書籍名 |
新女性医学大系 12 排卵と月経 |
出版社 |
中山書店
|
発行日 |
1998-03-31 |
著者 |
- 武谷雄二(総編集)
- 青野敏博(編集)
- 麻生武志(編集)
- 中野仁雄(編集)
- 野澤志朗(編集)
- 岡村均(担当編集)
|
ISBN |
4521540112 |
ページ数 |
420 |
版刷巻号 |
第1版第1刷 |
分野 |
|
シリーズ |
新女性医学大系
|
閲覧制限 |
未契約 |
日常診療の科学的な根拠を提供し、これからの産婦人科医をサポートする新大系の第1回配本。発展著しい生殖・内分泌学の中から間脳、下垂体、卵巣、子宮の役割などを詳説。
目次
- 表紙
- 執筆者一覧
- 目次
- I 月経周期と間脳 - 下垂体 - 卵巣 - 子宮系
- はじめに
- 1. 内分泌学の概念の変遷と広がり
- 2. 細胞内情報伝達機構
- 3. 間脳 - 下垂体 - 卵巣 - 子宮系の概要
- II 間脳 - 下垂体系
- A. 間脳 - 下垂体系の形態と機能
- 1. 間脳 - 下垂体系の肉眼解剖学と組織学
- 2. 下垂体の肉眼的構造と血管系, 特に下垂体門脈系
- a. 下垂体の肉眼的構造
- b. 下垂体の血管系, 特に下垂体門脈系
- 3. 下垂体前葉の組織学と組織化学
- a. 下垂体前葉ホルモン
- b. 下垂体前葉の光学顕微鏡的組織学
- c. 下垂体前葉細胞の光顕による免疫組織化学
- 4. 下垂体前葉細胞の超微細構造
- a. 下垂体前葉全般の電子顕微鏡的研究
- b. 生殖機能に関連する下垂体前葉細胞の超微細構造
- B. GnRHの分泌調節機構
- はじめに
- 1. GnRH分泌ニューロン
- a. GnRH
- b. GnRHニューロンの発生と脳内への移動
- c. GnRHニューロンの脳内局在
- d. Kallmann症候群
- e. GnRHニューロンとエストロゲン受容ニューロンの関係
- 2. GnRH分泌の2つの様式
- a. LHの基礎分泌と排卵性分泌
- b. GnRH分泌様式
- 3. GnRHパルス発生器
- a. エストロゲンの作用
- b. オピオイドニューロンとの関係
- c. 局在と神経回路
- 4. GnRHサージ発生器
- a. GnRHサージ発生器存在の理由
- b. GABAニューロンとの関係
- c. 局在と神経回路
- おわりに
- C. GnRHの構造と作用
- はじめに
- 1. GnRHおよびGnRH作動薬の構造
- 2. GnRH受容体
- a. GnRH受容体の構造
- b. GnRH受容体の調節
- 3. GnRHおよびそのアナログの作用
- a. GnRHの作用
- b. GnRH律動的分泌の下垂体への影響
- c. GnRH作動薬の作用
- 4. ゴナドトロピン遺伝子発現とその調節
- a. LH-β, FSH-β-サブユニット遺伝子発現
- b. α-サブユニット遺伝子発現
- 5. ゴナドトロピン分泌細胞における細胞内情報伝達機構
- a. Gタンパク質
- b. イノシトールリン脂質
- c. 細胞内カルシウム
- d. プロテインキナーゼC
- e. cAMP
- f. MAPキナーゼ
- 6. 脱感作
- 7. GnRH作動薬の臨床応用
- a. 子宮内膜症
- b. 子宮筋腫
- c. 思春期早発症
- d. 体外受精胚移植時の卵巣刺激
- 8. GnRH拮抗薬
- a. GnRH拮抗薬の構造
- b. GnRH拮抗薬の作用機序
- c. GnRH拮抗薬の作用
- d. GnRH拮抗薬の優位点
- 9. GnRHの下垂体外作用
- a. 卵巣, 胎盤, 乳腺
- b. 卵巣癌, 子宮内膜癌, 乳癌
- D. GnRHによる下垂体性ゴナドトロピン分泌機構
- はじめに
- 1. ヒトにおけるゴナドトロピン分泌
- a. 年齢とゴナドトロピン分泌
- b. 月経周期とゴナドトロピン分泌基礎値
- 2. GnRH受容体の構造と機能
- a. GnRH受容体の構造
- b. GnRH受容体の合成調節
- 3. GnRHによるゴナドトロピン分泌調節機序
- a. GnRHによるゴナドトロピン分泌と細胞内カルシウム
- b. GnRHによるゴナドトロピン分泌とプロテインキナーゼ
- c. GnRHによるゴナドトロピン分泌と低分子量GTP結合タンパク質
