書籍詳細

Part1: 薬物間相互作用の基礎知識

P.29 掲載の参考文献

• 1) 千葉寛:チトクロームP-450を介した薬物相互作用. ファルマシア 31:992-996, 1995

• 2) 千葉寛:相互作用から見た薬物代謝. 日本病院薬剤師会雑誌 31:981-987, 1995

• 3) Wagner, F., Kalusche, D., Trenk, D. et al.:Drug interaction between propafenone and metoprolol. Br. J. CIin. Pharmacol. 24:213-220, 1987

• 4) Wijnands, W. J., Vree, T. B. and van Herwaarden, C. L.:The influence of quinolone derivatives on theophylline clearance. Br. J. Clin. Pharmacol. 22:677-683, 1986
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• 5) Upton, R. A.:Pharmacokinetic interaction between theophylline and other medication (part I, II) Clin. Pharmacokinet. 20:66-80, 135-150, 1991

• 6) Periti, P., Mazzei, T., Mini, E. et al.:Pharmacokinetic drug interactions of macrolides. Clin. Pharmacokinet. 23:106-131, 1992
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• 7) Zimmermann, M., Duruz, H., Guinand, O. et al.:Torsades de pointes after treatment with terfenadine and ketoconazole. Eur. Heart J. 113:1002-1003, 1992

• 8) Goss, J. E., Ramo, B. W., Blake, K. et al.:Torsades de pointes associated with astemizole (Hismanal) therapy. Arch. Intern. Med. 153:2705, 1993
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• 9) Murray, M.:P-450 enzymes. Clin. Pharmacofeinet. 23:132-146, 1992

• 10) Somogyi, A. and Murhead, M:Pharmacokinetic interaction of cimetidine 1987. Clin. Pharmacokinet. 12:321-366, 1987

• 11) Knodell, R. G., Browne, D. G., Gwozdz, G. P. et al.:Differential inhibition of individual human liver cytochromes P-450 by cimetidine. Gastroenterology 101:1680-691, 1991
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• 12) Maurice, M., Pichard, L., Daujat, M. et al. Effects of imidazole derivatives on cytochromes P-450 from human hepatocytes in primary culture. FASEB J. 6:752-758, 1992
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• 13) Schein, J. R.,:Cigarette smoking and clinical significant drug interactions. Ann. Pharmather. 29:1139-1148, 1995

• 14) Kivistro, K. T., Kroemer, H. K. and Eichelbaum, M.:The role of human cytochrome P-450 enzymes in the metabolism of anticancer agents:implications for drug interactions. Br. J. Clin. Pharmacol. 40:523-530, 1995

P.43 掲載の参考文献

• 1) 厚生省薬務局企画課監修:医薬品相互作用ハンドブック. 薬業時報社, 東京, 1992

• 2) 乾賢一:小腸及び腎尿細管上皮細胞膜における薬物輸送機構に関する研究. 薬学雑誌 108:921-937, 1988

• 3) 高野幹久, 乾賢一:医薬品の腎排泄機構. ファルマシア 32:400-405, 1996

• 4) 乾賢一:尿細管上皮細胞の. 薬物輸送系. BIO Clinica 11:970-973, 1996

• 5) Pritchard, J. B. and Miller, D. S.:Mechanisms mediating renal secretion of organic anions and cations. Physiol. Rev. 73:765-796, 1993
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• 6) Katsura, T., Takano, M., Tomita, Y. et al.:Characteristics of organic cation transporter in rat renal basolateral membrane. Biochim. Biophys. Acta 1146:197-202, 1993
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• 7) Saito, H., Yamamoto, M., Inui, K. et al.:Transcellular transport of organic cation across monolayers of kidney epithelial cell line LLC-PK,. Am. J. Physiol. 262:C59-C66, 1992
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• 8) Grundemann, D., Gorboulev, V., Gambaryan, S. et al.:Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372:549-552, 1994
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• 9) Okuda, M., Saito, H., Urakami, Y. et al.:cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem. Biophys. Res. Commun. 224:500-507, 1996
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• 10) Nagai, J., Takano, M., Hirozane, K. et al.:Specificity of p-amino-hippurate transport system in the OK kidney epithelial cell line. J. Pharmacol. Exp. Ther. 274:1161-1166, 1995

