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[特別講演]

P.10 掲載の参考文献

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• 2) Ishibashi T: Three-dimensional skin cultured model testskin, fabrication and applications. Soshiki Baiyo Kogaku 25: 121-124, 1999.

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• 5) Ishii N, Kobayashi T, Matsumiya K, Ryu M, Hirata Y et al.: Transdermal administration of lactoferrin with sophorolipid. Biochem Cell Biol 90: 504-512, 2012.
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• 6) Braun E, Wagner A, Furnschlief E, Katinger H, Vorauer-Uhl K: Experimental design for in vitro skin penetration study of liposomal superoxide dismutase. J Pharm Biomed Anal 40: 1187-1197, 2006.
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• 7) Suzuki YA, Lonnerdal B: Lactoferrin: structure, functions, and applications. Funct Food Rev 2: 69-79, 2010.

• 8) DuPlessis ER, Rohlfs RJ, Hille R, Thorpe C: Electron-transferring flavoprotein from pig and the methylotrophic bacterium W3A1 contains AMP as well as FAD. Biochem Mol Biol Int 32: 195-199, 1994.
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• 9) Anderson BF, Baker HM, Dodson EJ, Norris GE, Rumball SV et al.: Structure of human lactoferrin at 3. 2-A resolution. Proc Natl Acad Sci USA 84: 1769-1773, 1987.
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• 10) Sharma S, Jasti J, Kumar J, Mohanty AK, Singh TP: Crystal structure of a proteolytically generated functional monoferric C-lobe of bovine lactoferrin at 1. 9A resolution. J Mol Biol 331: 485-496, 2003.

• 11) Almond A: Hyaluronan. Cell Mol Life Sci 64: 1591-1596, 2007.
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• 12) Saito S, Takayama Y, Mizumachi K, Suzuki C: Lactoferrin promotes hyaluronan synthesis in human dermal fibroblasts. Biotechnol Lett 33: 33-39, 2011.
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• 13) Antonicelli F, Bellon G, Lorimier S, Homebeck W: Role of the elastin receptor complex(S-Gal/Cath-A/Neu-1)in skin repair and regeneration. WoundRepair Regen 17: 631-638, 2009.

• 14) Saunders J, Davis H, Coetzee L, Botha S, Kruger A et al.: A novel skin penetration enhancer: evaluation by membrane diffusion and confocal microscopy. J Pharm Pharm Sci 2: 99-107, 1999.

• 15) Hirata Y, Ryu M, Oda Y, Igarashi K, Nagatsuka A et al.: Novel characteristics of sophorolipids, yeast glycolipid biosurfactants, as biodegradable lowfoaming surfactants. J Biosci Bioeng 108: 142-146, 2009.
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P.18 掲載の参考文献

• 1) Otsuki K, Yoda A, Hirose K, Shimizu Y, Saito H et al.: Salivary lactoferrin in neonates with chorioamnionitis. Showa Univ J Med Sci 9(1): 39-44, 1997.

• 2) Otsuki K, Yoda A, Toma Y, Shimizu Y, Saito H et al.: Lactoferrin and interleukin-6 interaction in amniotic infection. Adv Exp Med Biola 443: 267-271, 1998.

• 3) Sawada M, Otsuki K, Yakuwa K, Mitsukawa K, Nagatsuka M et al.: Cervical inflammatory cytokines and other markers in cervical mucus of pregnant women with lower genital tract infections. Int J Gynecol Obstet: 117-121, 2006.

• 4) 大槻克文, 斎藤 裕, 矢内原巧: サンドイッチ ELISA法を用いた新生児唾液中ラクトフェリン濃度の測定. 日本産科婦人科栄養・代謝研究会誌 2(1): 67, 1996.

• 5) 依田 暁, 大槻克文, 藤間芳郎, 清水幸子, 斎藤 裕・他: 絨毛膜羊膜炎における羊水中Lactoferrin 測定の臨床的意義. 日本産科婦人科栄養・代謝研究会誌 3(1): 57-58, 1997.

• 6) Otsuki K, Yoda A, Mitsuhashi Y, Toma Y, Shimizu Y et al.: Amniotic fluid lactoferrin in intrauterine infection. Placenta Mar-Apr 20(2-3): 175-179, 1999.

• 7) Otsuki K, Yoda Y, Mitsuhashi Y, Shimizu Y, Saito H et al.: Isolation and detection of human lactoferrin binding protein in human amniotic membrane. Lactoferrin: Structure. Function and Applications: 343-346, 2000.

• 8) 齋藤 裕, 大槻克文, 依田 暁, 矢内原巧: 子宮内感染と早産-子宮内感染におけるラクトフェリンの感染防御機構について. 周産期学シンポジウム 16号: 111-114, 1998.

