書籍詳細

I. 関節リウマチ治療を一変させたTNF阻害療法

P.7 掲載の参考文献

• 1) O'Dell JR : N Engl J Med 340 : 310, 1999
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• 2) Choy EH, Panayi GS : N Engl J Med 344 : 907, 2001
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• 3) 日本リウマチ学会http://www.ryumachi-jp. com/

• 4) Goekoop-Ruiterman YP et al : Ann Rheum Dis 66 : 1227, 2007
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• 5) Goekoop-Ruiterman YP et al : Intern Med 146 : 406, 2007
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• 6) Takeuchi T et al : Ann Rheum Dis 67 : 189, 2008
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• 7) Tokuda et al : Intern Med 47 : 915, 2008
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• 8) Harigai M et al : N Engl J Med 357 : 1874, 2007
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• 9) Komano Y et al : Arthritis Rheum 54 : S516, 2006

• 10) Miyasaka N et al : Mod Rheumatol 15 : 4, 2005

• 11) Komano Y et al : Arthritis Rheum 54 : S516, 2006

• 12) Nathan DM et al : J Gastroenterol Hepatol 21 : 1366, 2006
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• 13) Chung ES et al : Circulation 107 : 3133, 2003
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• 14) Kwon HJ et al : Ann Intern Med 138 : 807, 2003
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• 15) Mohan N et al : Arthritis Rheum 44 : 2862, 2001
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• 16) Cheifetz A et al : Am Con of Gastroenterology 98 : 1315, 2003

P.17 掲載の参考文献

• 1) Miyasaka N, Takeuchi T, Eguchi K : Guidelines for the proper use of etanercept in Japan. Mod Rheumatol ; 16 : 63, 2006
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• 2) Klareskog L, van der Heijde D, de Jager JP, Gough A, Kalden J, Malaise M et al : Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis : double-blind randomised controlled trial. Lancet ; 363 : 675, 2004
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• 3) Van Der Kooij SM, Van Der Bijl AE, Allaart CF, Goekoop-Ruiterman YPM, De Vries-Bouwstra JK, Gerards AH, et al : Remission Induction in Early Rheumatoid Arthritis (RA) with Initial Infliximab (IFX) and Methotrexate (MTX) Therapy : The Disease Course After IFX Discontinuation in The Best Trial. Arthritis Rheum ; 54 : S302, 2006

• 4) 日本リウマチ学会ホームページ : 関節リウマチ (RA) に対するTNF阻害療法施行ガイドライン (改訂版), http://www.ryumachi-jp.com/info/080201.html.

• 5) Koike R, Takeuchi T, Eguchi K, Miyasaka N : Update on the Japanese guidelines for the use of infliximab and etanercept in rheumatoid arthritis. Mod Rheumatol ; 17 : 451, 2007
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• 6) Vol.9, 全例調査の中間報告および死亡症例についてエ. ワイス株式会社, 武田薬品工業株式会社, 2008年12月

• 7) Harigai M : Efficacy and safety of etanercept in Japan : results from the postmarketing surveillance with 14,000 rheumatoid arthritis patients. Mod Rheumatol ; 18 : S9, 2008

• 8) Vol.8, ニューモシスチス肺炎および間質性肺炎についての検討結果 (抜粋). ワイス株式会社, 武田薬品工業株式会社, 2008年4月

• 9) Harigai M, Koike R, Miyasaka N : Pneumocystis pneumonia associated with infliximab in Japan. N Engl J Med ; 357 : 1874, 2007
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P.24 掲載の参考文献

• 1) Anderson P J : Tumor necrosis factor inhibitors : clinical implications of their different immunogenicity profiles. Semin Arthritis Rheum 34 : 19-22, 2005

• 2) den Broeder A A, L A Joosten, Saxne T et al : Long term anti-tumour necrosis factor alpha monotherapy in rheumatoid arthritis : effect on radiological course and prognostic value of markers of cartilage turnover and endothelial activation. Ann Rheum Dis 61 : 311-318, 2002

• 3) Weinblatt M E, Keystone E C, Furst D E et al : Long term efficacy and safety of adalimumab plus methotrexate in patients with rheumatoid arthritis : ARMADA 4 year extended study. Ann Rheum Dis 65 : 753-759, 2006
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• 4) Keystone E C, Kavanaugh A E Sharp J T et al : Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy : arandomized, placebo-controlled, 52-week trial. Arthritis Rheum 50 : 1400-1411, 2004

