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書籍詳細

未契約
書籍名 新女性医学大系 12 排卵と月経
出版社 中山書店
発行日 1998-03-31
著者
  • 武谷雄二(総編集)
  • 青野敏博(編集)
  • 麻生武志(編集)
  • 中野仁雄(編集)
  • 野澤志朗(編集)
  • 岡村均(担当編集)
ISBN 4521540112
ページ数 420
版刷巻号 第1版第1刷
分野
シリーズ 新女性医学大系
閲覧制限 未契約

日常診療の科学的な根拠を提供し、これからの産婦人科医をサポートする新大系の第1回配本。発展著しい生殖・内分泌学の中から間脳、下垂体、卵巣、子宮の役割などを詳説。

目次

  • 表紙
  • 執筆者一覧
  • 目次
  • I 月経周期と間脳 - 下垂体 - 卵巣 - 子宮系
    • はじめに
    • 1. 内分泌学の概念の変遷と広がり
    • 2. 細胞内情報伝達機構
    • 3. 間脳 - 下垂体 - 卵巣 - 子宮系の概要
  • II 間脳 - 下垂体系
    P.11閲覧
    • A. 間脳 - 下垂体系の形態と機能
      • 1. 間脳 - 下垂体系の肉眼解剖学と組織学
        • a. 間脳とは
        • b. 視床下部 - 下垂体系
      • 2. 下垂体の肉眼的構造と血管系, 特に下垂体門脈系
        • a. 下垂体の肉眼的構造
        • b. 下垂体の血管系, 特に下垂体門脈系
      • 3. 下垂体前葉の組織学と組織化学
        • a. 下垂体前葉ホルモン
        • b. 下垂体前葉の光学顕微鏡的組織学
        • c. 下垂体前葉細胞の光顕による免疫組織化学
      • 4. 下垂体前葉細胞の超微細構造
        • a. 下垂体前葉全般の電子顕微鏡的研究
        • b. 生殖機能に関連する下垂体前葉細胞の超微細構造
    • B. GnRHの分泌調節機構
      • はじめに
      • 1. GnRH分泌ニューロン
        • a. GnRH
        • b. GnRHニューロンの発生と脳内への移動
        • c. GnRHニューロンの脳内局在
        • d. Kallmann症候群
        • e. GnRHニューロンとエストロゲン受容ニューロンの関係
      • 2. GnRH分泌の2つの様式
        • a. LHの基礎分泌と排卵性分泌
        • b. GnRH分泌様式
      • 3. GnRHパルス発生器
        • a. エストロゲンの作用
        • b. オピオイドニューロンとの関係
        • c. 局在と神経回路
      • 4. GnRHサージ発生器
        • a. GnRHサージ発生器存在の理由
        • b. GABAニューロンとの関係
        • c. 局在と神経回路
      • おわりに
    • C. GnRHの構造と作用
      • はじめに
      • 1. GnRHおよびGnRH作動薬の構造
      • 2. GnRH受容体
        • a. GnRH受容体の構造
        • b. GnRH受容体の調節
      • 3. GnRHおよびそのアナログの作用
        • a. GnRHの作用
        • b. GnRH律動的分泌の下垂体への影響
        • c. GnRH作動薬の作用
      • 4. ゴナドトロピン遺伝子発現とその調節
        • a. LH-β, FSH-β-サブユニット遺伝子発現
        • b. α-サブユニット遺伝子発現
      • 5. ゴナドトロピン分泌細胞における細胞内情報伝達機構
        • a. Gタンパク質
        • b. イノシトールリン脂質
        • c. 細胞内カルシウム
        • d. プロテインキナーゼC
        • e. cAMP
        • f. MAPキナーゼ
      • 6. 脱感作
      • 7. GnRH作動薬の臨床応用
        • a. 子宮内膜症
        • b. 子宮筋腫
        • c. 思春期早発症
        • d. 体外受精胚移植時の卵巣刺激
      • 8. GnRH拮抗薬
        • a. GnRH拮抗薬の構造
        • b. GnRH拮抗薬の作用機序
        • c. GnRH拮抗薬の作用
        • d. GnRH拮抗薬の優位点
      • 9. GnRHの下垂体外作用
        • a. 卵巣, 胎盤, 乳腺
        • b. 卵巣癌, 子宮内膜癌, 乳癌
    • D. GnRHによる下垂体性ゴナドトロピン分泌機構
      • はじめに
