書籍詳細

序章 個人対応栄養学の潮流

P.11 掲載の参考文献

• 1) Khaw K.T., Wareham N., Luben R. et al.:Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European prospective investigation of cancer and nutrition (EPIC-Norfork). Br Med J 2001; 322; 15-18.

• 2) Lyssenko V., Almgren P., Anevski D. et al.:Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type two diabetes. Diabetes 2005; 54; 166-174.

• 3) Spranger J., Kroke A., Mohlig M. et al.:Adiponectin and protection against type two diabetes mellitus. Lancet 2003; 361; 226-228.

• 4) Trujillo M.E., Scherer P.E.:Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Inten Med 2005; 257;167-175.

• 5) Spranger J., Kroke A., Mohlig M. et al.:Inflammatory cytokines and the risk to develop type two diabetes:results of the prospective population based European Prospective Investigation into Cancer and Nutrition(EPIC)-Potsdam Study. Diabetes 2003; 52; 812-817.

• 6) German J.B., Roberts M.A., Watkins S.M.:Personal metabolomics as a next generation nutritional assessment. J Nutr 2003; 133; 4260-4266.
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• 7) Zeisel S.H., Freake H.C., Bauman D.E. et al.:The nutritional phenotype in the age of metabolomics. J Nutr 2005; 135; 1613-1616.
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第1編 個人対応栄養学の原理と技術

P.26 掲載の参考文献

• 1) Sebat J., Lakshmi B., Troge J. et al.:Large-scale copy number polymorphism in the human genome. Science 2004; 305; 525-528.
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• 2) Manolio T.A., Brooks L.D., Collins F.S.:A Hap Map harvest of insights into the genetics of common disease. J Clin Invest 2008; 118; 1590-1605.

• 3) Weinshilboum R.:Inheritance and drug response. N Engl J Med 2003; 348;529-537.
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• 4) Klerk M., Verhoef P., Clarke R. et al.:MTHFR 677CT polymorphism and risk of coronary heart disease:a meta-analysis. JAMA 2002; 288; 2023-2031.

• 5) Ward R.:Familial aggregation and genetic epidemiology of blood pressure. In:Hypertension Pathophysiology, Diagnosis, and Management, Laragh J.H.,Brenner B.M.(ed), Raven press, New York, 1995.

• 6) Khaw K.T., Barrett-Connor E.:The association between blood pressure, age, and dietary sodium and potassium:a population study. Circulation 1988; 77;53-61.
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• 7) Morris R.C. Jr, Schmidlin O., Frassetto L.A. et al.:Relationship and interaction between sodium and potassium. J Am Coll Nutr 2006; 25; 262S-270S.
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• 8) Katsuya T., Ishikawa K., Sugimoto K. et al.:Salt sensitivity of Japanese from the viewpoint of gene polymorphism. Hypertens Res 2003; 26; 521-525.
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• 9) Beeks E., Kessels A.G., Kroon A.A. et al.:Genetic predisposition to saltsensitivity:a systematic review. J Hypertens 2004; 22; 1243-1249.
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• 10) Wilson F.H., Disse-Nicodeme S., Choate K.A. et al.:Human hypertension caused by mutations in WNK kinases. Science 2001; 293; 1107-1112.
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• 11) Jeunemaitre X., Soubrier F., Kotelevtsev Y. et al.:Molecular basis of human hypertension:role of angiotensinogen. Cell 1992; 71; 169-180.
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• 12) Wade J.B., Fang L., Liu J. et al.:WNK1 kinase isoform switch regulates renal potassium excretion. Proc Natl Acad Sci USA 2006; 103; 8558-8563.
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• 13) Subramanya A.R., Yang C.L., Mc Cormick J.A. et al.:WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron. Kidney Int 2006; 70; 630-634.
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• 14) Mc Cormick J.A., Yang C.L., Ellison D.H.:WNK kinases and renal sodium transport in health and disease:an integrated view. Hypertension 2008; 51;588-596.
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• 15) Neel J.V.:Diabetes mellitus a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 1962; 14; 352-353.