• 11) Jacqemin, E., Hagenbuch, B., Stieger, B. et al.:Expression cloning of a rat liver Na+-independent organic anion transporter. Proc. Natl. Acad. Sci. USA 91:133-137, 1994
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• 12) Saito, H., Masuda, S. and Inui, K:Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J. Biol. Chem. 271:20719-20725, 1996
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• 13) Gottesman, M. M. and Pastan, I.:Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:385-427, 1993
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• 14) Tanigawara, Y., Okamura, N, Hirai, M. et al.:Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J. Pharmacol. Exp. Ther. 263:840-845, 1992

• 15) Fei, Y.-J., Kanai, Y., Nussberger, S. et al.:Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368:563-566, 1994
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• 16) Saito, H., Okuda, M., Terada, T. et al.:Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of B-lactam antibiotics in the intestine and kidney. J Pharmacol. Exp Ther. 275:1631-1637, 1995

• 17) Saito, H., Terada, T., Okuda, M. et al.:Molecular cloning and tissue distribution of rat peptide transporter PEPT2. Biochim. Biophys. Acta 1280:173-177, 1996
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• 18) Takano, M., Ohishi, Y., Okuda, M. et al.:Transport of gentamicin and fluid-phase endocytosis markers in the LLC-PK1 kidney epithelial cell line. J. Pharmacol. Exp. Ther. 268:669-674, 1994

• 19) Moestrup, S. K., Cui, S., Vorum, H. et al.:Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J. Clin. Invest. 96:1404-1413, 1995
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P.60 掲載の参考文献

• 1) Klaassen, C. D. and Watkins, III, J. B.:Mechanisms of bile formation, hepatic uptake, and biliary excretion. Pharmacol. Rev. 36:1-68, 1984

• 2) Oude Elferink, R. P. J., Meijer, D. K. F., Kuipers, F. et al.:Hepatobiliary secretion of organic compounds;molecular mechanisms of membrane transport. Biochim. Biophys. Acta 1241:21-268, 1995

• 3) Yamazaki, M., Suzuki, H. and Sugiyama, Y.:Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenbiotics. Pharm. Res. 13:497-513, 1996

• 4) Joseph, S. K., Bradford, N. M. and Mcgivan, J. D.:Characteristics of the transport of alanine, serine and glutamine across the plasma membrane of isolated rat liver cells. Biochem. J. 176:827-836, 1978
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• 5) LeCam, A. and Freychat, P.:Neutral amlno Characterization of the A and L systems in isolated rat hepatocytes. J. Biol. Chem. 252:148-156, 1977

• 6) Goldenberg, G., Lam, H. and Begleiter, A.:Active carrier-mediated transport of melphalan by two separate amino acid transport systems in LPC-1 plasmacytoma cells in vitro. J. Biol. Chem. 254:1057-1064, 1979
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• 7) Arric, B. A. and Nathan, C. F.:Glutathione metabolism as a determinant of therapeutic efficacy:a review. Cancer Res. 44:4224-4232, 1984

• 8) Plagemann, P. G. W., Wohlhueter, R. M. and Woffendin, C.:Nucleoside and nucleobace transport in animal cells. Biochim. Biophys. Acta 974:405-443, 1988

• 9) Pritchard, J. B., O' connor, N., Oliver, J. M. et al.:Uptake and supply of purine compounds by the liver. Am. J. Physiol. 229:967-972, 1975
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• 10) Frimmer, M. and Ziegler, K.:The transport of bile acids in liver cells. Biochim. Biophys. Acta 947:75-99, 1988
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• 11) Hagenbuch, B., Stieger, B., Foguet, M. et al.:Functional expresstion cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc. Natl. Acad. Sci. USA 488:10692-10633, 1991