• 5) Burmester G R, Mariette X, Montecucco C et al : Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice : the Research in Active Rheumatoid Arthritis (ReAct) trial. Ann Rheum Dis 66 : 732-739, 2007
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• 6) Burmester G R, Ferraccioli G, Flipo R M et al : Clinical remission and/or minimal disease activity in patients receiving adalimumab treatment in a multinational, open-label, twelve-week study. Arthritis Rheum 59 : 32-41, 2008
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• 7) van de Putte L B, Atkins C, Malaise M et al : Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease modifying antirheumatic drug treatment has failed. Ann Rheum Dis 63 : 508-516, 2004
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• 8) Miyasaka N : Clinical investigation in highly disease-affected rheumatoid arthritis patients in Japan with adalimumab applying standard and general evaluation : the CHANGE study. Mod Rheumatol 18 : 252-262, 2008
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• 9) Breedveld F C, Weisman M H, Kavanaugh A Fet al : The PREMIER study : amulticenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum 54 : 26-37, 2006

• 10) Mease P J, Gladman D D, Ritchlin C T et al : Adalimumab for the treatment of patients with moderately to severely active psoriatic arthritis : results of a double-blind, randomized, placebo-controlled trial. Arthritis Rheum 52 : 3279-3289, 2005
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• 11) Gladman D D, Mease P J, Ritchlin C T et al : Adalimumab for long-term treatment of psoriatic arthritis : forty-eight week data from the adalimumab effectiveness in psoriatic arthritis trial, Arthritis Rheum 56 : 476-488, 2007
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• 12) van der Heijde D, Kivitz A, Schiff M H et al : Efficacy and safety of adalimumab in patients with ankylosing spondylitis : results of a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 54 : 2136-2146, 2006
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• 13) van der Heijde D, Pangan A I., Schiff M H et al : Adalimumab effectively reduces the signs and symptoms of active ankylosing spondylitis in patients with total spinal ankylosis. Ann Rheum Dis 67 : 1218-1221, 2008
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• 14) Furst D E M H Schiff, R M Fleischmann et al : Adalimumab, a fully human anti tumor necrosis factor-alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis. results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis). J Rheumatol 30 : 2563-2571, 2003

• 15) Schiff M H, Burmester G R, Kent J D et al : Safety analyses of adalimumab (HUMIRA) in Efficacy and safety of adalimumab in patients with ankylosing spondylitis : results of a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 54 : 2136-2146, 2006

• 16) Geborek P, Bladstrom A, Turesson C et al : Tumour necrosis factor blockers do not increase overall tumour risk in patients with rheumatoid arthritis, but may be associated with an increased risk of lymphomas. Ann Rheum Dis 64 : 699-703, 2005.

• 17) Bartelds G M, Wolbink G J, Stapel S et al : High levels of human anti-human antibodies to adalimumab in a patient not responding to adalimumab treatment. Ann Rheum Dis 65 : 1249-1250, 2006

• 18) Kay J E L Matteson, B Dasgupta et al : Golimumab in patients with active rheumatoid arthritis despite treatment with methotrexate : arandomized, double-blind, placebo-controlled, dose-ranging study. Arthritis Rheum 58 : 964-975, 2008

P.34 掲載の参考文献

• 1) Nemeth E, Rivera S, Gabayan V et al : IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113 : 1271-1276, 2004

• 2) Nakahara H, Song J, Sugimoto M et al : Anti-interleukin-6 receptor antibody therapy reduced vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum 48 : 1521-1529, 2003
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• 3) Iwakura Y, Ishigame H : The IL-23/IL-17 axis in inflammation. J Clin Invest 116, 1218-1222, 2006
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• 4) Taga T, Kishimoto T : gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 15 : 797-819, 1997
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• 5) Nishimoto N, Yoshizaki Y, Maeda K et al : Toxicity, phamacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis : phase I/II clinical study. J Rheumatol 30 : 1426-1435, 2003