      • 1. ヒトにおけるゴナドトロピン分泌
        • a. 年齢とゴナドトロピン分泌
        • b. 月経周期とゴナドトロピン分泌基礎値
      • 2. GnRH受容体の構造と機能
        • a. GnRH受容体の構造
        • b. GnRH受容体の合成調節
      • 3. GnRHによるゴナドトロピン分泌調節機序
        • a. GnRHによるゴナドトロピン分泌と細胞内カルシウム
        • b. GnRHによるゴナドトロピン分泌とプロテインキナーゼ
        • c. GnRHによるゴナドトロピン分泌と低分子量GTP結合タンパク質
      • 4. インヒビン, アクチビン, フォリスタチンとゴナドトロピン分泌
    • E. ゴナドトロピンの構造と作用
      • はじめに
      • 1. ゴナドトロピン遺伝子の構造
        • a. α鎖の遺伝子構造
        • b. β鎖の遺伝子構造
      • 2. ゴナドトロピンの分子構造と作用
        • a. S-S結合
        • b. 糖鎖
        • c. C末端ペプチド
        • d. その他の特徴的構造
      • 3. 持続性ゴナドトロピンの作製
      • 4. ゴナドトロピン異常症
        • a. Kallmann症候群
        • b. LH構造異常
        • c. FSH構造異常
      • おわりに
    • F. プロラクチンと性機能
      • 1. プロラクチンの化学構造
      • 2. 分泌調節機構
        • a. プロラクチン放出抑制因子
        • b. プロラクチン放出因子
      • 3. 生理作用
        • a. プロラクチン受容体
        • b. 生理作用
      • 4. 高プロラクチン血症と排卵障害
        • a. 臨床的意義
        • b. 中枢への影響
        • c. 卵巣への影響
    • G. インヒビン, アクチビン, フォリスタチン
      • 1. 構造と活性
        • a. 構造
        • b. 分子の多様性と活性の相違
      • 2. 産生と分泌調節
        • a. プロモーターの構造と発現調節
        • b. 産生臓器
        • c. ラット顆粒膜細胞での分泌調節
        • d. ヒトの卵胞発育とインヒビン, アクチビンの産生
        • e. 胎盤でのインヒビン産生
      • 3. 作用機序
      • 4. 作用
        • a. 各部位での作用
        • b. 腫瘍
        • c. 発生
      • 5. 測定法
        • a. バイオアッセイ
        • b. イムノアツセイほか
      • 6. 血中濃度の生理的変動と疾患による変化
        • a. 生理的変動
        • b. 疾患に伴う変動
        • c. 男子
        • d. その他の疾患
    • メラトニンと性機能
      • はじめに
      • 1. メラトニンの産生と調節
      • 2. メラトニンの作用機序
      • 3. メラトニンと性機能
        • a. 思春期発来とメラトニン
        • b. メラトニンと性機能障害
        • c. メラトニンとプロラクチン分泌
        • d. メラトニンと卵巣機能
  • III 卵巣
    P.131閲覧
    • A. 卵巣の組織と機能
      • 1. 卵巣の解剖
        • a. 支持装置
        • b. 血管系
        • c. リンパ系
        • d. 神経系
      • 2. 卵巣の組織
        • a. 卵巣表層上皮
        • b. 卵巣白膜
        • c. 卵巣皮質
        • d. 卵巣髄質
        • e. 卵巣門
      • 3. 卵胞の組織構築と機能
        • a. 原始卵胞
        • b. 発育卵胞
        • c. 成熟卵胞
        • d. 排卵
        • e. 黄体
        • f. 白体
    • B. ゴナドトロピンの作用
      • 1. ゴナドトロピン受容体の構造
        • a. LH/CG受容体の構造
        • b. FSH受容体の構造
      • 2. ゴナドトロピン受容体の局在とその変動
      • 3. ゴナドトロピンとその作用
      • 4. ゴナドトロピン受容体と情報伝達系
        • a. cAMP-プロテインキナーゼA系
        • b. ホスホリパーゼC-プロテインキナーゼC系