- 4. インヒビン, アクチビン, フォリスタチンとゴナドトロピン分泌
- E. ゴナドトロピンの構造と作用
- はじめに
- 1. ゴナドトロピン遺伝子の構造
- 2. ゴナドトロピンの分子構造と作用
- a. S-S結合
- b. 糖鎖
- c. C末端ペプチド
- d. その他の特徴的構造
- 3. 持続性ゴナドトロピンの作製
- 4. ゴナドトロピン異常症
- a. Kallmann症候群
- b. LH構造異常
- c. FSH構造異常
- おわりに
- F. プロラクチンと性機能
- 1. プロラクチンの化学構造
- 2. 分泌調節機構
- a. プロラクチン放出抑制因子
- b. プロラクチン放出因子
- 3. 生理作用
- 4. 高プロラクチン血症と排卵障害
- a. 臨床的意義
- b. 中枢への影響
- c. 卵巣への影響
- G. インヒビン, アクチビン, フォリスタチン
- 1. 構造と活性
- 2. 産生と分泌調節
- a. プロモーターの構造と発現調節
- b. 産生臓器
- c. ラット顆粒膜細胞での分泌調節
- d. ヒトの卵胞発育とインヒビン, アクチビンの産生
- e. 胎盤でのインヒビン産生
- 3. 作用機序
- 4. 作用
- 5. 測定法
- 6. 血中濃度の生理的変動と疾患による変化
- a. 生理的変動
- b. 疾患に伴う変動
- c. 男子
- d. その他の疾患
- メラトニンと性機能
- はじめに
- 1. メラトニンの産生と調節
- 2. メラトニンの作用機序
- 3. メラトニンと性機能
- a. 思春期発来とメラトニン
- b. メラトニンと性機能障害
- c. メラトニンとプロラクチン分泌
- d. メラトニンと卵巣機能
- III 卵巣
- A. 卵巣の組織と機能
- 1. 卵巣の解剖
- a. 支持装置
- b. 血管系
- c. リンパ系
- d. 神経系
- 2. 卵巣の組織
- a. 卵巣表層上皮
- b. 卵巣白膜
- c. 卵巣皮質
- d. 卵巣髄質
- e. 卵巣門
- 3. 卵胞の組織構築と機能
- a. 原始卵胞
- b. 発育卵胞
- c. 成熟卵胞
- d. 排卵
- e. 黄体
- f. 白体
- B. ゴナドトロピンの作用
- 1. ゴナドトロピン受容体の構造
- a. LH/CG受容体の構造
- b. FSH受容体の構造
- 2. ゴナドトロピン受容体の局在とその変動
- 3. ゴナドトロピンとその作用
- 4. ゴナドトロピン受容体と情報伝達系
- a. cAMP-プロテインキナーゼA系
- b. ホスホリパーゼC-プロテインキナーゼC系
- 5. ゴナドトロピン受容体の異常
- C. 性ステロイドホルモンの合成と分泌
- はじめに
- 1. ステロイドホルモンとは
- 2. 卵巣におけるステロイドホルモン産生
- a. コレステロールよりプレグネノロンへ
- b. プレグネノロンよりプロゲステロンへ
- c. プロゲステロンからアンドロゲンへ
- d. C19ステロイドよりエストロゲンへ
- e. 卵巣におけるその他のステロイド合成代謝
- f. 各種ステロイド合成酵素の局在と遺伝子発現の月経周期変動
- 3. 卵巣の性ステロイドホルモン合成・分泌の調節
- a. エストロゲンによる調節
- b. アンドロゲンによる調節
- D. 細胞内コレステロール輸送機構 卵巣におけるステロイドホルモン産生の調節を理解するために
- はじめに
- 1. LDL受容体
- 2. LDL受容体からミトコンドリアの外膜まで
- a. ペルオキシソーム
- b. sterol carrier protein 2 (SCP2)
- 3. ミトコンドリアの外膜から内膜へ
- a. 末梢性ベンゾジアゼピン受容体
- b. steroidogenic acute regulatory protein (StAR)
- おわりに ― StARからCSCCへ
- IV 卵胞の発育と閉鎖
- A. 卵胞発育と単一排卵の機序
- 1. 卵子の発生と卵胞の形成
- 2. 幼小児期の卵胞の発育と閉鎖
- 3. 月経周期にみられる卵胞発育と主席卵胞の選別
- a. 原始卵胞から主席卵胞予備群まで
- b. 主席卵胞発現から排卵まで
- 4. 黄体機能と卵胞発育
- 5. 加齢に伴う卵胞発育の変化
- 6. 卵胞の発育と閉鎖の主要調節因子
- B. 顆粒膜 - 莢膜細胞間相互作用による卵胞機能調節