• 6) Nishimoto N, Yoshizaki K, Miyasaka N et al : Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor anti-body : amulticenter, double-blind, placebo-controlled trial. Arthritis Rheum 50 : 1761-1769, 2004

• 7) Maini RN, Taylor PC, Szechinski J et al : Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 54 : 2817-2829, 2006
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• 8) Nishimoto N, Hashimoto J, Miyasaka N et al : Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI) : evidence of clinical and radiographic benefit from an x-ray reader-blinded randomized controlled trial of tocilizumab. Ann Rheum Dis 66 : 1162-1167, 2007

• 9) Gillmore JD, Lovat LB, Persey MR, Pepys MB, Hawkins PN : Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein. Lancet 358 . 24-29, 2001
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• 10) Okuda Y, Takasugi K : Successful use of a humanized anti-interleukin-6 receptor antibody, tocilizumab, to treat amyloid a amyloidosis complicating juvenile idiopathic arthritis. Arthritis Rheum 54 : 2997-3000, 2006
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• 11) Roach DR, Bean AG, Demangel C, France MP, Briscoe H, Britton WJ : TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection. J Immunol 168 : 4620-4627, 2002
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• 12) Yokota S, Imagawa T, Mori M, Miyamae T, Aihara Y, Takei S, Iwata N, Umebayashi H, Murata T, Miyoshi M, Tomiita M, Nishimoto N, Kishimoto T : Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis : arandomised, double-blind, placebo-controlled, withdrawal phase m triaL Lancet 371 (9617) : 998-1006, 2008

• 13) Ito H, Takazoe M, Fukuda Y, Hibi T, Kusugami K, Andoh A, Matsumoto T, Yamamura T, Azuma J, Nishimoto N, Yoshizaki K, Shimoyama T, Kishimoto T : A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 126 : 989-996, 2004
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• 14) Iwamoto M, Nara H, Hirata D, Minota S, Nishimoto N, Yoshizaki K : Humanized monoclonal anti-interleukin-6 receptor antibody for treatment of intractable adult-onset Stilr s disease. Arthritis Rheum 46 : 3388-3389, 2002
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• 15) Nakahara H, Mima T, Yoshio-Hoshino N, Matsushita M, Hashimoto J, Nishimoto N : A case report of a patient with refractory adultonset Still's disease who was successfully treated with tocilizumab over 6 years (in press)

• 16) Nishimoto N, Nakahara H, Yoshio-Hoshino N, Mima T : Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody. Arthritis Rheum 58 : 1197-1200, 2008
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P.42 掲載の参考文献

• 1) Yamanaka H, Tanaka Y et al : Retrospective clinical study on the notable ethcacy and related factors of infliximab therapy in a rheumatoid arthritis management group in Japan (RECONFIRM). Mod Rheumatol 17 : 28-32, 2007

• 2) Tanaka Y, Takeuchi T, Inoue E et al : Retrospective clinical study on the notable efficacy and related factors of in fiximab therapy in a rheumatoid arthritis management group in Japan : one-year clinical outcomes (RECONFIRM-2). Mod Rheumatol 18 (2) : 146-152, 2008

• 3) Klareskog L, van der Heijde D, de Jager JP et al : TEMPO (Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes) study investigators. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis : double-blind randomised controlled trial. Lancet 363 : 675-681, 2004
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• 4) van der Heijde D, Klareskog L, Rodriguez-Valverde V et al : TEMPO Study lnvestigators. Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis : two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial. Arthritis Rheum 54 : 1063-1074, 2006
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• 5) Breedveld FC, Weisman MH, Kavanaugh AF et al : The PREMIER study : amulticenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum 54 : 26-37, 2006

• 6) Quinn MA, Conaghan PG et al : Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal : results from a twelve-month randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 52 : 27-35, 2005
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• 7) van der Bijl AE, Goekoop-Ruiterman YP et al : Infliximab and methotrexate as induction therapy in patients with early rheumatoid arthritis. Arthritis Rheum 56 : 2129-2134, 2007
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• 8) Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Allaart CF et al : Patient preferences for treatment : report from a randomised comparison of treatment strategies in early rheumatoid arthritis (Best trial). Ann Rheum Dis 66 : 1227-1232, 2007
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• 9) Nawata M, Saito K, Nakayamada S et al : Discontinuation of infliximab in rheumatoid arthritis patients in clinical remission. Mod Rheumatol, 2008 (in print)

P.52 掲載の参考文献

• 1) Pinals RS et al : Arthritis Rheum 24 : 1308-1315, 1981
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• 2) Makinen H et al : Clin Exp Rheumatol 24 (Supple 43) : SS22-SS28, 2006

• 3) Yamanaka H et al. : Mod Rheumatol., 17 : 28-32, 2007.