• 16) Walston J., Silver K., Bogardus C. et al.:Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med 1995; 333; 343-347.

• 17) Kagawa Y., Yanagisawa Y., Hasegawa K. et al.:Single nucleotide polymorphisms of thrifty genes for energy metabolism:evolutionary origins and prospects for intervention to prevent obesity-related diseases. Biochem Biophys Res Commun 2002; 295; 207-222.
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• 18) Kadowaki T., Hara K., Yamauchi T. et al.:Molecular mechanism of insulin resistance and obesity. Exp Biol Med 2003; 228:1111-1117.
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• 19) Ordovas J.M., Tai E.S.:Why study gene-environment interactions? Curr Opin Lipidol 2008; 19; 158-167.

• 20) Wellcome Trust Case Control Consortium:Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447; 661-678.

• 21) Saxena R., Voight B.F., Lyssenko V. et al.:Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007; 316;331-336.

• 22) Zeggini E., Weedon M.N., Lindgren C.M. et al.:Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316; 1336-1341.
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• 23) Scott L.J., Mohlke K.L., Bonnycastle L.L. et al.:A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316; 1341-1345.
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• 24) Omori S., Tanaka Y., Takahashi A. et al.:Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 2008; 57; 791-795.

• 25) Tabara Y., Osawa H., Kawamoto R. et al.:Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. Diabetes 2009; 58; 493-498.
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• 26) Yasuda K., Miyake K., Horikawa Y. et al.:Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 2008; 40; 1092-1097.
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• 27) Unoki H., Takahashi A., Kawaguchi T. et al.:SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 2008; 40; 1098-1102.
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第2章 ニュートリゲノミクスのヒトへの応用戦略

P.59 掲載の参考文献

• 1) Afman L.A., Muller M.:Nutrigenomics and transcriptomics:Applications of microarray analyses in nutrition research. In:Personalized Nutrition-Principles and Applications, Kok F., Bouwman L., Desiere F.( ed), CRC Press, Boca Raton, 2008, p3-12.

• 2) Chatterjee S.K., Zetter B.R.:Cancer biomarkers:knowing the present and predicting the future. Future Oncol 2005; 1; 37-50.
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• 3) German J.B., Roberts M.A., Watkins S.M.:Personal metabolomics as a next generation nutritional assessment. J Nutr 2003; 133; 4260-4266.
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• 4) Clement K., Viguerie N., Poitou C. et al.:Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J 2004; 18;1657-1669.
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• 5) Mootha V.K., Lindgren C.M., Eriksson K.F. et al.:PGC-1alpha-responsive genes involved in oxidative phosphorylation arecordinately down regulated in human diabetes. Nat Genet 2003; 34; 267-273.

• 6) Sparks L.M., Xie H., Koza R.A. et al.:A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 2005; 54; 1926-1933.
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• 7) Martin K.J., Graner E., Li Y. et al.:High-sensitivity array analysis of gene expression for the early detection of disseminated breast tumor cells in peripheral blood. Proc Natl Acad Sci USA 2001; 98; 2646-2651.
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• 8) Valk P.J., Verhaak R.G., Beijen M.A. et al.:Prognostically useful gene-expression profiles in acute myeloid leukemia. N Eng J Med 2004; 350;1617-1628.

• 9) Cobb J.P., Mindrinos M.N., Miller-Graziano C. et al.:Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci USA 2005; 102; 4801-4806.
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• 10) Fukaya N., Mochizuki K., Shimada M., Goda T.:The α-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of inflammatory cytokines induced by hyperglycemia in peripheral leukocytes. Nutrition 2009;in press.

• 11) Tanaka Y., Mochizuki K., Fukaya N. et al.:The α-glucosidase inhibitor miglitol suppresses postprandial hyperglycemia and interleukin-1β and tumour necrosis factor- α gene expression in rat peripheral leucocytes induced by intermittent sucrose loading. Br J Nutr 2009; 13; 1-5.