• 9) 依田 暁, 大槻克文, 三橋裕一, 清水幸子, 齋藤 裕・他: 絨毛膜羊膜炎をきたした早産症例における羊水中ラクトフェリンとIL-6の動態. 日本新生児学会雑誌 34巻3号 506-510, 1998.

• 10) Saito H, Otsuki K, Mitsuhashi Y, Yoda Y, Yanaihara Aet al.: Role of lactoferrin in the prevention of preterm delivery. Lactoferrin: Structure, Function and Applications: 347-352, 2000.

• 11) Mitsuhashi Y, Otsuki K, Yoda Y, Shimizu Y, Saito H et al.: Effect of lactoferrin on lipopolysaccharide(LPS)induced preterm delivery in mice. Acta Obstet Gynecol Scand 79: 355-358, 2000.

• 12) Sherman MP, Otsuki K, Lonnerdal BL: Preventing Escherichia coli growth on cervical epithelium. Pediatr Res 49: 232A, 2001.

• 13) Otsuki K, Lonnerdal BL, Sherman MP: Lactoferrin: Bacterial opsonin for macrophages? Biochemistry and Cell Biology 80: 158, 2002.

• 14) Otsuki K, Lonnerdal BL, Sherman MP: Bacterial growth on human cervical epithelia: A new assay for testing killing by lactoferrin. Biochemistry and Cell Biology 80: 165, 2002.

• 15) Sasaki Y, Otsuki K, Hasegawa A, Sawada M, Chiba H, Negishi M, Nagatsuka M, Okai T: Preventive effect of recombinant human Lactoferrin on lipopolysaccharide-induced preterm delivery in mice. Acta Obstet Gynecol Scand 83: 1035-1038, 2004.
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• 16) Otsuki K, Sasaki Y, Hasegawa A, Sawada M, Mitsukawa K et al.: Lactoferrin concentrations in cervical mucus of pregnant women with and without infection. Am J Obstet Gynecol 191: S75, 2004.

• 17) Hasegawa A, Otsuki K, Sasaki Y, Sawada M, Mitsukawa K et al.: Preventive effect of recombinant human lactoferrin in a rabbit preterm delivery model. Am J Obstet Gynecol 192: 1038-1043, 2005.

• 18) Otsuki K, Hasegawa A, Sasaki Y, Sawada M, Yakuwa Ket al.: Potential of lactoferrin in the prevention of preterm delivery. Taiwanese J Obstet Gynecol 44: 123-127, 2005.

• 19) Otsuki K, Yakuwa K, Sawada M, Hasegawa A, Sasaki Yet al.: Recombinant human lactoferrin has a preventive effects on lipopolysaccharide-induced preterm delivery and production of inflammatory cytokines. J Perinat Med 33: 320-323, 2005.

• 20) 大槻克文, 長谷川明俊, 澤田真紀, 満川香織, 千葉 博・他: ラクトフェリンによる体内での炎症性サイトカイン産生抑制を解した早産予防の試み. Milk Science 53(4): 304-305, 2004.

• 21) 長谷川明俊, 大槻克文, 佐々木康, 澤田真紀, 満川香 織・他: ラビット早産モデルにおけるlactoferrinの早産防止効果. Milk Science 53(4): 306-308, 2004.

• 22) 長谷川明俊, 大槻克文, 佐々木康, 澤田真紀, 千葉 博・他: マウス早産モデルにおけるRecombinant human lactoferrinの早産防止効果. 日本周産期・新生児医学会雑誌 40(1): 35-39, 2004.
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• 23) 大槻克文: 超早産の病態, 予後及び予防への展望 Lactoferrinによる超早産予防の可能性. 日本周産期・新生児医学会雑誌 40(4): 759-762, 2004.

• 24) Romero R Yoon BH, Mazor M et al. The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and gram stain in patients with preterm labor and intact membranes. Am. J. Obstet Gynecol 169: 805-816, 1993.
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• 27) Sahlin, L. et al.: Impaired leukocyte influx in cervix of postterm women not responding to prostaglandin priming. Reprod Biol Endocrinol 6: 36, 2008.

• 28) Kaga N, Katsuki Y, Obata M et al.: Repeated administration of low-dose lipopolysaccharide induces preterm delivery in mice. A model for human preterm parturition and for assessment of the therapeutic ability of drugs against preterm delivery. Am J Obstet Gynecol 174: 754-759, 1996.

• 29) Kaga N, Katsuki Y, Futamura Y et al.: Role of urinary trypsin inhibitor in the maintenance of pregnancy in mice. Obstet Gynecol 88: 872-882, 1996.
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• 30) Kaga N, Katsuki Y, Kajikawa S et al.: Preventive effect of ritodrine hydrochloride and/or urinary trypsin inhibitor against lipopolysaccharide-induced preterm delivery in mice. Acta Obstet Gynecol Scand 76: 811-816, 1997.
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• 31) Machnicki M, Zimecki M, Zagulski T: Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin-6 in vivo. Int J Exp Pathol 74: 433-438, 1993.
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• 32) Zhang GH, Mann DM, Tsai CM: Neutralization of endotoxin in vivo and in vivo by a human lactoferrin-derived peptide. Infect Immun 67: 11353-1358, 1999.