• 4) 名和田雅夫ら : 最新医学別冊新しい診断と治療のABC関節リウマチ改訂第2版, 279-286, 2008

• 5) Quinn MA et al : Arthritis Rheum 52 : 27-35, 2005
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• 6) Ostergaard M et al : Arthritis Rheum 48 : 2128-2131, 2003
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• 7) 勝呂徹 : 整形外科医のための最新関節リウマチ治療-生物学的製剤の使い方と注意点 : 85-86, 2007

• 8) ACR Subcommittee on Rheumatoid Arthritis Guidelines : Arthritis Rheum 46 : 328-346, 2002

• 9) 駒野有希子ら : 医学のあゆみ221 : 463-466, 2007

• 10) Maini RN et al : Arthritis Rheum 50 : 1051-1065, 2004

• 11) Smolen JS et al : Arthritis and Rheum 52 : 1020-1030, 2005
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• 12) EWilliam, St Clair et al : Arthritis Rheum 50 : 3432-3443, 2004

• 13) Smolen JS et al : Arthritis Rheum 54 : 702-710, 2006
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• 14) Goekoop-Ruiterman YP et al : Arthritis Rheum 52 : 3381-3390, 2005
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• 15) van der Bijl AE et al. Arthritis Rheum 56 : 2129-2134, 2007
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• 16) Genovese MC et al : Arthritis Rheum 46 : 1443-1450, 2002
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• 17) Klareskog L et al : Lancet 363 : 675-681, 2004
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• 18) van der Heijde D et al : Arthritis and Rheum 54 : 1063-1074, 2006
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• 19) Landewe R et al : Arthritis Rheum 54 : 3119-3125, 2006
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P.60 掲載の参考文献

• 1) Cobbs S, Anderson F, Bauer W : Length of life and cause of death in rheumatoid arthritis. N Engl J Med 249 (14) : 553-556, 1953

• 2) Wolfe F, Mitchell DM, Sibley JT, Fries JF, Bloch DA, Williams CA, Spitz PW, Haga M, Kleinheksel SM, Cathey MA : The mortality of rheumatoid arthritis. Arthritis Rheum. 37 (4) : 481- 494, 1994

• 3) Mikuls TR, Saag KG, Criswell LA, Merlino LA, Kaslow RA, Shelton BJ, Cerhan JR : Mortality risk associated with rheumatoid arthritis in a prospective cohort of older women : results from the Iowa Women's Health Study. Ann Rheum Dis 61 (11) : 994-999, 2002

• 4) Gabriel SE, Crowson CS, Kremers HM, Doran MF, Turesson C, O'Fallon WM, Matteson EL : Survival in rheumatoid arthritis : a population-based analysis of trends over 40 years. Arthritis Rheum 48 (1) : 54-58. 2003
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• 5) Hakoda M, Oiwa H, Kasagi F, Masunari N, Yamada M, Suzuki G, Fujiwara S : Mortality of rheumatoid arthritis in Japan : alongitudinal cohort study. Ann Rheum Dis 64 (10) : 1451-1455. 2005

• 6) Chehata JC, Hassell AB, Clarke SA, Mattey DL, Jones MA, Jones PW, Dawes PT : Mortality in rheumatoid arthritis : relationship to single and composite measures of disease activity. Rheumatology (Oxford) 40 (4) : 447-452, 2001
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• 7) Pincus T, Callahan LF : Taking mortality in rheumatoid arthritis seriously-predictive markers, socioeconomic status and comorbidity. J Rheumatol 13 (5) : 841-845, 1986
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• 8) Nicola PJ, Maradit-Kremers H, Roger VL, Jacobsen SJ, Crowson CS, Ballman KV, Gabriel SE : The risk of congestive heart failure in rheumatoid arthritis : apopulation-based study over 46 years. Arthritis Rheum 52 (2) : 412-420, 2005