• 12) Hagenbuch, B. and Meier, P. J.:Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransport. J. Clin. Invest. 93:1326-1331, 1994
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• 13) Boelsterli, U. A., Zimmerli, B. and Meier, P. J.:Identification and characterization of a basolateral dicarboxylate/cholate antiport system in rat hepatocytes. Am. J. Physiol. 268:G797-G805, 1995
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• 14) Zimmerli, B., Valantinas, J. and Meier, P. J.:Multispecificity of Na+/dependent taurocholate uptake in basolateral (sinusoidal) rat liver plasma membrane vesicles. J. Pharm. Exp. Ther. 250:301-308, 1989

• 15) Siegler, K., Frimmer, M., Kessler, H. el al.:Modified somatostatins as inhibitors of a multispecific transport systems for bileacids and phallotoxin. Biochim. Biophys. Acta 845:86-93, 1985

• 16) Gewirtz, D., Randolph, J. K. and Goldman, I. D.:Potent bile saltand organic anion inhibition of methotrexate uptake and accumulation in the freshly isolated rat hepatocyte. Cancer Res. 40:1852-1857, 1980

• 17) Horne, D. W. and Reed, K. A.:Transport of methotrexate in basolateral membrane vesicles from rat liver. Arch. Biochem. Biophys. 298:121-128, 1992
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• 18) Rord, J. M. and Hait, W. N.:Pharmacology of drugs that altermultidrug resistance in cancer. Pharmacol. Rev. 42:155-199, 1990

• 19) Rohme, M, Muller, M., Leier, I. et al.:Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology 107:225-265, 1994

• 20) Jacquemin, E., Hagenbuch, B., Stieger, B. et al.:Expression cloning of a rat liver Na+-independent organic anion transporter. Proc. Natl. Acad. Sci. USA 91:133-137, 1994
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• 21) Steen, H. and Meijer, D. K F.:Biliary excretion of drugs and other chemicals. In:Progress in Pharmacology and Clinical Pharmacology, vol. 8/9, ed. by Siegers, C. P. and Watkins, J. B. G, Fischer Verlag, Stuttgart-New York, 1991

• 22) Mol, W. E. M., Fokkema, G. N., Weert, B. et al.:Mechanisms for the hepatic uptake of organic cations. Studies with the muscle relaxant vecuronium in isolated rat hepatocytes. J. Pharm. Exp. Ther. 244:268-275, 1988

• 23) Steen, H., Oosting, R. and Mejier, D. K. F.:Mechanisms for the uptake of cationic drugs by the liver:a study with tributylmethylammonium (TBuMA). J. Pharm. Exp. Ther. 258:537-543, 1991

• 24) 治療薬マニュアル96. 医学書院, 東京, 1996

• 25) Gatmaitan, Z. C. and Arias, I. M.:ATP-dependent transport systems in the canalicular membrane of the hepatocyte. Physiol. Rev. 75:261-275, 1995
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• 26) Arias, I. M., Gatmaitan, C. Z., Leveille, C. et al.:The biology ofthe bile canaliculus, 1993. Hepatology 17:318-319, 1993

• 27) Che, M., Nishida, T., Gatmaitan, Z. et al.:A nucleoside transporter is functionally linked to ectonucleotidases in rat liver canalicular membrane. J. Biol. Chem. 267:9684-9688, 1992
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• 28) Che, M., Ortiz, D. F. and Arias, I. M.:Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na+/nucleoside cotransporter. J. Biol. Chem. 270:13596-13599, 1995
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• 29) Adachi, Y., Kobayashi, H., Kurumi, Y. et al.:ATP-dependent taurocholate transport by rat liver canalicular membrane vesicles. Hepatology 14:655-659, 1991
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• 30) Paulusma, C. C., Bosma, P. J., Zaman, J. R. et al.:Congenital jaundice in rats with a mutation in a multidrug resistance-as-sociated protein gene. Science 271:1126-1128, 1996

• 31) Gupta, E., Lestingi, T. M., Mick, R. et al.:Melabolic fate of irinotecan in humans:correlation of glucuronidation with diarrhea. Cancer Res. 54:3723-3725, 1994
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• 32) Lien, E. A., Anker, G., Lonning, P. E. et al.:Decreased serum concentrations of tamoxifen and its metabolites induced by aminoglutethimide. Cancer Res. 50:5851-5857, 1990
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• 33) Hande, K., Anthony, L, Hamilton, R. et al.:Indentification of etoposide glucuronide as major metabolite of etoposide in the rat and rabbit. Cancer Res. 48:1829-1834, 1988