- はじめに
- 1. 原始卵胞から一次卵胞への発育
- 2. 一次卵胞から二次卵胞への発育
- 3. antral follicleへの発育
- a. 卵胞の形態変化
- b. 細胞間相互作用による発育調節
- 4. selectable follicleへの発育
- a. 顆粒膜 - 莢膜細胞の増殖調節機構
- b. 高アンドロゲン / 低エストロゲン環境形成メカニズム
- 5. 主席卵胞の選択と発育
- a. 顆粒膜細胞のaromatase活性亢進と主席卵胞選択のメカニズム
- b. two-cell, two-gonadotropin modeによるエストラジオール産生機構の完成
- c. 顆粒膜 - 莢膜細胞間相互作用によるtwo-cell, two-gonadotropin modeの修飾 (説)
- 6. 卵胞期後期の主席卵胞発育
- 7. コラーゲン膜両面培養系を用いた顆粒膜 - 莢膜細胞間相互作用の観察
- 8. 卵胞閉鎖と顆粒膜 - 莢膜細胞間相互作用
- おわりに
- C. 卵の成熟と卵胞内環境
- 1. 卵の発育と成熟
- a. 卵の発育
- b. 卵の成熟
- c. 卵成熟度の評価
- d. 卵成熟の分子機構
- 2. 卵胞内環境と卵の成熟
- a. 卵胞内因子
- b. ステロイドホルモン
- c. プロスタグランジン
- d. 上皮増殖因子
- e. アクチビン, フォリスタチン
- f. そのほかの局所因子
- D. 卵胞閉鎖とアポトーシス
- はじめに
- 1. アポトーシスの概念
- a. ネクローシスとの差異
- b. DNA断片化
- C. アポトーシスに関与する因子
- 2. 顆粒膜細胞でのアポトーシス
- a. ゴナドトロピン
- b. ステロイド
- c. 上皮増殖因子
- d. 酸化ストレス
- e. p53
- f. vasoactive intestinal peptide (VIP)
- g. cAMP
- h. 成長ホルモン
- i. ICE
- j. bcl-2ファミリー
- k. Fas-Fasリガンド
- l. 細胞接着
- m. セラミド
- 3. ヒト卵巣におけるアポトーシス
- a. 卵胞の発育とアポトーシス
- b. 子宮内膜症とアポトーシス
- E. 成長因子
- はじめに
- 1. 甲状腺ホルモン
- 2. インスリン
- 3. IGF-1
- 4. EGF
- 5. TGF-α
- 6. myc遺伝子産物
- 7. TNF-α
- 8. TGF-β
- 9. アポトーシスと卵胞閉鎖
- おわりに
- F. サイトカイン
- 1. reproduction and lymphohematopoietic system
- 2. 産生と局在
- a. IL-1
- b. IL-6
- c. TNF-α
- d. IFN-γ
- e. エンドセリン
- f. M-CSF
- 3. ステロイドホルモン産生への影響
- a. IL-1
- b. IL-6
- c. TNF-α
- d. IFN-γ
- e. エンドセリン
- 4. 卵胞発育への影響
- a. IL-1
- b. IL-6
- c. TNF-α
- d. エンドセリン
- e. M-CSF
- 5. 排卵現象への影響
- a. IL-1
- b. TNF-α
- c. エンドセリン2
- 6. サイトカイン研究の今後の展望
- アミノペプチダーゼ
- 1. 細胞膜結合型ペプチダーゼ
- 2. 卵巣における細胞膜結合型アミノペプチダーゼの発現
- a. アミノペプチダーゼN
- b. ジペプチジルペプチダーゼIV
- 3. 卵巣における膜結合型カルボキシペプチダーゼの発現
- 4. 卵胞発育とアミノペプチダーゼ
- 5. 細胞表面ペプチド代謝における各ペプチダーゼの協調作用
- V 排卵機構
- 1. 排卵機構に関する研究の進展
- 2. 排卵過程の形態生理学的変化の概観
- 3. 卵胞破裂に関与する因子
- a. プロスタグランジン
- b. プロゲステロン
- c. タンパク質分解酵素 (排卵酵素)
- d. キニン, カリクレイン
- e. サイトカイン
- f. プロラクチン
- g. レニン - アンジオテンシン系
- h. 成長ホルモンとインスリン様増殖因子-I
- i. 血小板活性化因子
- j. 活性酸素と排卵
- k. 平滑筋収縮