      • 5. ゴナドトロピン受容体の異常
    • C. 性ステロイドホルモンの合成と分泌
      • はじめに
      • 1. ステロイドホルモンとは
      • 2. 卵巣におけるステロイドホルモン産生
        • a. コレステロールよりプレグネノロンへ
        • b. プレグネノロンよりプロゲステロンへ
        • c. プロゲステロンからアンドロゲンへ
        • d. C19ステロイドよりエストロゲンへ
        • e. 卵巣におけるその他のステロイド合成代謝
        • f. 各種ステロイド合成酵素の局在と遺伝子発現の月経周期変動
      • 3. 卵巣の性ステロイドホルモン合成・分泌の調節
        • a. エストロゲンによる調節
        • b. アンドロゲンによる調節
    • D. 細胞内コレステロール輸送機構 卵巣におけるステロイドホルモン産生の調節を理解するために
      • はじめに
      • 1. LDL受容体
      • 2. LDL受容体からミトコンドリアの外膜まで
        • a. ペルオキシソーム
        • b. sterol carrier protein 2 (SCP2)
      • 3. ミトコンドリアの外膜から内膜へ
        • a. 末梢性ベンゾジアゼピン受容体
        • b. steroidogenic acute regulatory protein (StAR)
      • おわりに ― StARからCSCCへ
  • IV 卵胞の発育と閉鎖
    P.183閲覧
    • A. 卵胞発育と単一排卵の機序
      • 1. 卵子の発生と卵胞の形成
      • 2. 幼小児期の卵胞の発育と閉鎖
      • 3. 月経周期にみられる卵胞発育と主席卵胞の選別
        • a. 原始卵胞から主席卵胞予備群まで
        • b. 主席卵胞発現から排卵まで
      • 4. 黄体機能と卵胞発育
      • 5. 加齢に伴う卵胞発育の変化
      • 6. 卵胞の発育と閉鎖の主要調節因子
    • B. 顆粒膜 - 莢膜細胞間相互作用による卵胞機能調節
      • はじめに
      • 1. 原始卵胞から一次卵胞への発育
        • a. 原始卵胞の発育開始と細胞間相互作用
      • 2. 一次卵胞から二次卵胞への発育
        • a. 細胞間相互作用による発育調節
      • 3. antral follicleへの発育
        • a. 卵胞の形態変化
        • b. 細胞間相互作用による発育調節
      • 4. selectable follicleへの発育
        • a. 顆粒膜 - 莢膜細胞の増殖調節機構
        • b. 高アンドロゲン / 低エストロゲン環境形成メカニズム
      • 5. 主席卵胞の選択と発育
        • a. 顆粒膜細胞のaromatase活性亢進と主席卵胞選択のメカニズム
        • b. two-cell, two-gonadotropin modeによるエストラジオール産生機構の完成
        • c. 顆粒膜 - 莢膜細胞間相互作用によるtwo-cell, two-gonadotropin modeの修飾 (説)
      • 6. 卵胞期後期の主席卵胞発育
        • a. 顆粒膜 - 莢膜細胞間相互作用の役割
      • 7. コラーゲン膜両面培養系を用いた顆粒膜 - 莢膜細胞間相互作用の観察
      • 8. 卵胞閉鎖と顆粒膜 - 莢膜細胞間相互作用
      • おわりに
    • C. 卵の成熟と卵胞内環境
      • 1. 卵の発育と成熟
        • a. 卵の発育
        • b. 卵の成熟
        • c. 卵成熟度の評価
        • d. 卵成熟の分子機構
      • 2. 卵胞内環境と卵の成熟
        • a. 卵胞内因子
        • b. ステロイドホルモン
        • c. プロスタグランジン
        • d. 上皮増殖因子
        • e. アクチビン, フォリスタチン
        • f. そのほかの局所因子
    • D. 卵胞閉鎖とアポトーシス
      • はじめに
      • 1. アポトーシスの概念
        • a. ネクローシスとの差異
        • b. DNA断片化
        • C. アポトーシスに関与する因子
      • 2. 顆粒膜細胞でのアポトーシス
        • a. ゴナドトロピン
        • b. ステロイド
        • c. 上皮増殖因子
        • d. 酸化ストレス
        • e. p53
        • f. vasoactive intestinal peptide (VIP)