• 34) Sommadossi, J.-P., Cross, D. S., Gewirtz, D. A. et al.:Evidence from rat hepatocytes of an unrecognized pathway of 5-fluorour-acil metabolism with the formation of a glucuronide derivative. Cancer Res. 45:2450-2455, 1985

• 35) Gottesman, M. M. and Pastan, I.:Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:385-427, 1993
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• 36) Bellamy, W. T.:P-glycoprotein and multidrug resistance. Annu. Rev. Toxicol. 36:161-183, 1996
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• 37) Kamimoto, Y., Gatmaitan, Y. G., Hsu, J. et al.:The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles. J. Biol. Chem. 264:11693-11698, 1989

• 38) Watanabe, T., Miyauchi, S., Sawada, Y. et al.:Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver. J. Hepatol. 16:77-88, 1992

• 39) Bolombo, T., Zucchetti, M. and D'incalci, M.:Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats. J. Pharm. Exp. Ther. 269:22-27, 1994

• 40) Smit, J. J. M., Schinkel, A. H., Elferink, R. P. J. O. et al.:Homozygous disruption of the murine mdr2 p-glycoprotein gene leads to a complete absence of phospholipid from bile and liver disease. Cell 75:451-462, 1993

• 41) Raderer, M. and Scheithauer, W.:Clincal trials of agents that reverse multidrug resistance. Cancer 72:3533-3562, 1993

• 42) Lum, B. L., Fisher, G. A., Brophy, N. A. et al.:Clinical trials of modulation of multidrug resistance. Pharmacokinetic and pharmacodynamic considerations. Cancer 72:3502-3514, 1993
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• 43) Ford, J. M. and Hait, W. N.:Pharmacologic circumvention of multidrug resistance. Cytotechnology 12:171-212, 1993
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• 44) Schuets, E. G., Schinkel, A. H., Relling, M. V. et al.:P-glyco-protein:a major determinant of rifampicin-inducible expression of cytochrome P450A in mice and humans. Proc. Natl. Acad. Sci. USA 93:4001-4005, 1996

P.78 掲載の参考文献

• 1) Lipka, E., Crison, J. R., Schug, B. S. et al.:Drug interactions in the gastrointestinal tract and their impact on drug absorption and systemic availability:a mathematic review. In:Handbook of Experimental Pharmacology, Mechanisms of Drug lnteractions, vol. 122, ed. by D'Arcy P. F., McElnay, J. C., Weling, P. G., Springer, 1996, pp.13-43

• 2) Lebsack, M. E., Nix, D., Ryeerson, B. et al.:Effect of gastric acidity on enoxacin absorption. Clin. Pharmacol. Ther. 52:252-256, 1992

• 3) Van del Meer, J. W., Keuning, J. J., Scheijgrond, H. W. et al.:The influence of gastric acidity on the bioavailability of ketoconazole. J. Antimicrob. Chemother. 6:552-554, 1980

• 4) Barr, W. H., Adir, J. and Garrettson, K.:Decrease of tetracycline absorption in man by sodium bicarbonate. Clin. Pharmacol. Ther. 12:779-784, 1971

• 5) Nimmo, J., Heading, R. C., Tothill, P. et al.:Pharmacological modification of gastric emptying:effects of propantheline and metoclopramide on paracetamol absorption. Br. Med. J. 1:587-589, 1973
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• 6) Manninen, V., Apajalahti, A., Melin, J. et al.:Altered absorption of digoxin in patients given propantheline and metoclopramide. Lancet 800:398-400, 1973

• 7) Levy, G. and Rao, B. K.:Enhanced intestinal absorption of rivoflavin from sodium alginate solution in man. J. Pharm. Sci. 61:279-280, 1972

• 8) Friedman, H. S. and Bonvetre, M. V.:Erythromycin-induced digoxin toxicity. Chest 82:202, 1982

• 9) Neuvonen, P. J., Gothoni, G. and Hackman, R.:Interference of iron with the absorption of tetracyclines in man. Br. Med. J. 4:532-534, 1970