- 4. 卵胞破裂機序の作業仮説
- VI 黄体の形成と退行
- A. 動物の進化と黄体
- 1. 黄体の意義と起源
- a. 黄体の起源
- b. ステロイド生合成系におけるプロゲステロンの位置付け
- c. プロゲステロンの標的 - 卵管と子宮
- 2. 性周期と妊娠期の黄体
- a. 性周期の多様性と適応
- b. 不完全性周期動物の性周期黄体 - プロラクチンと20α-HSD
- c. 性周期黄体の寿命と妊娠黄体
- 3. ラット黄体の形成と退行
- a. 黄体の形成と維持 ― プロラクチンと20α-HSD
- b. 黄体の機能的退行 ― 20α-HSDとP450c26
- c. 黄体の形態的退行とアポトーシス
- B. 黄体機能の調節機序
- 1. 概略
- 2. 哺乳類における黄体形成
- 3. 黄体調節因子
- C. 黄体の退行
- 1. 黄体の比較内分泌学
- 2. 下垂体性ゴナドトロピンによる黄体機能の調節と黄体退行
- 3. 黄体退行とゴナドトロピン受容体
- a. 形態学的検討
- b. 125I-LHの結合実験
- c. LH/CG受容体mRNAの発現
- 4. 黄体退行とプロスタグランジン
- 5. 黄体退行と成長因子, サイトカイン
- 6. 黄体のアポトーシス (細胞自死) と活性酸素
- D. 妊娠黄体
- はじめに
- 1. 妊娠黄体の種類
- 2. プロゲステロン産生機構
- 3. 黄体機能調節因子
- a. プロラクチン
- b. LH
- c. エストロゲン
- d. プロスタグランジン
- e. 活性酸素と消去系
- f. その他の因子
- 4. 妊娠に伴う黄体機能の延長
- a. ultrashort-lived黄体
- b. short-lived黄体
- おわりに
- VII 他内分泌系と性機能
- 1. 甲状腺
- a. 視床下部 - 下垂体 - 甲状腺系の機能環と甲状腺ホルモンの作用機序
- b. 甲状腺と卵巣の機能相関
- c. 甲状腺機能異常症と月経異常
- d. 切迫流産患者の甲状腺機能
- 2. 副腎
- a. 副腎性器症候群
- b. Cushing症候群
- c. Addison病
- 3. 膵疾患
- 4. 膠原病
- 5. 自己免疫疾患
- VIII 子宮内膜
- A. 機能と形態
- 1. 子宮内膜組織の発生
- 2. 新生児から思春期までの子宮内膜組織の発達
- 3. 子宮内膜周期的変化の形態学
- 4. 正常閉経後子宮内膜
- 5. 子宮内膜周期的変化の機能学
- a. 細胞成長因子
- b. 細胞外基質
- c. サイトカインネットワーク
- d. 血流調節物質
- e. 子宮内膜波状運動
- B. 脱落膜化
- 1. 脱落膜の定義と由来
- 2. 脱落膜と動物種差
- 3. 月経周期での脱落膜化
- 4. 脱落膜化の意義
- 5. 脱落膜化により増加する因子
- 6. 脱落膜化に関与する諸因子
- 7. 脱落膜化の抑制
- 8. implantation windowと脱落膜化
- C. 剥脱機構
- 1. 月経期における子宮内膜の組織学的変化
- 2. 月経期における子宮内膜剥脱の生化学的調節機構
- a. リソソーム酵素
- b. マトリックスメタロプロテアーゼ / 組織メタロプロテアーゼインヒビター系
- c. プラスミノーゲンアクチベーター / プラスミノーゲンアクチベーターインヒビター系
- d. エイコサノイド
- e. 増殖因子, サイトカイン
- f. Bcl-2 ファミリー
- 3. 月経困難症
- D. 子宮頸管, 腟の周期性変化
- 1. 子宮頸管
- a. 子宮頸管組織
- b. 頸管粘液
- c. 頸管粘液分泌異常
- d. 頸管内精子上昇
- e. 性交後試験
- 2. 腟
- Glossary
- 索引
- 奥付
参考文献
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V 排卵機構
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VI 黄体の形成と退行
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VIII 子宮内膜
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