        • g. cAMP
        • h. 成長ホルモン
        • i. ICE
        • j. bcl-2ファミリー
        • k. Fas-Fasリガンド
        • l. 細胞接着
        • m. セラミド
      • 3. ヒト卵巣におけるアポトーシス
        • a. 卵胞の発育とアポトーシス
        • b. 子宮内膜症とアポトーシス
    • E. 成長因子
      • はじめに
      • 1. 甲状腺ホルモン
      • 2. インスリン
      • 3. IGF-1
      • 4. EGF
      • 5. TGF-α
      • 6. myc遺伝子産物
      • 7. TNF-α
      • 8. TGF-β
      • 9. アポトーシスと卵胞閉鎖
      • おわりに
    • F. サイトカイン
      • 1. reproduction and lymphohematopoietic system
      • 2. 産生と局在
        • a. IL-1
        • b. IL-6
        • c. TNF-α
        • d. IFN-γ
        • e. エンドセリン
        • f. M-CSF
      • 3. ステロイドホルモン産生への影響
        • a. IL-1
        • b. IL-6
        • c. TNF-α
        • d. IFN-γ
        • e. エンドセリン
      • 4. 卵胞発育への影響
        • a. IL-1
        • b. IL-6
        • c. TNF-α
        • d. エンドセリン
        • e. M-CSF
      • 5. 排卵現象への影響
        • a. IL-1
        • b. TNF-α
        • c. エンドセリン2
      • 6. サイトカイン研究の今後の展望
    • アミノペプチダーゼ
      • 1. 細胞膜結合型ペプチダーゼ
      • 2. 卵巣における細胞膜結合型アミノペプチダーゼの発現
        • a. アミノペプチダーゼN
        • b. ジペプチジルペプチダーゼIV
      • 3. 卵巣における膜結合型カルボキシペプチダーゼの発現
      • 4. 卵胞発育とアミノペプチダーゼ
      • 5. 細胞表面ペプチド代謝における各ペプチダーゼの協調作用
  • V 排卵機構
    P.263閲覧
    • 1. 排卵機構に関する研究の進展
    • 2. 排卵過程の形態生理学的変化の概観
    • 3. 卵胞破裂に関与する因子
      • a. プロスタグランジン
      • b. プロゲステロン
      • c. タンパク質分解酵素 (排卵酵素)
      • d. キニン, カリクレイン
      • e. サイトカイン
      • f. プロラクチン
      • g. レニン - アンジオテンシン系
      • h. 成長ホルモンとインスリン様増殖因子-I
      • i. 血小板活性化因子
      • j. 活性酸素と排卵
      • k. 平滑筋収縮
    • 4. 卵胞破裂機序の作業仮説
  • VI 黄体の形成と退行
    P.283閲覧
    • A. 動物の進化と黄体
      • 1. 黄体の意義と起源
        • a. 黄体の起源
        • b. ステロイド生合成系におけるプロゲステロンの位置付け
        • c. プロゲステロンの標的 - 卵管と子宮
      • 2. 性周期と妊娠期の黄体
        • a. 性周期の多様性と適応
        • b. 不完全性周期動物の性周期黄体 - プロラクチンと20α-HSD
        • c. 性周期黄体の寿命と妊娠黄体
      • 3. ラット黄体の形成と退行
        • a. 黄体の形成と維持 ― プロラクチンと20α-HSD
        • b. 黄体の機能的退行 ― 20α-HSDとP450c26
        • c. 黄体の形態的退行とアポトーシス
    • B. 黄体機能の調節機序
      • 1. 概略
      • 2. 哺乳類における黄体形成
        • a. 形態学的変化
        • b. ステロイド合成
      • 3. 黄体調節因子
        • a. 内分泌的因子
        • b. 局所因子
    • C. 黄体の退行
      • 1. 黄体の比較内分泌学
      • 2. 下垂体性ゴナドトロピンによる黄体機能の調節と黄体退行
      • 3. 黄体退行とゴナドトロピン受容体
        • a. 形態学的検討
        • b. 125I-LHの結合実験