• 10) Shiba, K., Saito, A., Miyahara, T. et al.:Effect of aluminum hydroxide, an antacid, on the pharmacokinetics of new quinolones in humans. 薬物動態 3:717-722, 1988

• 11) Ueno, K., Tanaka, K., Tsujimura, K. et al.:Impairment of cefdinir absorption by iron ion. Clin. Pharmacol. Ther. 54:473-475, 1993
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• 12) Tsuji, A. and Tamai, I.:Carrier-mediated intestinal transport of drugs. Pham. Res. 13:963-967, 1996

• 13) Garrigues, T. M., Martin, U., Peris-Ribera, J. E. et al.:Dose-dependent absorption and elimination of cefadroxil in man. Euz. J. Clin. Pharmacol. 41:179-183, 1991

• 14) 林喜代美, 崔吉道, 玉井郁巳ほか:小腸オリゴペプチド輸送担体クローンを利用したβ-ラクタム抗生物質の経口デリバリースクリーニング系開発への試み. Drug Delivery System 11:205-213, 1996

• 15) 玉井郁巳, 辻彰:ジペプチドトランスポーターと医薬品の消化管吸収. ファルマシア 31:493-497, 1995

• 16) Terao, T., Hisanaga, H., Sai, Y. et al.:Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. J. Pharm. Pharmacol. 48:1083-1089, 1996

• 17) Hunter, J., Hirst, B. H. and Simmons, N. L.:Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharm. Res. 10:743-749, 1993
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• 18) Leu, B.-L. and Huang, J.-D:Inhibition of intestinal P-glyco-protein and effects on etoposide absorption. Cancer Chemother. Pharmacol. 35:432-436, 1995

• 19) Lennernas, H. and Regardh, C. G.:Dose-dependent intestinal absorption and significant intestinal secretion (exsorption) of the beta-blocker pafenolol in the rat. Pharm. Res. 10:727-731, 1993

• 20) Murray, G. I., Barnes, T. S., Sewell, H. F. et al.:The immunocytochemical localization and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450. Br. J. Clin. Pharmacol. 25:465-475, 1988
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• 21) Ducharme, M. P., Warbasse, L. H. and Edwards, D. J.:Disposition of intravenous and oral cyclosporin after administration with grapefruit juice. Clin. Pharmacol. Ther. 57:485-491, 1995
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• 22) Gomez, D. Y., Wacher, V. J, Tomlanovich, S. H. et al.:The effects of ketoconazole on the intestinal metabolism and biovailability of cyclosporine. Clin. Pharmacol. Ther. 58:15-19, 1995

• 23) Holtbecker, N., Fromm, M. F., Kroemer, H. K. et al.:The nifedipine-rifampicin interaction. Evidence for induction of gut wall metabolism. Drug. Metab. Disp. 24:1221-1123, 1996

P.91 掲載の参考文献

• 1) Yokogawa, K., Nakashima, E., Ishizaki, J. et al.:Relationships in the structure-tissue distribution of basic drugs in the rabbit. Pharm. Res. 7:691-696, 1990
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• 2) Nakashima, E. and Benet, L. Z.:General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment. J. Pharmacokinet. Biopharm. 16:475-492, 1988
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• 3) Deguchi, Y., Koshida, R., Nakashima, E. et al.:Interindividual changes in volume of distribution of cefazolin in newborn infants and its prediction based on physiological pharmacokinetic concepts. J. Pharm. Sci. 77:674-678, 1988
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• 4) Yamada, K., Yasuhara, M., Yatsuzuka, A. et al.:Mechanisms of pharmacokinetic interaction between propranolol and quinidine in rats. Chem. Pharm. Bull. Tokyo 40:1876-1879, 1992
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• 5) Jacolot, A., Tod, M. and Petitjean, O.:Pharmacokinetic interaction between cefdinir and two angiotensin-converting enzyme inhibitors in rats. Antimicrob. Agents Chemother. 40:979-982 1996
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• 6) Ball, W. J., Tse, E. D., Wallick, E. T. et al.:Effect of quinidine on the digoxin receptor in vitro. J. Clin. Invest. 68:1065-1074, 1981