• 12) Shoelson S.E., Lee J., Goldfine A.B.:Inflammation and insulin resistance. J Clin Invest 2006; 116; 1793-1801.
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• 13) Goda T., Suruga K., Komori A. et al.:Effects of miglitol, an ｦﾁ-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in nonobese,none-insulin-dependent diabetic Goto-Kakizaki rats. Br J Nutr 2007; 98;702-710.

• 14) Fujimoto S., Mochizuki K., Shimada M. et al.:Variation in gene expression of inflammatory cytokines in leukocyte-derived cells of high-fat-diet-induced insulin-resistant rats. Biosci Biotechnol Biochem 2008; 72; 2572-2579.
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• 15) Hanefeld M., Koehler C., Henkel E. et al.:Post-challenge hyperglycaemia relates more strongly than fasting hyperglycaemia with carotid intima-media thickness:the RIADStudy. Risk factors in impaired glucose tolerance for atherosclerosis and diabetes. Diabet Med 2000; 17; 835-840.
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• 16) Lazar M.A.:The humoral side of insulin resistance. Nat Med 2006; 12; 43-44.
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• 17) Weyer C., Funahashi T., Tanaka S. et al.:Hypoadiponectinemia in obesity and type 2 diabetes:close association with insulin resistance and hyper insulinemia. J Clin Endocrinol Metab; 86; 1930-1935.

• 18) 加瀬澤信彦, 遠山和成, 島田昌也ほか: 人間ドック男性受診者におけるコンピュータ断層撮影スキャン腹部皮下および内臓脂肪面積の増減と生活習慣の関連性. 人間ドック 2007; 22; 370-377.
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• 19) Weisberg S.P., Mc Cann D., Desai M. et al.:Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112; 1796-1808.
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• 20) Suganami T., Nishida J., Ogawa Y.:A paracrine loop between adipocytes and macrophages aggravates inflammatory changes:role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thrombo Vasc Biol; 25; 2062-2068.

• 21) Esmaillzadeh A., Kimiagar M., Mehrabi Y. et al.:Dietary patterns, insulin resistance, and prevalence of the metabolic syndrome in women. Am J Clin Nutr 2007; 85; 910-918.
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• 22) Nettleton J.A., Steffen L.M., Mayer-Davis E.J. et al.:Dietary patterns are associated with biochemical markers of inflammation and endothelial activation in the Multi-Ethnic Study of Atherosclerosis(MESA). Am J Clin Nutr 2006;83; 1369-1379.

第3章 プロテオミクスによる生活習慣病リスクバイオマーカーの探索

P.69 掲載の参考文献

• 1) Ahsan H., Ali A., Ali R.:Oxygen free radicals and systemic autoimmunity. Clin Exp Immunol 2003; 131; 398-404.

• 2) Kovacic P., Jacintho J.D.:Systemic lupus erythematosus and other autoimmune diseases from endogenous and exogenous agents:unifying theme of oxidative stress. Mini Rev Med Chem 2003; 3; 568-575.
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• 3) Toyoda K., Nagae R., Akagawa M. et al.:Protein-bound 4-hydroxy-2-nonenal:an endogenous triggering antigen of anti-DNA response. J Biol Chem 2007;282; 25769-25778.
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• 4) Chou M.Y., Hartvigsen K., Hansen L.F. et al.:Oxidation-specific epitopes are important targets of innate immunity. J Intern Med 2008; 263; 479-488.
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• 5) Manabe E., Handa O., Naito Y. et al.:Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. J Cell Biochem 2008; 103:1925-1937.
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• 6) Naito Y., Takagi T., Yoshikawa T.:Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease. J Gastroenterol 2007; 42; 787-798.
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• 7) Aoi W., Naito Y., Takanami Y. et al.:Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPTI modification. Biochem Biophys Res Commun 2008; 366; 892-897.

