌と免疫異常症

P.217 掲載の参考文献

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20. 人癌の免疫学的診断

P.233 掲載の参考文献

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21. 癌患者の免疫能

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22. 癌の免疫療法の概念

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23. 癌の免疫療法の実際

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24. 癌の免疫外科

P.289 掲載の参考文献

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25. 癌の免疫放射線療法

P.298 掲載の参考文献

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26. 癌の免疫化学療法

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27. 癌の免疫学的予防

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