• 7) Robieux, I., Dorian, P., Klein, J. et al.:The effects of cardiac transplantation and cyclosporine therapy on digoxin pharmacokinetics. J. Clin. Pharmacol. 32:338-343, 1992

• 8) Baughman, G., Wiederrecht, G. J., Campbell, N. F. et al.:FKBP51, anovel T-cell-specific immunophilin capable of calcineurin inhibition. Mol. Cell. Biol. 15:4395-4402, 1995

• 9) Grem, J. L, Mulcahy, R. T., Miller, E. M. et al.:Interaction of deoxyuridine with fluorouracil and dipyridamole in a human colon cancer cell line. Biochem. Pharmacol. 38:51-59, 1989

• 10) Lombes, M., Binart, N., Delahaye, F. et al.:Differential intracellular localization of human mineralocorticosteroid receptor on binding of agonists and antagonists. Biochem. J. 302:191-197, 1994
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• 11) Buhrer, M., Mappes, A., Lauber, R. et al.:Dexmedetomidine decreases thiopental dose requirement and alters distribution pharmacokinetics. Anesthesiology 80:1216-1227, 1994
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• 12) Lourwood, D. L., Berchou, R. C. and Louis, F. R.:Diminished mephobarbital anticonvulsant action following diphenhydramine pretreatment. Res. Commun. Chem. Pathol. Pharmacol. 77:273-284, 1992

P.101 掲載の参考文献

• 1) 緊急安全性情報「抗ウイルス剤 ユースビル剤 (ソリブジン) とフルオロウラシル系薬剤との併用による重篤な血液障害について」平成5年10月

• 2) Desgranges,C., Razaka,G., De Clercq,E. et al.:Effect of (E)-5-(2-bromovinyl) uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice. Cancer Res. 46:1094-1101, 1986
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• 3) 吉船伸一, 笠井浩, 長坂保則ほか:ラットにおけるYN (ソリブジン) とフルオロウラシル系薬剤との相互作用の検討. 基礎と臨床 26:2675-2688, 1994

• 4) 西本敬史, 横山信治, 坂本博彦ほか:ブロバビル (YN-72) の生体内動態 (第2報), ラットにおける代謝. 医薬品研究 21:378-389, 1990

• 5) Diasio, R. B. and Harris,B. E.:Clinical pharmacology of 5-fluorouracil. Clin.Pharmacokin. 16:215-237, 1989

• 6) 奥田晴宏, 西山貴仁, 小倉健一郎ほか:ラットにおけるソリブジンと 5-フルオロウラシル誘導体の併用経口投与による致死的毒性発現とそのメカニズム. 薬物動態10 (suppl.):S166-S169, 1995

• 7) 荻原俊男, 三上洋, 中丸光昭ほか:抗ウイルス剤YN-72 (BV-araU, ブロバビル) の臨床第一相試験. 薬理と治療18:507-523, 1990

• 8) 澤田康文:薬の飲み合わせ. 講談社ブルーバックス, 東京, 1996

Part2: 分類別抗癌剤の薬物間相互作用

P.115 掲載の参考文献

• 1) Colvin,M.:The alkylating agents. In:Pharmacologic Principles Of Cancer Treatment. (Chabner, B.A. ed.)

• 2) Struck,R.F., Alberts,D.S., Horne,K. et al.:Plasma pharmacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous versus oral administration in a randomized, crossover trial Cancer Res. 47:2723-2726, 1987

• 3) Kupari, M., Volin, L., Suokas,A. et al.:Cardiac involvement in bone marrow transplantation:serial changes ill left ventricular size, mass and performance. J.Intern.Med. 227:259-266, 1990