• 8) Aoi W., Naito Y., Sakuma K. et al.:Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal 2003; 5;139-144.
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• 9) Tirumalai R.S., Chan K.C., Prieto D.A. et al.:Characterization of the low molecular weight human serum proteome. Mol Cell Proteomics 2003; 2;1096-1103.
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• 10) Shen Y., Kim J., Strittmatter E.F. et al.(2nd) Fang R., Tolie N., Moore R.J. et al.:Characterization of the human blood plasma proteome. Proteomics 2005;5; 4034-4045.

• 11) Hortin G.L.:The MALDI-TOF mass spectrometric view of the plasma proteome and peptidome. Clin Chem 2006; 52; 1223-1237.
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• 12) Lowenthal M.S., Mehta A.I., Frogale K. et al.(3rd) Liotta L.A.:Analysis of albumin-associated peptides and proteins from ovarian cancer patients. Clin Chem 2005; 51; 1933-1945.

• 13) Yamato M., Shiba T., Yoshida M. et al.:Fatty acids increase the circulating levels of oxidative stress factors in mice with diet-induced obesity via redox changes of albumin. Febs J 2007; 274; 3855-3863..
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• 14) Vay D., Parodi M., Rolla R. et al.:Circulating antibodies recognizing malondialdehyde-modified proteins in healthy subjects. Free Radic Biol Med 2001; 30; 277-286.
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• 15) Palacio J.R., Iborra A., Ulcova-Gallova Z. et al.:The presence of antibodies to oxidative modified proteins in serum from polycystic ovary syndrome patients. Clin Exp Immunol 2006; 144; 217-222.
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• 16) Glushchenko A.V., Jacobsen D.W.:Molecular targeting of proteins by L-homocysteine:mechanistic implications for vascular disease. Antioxid Redox Signal 2007; 9; 1883-1898.
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第4章 抗体チップによる未病診断・食品機能性評価の新しい展開

P.82 掲載の参考文献

• 1) 大澤俊彦: 生活習慣病とがん罹患リスク-肥満, 脂質摂取など. 医学と薬学 2006; 55(3); 311-321.
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• 2) 大澤俊彦: タンパクチップ. ストレスの科学と健康 (二木鋭雄編著), 共立出版, 2008, p282-287.

• 3) 大澤俊彦: バイオマーカーの開発. 抗肥満食品・素材開発と応用展開-メタボリックシンドロームにおけるバイオマーカーの確立と応用 (大澤俊彦監修), シーエムシー出版, 2007, p1-10.

• 4) 大澤俊彦: 健康機能食品とバイオマーカー (ORAC, AOUを含む). アンチエイジング医学-日本抗加齢医学会雑誌 2008; 4(1); 37-43.

• 5) Kato Y., Yoshida A., Naito M. et al.:Identification and quantification of Nε-(Hexanoyl)lisine in human urine by liquid chromatography/tandem mass spectrometry. Free Radic Biol Med 2004; 37; 1864-1874.

• 6) Kawai Y., Kato Y., Fujii H. et al.:Immunochemical characterization of a novel lysine adduct using an antibody to linoleic acid hydroperoxide-modified protein. J Lipid Res 2003; 44; 1124-1131.

• 7) Hisaka S., Dozaki N., Nakamura T. et al.:Chemical and immunochemical identification of propanoyllysine derived from oxidized n-3 poly unsaturated fatty acid.Free Radic Biol Med 2009(in press).

• 8) Kawai Y., Fujii H., Okada M. et al.:Formation of N-epsilon-(succinyl)lysine in vivo:a novel marker for docosahexaenoic acid-derived protein modification. J Lipid Res 2006; 47(7); 1386-1398.

• 9) Liu X., Yamada N., Maruyama W. et al.:Formation of dopamine adducts derived from brain polyunsaturated fatty acid:Mechanism for Parkinson's disease. J Biol Chem 2008; 283(50); 34887-34895.
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• 10) Kato Y., Kawai Y., Morinaga H. et al.:Immunogenicity of a brominated protein and successive establishment of a monoclonal antibody to dihalogenated tyrosine. Free Radic Biol Med 2005; 38(1); 24-31.
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• 11) Ishitsuka Y., Maniwa F., Koide C. et al.:Detection of modified tyrosines as an inflammation marker in a photo-aged skin model. Photochem Photobiol 2007;83; 698-705.