• 9) 宗圓聰 : RA患者の死亡率と死因. リウマチ科 37 (2) : 164-168, 2007

• 10) Shinomiya F, Mima N, Nanba K, Tani K, Nakano S, Egawa H, Sakai T, Miyoshi H, Hamada D : Life expectancies of Japanese patients with rheumatoid arthritis : a review of deaths over a 20-year period. Mod Rheumatol 18 (2) : 165-169, 2008

• 11) Nadareishvili Z, Michaud K, Hallenbeck JM, Wolfe F : Cardiovascular, rheumatologic, and pharmacologic predictors of stroke in patients with rheumatoid arthritis : a nested, case-control study. Arthritis Rheum 59 (8) : 1090-1096, 2008
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• 12) Wolfe F, Cathey MA : Analysis of methotrexate treatment effect in a longitudinal observational study : utility of cluster analysis. J Rheumatol 18 (5) : 672-727, 1991

• 13) Kremer JM : Safety, efficacy, and mortality in a long-term cohort of patients with rheumatoid arthritis taking methotrexate : followup after amean of 13. 3 years. Arthritis Rheum 40 (5) : 984-985, 1997

• 14) Choi HK, Hernan MA, Seeger JD, Robins JM, Wolfe F : Methotrexate and mortality in patients with rheumatoid arthritis : a prospective study. Lancet 359 (9313) : 1173-1177, 2002
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• 15) Michaud K, Wolfe F : Reduced mortality among RA patients treated with anti-TNF therapy and methotrexate. Arthritis Rheum 52 : S145. 2005 (abstract)

• 16) Greenberg J, Lin SL, Decktor D et al : Association of duration of TNF antagonist treatment with reduction in cardiovascular outcomes in RA patients. Arthritis Rheum 54 : S422, 2006 (abstract)

• 17) Dixon WG, Watson KD, Lunt M, Hyrich KL, Rates of Myocardial Infarction (MI) and Cerebrovascular Accident (CVA) In Patients with Rheumatoid Arthritis (RA) Treated with Anti-TNF Therapy : Results From the British Society for Rheumatology Biologics Register (BSRBR). Arthritis Rheum 54 : S311, 2006 (abstract)

• 18) Jacobsson LT, Turesson C, Nilsson JA, Petersson IF, Lindqvist E, Saxne T, Geborek P : Treatment with TNF blockers and mortality risk in patients with rheumatoid arthritis. Ann Rheum Dis. 66 (5) : 670-5. 2007
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• 19) Jacobsson LT, Turesson C, Giffe A, Kapetanovic MC, Petersson IF, Saxne T, Geborek P : Treatment with tumor necrosis factor blockers is associated with a lower incidence of first cardiovascular events in patients with rheumatoid arthritis. J Rheumatol 32 (7) : 1213-1218, 2005

• 20) Carmona L, Descalzo MA, Pampin PE, Montesinos RD, Erra A, Cobo T, Reino GJJ : All-cause and cause-specific mortality in rheumatoid arthritis are not greater than expected when treated with tumour necrosis factor antagonists. Ann Rheum Dis 66 (7) : 880-885, 2007

• 21) Dixon WG, Symmons DP : What effects might anti-TNF alpha treatment be expected to have on cardiovascular morbidity and mortality in rheumatoid arthritis? areview of the role of TNF alpha in cardiovascular pathophysiology. Ann Rheum Dis 66 (9) : 1132-1136, 2007

• 22) Hulimann D, Forster A, Noll G, Enseleit F, Chenevard R, Distler O, Behir M, Spieker LE, Neidhart M, Michel BA, Gay RE, Lucher TF, Gay S, Ruschitzka F. Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis. Circulation 22 ; 106 (17) : 2184-2187, 2002