• 4) Gryn,J., Gordon,R., Bapat,A. et al.:Pentostatin increases the acute toxicity of high dose cyclophosphamide. Bone Marrow Transplant. 12:217-220, 1993
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• 5) 下山正徳, 仁井谷久暢, 木村禧代二:Cyclophosphamide及びその関連活性型物質の化学療法効果. 1. Phenobarbitalによるcyclophosphamideの活性化増強の意義と血中活性型物質の殺細胞作用. 癌と化学療法 2:877-882, 1975
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• 6) Faber,O. K., Mouridsen,H.T. and Skovsted,L.:The biotransformation of cyclophosphamide in man:influence of prednisone. Acta Pharmacol. Toxicol. 35:195-200, 1974
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• 7) Kuhlmann, J., Zilly,W. and Wilke, J.:Effects of cytostatic drugs on plasma level and renal excretion on beta-acetyldigoxin. Clin. Pharmacol. Ther. 30:518-527, 1981
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• 8) Dillman, J.B.:Safe use of succinylcholine during repeated aneshetics in patient treated with cyclophosphamide. Anesth. Analg. 66:351-353, 1987
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• 9) Boston Collaborative Drug Surveillance Program:Allopurinol and cytotoxic drugs. JAMA 227:1036-1040, 1974
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• 10) Witten, J., Frederiksen, P.L. and Mouridsen, H.T.:The pharmacokinetics of cyclophosphamide in man after treatment with allopurinol. Acta Pharmacol. Toxicol. 46:392-394, 1980
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Part3: 各臓器癌に対する多剤併用療法の薬物間相互作用

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Part4: 薬物間相互作用を回避するためのソフトと八ード

P.419 掲載の参考文献

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• 3) 澤田康文, 伊賀立二:Part 3:薬物間相互作用研究の問題点と今後の展望, 大学における研究者からの提言 (その1). 総合特集:薬物間相互作用と医薬品の適性使用. 月刊薬事 (2月臨時増刊号) 38:725-750, 1996

• 4) 澤田康文編, 伊賀立二監修:総合特集:薬物間相互作用と医薬品の適性使用. 月刊薬事 (2月臨時増刊号) 38:449-905, 1996

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• 8) 澤田康文, 伊賀立二編:特集/臨床医のための薬物間相互作用. 治療 76:2213-2372, 1994

• 9) 澤田康文, 山田安彦著, 伊賀立二監修:シリーズ:GPのためのファーマコロジー (1)〜(29). Clinician, エーザイ, 1993-1996

• 10) 澤田康文著, 伊賀立二監修:臨床医のための薬の相互作用とそのマネージメント. 南山堂, 東京, 1996

• 11) 澤田康文, 山田安彦, 伊賀立二:薬物療法のQuality-of-Lifeへの影響;その実態, 予測と制御-テルフェナジンと他の薬物との相互作用によるQOLの悪化;テルフェナジンによる心血管系副作用. 月刊薬事 36:1293, 1994, 36:1563, 1994, 36:2051, 1994

P.433 掲載の参考文献

• 1) 伊賀立二, 澤田康文:とくに注意を要する薬物間相互作用. 医学のあゆみ 136:442-601, 1992

• 2) 澤田康文, 伊賀立二:薬剤の相互作用. 研修医ノート, 診断と治療社, 東京, 1995, pp.592-595

• 3) 山田安彦, 伊賀立二:薬物‐薬物間相互作用. 臨床麻酔 20:1112-1118 1996

• 4) 伊賀立二, 山田安彦, 澤田康文:特集「医療用医薬品添付文書」はどうあるべきか:薬物間相互作用と医薬品添付文書. 薬局 47:1517-1531, 1996

• 5) 伊賀立二:平成7年度厚生科学研究, 医薬品添付文書の見直し等に関する研究,-相互作用欄の見直し-, 報告書. 臨床評価 24:125-146, 1996

• 6) 溝上直子, 松山恭子, 山田安彦ほか:新たな外来業務の展開6‐外来患者への能動的薬品情報提供 (2) 『お薬説明カード』による薬品情報提供-相互作用.副作用の回避へ向けて-. 薬局 48:841-849, 1997

• 7) 鈴木あやな, 溝上直子, 折井孝男ほか:患者への薬品情報の適正な提供-「処方カード」を利用した処方情報の提供-. JJSHP 31:199-205, 1995

• 8) 高柳理早, 松山恭子, 伊賀立二ほか:新たな外来業務の展開4-「お薬手帳」を活用した患者自身による薬歴の一元管理-患者本位の適正使用の実現へ. 薬局 48:78-95, 1997

付

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