• 12) 大澤俊彦: 抗酸化成分の役割とフィトケミカルへの期待. アンチエイジング・ヘルスフード-抗加齢・疾病予防・健康寿命延長への応用 (水島裕監修, 青木晃, 白澤卓二, 矢澤一良, 米井嘉一編集), サイエンスフォーラム, 2008, p39-47.

第5章 個人対応栄養指標確立に向けたメタボリックプロファイリング法の重要性と可能性

P.103 掲載の参考文献

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• 2) Raamsdonk L.M., Teusink B., Broadhurst D. et al.:A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat Biotechnol 2001; 19; 45-50.

• 3) Tweeddale H., Notley-McRobb L., Ferenci T.:Effect of slow growth on metabolism of Escherichia coli, as revealed by global metabolite poo l("Metabolome") analysis. J Bacteriol 1998; 180; 5109-5116.

• 4) Trethewey R.N., Krotzky A.J., Willmitzer L.:Metabolic profiling:a Rosetta stone for genomics? Curr Opin Plant Biol 1999; 2; 83-85.
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• 5) Harrigan G.G., Goodacre R.:Metabolic Profiling:Its role in Biomarker Discovery and Gene Function Analysis, Kluwer, Boston, 2003.

• 6) 西岡孝明, 藤田捻夫: 構造活性相関とドラッグデザインにおける計算機の利用. 有機合成とコンピューター(有機合成化学協会編), シュプリンガー・フェアラーク東京(株), 1983, p27-48.

• 7) Reo N.V.:NMR-based metabolomics. Drug Chem Toxicol 2002; 25; 375-382.
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• 8) Aharoni A., Ric de Vos C.H., Verhoeven H.A. et al.:Nontargeted metabolome analysis by use of Fourier Transform Ion Cyclotron Mass Spectrometry. OMICS 2002; 6; 217-234.
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• 9) Castrillo J.I., Hayes A., Mohammed S. et al.:An optimized protocol for metabolome analysis in yeast using direct infusion electrospray mass spectrometry. Phytochemistry 2003; 62; 929-937.
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• 10) Fiehn O., Kopka J., Dormann P. et al.:Metabolite profiling for plant functional genomics. Nat Biotechnol 2000; 18; 1157-1161.
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• 11) Johnson S.K., Houk L.L., Johnson D.C. et al.:Determination of small carboxylic acids by capillary electrophoresis with electrospray-mass spectrometry. Anal Chim Acta 1999; 389; 1-8.

• 12) Soga T., Ohashi Y., Ueno Y. et al.:Quantitative metabolome analysis using capillary electrophoresis mass spectrometry. J Proteome Res 2003; 2;488-494.
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• 13) Kanehisa M., Goto S., Kawashima S. et al.:The KEGG databases at genome net. Nucleic Acids Res 2002; 30; 42-46.

• 14) Tomita M., Hashimoto K., Takahashi K. et al.:E-CELL:software environment for whole-cell simulation. Bioinformatics 1999; 15; 72-84.
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• 15) Sugiura K., Min J.Z., Toyo'oka T. et al.:Rapid, sensitive and simultaneous determination of fluorescence-labeled polyamines in human hair by high-pressure liquid chromatography coupled with electrospray-ionization time-of-flight mass spectrometry. J Chromatogr A 2008; 1205; 94-102.

• 16) Kawanishi H., Toyo'oka T., Ito K., et al.:Rapid determination of histamine and its metabolites in mice hair by ultra-performance liquid chromatography with time-of-flight mass spectrometry. J Chromatogr A 2006; 1132; 148-156.

• 17) Inagaki S., Noda T., Min J.Z. et al.:Metabolic profiling of rat hair and screening biomarkers using ultra performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. J Chromatogr A 2007;1176; 94-99.
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• 18) Taguchi R., Hayakawa J., Takeuchi Y. et al.:Two-dimensional analysis of phospholipidsnby capillary liquid chromatography/electrospray ionization mass spectrometry. J Mass Spectrom 2000; 35; 953-966.
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• 19) Noguchi Y., Zhang Q.W., Sugimoto T. et al.:Network analysis of plasma and tissue amino acids and the generation of an amino index for potential diagnostic use. Am J Clin Nutr 2006; 83(suppl); 513S-519S.