• 23) Del Porto F, Lagana B, Lai S, Nofroni I, Tinti F, Vitale M, Podesta Mitterhofer AP, D'Amelio R : Response to anti-tumour necrosis factor alpha blockade is associated with reduction of carotid intima-media thickness in patients with active rheumatoid arthritis. Rheumatology (Oxford) 46 (7) : 1111-1115, 2007
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• 24) Vis M, Nurmohamed MT, Wolbink G, Voskuyl AE, de Koning M, van de Stadt R, Twisk JW, Dijkmans BA, Lems WF : Short term effects of infliximab on the lipid profile in patients with rheumatoid arthritis. J Rheumatol 32 (2) : 252-255, 2005
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• 25) Dominguez H, Storgaard H, Madsen RC, Hermann ST, Ihlemann N, Nielsen BD, Spohr C, Kober L, Vaag A, Pedersen TC : Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes. J Vasc Res 42 (6) : 517-525, 2005

• 26) Komai N, Morita Y, Sakuta T, Kuwabara A, Kashihara N : Anti-tumor necrosis factor therapy increases serum adiponectin levels with the improvement of endothelial dysfunction in patients with rheumatoid arthritis. Mod Rheumatol 17 (5) : 385-390, 2007
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• 27) Grisar J, Aletaha D, Steiner CW, Kapral T, Steiner S, Seidinger D, Weigel G, Schwarzinger I, Wolozcszuk W, Steiner G, Smolen JS : Depletion of endothelial progenitor cells in the peripheral blood of patients with rheumatoid arthritis. Circulation 111 (2) : 204-211, 2005
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II. 期待される多様な分野への臨床応用

P.70 掲載の参考文献

• 1) Maini RN, Brennan FM, Williams R, Chu CQ, Cope AP, Gibbons D, Elliott M, Feldmann M : TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy. Clin Exp Rheumatol 11 (Suppl 8) : S173-175, 1993

• 2) van DuUemen HM, van Deventer SJ, Hommes DW, Bijl HA, Jansen J, Tytgat GN, Woody J : Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 109 : 129-135, 1995

• 3) Targan SR, Hanauer SB, van Deventer SJ, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ : Ashort-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 337 : 1029-1035, 1997

• 4) D'Haens G, Van Deventer S, Van Hogezand R, Chalmers D, Kothe C, Baert F, Braakman T, Schaible T, Geboes K, Rutgeerts P : Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease : a European multicenter trial. Gastroenterology 116 : 1029-1034, 1999
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• 5) Present DH, Rutgeerts P, Targan S, Hanauer SB, Mayer L, van Hogezand RA, Podolsky DK, Sands BE, Braakman T, DeWoody KL, Schaible TF, van Deventer SJ : Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 340 : 1398-1405, 1999
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• 6) Rutgeerts P, D'Haens G, Targan S, Vasiliauskas E, Hanauer SB, Present DH, Mayer L, Van Hogezand RA, Braakman T, DeWoody KL, Schaible TF, Van Deventer SJ : Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease. Gastroenterology 117 : 761-769, 1999
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• 7) Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, Rachmilewitz D, Wolf DC, Olson A, Bao W, Rutgeerts P : Maintenance infliximab for Crohn's disease : the ACCENT I randomised trial. Lancet 359 : 1541-1549, 2002
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• 8) Sands BE, Blank MA, Patel K, van Deventer SJ : Long-term treatment of rectovaginal fistulas in Crohn's disease : response to infliximab in the ACCENT II Study. Clin Gastroenterol Hepatol 2 : 912-920, 2004
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• 9) Rutgeerts P, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, Rachmilewitz D, Wolf DC, Olson A, Bao W, Hanauer SB : Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease. Gastroenterology 126 : 402-413, 2004
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• 10) van Deventer SJ : Transmembrane TNF alpha, induction of apoptosis, and the efficacy of TNF-targeting therapies in Crohn's disease. Gastroenterology 121 : 1242-1246, 2001
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• 11) Lugering A, Schmidt M, Lugering N, Pauels HG, Domschke W, Kucharzik T : Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway. Gastroenterology 121 : 1145-1157, 2001
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• 12) Garrett WS, Lord GM, Punit S, Lugo-Villarino G, Mazmanian SK, Ito S, Glickman JN, Glimcher LH : Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 131 : 33-45, 2007

• 13) Nenci A, Becker C, WuUaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M : Epithelial NEMO Iinks innate immunity to chronic intestinal inflammation. Nature 446 : 557-561, 2007

• 14) Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, May MJ, Greten FR, Eckmann L, Karin M, Artis D : Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature 446 : 552-556, 2007
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