        • c. LH/CG受容体mRNAの発現
      • 4. 黄体退行とプロスタグランジン
      • 5. 黄体退行と成長因子, サイトカイン
      • 6. 黄体のアポトーシス (細胞自死) と活性酸素
    • D. 妊娠黄体
      • はじめに
      • 1. 妊娠黄体の種類
      • 2. プロゲステロン産生機構
      • 3. 黄体機能調節因子
        • a. プロラクチン
        • b. LH
        • c. エストロゲン
        • d. プロスタグランジン
        • e. 活性酸素と消去系
        • f. その他の因子
      • 4. 妊娠に伴う黄体機能の延長
        • a. ultrashort-lived黄体
        • b. short-lived黄体
      • おわりに
  • VII 他内分泌系と性機能
    P.331閲覧
    • 1. 甲状腺
      • a. 視床下部 - 下垂体 - 甲状腺系の機能環と甲状腺ホルモンの作用機序
      • b. 甲状腺と卵巣の機能相関
      • c. 甲状腺機能異常症と月経異常
      • d. 切迫流産患者の甲状腺機能
    • 2. 副腎
      • a. 副腎性器症候群
      • b. Cushing症候群
      • c. Addison病
    • 3. 膵疾患
      • a. 糖尿病
      • b. 多嚢胞性卵巣症候群と糖代謝異常
    • 4. 膠原病
      • a. 全身性エリテマトーデス
      • b. Behcet病
    • 5. 自己免疫疾患
      • a. 続発性無月経と自己免疫疾患
  • VIII 子宮内膜
    P.345閲覧
    • A. 機能と形態
      • 1. 子宮内膜組織の発生
      • 2. 新生児から思春期までの子宮内膜組織の発達
      • 3. 子宮内膜周期的変化の形態学
        • a. 増殖期
        • b. 分泌期
        • c. 月経期
      • 4. 正常閉経後子宮内膜
      • 5. 子宮内膜周期的変化の機能学
        • a. 細胞成長因子
        • b. 細胞外基質
        • c. サイトカインネットワーク
        • d. 血流調節物質
        • e. 子宮内膜波状運動
    • B. 脱落膜化
      • 1. 脱落膜の定義と由来
      • 2. 脱落膜と動物種差
      • 3. 月経周期での脱落膜化
      • 4. 脱落膜化の意義
      • 5. 脱落膜化により増加する因子
      • 6. 脱落膜化に関与する諸因子
      • 7. 脱落膜化の抑制
      • 8. implantation windowと脱落膜化
    • C. 剥脱機構
      • 1. 月経期における子宮内膜の組織学的変化
      • 2. 月経期における子宮内膜剥脱の生化学的調節機構
        • a. リソソーム酵素
        • b. マトリックスメタロプロテアーゼ / 組織メタロプロテアーゼインヒビター系
        • c. プラスミノーゲンアクチベーター / プラスミノーゲンアクチベーターインヒビター系
        • d. エイコサノイド
        • e. 増殖因子, サイトカイン
        • f. Bcl-2 ファミリー
      • 3. 月経困難症
    • D. 子宮頸管, 腟の周期性変化
      • 1. 子宮頸管
        • a. 子宮頸管組織
        • b. 頸管粘液
        • c. 頸管粘液分泌異常
        • d. 頸管内精子上昇
        • e. 性交後試験
      • 2. 腟
        • a. 組織学
        • b. 剥離細胞および周期性変化
  • Glossary
    P.385閲覧
  • 索引
    P.395閲覧
    • 和文索引
    • 欧文索引
  • 奥付

参考文献

I 月経周期と間脳 - 下垂体 - 卵巣 - 子宮系

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II 間脳 - 下垂体系

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V 排卵機構

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VI 黄体の形成と退行

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VIII 子宮内膜

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