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• 21) Satoh S., Toyo'oka T., Fukushima T. et al.:Simultaneous determination of α-lipoic acid and its reduced form by high-performance liquid chromatography with fluorescence detection. J Chromatogr B 2007; 854; 109-115.

• 22) Yamaguchi M., Ishida J.:Reagent for FL detection. In:Modern derivatization method for separation sciences, Toyo'oka T(ed), John Wiley & Sons,Chichester, England, 1999, p99-165.

• 23) Satoh S., Shindoh M., Min J.Z. et al.:Selective and sensitive determination of lipoyllysine (protein-bound a-lipoic acid) in biological specimens by high-performance liquid chromatography with fluorescence detection. Anal Chim Acta 2008; 618; 210-217.

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第2編 個人対応栄養学の応用と実践

P.128 掲載の参考文献

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• 3) Gluckman P.D., Hanson M.A., Beedle A.S.:Early life events and their consequences for later disease:a life history and evolutionary perspective. Am J Hum Biol 2007; 19(1); 1-19.

• 4) Harder T., Rodekamp E., Schellong K. et al.:Birth weight and subsequent risk of type 2 diabetes:a meta-analysis. Am J Epidemiol 2007; 165; 849-857.
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• 5) de Boo H.A., Harding J.E.:The developmental origins of adult disease (Barker) hypothesis. Aust N Z J Obstet Gynaecol 2006; 46; 4-14.
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• 6) Hughson M., Farris A.B. 3rd, Douglas-Denton R. et al.:Glomerular number and size in autopsy kidneys:the relationship to birth weight. Kidney Int 2003; 63; 2113-2122.
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• 7) Pham T.D., MacLennan N.K., Chiu C.T. et al.:Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney. Am J Physiol Regul Integr Comp Physiol 2003; 285; R962-970.
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• 8) Baserga M., Hale M.A., Mc Knight R.A. et al.:Uteroplacental insufficiency alters hepatic expression, phosphorylation, and activity of the glucocorticoid receptor in fetal IUGR rats. Am J Physiol Regul Integr Comp Physiol 2005;289; R1348-1353.
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• 9) Sinclair K.D., Allegrucci C., Singh R. et al.:DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci USA 2007; 104:19351-19356.
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• 10) Tra J., Kondo T., Lu Q. et al.:Infrequent occurrence of age-dependent changes in Cp G island methylation as detected by restriction landmark genome scanning. Mech Ageing Dev 2002; 123; 1487-1503.

• 11) Smiraglia D.J., Plass C.:The study of aberrant methylation in cancer via restriction landmark genomic scanning. Oncogene 2002; 21; 5414-5426.

• 12) Ehrlich M.:Cancer-linked DNA hypomethylation and its relationship to hypermethylation. Curr Top Microbiol Immunol 2006; 310; 251-274.
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• 13) MacLennan N.K., James S.J., Melnyk S. et al.:Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. Physiol Genomics 2004; 18; 43-50.alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. Physiol Genomics 2004; 18; 43-50.

• 14) Lillycrop K.A., Phillips E.S., Jackson A.A. et al.:Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 2005; 135;1382-1386.
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• 15) Weaver I.C., Cervoni N., Champagne F.A. et al.:Epigenetic programming by maternal behavior. Nat Neurosci 2004; 7:847-854.
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• 16) Diorio J., Meaney M.J.:Maternal programming of defensive responses through sustained effects on gene expression. J Psychiatry Neurosci 2007; 32; 275-284.
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第7章 葉酸代謝関連遺伝子多型に基づくテーラーメイド栄養の実践

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第8章 骨粗鬆症とテーラーメイド栄養学

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終章 個人対応栄養学の展望

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