• 33) Kanayama N, el Maradny E et al.: Urinary trypsin inhibitor suppresses premature cervical ripening. Eur J Obstet Gynecol Reprod Biol 60: 181-186, 1995.
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[シンポジウム2]

P.28 掲載の参考文献

• 1) Yamano E, Miyauchi M, Furusyo H, Kawazoe A, Ishikado A, et al.: Inhibitory effects of orally administrated liposomal bovine lactoferrin on the LPS-induced osteoclastogenesis. Lab Invest 90: 1236-1246, 2010.
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• 2) Ishikado A, Uesaki S, Suido H, Nomura Y, Sumikawa K, et al.: Human trial of liposomal lactoferrin supplementation for periodontal disease. Biol Pharm Bull 33: 1758-1762, 2010.
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• 3) Haversen L, Ohlsson B G, Hahn-Zoric M, Hanson L A, Mattsby-Baltzer I: Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-kappa B. Cell Immunol 220: 83-95, 2002.
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• 4) Machnicki M, Zimecki M, Zagulski T: Lactoferrin regulates the release of tumor necrosis factor α and interleukin 6 in vivo. Int J Exp Pathol 74: 433-439, 1993.

• 5) Appelmelk B J, An Y Q, Geerts M, Thijs B G, de Boer HA, MacLaren D M, de Graaff J, Nuijens J H: Lactoferrin is a lipid A-binding protein. Infect Immun 62: 2628-2632, 1994.
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• 6) Elass-Rochard E, Legr D, Salmon V, Roseanu A, Trif M, et al.: Lactoferrin inhibits the endotoxin interaction with CD14 by competition with the lipopolysaccharide-binding protein. Infect Immun 66: 486-491, 1998.

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P.34 掲載の参考文献

• 1) Duarte DC, Nicolau A, Teixeira JA, Rodrigues LR: The effect of bovine milk lactoferrin on human breast cancer cell lines. J Dairy Sci 94(1): 66-76, 2011.
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• 2) Ivanov AA, Ulanova AM, Stavrakova NM, Deshevoi IuB, Nasonova TA et al.: Antiradiation effects of lactoferrin. Radiats Biol Radioecol 49(4): 456-461, 2009.
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• 3) Wen P, Guo H, Zhang H, Gan B, Ding Q, Ren F: Effect of glucose on the lactoferrin's conformation and its effect on MC3T3-E1 cell proliferation. Protein J 31(4): 300-305, 2012.

• 4) Allaeys I, Rusu D, Picard S, Pouliot M, Borgeat P, Poubelle PE: Osteoblast retraction induced by adherent neutrophils promotes osteoclast bone resorption: implication for altered bone remodeling in chronic gout. Lab Invest 91(6): 905-920, 2011.
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• 5) Naot D, Grey A, Reid IR, Cornish J: Lactoferrin-a novel bone growth factor. Clin Med Res 3(2): 93-101, 2005.
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• 8) Wang D, Liao X, Qin X, Shi W, Zhou B: A novel chimeric peptide binds MC3T3-El cells to titanium and enhances their proliferation and differentiation. Mol Med Rep 7(5): 1437-1441, 2013.

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P.39 掲載の参考文献

• 1) Cornish J: Lactoferrin promotes bone growth. Biometals 7: 331-335, 2004.

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• 4) Takayama Y, Mizumachi K, : Effect of lactoferrin-embedded collagen membrane on ostogenic differentiation of human osteoblastic-like cells. J Biosci Bioeng 107: 191-195, 2009.

• 5) Baveye S, Elass E, Mazurier J, Spik G, Legrand D: Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process. Clin Chem Lab Med 37: 281-286, 1999.
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[一般演題およびポスターセッション]

P.49 掲載の参考文献

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P.53 掲載の参考文献

• 1) Kaido M, Ishida R, Dogru M, Tsubota K: Visual function changes after punctal occlusion with the treatment of short BUT type of dry eye. Cornea 31: 1009-1013, 2012.
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P.59 掲載の参考文献

• 1) Suzuki YA, Lonnerdal B: Lactoferrin: structure, functions, and applications. Funct Food Rev 2: 69-79, 2010.

• 2) 平田善彦: 抗菌技術への取り組みの現状課題(1)環境浄化薬剤(5)バイオサーファクタント(ソホロリピッド)の工業的生産と洗浄剤への応用. 防菌防黴 39: 261-267, 2011.

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• 7) Saito S, Takayama Y, Mizumachi K, Suzuki C: Lactoferrin promotes hyaluronan synthesis in human dermal fibroblasts. Biotechnol Lett 33: 33-39, 2011.
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